Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X7P4_LEIDO

TriTrypDb:

LdBPK_341080.1 , LdCL_340016300 , LDHU3_34.1760

Length:

588

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X7P4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7P4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	23	27	PF00656	0.577
CLV_C14_Caspase3-7	71	75	PF00656	0.729
CLV_C14_Caspase3-7	84	88	PF00656	0.530
CLV_NRD_NRD_1	223	225	PF00675	0.474
CLV_NRD_NRD_1	356	358	PF00675	0.454
CLV_NRD_NRD_1	428	430	PF00675	0.536
CLV_PCSK_KEX2_1	223	225	PF00082	0.474
CLV_PCSK_KEX2_1	358	360	PF00082	0.506
CLV_PCSK_KEX2_1	375	377	PF00082	0.767
CLV_PCSK_KEX2_1	419	421	PF00082	0.605
CLV_PCSK_KEX2_1	428	430	PF00082	0.511
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.492
CLV_PCSK_PC1ET2_1	375	377	PF00082	0.626
CLV_PCSK_PC1ET2_1	419	421	PF00082	0.605
CLV_PCSK_SKI1_1	298	302	PF00082	0.417
CLV_PCSK_SKI1_1	428	432	PF00082	0.565
CLV_PCSK_SKI1_1	555	559	PF00082	0.473
CLV_Separin_Metazoa	497	501	PF03568	0.373
DEG_APCC_DBOX_1	554	562	PF00400	0.446
DEG_SPOP_SBC_1	422	426	PF00917	0.615
DOC_CKS1_1	175	180	PF01111	0.557
DOC_CYCLIN_yCln2_LP_2	332	338	PF00134	0.428
DOC_MAPK_MEF2A_6	325	332	PF00069	0.407
DOC_MAPK_MEF2A_6	56	63	PF00069	0.438
DOC_USP7_MATH_1	138	142	PF00917	0.621
DOC_USP7_MATH_1	176	180	PF00917	0.636
DOC_USP7_MATH_1	35	39	PF00917	0.676
DOC_USP7_MATH_1	422	426	PF00917	0.612
DOC_USP7_MATH_1	476	480	PF00917	0.515
DOC_USP7_MATH_1	508	512	PF00917	0.566
DOC_USP7_MATH_1	94	98	PF00917	0.634
DOC_USP7_UBL2_3	317	321	PF12436	0.458
DOC_USP7_UBL2_3	371	375	PF12436	0.598
DOC_WW_Pin1_4	102	107	PF00397	0.557
DOC_WW_Pin1_4	174	179	PF00397	0.561
DOC_WW_Pin1_4	201	206	PF00397	0.577
DOC_WW_Pin1_4	247	252	PF00397	0.560
DOC_WW_Pin1_4	38	43	PF00397	0.481
DOC_WW_Pin1_4	406	411	PF00397	0.701
DOC_WW_Pin1_4	414	419	PF00397	0.634
LIG_14-3-3_CanoR_1	113	121	PF00244	0.551
LIG_14-3-3_CanoR_1	164	172	PF00244	0.644
LIG_14-3-3_CanoR_1	247	251	PF00244	0.511
LIG_14-3-3_CanoR_1	399	407	PF00244	0.569
LIG_14-3-3_CanoR_1	420	430	PF00244	0.593
LIG_14-3-3_CanoR_1	451	459	PF00244	0.377
LIG_14-3-3_CanoR_1	518	527	PF00244	0.471
LIG_14-3-3_CanoR_1	555	565	PF00244	0.462
LIG_14-3-3_CanoR_1	56	60	PF00244	0.492
LIG_14-3-3_CanoR_1	569	573	PF00244	0.317
LIG_BRCT_BRCA1_1	426	430	PF00533	0.573
LIG_Clathr_ClatBox_1	307	311	PF01394	0.396
LIG_FHA_1	125	131	PF00498	0.520
LIG_FHA_1	153	159	PF00498	0.716
LIG_FHA_1	175	181	PF00498	0.580
LIG_FHA_1	243	249	PF00498	0.464
LIG_FHA_1	473	479	PF00498	0.606
LIG_FHA_1	56	62	PF00498	0.446
