LisH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X7I5_LEIDO

TriTrypDb:

LdBPK_340620.1 , LdCL_340011800 , LDHU3_34.1030

Length:

845

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X7I5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7I5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	238	242	PF00656	0.696
CLV_C14_Caspase3-7	600	604	PF00656	0.661
CLV_C14_Caspase3-7	767	771	PF00656	0.600
CLV_NRD_NRD_1	139	141	PF00675	0.605
CLV_NRD_NRD_1	142	144	PF00675	0.643
CLV_NRD_NRD_1	287	289	PF00675	0.567
CLV_NRD_NRD_1	372	374	PF00675	0.541
CLV_NRD_NRD_1	432	434	PF00675	0.490
CLV_NRD_NRD_1	438	440	PF00675	0.490
CLV_NRD_NRD_1	593	595	PF00675	0.629
CLV_NRD_NRD_1	779	781	PF00675	0.579
CLV_NRD_NRD_1	92	94	PF00675	0.807
CLV_PCSK_FUR_1	140	144	PF00082	0.627
CLV_PCSK_FUR_1	777	781	PF00082	0.441
CLV_PCSK_KEX2_1	139	141	PF00082	0.605
CLV_PCSK_KEX2_1	142	144	PF00082	0.643
CLV_PCSK_KEX2_1	269	271	PF00082	0.625
CLV_PCSK_KEX2_1	287	289	PF00082	0.567
CLV_PCSK_KEX2_1	372	374	PF00082	0.541
CLV_PCSK_KEX2_1	432	434	PF00082	0.497
CLV_PCSK_KEX2_1	438	440	PF00082	0.475
CLV_PCSK_KEX2_1	533	535	PF00082	0.608
CLV_PCSK_KEX2_1	593	595	PF00082	0.629
CLV_PCSK_KEX2_1	779	781	PF00082	0.517
CLV_PCSK_KEX2_1	788	790	PF00082	0.707
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.725
CLV_PCSK_PC1ET2_1	533	535	PF00082	0.608
CLV_PCSK_PC1ET2_1	788	790	PF00082	0.713
CLV_PCSK_SKI1_1	201	205	PF00082	0.620
CLV_PCSK_SKI1_1	260	264	PF00082	0.657
CLV_PCSK_SKI1_1	343	347	PF00082	0.530
CLV_PCSK_SKI1_1	52	56	PF00082	0.616
CLV_PCSK_SKI1_1	780	784	PF00082	0.672
DEG_APCC_DBOX_1	342	350	PF00400	0.528
DEG_APCC_DBOX_1	458	466	PF00400	0.640
DEG_SIAH_1	576	584	PF03145	0.697
DEG_SPOP_SBC_1	500	504	PF00917	0.737
DEG_SPOP_SBC_1	626	630	PF00917	0.665
DEG_SPOP_SBC_1	674	678	PF00917	0.729
DEG_SPOP_SBC_1	717	721	PF00917	0.610
DOC_ANK_TNKS_1	319	326	PF00023	0.626
DOC_CKS1_1	106	111	PF01111	0.761
DOC_CYCLIN_RxL_1	340	350	PF00134	0.548
DOC_MAPK_gen_1	139	149	PF00069	0.622
DOC_MAPK_gen_1	399	407	PF00069	0.501
DOC_MAPK_gen_1	457	464	PF00069	0.486
DOC_MAPK_MEF2A_6	140	149	PF00069	0.623
DOC_MAPK_NFAT4_5	142	150	PF00069	0.605
DOC_PP2B_PxIxI_1	108	114	PF00149	0.808
DOC_USP7_MATH_1	112	116	PF00917	0.738
DOC_USP7_MATH_1	181	185	PF00917	0.684
DOC_USP7_MATH_1	194	198	PF00917	0.693
DOC_USP7_MATH_1	24	28	PF00917	0.703
DOC_USP7_MATH_1	246	250	PF00917	0.574
DOC_USP7_MATH_1	480	484	PF00917	0.734
DOC_USP7_MATH_1	500	504	PF00917	0.531
DOC_USP7_MATH_1	583	587	PF00917	0.693
DOC_USP7_MATH_1	596	600	PF00917	0.780
DOC_USP7_MATH_1	607	611	PF00917	0.686
DOC_USP7_MATH_1	615	619	PF00917	0.697
DOC_USP7_MATH_1	626	630	PF00917	0.712
DOC_USP7_MATH_1	631	635	PF00917	0.712
DOC_USP7_MATH_1	655	659	PF00917	0.689
DOC_USP7_MATH_1	675	679	PF00917	0.502
DOC_USP7_MATH_1	699	703	PF00917	0.741
DOC_USP7_MATH_1	768	772	PF00917	0.592
