CBF/Mak21 family, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CBF/Mak21 family, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X7L0_LEIDO

TriTrypDb:

LdBPK_340780.1 , LdCL_340013300 , LDHU3_34.1260

Length:

468

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0005730	nucleolus	5	1
GO:0030684	preribosome	3	1
GO:0030689	Noc complex	3	1
GO:0030692	Noc4p-Nop14p complex	4	1
GO:0032040	small-subunit processome	4	1
GO:0032991	protein-containing complex	1	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3S7X7L0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7L0

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	12
GO:0022613	ribonucleoprotein complex biogenesis	4	12
GO:0042254	ribosome biogenesis	5	12
GO:0044085	cellular component biogenesis	3	12
GO:0071840	cellular component organization or biogenesis	2	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.373
CLV_NRD_NRD_1	159	161	PF00675	0.514
CLV_NRD_NRD_1	321	323	PF00675	0.221
CLV_NRD_NRD_1	97	99	PF00675	0.405
CLV_PCSK_KEX2_1	159	161	PF00082	0.514
CLV_PCSK_KEX2_1	300	302	PF00082	0.277
CLV_PCSK_KEX2_1	99	101	PF00082	0.384
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.277
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.384
CLV_PCSK_PC7_1	95	101	PF00082	0.340
CLV_PCSK_SKI1_1	179	183	PF00082	0.540
CLV_PCSK_SKI1_1	322	326	PF00082	0.247
CLV_PCSK_SKI1_1	434	438	PF00082	0.298
CLV_PCSK_SKI1_1	62	66	PF00082	0.295
DEG_APCC_DBOX_1	273	281	PF00400	0.410
DEG_COP1_1	284	293	PF00400	0.435
DEG_MDM2_SWIB_1	182	190	PF02201	0.296
DEG_Nend_UBRbox_2	1	3	PF02207	0.534
DEG_SPOP_SBC_1	390	394	PF00917	0.434
DEG_SPOP_SBC_1	415	419	PF00917	0.568
DOC_CDC14_PxL_1	308	316	PF14671	0.421
DOC_CKS1_1	263	268	PF01111	0.421
DOC_CYCLIN_RxL_1	273	287	PF00134	0.420
DOC_CYCLIN_yCln2_LP_2	214	220	PF00134	0.250
DOC_MAPK_DCC_7	403	413	PF00069	0.421
DOC_MAPK_gen_1	300	307	PF00069	0.435
DOC_MAPK_MEF2A_6	403	411	PF00069	0.421
DOC_PP1_RVXF_1	130	136	PF00149	0.313
DOC_PP2B_LxvP_1	288	291	PF13499	0.421
DOC_PP2B_LxvP_1	307	310	PF13499	0.421
DOC_PP4_FxxP_1	316	319	PF00568	0.410
DOC_USP7_MATH_1	303	307	PF00917	0.512
DOC_USP7_MATH_1	390	394	PF00917	0.434
DOC_USP7_MATH_1	415	419	PF00917	0.541
DOC_USP7_MATH_1	443	447	PF00917	0.532
DOC_WW_Pin1_4	104	109	PF00397	0.378
DOC_WW_Pin1_4	262	267	PF00397	0.421
DOC_WW_Pin1_4	27	32	PF00397	0.576
DOC_WW_Pin1_4	36	41	PF00397	0.602
DOC_WW_Pin1_4	421	426	PF00397	0.592
DOC_WW_Pin1_4	47	52	PF00397	0.539
DOC_WW_Pin1_4	72	77	PF00397	0.607
LIG_AP2alpha_2	377	379	PF02296	0.421
LIG_APCC_ABBA_1	170	175	PF00400	0.239
LIG_BRCT_BRCA1_1	316	320	PF00533	0.500
LIG_Clathr_ClatBox_1	244	248	PF01394	0.262
