3'-5' exonuclease, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3'-5' exonuclease, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X7Q1_LEIDO

TriTrypDb:

LdBPK_341340.1 , LdCL_340019400 , LDHU3_34.2090

Length:

548

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X7Q1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7Q1

Function

Biological processes
Term	Name	Level	Count
GO:0000459	exonucleolytic trimming involved in rRNA processing	8	1
GO:0000467	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	1
GO:0000469	cleavage involved in rRNA processing	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0031123	RNA 3'-end processing	7	1
GO:0031125	rRNA 3'-end processing	9	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043628	regulatory ncRNA 3'-end processing	8	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	7	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003824	catalytic activity	1	8
GO:0004518	nuclease activity	4	8
GO:0004527	exonuclease activity	5	8
GO:0005488	binding	1	8
GO:0008408	3'-5' exonuclease activity	6	8
GO:0016787	hydrolase activity	2	8
GO:0016788	hydrolase activity, acting on ester bonds	3	8
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8
GO:0003723	RNA binding	4	1
GO:0000175	3'-5'-RNA exonuclease activity	7	1
GO:0004532	RNA exonuclease activity	5	1
GO:0004540	RNA nuclease activity	4	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	268	270	PF00675	0.517
CLV_NRD_NRD_1	344	346	PF00675	0.360
CLV_NRD_NRD_1	422	424	PF00675	0.494
CLV_PCSK_KEX2_1	380	382	PF00082	0.537
CLV_PCSK_KEX2_1	422	424	PF00082	0.514
CLV_PCSK_KEX2_1	492	494	PF00082	0.447
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.452
CLV_PCSK_PC1ET2_1	492	494	PF00082	0.412
CLV_PCSK_PC7_1	488	494	PF00082	0.306
CLV_PCSK_SKI1_1	125	129	PF00082	0.296
CLV_PCSK_SKI1_1	195	199	PF00082	0.389
CLV_PCSK_SKI1_1	238	242	PF00082	0.373
CLV_PCSK_SKI1_1	269	273	PF00082	0.394
CLV_PCSK_SKI1_1	332	336	PF00082	0.490
CLV_PCSK_SKI1_1	353	357	PF00082	0.456
CLV_PCSK_SKI1_1	407	411	PF00082	0.404
CLV_PCSK_SKI1_1	56	60	PF00082	0.304
DEG_SCF_SKP2-CKS1_1	532	539	PF00560	0.569
DOC_CYCLIN_RxL_1	401	413	PF00134	0.423
DOC_MAPK_gen_1	269	276	PF00069	0.581
DOC_MAPK_gen_1	281	288	PF00069	0.243
DOC_MAPK_gen_1	471	480	PF00069	0.419
DOC_MAPK_gen_1	77	86	PF00069	0.549
DOC_MAPK_MEF2A_6	269	278	PF00069	0.423
DOC_MAPK_MEF2A_6	471	480	PF00069	0.419
DOC_PP4_FxxP_1	347	350	PF00568	0.432
DOC_PP4_MxPP_1	348	351	PF00568	0.414
