Leucine-rich repeat protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cysteine leucine rich protein

Species:

Leishmania donovani

UniProt:

A0A3S7X7J0_LEIDO

TriTrypDb:

LdBPK_340570.1 , LdCL_340011300 , LDHU3_34.0960

Length:

621

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7
GO:0000151	ubiquitin ligase complex	3	1
GO:0005634	nucleus	5	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0019005	SCF ubiquitin ligase complex	5	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A0A3S7X7J0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7J0

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	7	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	571	573	PF00675	0.622
CLV_PCSK_KEX2_1	500	502	PF00082	0.431
CLV_PCSK_PC1ET2_1	500	502	PF00082	0.431
CLV_PCSK_SKI1_1	23	27	PF00082	0.663
CLV_PCSK_SKI1_1	285	289	PF00082	0.469
CLV_PCSK_SKI1_1	500	504	PF00082	0.491
CLV_PCSK_SKI1_1	551	555	PF00082	0.473
DEG_SPOP_SBC_1	140	144	PF00917	0.622
DEG_SPOP_SBC_1	211	215	PF00917	0.643
DOC_CDC14_PxL_1	543	551	PF14671	0.490
DOC_CKS1_1	595	600	PF01111	0.605
DOC_CYCLIN_RxL_1	432	440	PF00134	0.484
DOC_MAPK_gen_1	500	507	PF00069	0.481
DOC_MAPK_gen_1	572	580	PF00069	0.515
DOC_MAPK_MEF2A_6	519	528	PF00069	0.403
DOC_PP1_RVXF_1	458	465	PF00149	0.572
DOC_PP2B_LxvP_1	466	469	PF13499	0.611
DOC_PP4_FxxP_1	229	232	PF00568	0.744
DOC_PP4_FxxP_1	97	100	PF00568	0.674
DOC_USP7_MATH_1	139	143	PF00917	0.719
DOC_USP7_MATH_1	200	204	PF00917	0.695
DOC_USP7_MATH_1	212	216	PF00917	0.658
DOC_USP7_MATH_1	244	248	PF00917	0.740
DOC_USP7_MATH_1	259	263	PF00917	0.420
DOC_USP7_MATH_1	378	382	PF00917	0.433
DOC_USP7_MATH_1	474	478	PF00917	0.488
DOC_USP7_MATH_1	581	585	PF00917	0.613
DOC_USP7_MATH_1	76	80	PF00917	0.793
DOC_WW_Pin1_4	142	147	PF00397	0.700
DOC_WW_Pin1_4	162	167	PF00397	0.681
DOC_WW_Pin1_4	305	310	PF00397	0.556
DOC_WW_Pin1_4	594	599	PF00397	0.723
DOC_WW_Pin1_4	607	612	PF00397	0.691
DOC_WW_Pin1_4	72	77	PF00397	0.711
LIG_14-3-3_CanoR_1	336	343	PF00244	0.370
LIG_14-3-3_CanoR_1	403	410	PF00244	0.467
LIG_14-3-3_CanoR_1	501	506	PF00244	0.476
LIG_14-3-3_CanoR_1	519	523	PF00244	0.486
LIG_Actin_WH2_2	487	505	PF00022	0.420
LIG_BIR_II_1	1	5	PF00653	0.706
LIG_BIR_III_1	1	5	PF00653	0.808
LIG_BIR_III_2	339	343	PF00653	0.436
LIG_BIR_III_3	1	5	PF00653	0.808
LIG_BRCT_BRCA1_1	346	350	PF00533	0.468
LIG_FHA_1	152	158	PF00498	0.748
LIG_FHA_1	165	171	PF00498	0.592
LIG_FHA_1	20	26	PF00498	0.695
LIG_FHA_1	359	365	PF00498	0.561
LIG_FHA_1	424	430	PF00498	0.429
LIG_FHA_1	502	508	PF00498	0.469
LIG_FHA_1	548	554	PF00498	0.558
LIG_FHA_1	76	82	PF00498	0.735
LIG_FHA_2	142	148	PF00498	0.800
LIG_FHA_2	511	517	PF00498	0.513
LIG_FHA_2	536	542	PF00498	0.474
LIG_FHA_2	572	578	PF00498	0.543
LIG_FHA_2	611	617	PF00498	0.772
LIG_LIR_Apic_2	592	598	PF02991	0.624
LIG_LIR_Nem_3	171	176	PF02991	0.788
LIG_LIR_Nem_3	63	67	PF02991	0.691
LIG_LYPXL_yS_3	67	70	PF13949	0.681
LIG_NRBOX	461	467	PF00104	0.574
LIG_Rb_pABgroove_1	344	352	PF01858	0.462
LIG_SH2_CRK	595	599	PF00017	0.608
LIG_SH2_CRK	98	102	PF00017	0.712
LIG_SH2_SRC	98	101	PF00017	0.711
LIG_SH2_STAP1	404	408	PF00017	0.468
LIG_SH2_STAT3	96	99	PF00017	0.800
