EF-hand domain pair, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

EF-hand domain pair, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X7M0_LEIDO

TriTrypDb:

LdBPK_341100.1 , LdCL_340016500 , LDHU3_34.1790

Length:

251

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X7M0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7M0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0005509	calcium ion binding	5	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	205	211	PF00089	0.524
CLV_NRD_NRD_1	240	242	PF00675	0.449
CLV_PCSK_KEX2_1	240	242	PF00082	0.449
CLV_PCSK_SKI1_1	152	156	PF00082	0.635
DEG_SPOP_SBC_1	63	67	PF00917	0.716
DOC_MAPK_JIP1_4	76	82	PF00069	0.717
DOC_PP1_RVXF_1	206	212	PF00149	0.524
DOC_USP7_MATH_1	104	108	PF00917	0.770
DOC_USP7_MATH_1	27	31	PF00917	0.798
DOC_USP7_MATH_1	36	40	PF00917	0.679
DOC_USP7_MATH_1	63	67	PF00917	0.730
DOC_USP7_MATH_1	71	75	PF00917	0.613
DOC_USP7_UBL2_3	246	250	PF12436	0.569
LIG_14-3-3_CanoR_1	233	237	PF00244	0.524
LIG_14-3-3_CanoR_1	240	246	PF00244	0.449
LIG_14-3-3_CanoR_1	61	70	PF00244	0.627
LIG_14-3-3_CanoR_1	7	15	PF00244	0.626
LIG_BIR_III_4	180	184	PF00653	0.449
LIG_CaM_IQ_9	125	141	PF13499	0.758
LIG_deltaCOP1_diTrp_1	119	128	PF00928	0.711
LIG_FHA_1	192	198	PF00498	0.449
LIG_FHA_1	63	69	PF00498	0.723
LIG_FHA_1	86	92	PF00498	0.609
LIG_FHA_2	14	20	PF00498	0.729
LIG_FHA_2	213	219	PF00498	0.449
LIG_LIR_Gen_1	119	128	PF02991	0.711
LIG_LIR_Gen_1	176	186	PF02991	0.524
LIG_LIR_Nem_3	119	125	PF02991	0.711
LIG_LIR_Nem_3	127	131	PF02991	0.590
LIG_LIR_Nem_3	158	162	PF02991	0.660
LIG_LIR_Nem_3	17	23	PF02991	0.546
LIG_LIR_Nem_3	176	182	PF02991	0.620
LIG_LIR_Nem_3	184	189	PF02991	0.306
LIG_LIR_Nem_3	237	242	PF02991	0.524
LIG_LIR_Nem_3	9	15	PF02991	0.733
LIG_LYPXL_S_1	11	15	PF13949	0.665
LIG_LYPXL_yS_3	12	15	PF13949	0.661
LIG_Pex14_2	155	159	PF04695	0.665
LIG_SH2_CRK	20	24	PF00017	0.743
LIG_SH2_SRC	189	192	PF00017	0.345
LIG_SH2_STAT5	162	165	PF00017	0.742
LIG_SH2_STAT5	196	199	PF00017	0.524
LIG_SH3_3	21	27	PF00018	0.721
LIG_SUMO_SIM_anti_2	215	225	PF11976	0.517
LIG_TRAF2_1	215	218	PF00917	0.405
LIG_WRC_WIRS_1	125	130	PF05994	0.706
MOD_CK1_1	28	34	PF00069	0.811
MOD_CK1_1	78	84	PF00069	0.724
MOD_CK2_1	13	19	PF00069	0.735
MOD_CK2_1	212	218	PF00069	0.524
MOD_CK2_1	78	84	PF00069	0.624
MOD_GlcNHglycan	101	104	PF01048	0.764
MOD_GlcNHglycan	152	155	PF01048	0.610
MOD_GlcNHglycan	164	167	PF01048	0.604
MOD_GlcNHglycan	173	176	PF01048	0.595
MOD_GlcNHglycan	25	30	PF01048	0.678
MOD_GlcNHglycan	38	41	PF01048	0.794
MOD_GlcNHglycan	42	45	PF01048	0.640
MOD_GlcNHglycan	73	76	PF01048	0.671
MOD_GlcNHglycan	8	11	PF01048	0.740
MOD_GSK3_1	36	43	PF00069	0.697
MOD_GSK3_1	57	64	PF00069	0.763
MOD_GSK3_1	71	78	PF00069	0.533
MOD_N-GLC_1	155	160	PF02516	0.646
MOD_N-GLC_1	78	83	PF02516	0.722
MOD_NEK2_1	124	129	PF00069	0.703
MOD_NEK2_1	131	136	PF00069	0.655
MOD_NEK2_1	70	75	PF00069	0.592
MOD_PKA_2	232	238	PF00069	0.524
MOD_PKA_2	6	12	PF00069	0.744
MOD_PKA_2	75	81	PF00069	0.717
MOD_Plk_1	155	161	PF00069	0.740
MOD_Plk_1	78	84	PF00069	0.724
MOD_SUMO_rev_2	17	23	PF00179	0.667
TRG_DiLeu_BaEn_1	19	24	PF01217	0.741
TRG_DiLeu_BaEn_1	218	223	PF01217	0.524
TRG_ENDOCYTIC_2	12	15	PF00928	0.706
TRG_ENDOCYTIC_2	20	23	PF00928	0.643
TRG_ER_diArg_1	239	241	PF00400	0.449
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.761

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HAL6	Leishmania braziliensis	62%	91%
A4I9Q9	Leishmania infantum	100%	100%
E9B4S5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q3A2	Leishmania major	91%	100%