LIG_eIF4E_1	275	281	PF01652	0.417
LIG_FHA_1	120	126	PF00498	0.408
LIG_FHA_1	165	171	PF00498	0.307
LIG_FHA_1	213	219	PF00498	0.254
LIG_FHA_1	263	269	PF00498	0.430
LIG_FHA_1	367	373	PF00498	0.478
LIG_FHA_1	386	392	PF00498	0.513
LIG_FHA_1	435	441	PF00498	0.505
LIG_FHA_1	461	467	PF00498	0.612
LIG_FHA_2	15	21	PF00498	0.464
LIG_FHA_2	392	398	PF00498	0.435
LIG_FHA_2	417	423	PF00498	0.546
LIG_FHA_2	47	53	PF00498	0.614
LIG_FHA_2	73	79	PF00498	0.564
LIG_LIR_Apic_2	313	319	PF02991	0.477
LIG_LIR_Apic_2	451	457	PF02991	0.560
LIG_LIR_Gen_1	114	125	PF02991	0.341
LIG_LIR_Gen_1	17	25	PF02991	0.462
LIG_LIR_Gen_1	183	190	PF02991	0.341
LIG_LIR_Gen_1	258	269	PF02991	0.477
LIG_LIR_Nem_3	114	120	PF02991	0.341
LIG_LIR_Nem_3	17	21	PF02991	0.452
LIG_LIR_Nem_3	252	256	PF02991	0.413
LIG_LIR_Nem_3	258	264	PF02991	0.406
LIG_LIR_Nem_3	276	281	PF02991	0.318
LIG_LIR_Nem_3	313	318	PF02991	0.482
LIG_LIR_Nem_3	402	408	PF02991	0.512
LIG_LIR_Nem_3	429	435	PF02991	0.507
LIG_LIR_Nem_3	79	85	PF02991	0.444
LIG_NRBOX	259	265	PF00104	0.420
LIG_NRBOX	276	282	PF00104	0.349
LIG_PDZ_Class_2	463	468	PF00595	0.585
LIG_Pex14_1	82	86	PF04695	0.456
LIG_Pex14_2	182	186	PF04695	0.228
LIG_Pex14_2	316	320	PF04695	0.410
LIG_SH2_CRK	261	265	PF00017	0.419
LIG_SH2_CRK	432	436	PF00017	0.500
LIG_SH2_CRK	86	90	PF00017	0.484
LIG_SH2_NCK_1	454	458	PF00017	0.612
LIG_SH2_STAP1	257	261	PF00017	0.477
LIG_SH2_STAP1	428	432	PF00017	0.548
LIG_SH2_STAT3	256	259	PF00017	0.421
LIG_SH2_STAT5	151	154	PF00017	0.294
LIG_SH2_STAT5	223	226	PF00017	0.271
LIG_SH2_STAT5	293	296	PF00017	0.410
LIG_SH2_STAT5	315	318	PF00017	0.410
LIG_SH3_3	206	212	PF00018	0.256
LIG_SH3_3	39	45	PF00018	0.638
LIG_SH3_3	404	410	PF00018	0.426
LIG_SUMO_SIM_par_1	167	175	PF11976	0.258
LIG_SUMO_SIM_par_1	215	222	PF11976	0.256
LIG_SUMO_SIM_par_1	232	238	PF11976	0.299
LIG_SUMO_SIM_par_1	243	248	PF11976	0.222
LIG_SUMO_SIM_par_1	279	284	PF11976	0.421
LIG_SUMO_SIM_par_1	409	414	PF11976	0.431
LIG_TYR_ITIM	84	89	PF00017	0.484
LIG_WRC_WIRS_1	181	186	PF05994	0.187
MOD_CDK_SPK_2	52	57	PF00069	0.593
MOD_CDK_SPxK_1	421	427	PF00069	0.592
MOD_CDK_SPxxK_3	36	43	PF00069	0.547
MOD_CK1_1	154	160	PF00069	0.374
MOD_CK1_1	168	174	PF00069	0.182
MOD_CK1_1	235	241	PF00069	0.385
MOD_CK1_1	262	268	PF00069	0.461
MOD_CK1_1	284	290	PF00069	0.432
MOD_CK1_1	3	9	PF00069	0.477
MOD_CK1_1	414	420	PF00069	0.549
MOD_CK2_1	335	341	PF00069	0.425
MOD_CK2_1	391	397	PF00069	0.434
MOD_CK2_1	415	421	PF00069	0.519
MOD_CK2_1	47	53	PF00069	0.523
MOD_CK2_1	72	78	PF00069	0.576
MOD_GlcNHglycan	229	232	PF01048	0.301
MOD_GlcNHglycan	359	362	PF01048	0.311
MOD_GlcNHglycan	413	416	PF01048	0.289