LIG_SH2_STAT5	401	404	PF00017	0.406
LIG_SH2_STAT5	96	99	PF00017	0.722
LIG_SH3_1	601	607	PF00018	0.825
LIG_SH3_1	98	104	PF00018	0.789
LIG_SH3_3	160	166	PF00018	0.702
LIG_SH3_3	185	191	PF00018	0.787
LIG_SH3_3	204	210	PF00018	0.610
LIG_SH3_3	601	607	PF00018	0.825
LIG_SH3_3	98	104	PF00018	0.737
LIG_SUMO_SIM_par_1	479	484	PF11976	0.442
LIG_TRAF2_1	513	516	PF00917	0.468
LIG_WRC_WIRS_1	489	494	PF05994	0.537
MOD_CDK_SPxxK_3	594	601	PF00069	0.740
MOD_CK1_1	142	148	PF00069	0.625
MOD_CK1_1	165	171	PF00069	0.682
MOD_CK1_1	213	219	PF00069	0.694
MOD_CK1_1	488	494	PF00069	0.476
MOD_CK1_1	518	524	PF00069	0.519
MOD_CK1_1	605	611	PF00069	0.755
MOD_CK1_1	75	81	PF00069	0.789
MOD_CK2_1	141	147	PF00069	0.796
MOD_CK2_1	259	265	PF00069	0.533
MOD_CK2_1	510	516	PF00069	0.514
MOD_CK2_1	571	577	PF00069	0.541
MOD_CK2_1	610	616	PF00069	0.773
MOD_GlcNHglycan	167	170	PF01048	0.791
MOD_GlcNHglycan	354	357	PF01048	0.390
MOD_GlcNHglycan	51	54	PF01048	0.625
MOD_GlcNHglycan	591	594	PF01048	0.814
MOD_GSK3_1	15	22	PF00069	0.664
MOD_GSK3_1	164	171	PF00069	0.713
MOD_GSK3_1	212	219	PF00069	0.760
MOD_GSK3_1	245	252	PF00069	0.594
MOD_GSK3_1	354	361	PF00069	0.399
MOD_GSK3_1	383	390	PF00069	0.470
MOD_GSK3_1	501	508	PF00069	0.514
MOD_GSK3_1	602	609	PF00069	0.747
MOD_GSK3_1	68	75	PF00069	0.768
MOD_GSK3_1	82	89	PF00069	0.637
MOD_N-GLC_1	244	249	PF02516	0.751
MOD_N-GLC_1	30	35	PF02516	0.691
MOD_N-GLC_1	352	357	PF02516	0.434
MOD_N-GLC_1	392	397	PF02516	0.570
MOD_N-GLC_1	79	84	PF02516	0.816
MOD_N-GLC_2	330	332	PF02516	0.543
MOD_N-GLC_2	380	382	PF02516	0.438
MOD_NEK2_1	201	206	PF00069	0.811
MOD_NEK2_1	249	254	PF00069	0.543
MOD_NEK2_1	352	357	PF00069	0.434
MOD_NEK2_1	358	363	PF00069	0.458
MOD_NEK2_1	437	442	PF00069	0.597
MOD_NEK2_1	494	499	PF00069	0.550
MOD_NEK2_1	507	512	PF00069	0.409
MOD_NEK2_1	571	576	PF00069	0.541
MOD_PIKK_1	454	460	PF00454	0.468
MOD_PIKK_1	79	85	PF00454	0.694
MOD_PIKK_1	86	92	PF00454	0.646
MOD_PKA_2	324	330	PF00069	0.418
MOD_PKA_2	335	341	PF00069	0.458
MOD_PKA_2	402	408	PF00069	0.458
MOD_PKA_2	505	511	PF00069	0.472
MOD_PKA_2	518	524	PF00069	0.495
MOD_PKA_2	571	577	PF00069	0.541
MOD_Plk_1	244	250	PF00069	0.713
MOD_Plk_1	30	36	PF00069	0.694
MOD_Plk_1	386	392	PF00069	0.461
MOD_Plk_1	454	460	PF00069	0.450
MOD_Plk_1	515	521	PF00069	0.514
MOD_Plk_1	79	85	PF00069	0.641
MOD_Plk_4	153	159	PF00069	0.785
MOD_Plk_4	201	207	PF00069	0.819
MOD_Plk_4	344	350	PF00069	0.471
MOD_Plk_4	354	360	PF00069	0.443
MOD_Plk_4	485	491	PF00069	0.419
MOD_Plk_4	524	530	PF00069	0.385
MOD_ProDKin_1	142	148	PF00069	0.702
MOD_ProDKin_1	162	168	PF00069	0.681
MOD_ProDKin_1	305	311	PF00069	0.551
MOD_ProDKin_1	594	600	PF00069	0.720
MOD_ProDKin_1	607	613	PF00069	0.691
MOD_ProDKin_1	72	78	PF00069	0.712
MOD_SUMO_rev_2	115	120	PF00179	0.794
MOD_SUMO_rev_2	390	400	PF00179	0.455
MOD_SUMO_rev_2	561	565	PF00179	0.551
TRG_ENDOCYTIC_2	67	70	PF00928	0.681
TRG_Pf-PMV_PEXEL_1	392	396	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N0	Leptomonas seymouri	64%	99%
A4H7D3	Leishmania braziliensis	82%	100%
A4I9M5	Leishmania infantum	99%	100%
E9B4M4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q3F2	Leishmania major	95%	100%