Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X7P6_LEIDO

TriTrypDb:

LdBPK_341430.1 , LdCL_340020300 , LDHU3_34.2200

Length:

784

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X7P6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7P6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	437	441	PF00656	0.772
CLV_C14_Caspase3-7	577	581	PF00656	0.798
CLV_C14_Caspase3-7	593	597	PF00656	0.541
CLV_NRD_NRD_1	163	165	PF00675	0.708
CLV_NRD_NRD_1	193	195	PF00675	0.754
CLV_NRD_NRD_1	235	237	PF00675	0.659
CLV_NRD_NRD_1	462	464	PF00675	0.660
CLV_NRD_NRD_1	466	468	PF00675	0.673
CLV_NRD_NRD_1	511	513	PF00675	0.620
CLV_NRD_NRD_1	569	571	PF00675	0.720
CLV_NRD_NRD_1	58	60	PF00675	0.720
CLV_NRD_NRD_1	650	652	PF00675	0.612
CLV_NRD_NRD_1	7	9	PF00675	0.632
CLV_NRD_NRD_1	715	717	PF00675	0.660
CLV_NRD_NRD_1	90	92	PF00675	0.766
CLV_PCSK_FUR_1	161	165	PF00082	0.762
CLV_PCSK_FUR_1	460	464	PF00082	0.714
CLV_PCSK_KEX2_1	160	162	PF00082	0.765
CLV_PCSK_KEX2_1	163	165	PF00082	0.757
CLV_PCSK_KEX2_1	235	237	PF00082	0.656
CLV_PCSK_KEX2_1	462	464	PF00082	0.669
CLV_PCSK_KEX2_1	465	467	PF00082	0.674
CLV_PCSK_KEX2_1	511	513	PF00082	0.603
CLV_PCSK_KEX2_1	569	571	PF00082	0.798
CLV_PCSK_KEX2_1	58	60	PF00082	0.793
CLV_PCSK_KEX2_1	650	652	PF00082	0.612
CLV_PCSK_KEX2_1	7	9	PF00082	0.632
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.748
CLV_PCSK_PC7_1	462	468	PF00082	0.733
CLV_PCSK_SKI1_1	157	161	PF00082	0.805
CLV_PCSK_SKI1_1	390	394	PF00082	0.662
CLV_PCSK_SKI1_1	638	642	PF00082	0.543
DEG_COP1_1	675	685	PF00400	0.574
DEG_MDM2_SWIB_1	392	399	PF02201	0.448
DEG_Nend_UBRbox_1	1	4	PF02207	0.613
DEG_SCF_FBW7_2	290	297	PF00400	0.775
DEG_SCF_TRCP1_1	573	579	PF00400	0.628
DEG_SPOP_SBC_1	125	129	PF00917	0.767
DEG_SPOP_SBC_1	223	227	PF00917	0.720
DEG_SPOP_SBC_1	363	367	PF00917	0.641
DEG_SPOP_SBC_1	479	483	PF00917	0.639
DOC_CKS1_1	485	490	PF01111	0.744
DOC_CYCLIN_RxL_1	635	642	PF00134	0.570
DOC_CYCLIN_yCln2_LP_2	207	213	PF00134	0.690
DOC_CYCLIN_yCln2_LP_2	419	422	PF00134	0.525
DOC_CYCLIN_yCln2_LP_2	631	637	PF00134	0.645
DOC_MAPK_gen_1	7	13	PF00069	0.540
DOC_MAPK_MEF2A_6	687	696	PF00069	0.607
DOC_PP1_RVXF_1	529	535	PF00149	0.581
DOC_PP2B_LxvP_1	207	210	PF13499	0.813
DOC_PP2B_LxvP_1	419	422	PF13499	0.544
DOC_PP2B_LxvP_1	425	428	PF13499	0.572
DOC_PP4_FxxP_1	476	479	PF00568	0.698
DOC_PP4_FxxP_1	534	537	PF00568	0.630
DOC_PP4_FxxP_1	602	605	PF00568	0.743
DOC_USP7_MATH_1	118	122	PF00917	0.772
DOC_USP7_MATH_1	125	129	PF00917	0.760
DOC_USP7_MATH_1	169	173	PF00917	0.763
DOC_USP7_MATH_1	224	228	PF00917	0.736
DOC_USP7_MATH_1	247	251	PF00917	0.734
DOC_USP7_MATH_1	356	360	PF00917	0.736