DOC_USP7_MATH_1	80	84	PF00917	0.648
DOC_WW_Pin1_4	102	107	PF00397	0.793
DOC_WW_Pin1_4	17	22	PF00397	0.732
DOC_WW_Pin1_4	192	197	PF00397	0.758
DOC_WW_Pin1_4	546	551	PF00397	0.672
DOC_WW_Pin1_4	557	562	PF00397	0.786
DOC_WW_Pin1_4	569	574	PF00397	0.635
DOC_WW_Pin1_4	592	597	PF00397	0.757
DOC_WW_Pin1_4	608	613	PF00397	0.582
DOC_WW_Pin1_4	622	627	PF00397	0.818
DOC_WW_Pin1_4	632	637	PF00397	0.692
DOC_WW_Pin1_4	682	687	PF00397	0.774
DOC_WW_Pin1_4	795	800	PF00397	0.711
LIG_14-3-3_CanoR_1	142	148	PF00244	0.627
LIG_14-3-3_CanoR_1	501	506	PF00244	0.727
LIG_14-3-3_CanoR_1	569	573	PF00244	0.581
LIG_14-3-3_CanoR_1	669	673	PF00244	0.828
LIG_14-3-3_CanoR_1	709	718	PF00244	0.832
LIG_14-3-3_CanoR_1	789	797	PF00244	0.670
LIG_Actin_WH2_2	126	141	PF00022	0.580
LIG_Actin_WH2_2	25	40	PF00022	0.716
LIG_Actin_WH2_2	342	359	PF00022	0.527
LIG_BIR_II_1	1	5	PF00653	0.839
LIG_CAP-Gly_1	839	845	PF01302	0.786
LIG_Clathr_ClatBox_1	346	350	PF01394	0.526
LIG_Clathr_ClatBox_1	420	424	PF01394	0.542
LIG_CtBP_PxDLS_1	85	89	PF00389	0.736
LIG_FHA_1	106	112	PF00498	0.761
LIG_FHA_1	11	17	PF00498	0.625
LIG_FHA_1	218	224	PF00498	0.756
LIG_FHA_1	242	248	PF00498	0.557
LIG_FHA_1	29	35	PF00498	0.753
LIG_FHA_1	333	339	PF00498	0.626
LIG_FHA_1	400	406	PF00498	0.623
LIG_FHA_1	46	52	PF00498	0.708
LIG_FHA_1	490	496	PF00498	0.714
LIG_FHA_1	502	508	PF00498	0.581
LIG_FHA_1	742	748	PF00498	0.602
LIG_FHA_1	782	788	PF00498	0.570
LIG_FHA_2	150	156	PF00498	0.753
LIG_FHA_2	230	236	PF00498	0.682
LIG_FHA_2	749	755	PF00498	0.624
LIG_LIR_Gen_1	305	316	PF02991	0.535
LIG_LIR_Nem_3	264	268	PF02991	0.573
LIG_LIR_Nem_3	305	311	PF02991	0.479
LIG_LIR_Nem_3	324	330	PF02991	0.539
LIG_LIR_Nem_3	798	803	PF02991	0.705
LIG_NRBOX	511	517	PF00104	0.580
LIG_PCNA_yPIPBox_3	201	212	PF02747	0.606
LIG_PDZ_Class_2	840	845	PF00595	0.662
LIG_Pex14_2	823	827	PF04695	0.698
LIG_REV1ctd_RIR_1	277	286	PF16727	0.603
LIG_SH2_CRK	327	331	PF00017	0.525
LIG_SH2_CRK	513	517	PF00017	0.569
LIG_SH2_STAP1	261	265	PF00017	0.564
LIG_SH2_STAP1	304	308	PF00017	0.541
LIG_SH2_STAP1	471	475	PF00017	0.631
LIG_SH2_STAT5	171	174	PF00017	0.645
LIG_SH3_2	496	501	PF14604	0.743
LIG_SH3_3	103	109	PF00018	0.730
LIG_SH3_3	493	499	PF00018	0.747
LIG_SH3_3	503	509	PF00018	0.649
LIG_SH3_3	630	636	PF00018	0.781
LIG_SH3_3	669	675	PF00018	0.747
LIG_SH3_3	683	689	PF00018	0.664
LIG_SH3_3	722	728	PF00018	0.776
LIG_SH3_3	793	799	PF00018	0.696
LIG_SH3_CIN85_PxpxPR_1	496	501	PF14604	0.743
LIG_SUMO_SIM_par_1	30	36	PF11976	0.742
LIG_TRAF2_1	165	168	PF00917	0.647
LIG_TRAF2_1	428	431	PF00917	0.514
LIG_TRAF2_1	751	754	PF00917	0.686
LIG_WRC_WIRS_1	308	313	PF05994	0.507
LIG_WW_3	498	502	PF00397	0.741
MOD_CDC14_SPxK_1	595	598	PF00782	0.654
MOD_CDC14_SPxK_1	798	801	PF00782	0.725
MOD_CDK_SPK_2	627	632	PF00069	0.805
MOD_CDK_SPxK_1	557	563	PF00069	0.761
MOD_CDK_SPxK_1	592	598	PF00069	0.661
