25_Kd_elongation_factor_1-beta_putative/GeneDB:Lm jF.34.0830

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

25 Kd elongation factor 1-beta, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X7M1_LEIDO

TriTrypDb:

LdBPK_340880.1 , LdCL_340014300 , LDHU3_34.1390

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X7M1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7M1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003746	translation elongation factor activity	4	6
GO:0005488	binding	1	6
GO:0008135	translation factor activity, RNA binding	3	6
GO:0045182	translation regulator activity	1	6
GO:0090079	translation regulator activity, nucleic acid binding	2	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	67	69	PF00675	0.461
CLV_PCSK_SKI1_1	33	37	PF00082	0.470
CLV_PCSK_SKI1_1	7	11	PF00082	0.557
LIG_14-3-3_CanoR_1	58	64	PF00244	0.431
LIG_14-3-3_CanoR_1	68	72	PF00244	0.483
LIG_FHA_2	62	68	PF00498	0.441
LIG_LIR_Apic_2	70	74	PF02991	0.493
LIG_LIR_Gen_1	40	51	PF02991	0.433
LIG_LIR_Nem_3	40	46	PF02991	0.459
LIG_Pex14_2	42	46	PF04695	0.432
LIG_SH3_3	71	77	PF00018	0.486
LIG_WRC_WIRS_1	60	65	PF05994	0.427
MOD_CK2_1	59	65	PF00069	0.427
MOD_GSK3_1	59	66	PF00069	0.432
MOD_PKA_2	67	73	PF00069	0.467
MOD_SUMO_rev_2	62	70	PF00179	0.451
TRG_ENDOCYTIC_2	43	46	PF00928	0.432
TRG_ENDOCYTIC_2	54	57	PF00928	0.419
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYB6	Leptomonas seymouri	79%	100%
A4HAJ2	Leishmania braziliensis	80%	100%
A4I9P0	Leishmania infantum	100%	100%
E9B4Q4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q3C2	Leishmania major	95%	100%