DOC_USP7_MATH_1	363	367	PF00917	0.781
DOC_USP7_MATH_1	43	47	PF00917	0.625
DOC_USP7_MATH_1	433	437	PF00917	0.744
DOC_USP7_MATH_1	443	447	PF00917	0.810
DOC_USP7_MATH_1	480	484	PF00917	0.675
DOC_USP7_MATH_1	545	549	PF00917	0.728
DOC_USP7_MATH_1	605	609	PF00917	0.770
DOC_USP7_MATH_1	660	664	PF00917	0.687
DOC_USP7_MATH_1	736	740	PF00917	0.798
DOC_USP7_MATH_1	76	80	PF00917	0.700
DOC_USP7_UBL2_3	332	336	PF12436	0.695
DOC_WW_Pin1_4	17	22	PF00397	0.708
DOC_WW_Pin1_4	176	181	PF00397	0.753
DOC_WW_Pin1_4	184	189	PF00397	0.771
DOC_WW_Pin1_4	209	214	PF00397	0.685
DOC_WW_Pin1_4	269	274	PF00397	0.748
DOC_WW_Pin1_4	276	281	PF00397	0.729
DOC_WW_Pin1_4	290	295	PF00397	0.538
DOC_WW_Pin1_4	484	489	PF00397	0.671
DOC_WW_Pin1_4	491	496	PF00397	0.498
DOC_WW_Pin1_4	630	635	PF00397	0.648
DOC_WW_Pin1_4	672	677	PF00397	0.673
LIG_14-3-3_CanoR_1	138	144	PF00244	0.582
LIG_14-3-3_CanoR_1	175	180	PF00244	0.654
LIG_14-3-3_CanoR_1	26	32	PF00244	0.711
LIG_14-3-3_CanoR_1	687	695	PF00244	0.606
LIG_14-3-3_CanoR_1	716	726	PF00244	0.747
LIG_14-3-3_CanoR_1	741	748	PF00244	0.799
LIG_BIR_III_4	246	250	PF00653	0.753
LIG_BRCT_BRCA1_1	315	319	PF00533	0.652
LIG_BRCT_BRCA1_1	43	47	PF00533	0.760
LIG_CaM_IQ_9	450	465	PF13499	0.739
LIG_CaM_IQ_9	499	514	PF13499	0.618
LIG_EH_1	473	477	PF12763	0.597
LIG_eIF4E_1	635	641	PF01652	0.653
LIG_FHA_1	256	262	PF00498	0.683
LIG_FHA_1	266	272	PF00498	0.653
LIG_FHA_1	306	312	PF00498	0.632
LIG_FHA_1	379	385	PF00498	0.719
LIG_FHA_1	404	410	PF00498	0.619
LIG_FHA_1	485	491	PF00498	0.774
LIG_FHA_1	62	68	PF00498	0.726
LIG_FHA_1	691	697	PF00498	0.623
LIG_FHA_2	365	371	PF00498	0.820
LIG_FHA_2	429	435	PF00498	0.706
LIG_FHA_2	451	457	PF00498	0.753
LIG_LIR_Gen_1	30	39	PF02991	0.751
LIG_LIR_Gen_1	389	399	PF02991	0.589
LIG_LIR_Nem_3	30	34	PF02991	0.710
LIG_LIR_Nem_3	389	395	PF02991	0.611
LIG_LIR_Nem_3	45	51	PF02991	0.648
LIG_LIR_Nem_3	671	677	PF02991	0.773
LIG_MLH1_MIPbox_1	44	48	PF16413	0.715
LIG_MYND_1	205	209	PF01753	0.710
LIG_MYND_1	491	495	PF01753	0.644
LIG_Pex14_2	392	396	PF04695	0.440
LIG_Pex14_2	47	51	PF04695	0.673
LIG_REV1ctd_RIR_1	45	51	PF16727	0.550
LIG_SH2_CRK	526	530	PF00017	0.594
LIG_SH2_CRK	775	779	PF00017	0.679
LIG_SH2_STAP1	285	289	PF00017	0.757
LIG_SH2_STAP1	610	614	PF00017	0.799
LIG_SH2_STAP1	677	681	PF00017	0.738
LIG_SH2_STAP1	688	692	PF00017	0.647
LIG_SH2_STAT5	285	288	PF00017	0.760
LIG_SH2_STAT5	334	337	PF00017	0.552
LIG_SH2_STAT5	520	523	PF00017	0.634
LIG_SH2_STAT5	635	638	PF00017	0.714
LIG_SH2_STAT5	775	778	PF00017	0.647
LIG_SH3_1	680	686	PF00018	0.635
LIG_SH3_3	105	111	PF00018	0.734
LIG_SH3_3	203	209	PF00018	0.735
LIG_SH3_3	346	352	PF00018	0.625