DOC_USP7_MATH_1	148	152	PF00917	0.459
DOC_USP7_MATH_1	33	37	PF00917	0.499
DOC_USP7_MATH_1	386	390	PF00917	0.464
DOC_USP7_MATH_1	400	404	PF00917	0.274
DOC_USP7_UBL2_3	110	114	PF12436	0.465
DOC_USP7_UBL2_3	397	401	PF12436	0.392
DOC_USP7_UBL2_3	431	435	PF12436	0.407
DOC_USP7_UBL2_3	539	543	PF12436	0.551
DOC_WW_Pin1_4	337	342	PF00397	0.395
DOC_WW_Pin1_4	533	538	PF00397	0.639
LIG_14-3-3_CanoR_1	181	188	PF00244	0.461
LIG_14-3-3_CanoR_1	471	477	PF00244	0.441
LIG_Actin_WH2_2	146	163	PF00022	0.515
LIG_APCC_ABBA_1	371	376	PF00400	0.397
LIG_APCC_ABBAyCdc20_2	435	441	PF00400	0.399
LIG_BRCT_BRCA1_1	18	22	PF00533	0.465
LIG_BRCT_BRCA1_1	35	39	PF00533	0.443
LIG_BRCT_BRCA1_1	435	439	PF00533	0.561
LIG_BRCT_BRCA1_1	95	99	PF00533	0.483
LIG_FHA_1	329	335	PF00498	0.418
LIG_FHA_1	368	374	PF00498	0.368
LIG_FHA_1	454	460	PF00498	0.329
LIG_FHA_1	473	479	PF00498	0.355
LIG_FHA_2	259	265	PF00498	0.352
LIG_FHA_2	382	388	PF00498	0.485
LIG_FHA_2	435	441	PF00498	0.449
LIG_IRF3_LxIS_1	39	44	PF10401	0.501
LIG_LIR_Apic_2	130	135	PF02991	0.486
LIG_LIR_Gen_1	403	412	PF02991	0.333
LIG_LIR_Gen_1	436	446	PF02991	0.478
LIG_LIR_Gen_1	540	548	PF02991	0.520
LIG_LIR_Nem_3	19	25	PF02991	0.579
LIG_LIR_Nem_3	343	347	PF02991	0.412
LIG_LIR_Nem_3	357	363	PF02991	0.262
LIG_LIR_Nem_3	403	408	PF02991	0.381
LIG_LIR_Nem_3	436	442	PF02991	0.386
LIG_LIR_Nem_3	516	520	PF02991	0.467
LIG_LIR_Nem_3	540	544	PF02991	0.567
LIG_PALB2_WD40_1	17	25	PF16756	0.420
LIG_PCNA_yPIPBox_3	77	90	PF02747	0.465
LIG_Pex14_2	442	446	PF04695	0.446
LIG_Pex14_2	490	494	PF04695	0.409
LIG_PTB_Apo_2	440	447	PF02174	0.410
LIG_Rb_pABgroove_1	272	280	PF01858	0.428
LIG_REV1ctd_RIR_1	43	51	PF16727	0.501
LIG_SH2_CRK	405	409	PF00017	0.402
LIG_SH2_CRK	541	545	PF00017	0.530
LIG_SH2_CRK	95	99	PF00017	0.465
LIG_SH2_NCK_1	383	387	PF00017	0.448
LIG_SH2_SRC	360	363	PF00017	0.464
LIG_SH2_STAP1	375	379	PF00017	0.441
LIG_SH2_STAP1	394	398	PF00017	0.281
LIG_SH2_STAP1	405	409	PF00017	0.382
LIG_SH2_STAP1	95	99	PF00017	0.501
LIG_SH2_STAT5	152	155	PF00017	0.390
LIG_SH2_STAT5	251	254	PF00017	0.383
LIG_SH2_STAT5	360	363	PF00017	0.464
LIG_SH2_STAT5	383	386	PF00017	0.440
LIG_SH2_STAT5	497	500	PF00017	0.411
LIG_SH3_5	537	541	PF00018	0.536
LIG_UBA3_1	392	401	PF00899	0.324
MOD_CDK_SPxK_1	533	539	PF00069	0.566
MOD_CK1_1	163	169	PF00069	0.532
MOD_CK1_1	212	218	PF00069	0.593
MOD_CK2_1	127	133	PF00069	0.484
MOD_CK2_1	197	203	PF00069	0.467
MOD_CK2_1	258	264	PF00069	0.514
MOD_CK2_1	381	387	PF00069	0.481
MOD_CK2_1	434	440	PF00069	0.527
