ATP-dependent DNA helicase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X7L7_LEIDO

TriTrypDb:

LdBPK_340920.1 , LdCL_340014700 , LDHU3_34.1460

Length:

560

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X7L7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7L7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	389	393	PF00656	0.585
CLV_C14_Caspase3-7	484	488	PF00656	0.650
CLV_NRD_NRD_1	125	127	PF00675	0.687
CLV_NRD_NRD_1	241	243	PF00675	0.637
CLV_NRD_NRD_1	348	350	PF00675	0.836
CLV_NRD_NRD_1	402	404	PF00675	0.570
CLV_NRD_NRD_1	431	433	PF00675	0.595
CLV_NRD_NRD_1	438	440	PF00675	0.656
CLV_NRD_NRD_1	547	549	PF00675	0.593
CLV_PCSK_FUR_1	400	404	PF00082	0.531
CLV_PCSK_KEX2_1	125	127	PF00082	0.585
CLV_PCSK_KEX2_1	241	243	PF00082	0.637
CLV_PCSK_KEX2_1	348	350	PF00082	0.836
CLV_PCSK_KEX2_1	400	402	PF00082	0.563
CLV_PCSK_KEX2_1	430	432	PF00082	0.586
CLV_PCSK_SKI1_1	103	107	PF00082	0.669
CLV_PCSK_SKI1_1	141	145	PF00082	0.499
CLV_PCSK_SKI1_1	440	444	PF00082	0.787
DOC_ANK_TNKS_1	298	305	PF00023	0.660
DOC_CKS1_1	478	483	PF01111	0.742
DOC_CYCLIN_yCln2_LP_2	188	194	PF00134	0.671
DOC_MAPK_FxFP_2	111	114	PF00069	0.508
DOC_MAPK_gen_1	436	444	PF00069	0.692
DOC_MAPK_JIP1_4	77	83	PF00069	0.563
DOC_PP1_RVXF_1	114	120	PF00149	0.473
DOC_PP2B_LxvP_1	32	35	PF13499	0.705
DOC_PP4_FxxP_1	111	114	PF00568	0.508
DOC_USP7_MATH_1	165	169	PF00917	0.583
DOC_USP7_MATH_1	22	26	PF00917	0.688
DOC_USP7_MATH_1	252	256	PF00917	0.812
DOC_USP7_MATH_1	37	41	PF00917	0.739
DOC_USP7_MATH_1	373	377	PF00917	0.561
DOC_USP7_MATH_1	448	452	PF00917	0.717
DOC_USP7_MATH_1	45	49	PF00917	0.662
DOC_USP7_UBL2_3	545	549	PF12436	0.655
DOC_WW_Pin1_4	156	161	PF00397	0.620
DOC_WW_Pin1_4	255	260	PF00397	0.789
DOC_WW_Pin1_4	298	303	PF00397	0.614
DOC_WW_Pin1_4	402	407	PF00397	0.578
DOC_WW_Pin1_4	46	51	PF00397	0.612
DOC_WW_Pin1_4	477	482	PF00397	0.744
LIG_14-3-3_CanoR_1	154	159	PF00244	0.594
LIG_14-3-3_CanoR_1	297	302	PF00244	0.633
LIG_14-3-3_CanoR_1	351	359	PF00244	0.747
LIG_Actin_WH2_2	531	547	PF00022	0.761
LIG_BIR_III_4	236	240	PF00653	0.747
LIG_BIR_III_4	487	491	PF00653	0.553
LIG_deltaCOP1_diTrp_1	392	398	PF00928	0.524
LIG_deltaCOP1_diTrp_1	410	414	PF00928	0.460
LIG_FHA_1	148	154	PF00498	0.518
LIG_FHA_1	359	365	PF00498	0.606
LIG_FHA_1	477	483	PF00498	0.819
LIG_FHA_2	244	250	PF00498	0.699
LIG_FHA_2	471	477	PF00498	0.826
LIG_FHA_2	507	513	PF00498	0.760
LIG_LIR_Apic_2	108	114	PF02991	0.486
LIG_LIR_Apic_2	25	31	PF02991	0.783
LIG_LIR_Apic_2	33	39	PF02991	0.570
LIG_LIR_Apic_2	368	373	PF02991	0.648
LIG_LIR_Nem_3	171	175	PF02991	0.574
LIG_LIR_Nem_3	420	426	PF02991	0.531
LIG_PCNA_yPIPBox_3	416	430	PF02747	0.577
LIG_SH2_CRK	28	32	PF00017	0.698