LIG_SH3_3	436	442	PF00018	0.814
LIG_SH3_3	482	488	PF00018	0.749
LIG_SH3_3	622	628	PF00018	0.742
LIG_SH3_3	680	686	PF00018	0.601
LIG_SH3_3	765	771	PF00018	0.717
LIG_SUMO_SIM_anti_2	689	697	PF11976	0.608
LIG_SUMO_SIM_par_1	308	314	PF11976	0.629
LIG_SUMO_SIM_par_1	692	697	PF11976	0.612
LIG_SUMO_SIM_par_1	704	711	PF11976	0.607
LIG_TRAF2_1	367	370	PF00917	0.600
LIG_UBA3_1	499	507	PF00899	0.614
LIG_WRC_WIRS_1	28	33	PF05994	0.764
LIG_WW_2	488	491	PF00397	0.685
MOD_CDK_SPK_2	290	295	PF00069	0.786
MOD_CDK_SPxxK_3	491	498	PF00069	0.550
MOD_CK1_1	178	184	PF00069	0.718
MOD_CK1_1	186	192	PF00069	0.766
MOD_CK1_1	238	244	PF00069	0.779
MOD_CK1_1	318	324	PF00069	0.636
MOD_CK1_1	371	377	PF00069	0.719
MOD_CK1_1	446	452	PF00069	0.791
MOD_CK1_1	553	559	PF00069	0.608
MOD_CK1_1	574	580	PF00069	0.717
MOD_CK1_1	581	587	PF00069	0.721
MOD_CK1_1	608	614	PF00069	0.764
MOD_CK1_1	633	639	PF00069	0.695
MOD_CK1_1	663	669	PF00069	0.669
MOD_CK1_1	672	678	PF00069	0.686
MOD_CK1_1	718	724	PF00069	0.740
MOD_CK1_1	757	763	PF00069	0.638
MOD_CK1_1	79	85	PF00069	0.705
MOD_CK2_1	124	130	PF00069	0.701
MOD_CK2_1	364	370	PF00069	0.797
MOD_CK2_1	450	456	PF00069	0.722
MOD_CK2_1	491	497	PF00069	0.567
MOD_CK2_1	705	711	PF00069	0.607
MOD_CK2_1	719	725	PF00069	0.685
MOD_CK2_1	756	762	PF00069	0.702
MOD_Cter_Amidation	161	164	PF01082	0.720
MOD_Cter_Amidation	229	232	PF01082	0.778
MOD_Cter_Amidation	233	236	PF01082	0.706
MOD_Cter_Amidation	460	463	PF01082	0.757
MOD_Cter_Amidation	56	59	PF01082	0.757
MOD_GlcNHglycan	171	174	PF01048	0.742
MOD_GlcNHglycan	180	183	PF01048	0.729
MOD_GlcNHglycan	237	240	PF01048	0.734
MOD_GlcNHglycan	249	252	PF01048	0.636
MOD_GlcNHglycan	313	316	PF01048	0.635
MOD_GlcNHglycan	370	373	PF01048	0.728
MOD_GlcNHglycan	445	448	PF01048	0.819
MOD_GlcNHglycan	468	471	PF01048	0.699
MOD_GlcNHglycan	482	485	PF01048	0.585
MOD_GlcNHglycan	547	550	PF01048	0.628
MOD_GlcNHglycan	573	576	PF01048	0.689
MOD_GlcNHglycan	580	584	PF01048	0.626
MOD_GlcNHglycan	662	665	PF01048	0.664
MOD_GlcNHglycan	721	724	PF01048	0.701
MOD_GlcNHglycan	738	741	PF01048	0.482
MOD_GlcNHglycan	743	746	PF01048	0.623
MOD_GlcNHglycan	749	752	PF01048	0.568
MOD_GlcNHglycan	78	81	PF01048	0.711
MOD_GlcNHglycan	85	88	PF01048	0.698
MOD_GSK3_1	114	121	PF00069	0.752
MOD_GSK3_1	132	139	PF00069	0.468
MOD_GSK3_1	171	178	PF00069	0.761
MOD_GSK3_1	183	190	PF00069	0.722
MOD_GSK3_1	238	245	PF00069	0.676
MOD_GSK3_1	265	272	PF00069	0.735
MOD_GSK3_1	289	296	PF00069	0.722
MOD_GSK3_1	311	318	PF00069	0.634
MOD_GSK3_1	320	327	PF00069	0.703
MOD_GSK3_1	364	371	PF00069	0.777
MOD_GSK3_1	443	450	PF00069	0.748
MOD_GSK3_1	474	481	PF00069	0.740
MOD_GSK3_1	574	581	PF00069	0.694