MOD_GlcNHglycan	6	9	PF01048	0.368
MOD_GSK3_1	104	111	PF00069	0.554
MOD_GSK3_1	145	152	PF00069	0.332
MOD_GSK3_1	164	171	PF00069	0.295
MOD_GSK3_1	222	229	PF00069	0.306
MOD_GSK3_1	310	317	PF00069	0.521
MOD_GSK3_1	385	392	PF00069	0.507
MOD_GSK3_1	411	418	PF00069	0.497
MOD_GSK3_1	434	441	PF00069	0.503
MOD_GSK3_1	460	467	PF00069	0.617
MOD_N-GLC_1	154	159	PF02516	0.575
MOD_N-GLC_1	164	169	PF02516	0.567
MOD_NEK2_1	119	124	PF00069	0.434
MOD_NEK2_1	164	169	PF00069	0.292
MOD_NEK2_1	281	286	PF00069	0.421
MOD_NEK2_1	314	319	PF00069	0.512
MOD_NEK2_1	366	371	PF00069	0.465
MOD_NEK2_1	385	390	PF00069	0.469
MOD_NEK2_1	391	396	PF00069	0.457
MOD_NEK2_1	411	416	PF00069	0.479
MOD_PK_1	205	211	PF00069	0.346
MOD_PKA_1	98	104	PF00069	0.633
MOD_PKA_2	336	342	PF00069	0.410
MOD_PKA_2	366	372	PF00069	0.436
MOD_Plk_1	164	170	PF00069	0.412
MOD_Plk_1	281	287	PF00069	0.435
MOD_Plk_1	396	402	PF00069	0.436
MOD_Plk_1	428	434	PF00069	0.513
MOD_Plk_2-3	455	461	PF00069	0.610
MOD_Plk_4	108	114	PF00069	0.406
MOD_Plk_4	165	171	PF00069	0.302
MOD_Plk_4	205	211	PF00069	0.347
MOD_Plk_4	259	265	PF00069	0.436
MOD_Plk_4	289	295	PF00069	0.421
MOD_Plk_4	303	309	PF00069	0.474
MOD_Plk_4	310	316	PF00069	0.498
MOD_Plk_4	391	397	PF00069	0.421
MOD_ProDKin_1	104	110	PF00069	0.378
MOD_ProDKin_1	262	268	PF00069	0.421
MOD_ProDKin_1	27	33	PF00069	0.573
MOD_ProDKin_1	36	42	PF00069	0.608
MOD_ProDKin_1	421	427	PF00069	0.594
MOD_ProDKin_1	47	53	PF00069	0.538
MOD_ProDKin_1	72	78	PF00069	0.599
MOD_SUMO_for_1	138	141	PF00179	0.336
MOD_SUMO_for_1	143	146	PF00179	0.352
MOD_SUMO_rev_2	20	30	PF00179	0.554
MOD_SUMO_rev_2	417	425	PF00179	0.626
TRG_DiLeu_BaEn_1	276	281	PF01217	0.477
TRG_DiLeu_LyEn_5	276	281	PF01217	0.512
TRG_ENDOCYTIC_2	18	21	PF00928	0.456
TRG_ENDOCYTIC_2	257	260	PF00928	0.410
TRG_ENDOCYTIC_2	261	264	PF00928	0.410
TRG_ENDOCYTIC_2	275	278	PF00928	0.318
TRG_ENDOCYTIC_2	315	318	PF00928	0.432
TRG_ENDOCYTIC_2	432	435	PF00928	0.497
TRG_ENDOCYTIC_2	86	89	PF00928	0.484
TRG_ER_diArg_1	272	275	PF00400	0.391
TRG_NES_CRM1_1	60	72	PF08389	0.527
TRG_NLS_MonoExtC_3	97	102	PF00514	0.550
TRG_NLS_MonoExtN_4	95	102	PF00514	0.547
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSH0	Leptomonas seymouri	81%	100%
A0A0S4JK57	Bodo saltans	48%	100%
A0A1X0P9H6	Trypanosomatidae	59%	100%
A0A422N8P2	Trypanosoma rangeli	59%	100%
A4HAI3	Leishmania braziliensis	92%	100%
C9ZN09	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AHS4	Leishmania infantum	100%	100%
E9B4P4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
F4IMH3	Arabidopsis thaliana	30%	81%
Q4Q3D2	Leishmania major	96%	100%
Q5ZJC7	Gallus gallus	27%	92%
V5BAB5	Trypanosoma cruzi	61%	100%