MOD_CK2_1	454	460	PF00069	0.248
MOD_Cter_Amidation	204	207	PF01082	0.474
MOD_GlcNHglycan	168	171	PF01048	0.542
MOD_GlcNHglycan	214	217	PF01048	0.597
MOD_GlcNHglycan	225	228	PF01048	0.480
MOD_GlcNHglycan	244	247	PF01048	0.396
MOD_GlcNHglycan	71	74	PF01048	0.281
MOD_GlcNHglycan	95	98	PF01048	0.326
MOD_GSK3_1	317	324	PF00069	0.429
MOD_GSK3_1	506	513	PF00069	0.427
MOD_GSK3_1	69	76	PF00069	0.481
MOD_LATS_1	223	229	PF00433	0.438
MOD_LATS_1	263	269	PF00433	0.382
MOD_N-GLC_1	117	122	PF02516	0.329
MOD_N-GLC_1	166	171	PF02516	0.447
MOD_N-GLC_1	367	372	PF02516	0.353
MOD_N-GLC_1	454	459	PF02516	0.319
MOD_N-GLC_1	82	87	PF02516	0.265
MOD_N-GLC_2	299	301	PF02516	0.351
MOD_NEK2_1	1	6	PF00069	0.551
MOD_NEK2_1	112	117	PF00069	0.474
MOD_NEK2_1	136	141	PF00069	0.465
MOD_NEK2_1	179	184	PF00069	0.454
MOD_NEK2_1	241	246	PF00069	0.428
MOD_NEK2_1	317	322	PF00069	0.381
MOD_NEK2_1	32	37	PF00069	0.496
MOD_NEK2_1	41	46	PF00069	0.469
MOD_NEK2_2	367	372	PF00069	0.353
MOD_NEK2_2	400	405	PF00069	0.332
MOD_NEK2_2	434	439	PF00069	0.412
MOD_PIKK_1	317	323	PF00454	0.352
MOD_PIKK_1	381	387	PF00454	0.395
MOD_PKA_2	180	186	PF00069	0.471
MOD_Plk_1	117	123	PF00069	0.529
MOD_Plk_1	367	373	PF00069	0.362
MOD_Plk_1	454	460	PF00069	0.323
MOD_Plk_1	73	79	PF00069	0.501
MOD_Plk_1	82	88	PF00069	0.425
MOD_Plk_4	148	154	PF00069	0.511
MOD_Plk_4	388	394	PF00069	0.618
MOD_Plk_4	400	406	PF00069	0.432
MOD_Plk_4	434	440	PF00069	0.467
MOD_Plk_4	454	460	PF00069	0.248
MOD_Plk_4	60	66	PF00069	0.469
MOD_Plk_4	85	91	PF00069	0.486
MOD_ProDKin_1	337	343	PF00069	0.401
MOD_ProDKin_1	533	539	PF00069	0.576
MOD_SUMO_for_1	198	201	PF00179	0.383
MOD_SUMO_rev_2	183	193	PF00179	0.425
MOD_SUMO_rev_2	273	282	PF00179	0.465
MOD_SUMO_rev_2	389	399	PF00179	0.405
MOD_SUMO_rev_2	513	519	PF00179	0.382
TRG_DiLeu_BaEn_3	387	393	PF01217	0.467
TRG_DiLeu_BaEn_3	424	430	PF01217	0.381
TRG_DiLeu_BaLyEn_6	404	409	PF01217	0.408
TRG_ENDOCYTIC_2	360	363	PF00928	0.529
TRG_ENDOCYTIC_2	405	408	PF00928	0.327
TRG_ENDOCYTIC_2	541	544	PF00928	0.521
TRG_ENDOCYTIC_2	95	98	PF00928	0.501
TRG_Pf-PMV_PEXEL_1	407	411	PF00026	0.374

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBV0	Leptomonas seymouri	54%	98%
A0A1X0NK05	Trypanosomatidae	27%	73%
A0A422NPF9	Trypanosoma rangeli	24%	69%
A4HAP1	Leishmania braziliensis	72%	100%
A4I9T6	Leishmania infantum	99%	100%
E9B4U7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q379	Leishmania major	90%	100%
Q8VEG4	Mus musculus	24%	84%
Q9NVH0	Homo sapiens	22%	88%