MOD_GSK3_1	605	612	PF00069	0.728
MOD_GSK3_1	629	636	PF00069	0.747
MOD_GSK3_1	639	646	PF00069	0.433
MOD_GSK3_1	686	693	PF00069	0.598
MOD_GSK3_1	701	708	PF00069	0.600
MOD_GSK3_1	711	718	PF00069	0.641
MOD_GSK3_1	743	750	PF00069	0.685
MOD_GSK3_1	76	83	PF00069	0.691
MOD_NEK2_1	124	129	PF00069	0.785
MOD_NEK2_1	289	294	PF00069	0.740
MOD_NEK2_1	319	324	PF00069	0.661
MOD_NEK2_2	27	32	PF00069	0.722
MOD_NEK2_2	43	48	PF00069	0.644
MOD_PIKK_1	356	362	PF00454	0.733
MOD_PIKK_1	450	456	PF00454	0.707
MOD_PIKK_1	513	519	PF00454	0.553
MOD_PIKK_1	613	619	PF00454	0.733
MOD_PK_1	435	441	PF00069	0.727
MOD_PKA_1	235	241	PF00069	0.714
MOD_PKA_1	466	472	PF00069	0.712
MOD_PKA_1	716	722	PF00069	0.738
MOD_PKA_2	235	241	PF00069	0.714
MOD_PKA_2	303	309	PF00069	0.565
MOD_PKA_2	32	38	PF00069	0.681
MOD_PKA_2	466	472	PF00069	0.676
MOD_PKA_2	686	692	PF00069	0.595
MOD_PKA_2	715	721	PF00069	0.698
MOD_PKA_2	83	89	PF00069	0.802
MOD_Plk_1	540	546	PF00069	0.590
MOD_Plk_1	595	601	PF00069	0.727
MOD_Plk_1	734	740	PF00069	0.760
MOD_Plk_2-3	705	711	PF00069	0.607
MOD_Plk_4	238	244	PF00069	0.727
MOD_Plk_4	272	278	PF00069	0.791
MOD_Plk_4	315	321	PF00069	0.607
MOD_Plk_4	43	49	PF00069	0.723
MOD_Plk_4	553	559	PF00069	0.582
MOD_Plk_4	581	587	PF00069	0.749
MOD_Plk_4	605	611	PF00069	0.777
MOD_Plk_4	63	69	PF00069	0.476
MOD_ProDKin_1	17	23	PF00069	0.706
MOD_ProDKin_1	176	182	PF00069	0.751
MOD_ProDKin_1	184	190	PF00069	0.772
MOD_ProDKin_1	209	215	PF00069	0.685
MOD_ProDKin_1	269	275	PF00069	0.747
MOD_ProDKin_1	276	282	PF00069	0.729
MOD_ProDKin_1	290	296	PF00069	0.531
MOD_ProDKin_1	484	490	PF00069	0.667
MOD_ProDKin_1	491	497	PF00069	0.493
MOD_ProDKin_1	630	636	PF00069	0.646
MOD_ProDKin_1	672	678	PF00069	0.671
MOD_SUMO_rev_2	452	459	PF00179	0.737
TRG_DiLeu_BaEn_1	415	420	PF01217	0.637
TRG_DiLeu_BaEn_2	625	631	PF01217	0.730
TRG_DiLeu_BaLyEn_6	636	641	PF01217	0.572
TRG_ENDOCYTIC_2	526	529	PF00928	0.595
TRG_ENDOCYTIC_2	775	778	PF00928	0.647
TRG_ER_diArg_1	161	164	PF00400	0.766
TRG_ER_diArg_1	460	463	PF00400	0.665
TRG_ER_diArg_1	465	467	PF00400	0.664
TRG_ER_diArg_1	510	512	PF00400	0.472
TRG_ER_diArg_1	531	534	PF00400	0.586
TRG_ER_diArg_1	649	651	PF00400	0.617
TRG_NLS_MonoExtC_3	159	164	PF00514	0.701
TRG_NLS_MonoExtN_4	157	164	PF00514	0.748
TRG_Pf-PMV_PEXEL_1	498	503	PF00026	0.603

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL05	Leptomonas seymouri	45%	100%
A0A1X0P9E8	Trypanosomatidae	32%	100%
A4HAP9	Leishmania braziliensis	74%	100%
A4I9U5	Leishmania infantum	99%	100%
E9B4V6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q370	Leishmania major	91%	100%
V5BT09	Trypanosoma cruzi	30%	100%