LIG_FHA_1	8	14	PF00498	0.557
LIG_FHA_2	141	147	PF00498	0.780
LIG_FHA_2	157	163	PF00498	0.580
LIG_FHA_2	189	195	PF00498	0.699
LIG_FHA_2	274	280	PF00498	0.438
LIG_FHA_2	489	495	PF00498	0.670
LIG_FHA_2	521	527	PF00498	0.384
LIG_FHA_2	548	554	PF00498	0.463
LIG_GBD_Chelix_1	221	229	PF00786	0.451
LIG_Integrin_RGD_1	532	534	PF01839	0.361
LIG_LIR_Apic_2	74	80	PF02991	0.633
LIG_LIR_Gen_1	302	313	PF02991	0.409
LIG_LIR_Gen_1	559	570	PF02991	0.508
LIG_LIR_Gen_1	577	587	PF02991	0.305
LIG_LIR_Nem_3	577	582	PF02991	0.369
LIG_LYPXL_yS_3	327	330	PF13949	0.400
LIG_PCNA_PIPBox_1	573	582	PF02747	0.456
LIG_PCNA_yPIPBox_3	569	580	PF02747	0.451
LIG_SH2_CRK	503	507	PF00017	0.379
LIG_SH2_STAP1	503	507	PF00017	0.359
LIG_SH2_STAP1	520	524	PF00017	0.368
LIG_SH2_STAT3	570	573	PF00017	0.452
LIG_SH2_STAT5	12	15	PF00017	0.540
LIG_SH2_STAT5	275	278	PF00017	0.453
LIG_SH2_STAT5	305	308	PF00017	0.406
LIG_SH2_STAT5	347	350	PF00017	0.484
LIG_SH2_STAT5	579	582	PF00017	0.423
LIG_SH3_3	225	231	PF00018	0.376
LIG_SH3_3	245	251	PF00018	0.577
LIG_SH3_3	289	295	PF00018	0.479
LIG_SH3_3	404	410	PF00018	0.680
LIG_SH3_3	93	99	PF00018	0.653
LIG_SUMO_SIM_anti_2	493	500	PF11976	0.516
LIG_SUMO_SIM_par_1	179	186	PF11976	0.537
LIG_TRAF2_1	192	195	PF00917	0.659
LIG_TRAF2_1	491	494	PF00917	0.476
LIG_TRAF2_1	523	526	PF00917	0.513
LIG_TRAF2_1	550	553	PF00917	0.465
MOD_CDC14_SPxK_1	417	420	PF00782	0.606
MOD_CDK_SPK_2	414	419	PF00069	0.738
MOD_CDK_SPxK_1	414	420	PF00069	0.610
MOD_CK1_1	105	111	PF00069	0.670
MOD_CK1_1	112	118	PF00069	0.588
MOD_CK1_1	152	158	PF00069	0.690
MOD_CK1_1	179	185	PF00069	0.581
MOD_CK1_1	186	192	PF00069	0.548
MOD_CK1_1	197	203	PF00069	0.488
MOD_CK1_1	250	256	PF00069	0.677
MOD_CK1_1	264	270	PF00069	0.455
MOD_CK1_1	379	385	PF00069	0.632
MOD_CK1_1	38	44	PF00069	0.630
MOD_CK1_1	471	477	PF00069	0.697
MOD_CK2_1	140	146	PF00069	0.800
MOD_CK2_1	188	194	PF00069	0.707
MOD_CK2_1	265	271	PF00069	0.594
MOD_CK2_1	385	391	PF00069	0.613
MOD_CK2_1	430	436	PF00069	0.500
MOD_CK2_1	488	494	PF00069	0.545
MOD_CK2_1	508	514	PF00069	0.508
MOD_CK2_1	520	526	PF00069	0.346
MOD_CK2_1	547	553	PF00069	0.465
MOD_DYRK1A_RPxSP_1	247	251	PF00069	0.512
MOD_GlcNHglycan	149	152	PF01048	0.833
MOD_GlcNHglycan	199	202	PF01048	0.570
MOD_GlcNHglycan	218	221	PF01048	0.504
MOD_GlcNHglycan	252	255	PF01048	0.546
MOD_GlcNHglycan	336	339	PF01048	0.408
MOD_GlcNHglycan	362	366	PF01048	0.711
MOD_GlcNHglycan	37	40	PF01048	0.661
MOD_GlcNHglycan	387	390	PF01048	0.657
MOD_GlcNHglycan	404	407	PF01048	0.575
MOD_GlcNHglycan	471	474	PF01048	0.464