LIG_SH2_CRK	36	40	PF00017	0.695
LIG_SH2_NCK_1	36	40	PF00017	0.788
LIG_SH2_NCK_1	370	374	PF00017	0.642
LIG_SH2_SRC	426	429	PF00017	0.578
LIG_SH2_STAT5	158	161	PF00017	0.618
LIG_SH2_STAT5	291	294	PF00017	0.530
LIG_SH2_STAT5	426	429	PF00017	0.680
LIG_SH3_1	432	438	PF00018	0.602
LIG_SH3_2	435	440	PF14604	0.651
LIG_SH3_3	16	22	PF00018	0.798
LIG_SH3_3	161	167	PF00018	0.596
LIG_SH3_3	372	378	PF00018	0.630
LIG_SH3_3	432	438	PF00018	0.557
LIG_SH3_3	525	531	PF00018	0.700
LIG_UBA3_1	169	176	PF00899	0.574
LIG_UBA3_1	537	545	PF00899	0.633
LIG_WRC_WIRS_1	86	91	PF05994	0.516
LIG_WW_3	378	382	PF00397	0.697
MOD_CDK_SPxK_1	156	162	PF00069	0.625
MOD_CK1_1	168	174	PF00069	0.564
MOD_CK1_1	255	261	PF00069	0.685
MOD_CK1_1	405	411	PF00069	0.594
MOD_CK1_1	48	54	PF00069	0.784
MOD_CK2_1	243	249	PF00069	0.805
MOD_CK2_1	506	512	PF00069	0.757
MOD_CMANNOS	395	398	PF00535	0.521
MOD_CMANNOS	411	414	PF00535	0.588
MOD_Cter_Amidation	239	242	PF01082	0.696
MOD_GlcNHglycan	10	13	PF01048	0.602
MOD_GlcNHglycan	197	200	PF01048	0.691
MOD_GlcNHglycan	254	257	PF01048	0.692
MOD_GlcNHglycan	316	319	PF01048	0.690
MOD_GlcNHglycan	39	42	PF01048	0.625
MOD_GlcNHglycan	407	410	PF01048	0.597
MOD_GlcNHglycan	449	453	PF01048	0.680
MOD_GlcNHglycan	541	544	PF01048	0.584
MOD_GSK3_1	154	161	PF00069	0.649
MOD_GSK3_1	255	262	PF00069	0.709
MOD_GSK3_1	39	46	PF00069	0.754
MOD_N-GLC_1	84	89	PF02516	0.543
MOD_NEK2_1	8	13	PF00069	0.649
MOD_NEK2_2	358	363	PF00069	0.726
MOD_OFUCOSY	272	278	PF10250	0.548
MOD_PIKK_1	105	111	PF00454	0.508
MOD_PIKK_1	338	344	PF00454	0.761
MOD_PKA_2	211	217	PF00069	0.678
MOD_PKA_2	314	320	PF00069	0.780
MOD_PKA_2	350	356	PF00069	0.724
MOD_PKA_2	79	85	PF00069	0.545
MOD_Plk_1	506	512	PF00069	0.718
MOD_Plk_1	84	90	PF00069	0.548
MOD_Plk_2-3	508	514	PF00069	0.625
MOD_Plk_4	165	171	PF00069	0.579
MOD_Plk_4	39	45	PF00069	0.791
MOD_ProDKin_1	156	162	PF00069	0.625
MOD_ProDKin_1	255	261	PF00069	0.780
MOD_ProDKin_1	298	304	PF00069	0.623
MOD_ProDKin_1	402	408	PF00069	0.584
MOD_ProDKin_1	46	52	PF00069	0.609
MOD_ProDKin_1	477	483	PF00069	0.741
TRG_DiLeu_BaLyEn_6	360	365	PF01217	0.578
TRG_ER_diArg_1	153	156	PF00400	0.561
TRG_ER_diArg_1	399	402	PF00400	0.557
TRG_ER_diArg_1	430	432	PF00400	0.586
TRG_ER_diArg_1	89	92	PF00400	0.515
TRG_NLS_Bipartite_1	430	444	PF00514	0.606
TRG_NLS_MonoExtC_3	438	443	PF00514	0.677
TRG_NLS_MonoExtN_4	436	443	PF00514	0.671
TRG_Pf-PMV_PEXEL_1	363	367	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2A7	Leptomonas seymouri	55%	100%
A4HAK0	Leishmania braziliensis	75%	100%
A4I9P4	Leishmania infantum	99%	100%
E9B4Q8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q3B8	Leishmania major	89%	100%