Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X7I7_LEIDO

TriTrypDb:

LdBPK_340810.1 , LdCL_340013600 , LDHU3_34.1300

Length:

212

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X7I7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7I7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	41	45	PF00656	0.641
CLV_C14_Caspase3-7	53	57	PF00656	0.611
CLV_NRD_NRD_1	8	10	PF00675	0.440
CLV_PCSK_KEX2_1	111	113	PF00082	0.422
CLV_PCSK_KEX2_1	7	9	PF00082	0.443
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.388
CLV_PCSK_SKI1_1	34	38	PF00082	0.427
DEG_COP1_1	142	151	PF00400	0.596
DOC_ANK_TNKS_1	51	58	PF00023	0.640
DOC_USP7_MATH_1	125	129	PF00917	0.675
DOC_USP7_MATH_1	32	36	PF00917	0.631
LIG_14-3-3_CanoR_1	112	120	PF00244	0.616
LIG_BIR_II_1	1	5	PF00653	0.634
LIG_FHA_1	71	77	PF00498	0.602
LIG_FHA_2	165	171	PF00498	0.694
LIG_FHA_2	51	57	PF00498	0.659
LIG_LIR_Gen_1	170	180	PF02991	0.460
LIG_LIR_Gen_1	25	32	PF02991	0.654
LIG_LIR_Nem_3	170	175	PF02991	0.687
LIG_LIR_Nem_3	25	30	PF02991	0.655
LIG_NRP_CendR_1	209	212	PF00754	0.619
LIG_Pex14_1	179	183	PF04695	0.265
LIG_Pex14_2	175	179	PF04695	0.265
LIG_Pex14_2	183	187	PF04695	0.265
LIG_PTB_Apo_2	21	28	PF02174	0.620
LIG_SH2_STAP1	12	16	PF00017	0.648
LIG_SH2_STAP1	185	189	PF00017	0.291
LIG_SH2_STAT5	182	185	PF00017	0.491
LIG_SH2_STAT5	206	209	PF00017	0.419
LIG_SH3_3	26	32	PF00018	0.614
MOD_CK1_1	139	145	PF00069	0.627
MOD_CK1_1	40	46	PF00069	0.659
MOD_CK1_1	50	56	PF00069	0.633
MOD_CK2_1	147	153	PF00069	0.615
MOD_CK2_1	164	170	PF00069	0.603
MOD_CK2_1	90	96	PF00069	0.613
MOD_GlcNHglycan	144	147	PF01048	0.414
MOD_GlcNHglycan	187	190	PF01048	0.288
MOD_GlcNHglycan	33	37	PF01048	0.425
MOD_GlcNHglycan	56	60	PF01048	0.443
MOD_GSK3_1	34	41	PF00069	0.658
MOD_GSK3_1	43	50	PF00069	0.636
MOD_N-GLC_1	38	43	PF02516	0.458
MOD_N-GLC_1	70	75	PF02516	0.380
MOD_NEK2_1	187	192	PF00069	0.291
MOD_NEK2_1	195	200	PF00069	0.398
MOD_NEK2_1	3	8	PF00069	0.636
MOD_NEK2_1	72	77	PF00069	0.645
MOD_NEK2_2	119	124	PF00069	0.601
MOD_PIKK_1	111	117	PF00454	0.748
MOD_PIKK_1	38	44	PF00454	0.628
MOD_PKA_1	111	117	PF00069	0.592
MOD_PKA_2	111	117	PF00069	0.592
MOD_PKA_2	154	160	PF00069	0.621
MOD_Plk_1	43	49	PF00069	0.649
MOD_Plk_2-3	90	96	PF00069	0.609
MOD_SUMO_rev_2	130	140	PF00179	0.621
TRG_DiLeu_BaEn_4	132	138	PF01217	0.640
TRG_ENDOCYTIC_2	177	180	PF00928	0.469
TRG_ER_diArg_1	7	9	PF00400	0.644
TRG_NES_CRM1_1	62	74	PF08389	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBG5	Leptomonas seymouri	43%	89%
A4HAI6	Leishmania braziliensis	64%	100%
E9AHS7	Leishmania infantum	100%	100%
E9B4P7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q3C9	Leishmania major	91%	100%