Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X7N4_LEIDO

TriTrypDb:

LdBPK_340980.1 , LdCL_340015300 , LDHU3_34.1550

Length:

107

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X7N4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7N4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.502
CLV_PCSK_SKI1_1	72	76	PF00082	0.503
DOC_MAPK_gen_1	71	77	PF00069	0.541
DOC_WW_Pin1_4	49	54	PF00397	0.571
LIG_BRCT_BRCA1_1	15	19	PF00533	0.528
LIG_BRCT_BRCA1_2	15	21	PF00533	0.539
LIG_FHA_2	50	56	PF00498	0.494
LIG_LIR_Gen_1	60	70	PF02991	0.389
LIG_LIR_Gen_1	73	81	PF02991	0.402
LIG_LIR_Gen_1	87	97	PF02991	0.508
LIG_LIR_Nem_3	16	22	PF02991	0.479
LIG_LIR_Nem_3	60	65	PF02991	0.390
LIG_LIR_Nem_3	73	77	PF02991	0.410
LIG_LIR_Nem_3	78	84	PF02991	0.395
LIG_SH2_SRC	22	25	PF00017	0.441
LIG_TRAF2_1	52	55	PF00917	0.540
LIG_TRFH_1	49	53	PF08558	0.573
MOD_CDK_SPxxK_3	49	56	PF00069	0.556
MOD_CK2_1	49	55	PF00069	0.475
MOD_CK2_1	76	82	PF00069	0.528
MOD_NEK2_1	1	6	PF00069	0.711
MOD_NEK2_1	75	80	PF00069	0.502
MOD_NMyristoyl	1	7	PF02799	0.514
MOD_Plk_4	76	82	PF00069	0.528
MOD_ProDKin_1	49	55	PF00069	0.560
MOD_SUMO_for_1	70	73	PF00179	0.498
TRG_DiLeu_BaEn_4	60	66	PF01217	0.387
TRG_ENDOCYTIC_2	66	69	PF00928	0.413
TRG_ENDOCYTIC_2	89	92	PF00928	0.518
TRG_ER_diArg_1	26	29	PF00400	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J0J3	Bodo saltans	46%	100%
A0A1X0P995	Trypanosomatidae	58%	100%
A0A422N277	Trypanosoma rangeli	58%	100%
A4HAK9	Leishmania braziliensis	92%	100%
A4I9Q0	Leishmania infantum	100%	100%
C6K3V4	Leptomonas seymouri	79%	100%
C9ZMY9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	98%
E9B4R4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
Q4Q3B2	Leishmania major	99%	100%