MOD_GlcNHglycan	83	86	PF01048	0.577
MOD_GSK3_1	105	112	PF00069	0.729
MOD_GSK3_1	122	129	PF00069	0.396
MOD_GSK3_1	147	154	PF00069	0.661
MOD_GSK3_1	179	186	PF00069	0.602
MOD_GSK3_1	190	197	PF00069	0.607
MOD_GSK3_1	242	249	PF00069	0.535
MOD_GSK3_1	250	257	PF00069	0.500
MOD_GSK3_1	261	268	PF00069	0.390
MOD_GSK3_1	361	368	PF00069	0.695
MOD_GSK3_1	376	383	PF00069	0.578
MOD_GSK3_1	398	405	PF00069	0.707
MOD_GSK3_1	414	421	PF00069	0.577
MOD_GSK3_1	464	471	PF00069	0.482
MOD_GSK3_1	472	479	PF00069	0.555
MOD_GSK3_1	547	554	PF00069	0.426
MOD_N-GLC_1	385	390	PF02516	0.623
MOD_N-GLC_2	34	36	PF02516	0.581
MOD_NEK2_1	109	114	PF00069	0.559
MOD_NEK2_1	243	248	PF00069	0.467
MOD_NEK2_1	287	292	PF00069	0.511
MOD_NEK2_1	412	417	PF00069	0.632
MOD_NEK2_1	430	435	PF00069	0.483
MOD_NEK2_1	468	473	PF00069	0.641
MOD_PIKK_1	124	130	PF00454	0.506
MOD_PIKK_1	466	472	PF00454	0.539
MOD_PIKK_1	534	540	PF00454	0.437
MOD_PIKK_1	547	553	PF00454	0.357
MOD_PKA_2	112	118	PF00069	0.612
MOD_PKA_2	138	144	PF00069	0.615
MOD_PKA_2	232	238	PF00069	0.476
MOD_PKA_2	246	252	PF00069	0.416
MOD_PKA_2	379	385	PF00069	0.663
MOD_PKA_2	398	404	PF00069	0.573
MOD_PKA_2	450	456	PF00069	0.504
MOD_PKA_2	55	61	PF00069	0.493
MOD_PKA_2	568	574	PF00069	0.404
MOD_PKB_1	376	384	PF00069	0.643
MOD_Plk_1	194	200	PF00069	0.725
MOD_Plk_4	126	132	PF00069	0.565
MOD_Plk_4	176	182	PF00069	0.633
MOD_Plk_4	183	189	PF00069	0.609
MOD_Plk_4	508	514	PF00069	0.446
MOD_ProDKin_1	102	108	PF00069	0.554
MOD_ProDKin_1	174	180	PF00069	0.561
MOD_ProDKin_1	201	207	PF00069	0.574
MOD_ProDKin_1	247	253	PF00069	0.561
MOD_ProDKin_1	38	44	PF00069	0.465
MOD_ProDKin_1	406	412	PF00069	0.705
MOD_ProDKin_1	414	420	PF00069	0.632
MOD_SUMO_rev_2	311	318	PF00179	0.468
TRG_DiLeu_BaEn_4	194	200	PF01217	0.660
TRG_ENDOCYTIC_2	305	308	PF00928	0.391
TRG_ENDOCYTIC_2	327	330	PF00928	0.400
TRG_ENDOCYTIC_2	45	48	PF00928	0.400
TRG_ENDOCYTIC_2	503	506	PF00928	0.381
TRG_ENDOCYTIC_2	562	565	PF00928	0.387
TRG_ENDOCYTIC_2	579	582	PF00928	0.391
TRG_ER_diArg_1	222	224	PF00400	0.474
TRG_ER_diArg_1	295	298	PF00400	0.656
TRG_ER_diArg_1	428	430	PF00400	0.536
TRG_NES_CRM1_1	342	355	PF08389	0.445
TRG_NLS_MonoExtC_3	356	361	PF00514	0.475
TRG_Pf-PMV_PEXEL_1	223	227	PF00026	0.400
TRG_Pf-PMV_PEXEL_1	298	303	PF00026	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P311	Leptomonas seymouri	41%	93%
A4HAL4	Leishmania braziliensis	68%	100%
A4I9R1	Leishmania infantum	100%	100%
E9B4S3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q3A4	Leishmania major	90%	100%