MOD_CDK_SPxK_1	682	688	PF00069	0.813
MOD_CDK_SPxK_1	795	801	PF00069	0.713
MOD_CK1_1	105	111	PF00069	0.682
MOD_CK1_1	148	154	PF00069	0.618
MOD_CK1_1	19	25	PF00069	0.698
MOD_CK1_1	199	205	PF00069	0.629
MOD_CK1_1	229	235	PF00069	0.691
MOD_CK1_1	3	9	PF00069	0.836
MOD_CK1_1	466	472	PF00069	0.603
MOD_CK1_1	599	605	PF00069	0.835
MOD_CK1_1	618	624	PF00069	0.545
MOD_CK1_1	658	664	PF00069	0.837
MOD_CK1_1	665	671	PF00069	0.702
MOD_CK1_1	677	683	PF00069	0.553
MOD_CK1_1	702	708	PF00069	0.702
MOD_CK1_1	711	717	PF00069	0.727
MOD_CK1_1	719	725	PF00069	0.663
MOD_CK1_1	748	754	PF00069	0.545
MOD_CK1_1	826	832	PF00069	0.637
MOD_CK1_1	98	104	PF00069	0.725
MOD_CK2_1	1	7	PF00069	0.839
MOD_CK2_1	149	155	PF00069	0.719
MOD_CK2_1	216	222	PF00069	0.686
MOD_CK2_1	229	235	PF00069	0.705
MOD_CK2_1	280	286	PF00069	0.572
MOD_CK2_1	299	305	PF00069	0.550
MOD_CK2_1	30	36	PF00069	0.641
MOD_CK2_1	388	394	PF00069	0.644
MOD_CK2_1	425	431	PF00069	0.512
MOD_CK2_1	746	752	PF00069	0.662
MOD_CK2_1	84	90	PF00069	0.821
MOD_DYRK1A_RPxSP_1	569	573	PF00069	0.581
MOD_GlcNHglycan	100	103	PF01048	0.735
MOD_GlcNHglycan	114	117	PF01048	0.576
MOD_GlcNHglycan	161	164	PF01048	0.725
MOD_GlcNHglycan	183	186	PF01048	0.694
MOD_GlcNHglycan	241	244	PF01048	0.623
MOD_GlcNHglycan	273	276	PF01048	0.660
MOD_GlcNHglycan	473	476	PF01048	0.708
MOD_GlcNHglycan	617	620	PF01048	0.737
MOD_GlcNHglycan	621	624	PF01048	0.748
MOD_GlcNHglycan	650	653	PF01048	0.707
MOD_GlcNHglycan	657	661	PF01048	0.792
MOD_GlcNHglycan	721	724	PF01048	0.705
MOD_GlcNHglycan	752	758	PF01048	0.562
MOD_GlcNHglycan	764	769	PF01048	0.580
MOD_GlcNHglycan	807	810	PF01048	0.750
MOD_GSK3_1	145	152	PF00069	0.693
MOD_GSK3_1	19	26	PF00069	0.688
MOD_GSK3_1	192	199	PF00069	0.693
MOD_GSK3_1	28	35	PF00069	0.587
MOD_GSK3_1	487	494	PF00069	0.711
MOD_GSK3_1	592	599	PF00069	0.711
MOD_GSK3_1	615	622	PF00069	0.708
MOD_GSK3_1	627	634	PF00069	0.818
MOD_GSK3_1	636	643	PF00069	0.796
MOD_GSK3_1	655	662	PF00069	0.733
MOD_GSK3_1	664	671	PF00069	0.657
MOD_GSK3_1	673	680	PF00069	0.541
MOD_GSK3_1	699	706	PF00069	0.795
MOD_GSK3_1	708	715	PF00069	0.598
MOD_GSK3_1	734	741	PF00069	0.623
MOD_GSK3_1	760	767	PF00069	0.544
MOD_GSK3_1	80	87	PF00069	0.708
MOD_GSK3_1	98	105	PF00069	0.761
MOD_N-GLC_1	332	337	PF02516	0.530
MOD_N-GLC_1	738	743	PF02516	0.655
MOD_N-GLC_1	823	828	PF02516	0.675
MOD_NEK2_1	1	6	PF00069	0.836
MOD_NEK2_1	138	143	PF00069	0.576
MOD_NEK2_1	145	150	PF00069	0.515
MOD_NEK2_1	159	164	PF00069	0.637
MOD_NEK2_1	268	273	PF00069	0.573
MOD_NEK2_1	341	346	PF00069	0.533
MOD_NEK2_1	415	420	PF00069	0.533
MOD_NEK2_1	45	50	PF00069	0.643
MOD_NEK2_1	617	622	PF00069	0.660
MOD_NEK2_1	703	708	PF00069	0.716
MOD_NEK2_1	710	715	PF00069	0.731
MOD_NEK2_1	746	751	PF00069	0.706
MOD_NEK2_1	823	828	PF00069	0.636
MOD_NEK2_1	95	100	PF00069	0.738
MOD_NEK2_2	196	201	PF00069	0.642
MOD_PIKK_1	10	16	PF00454	0.726
MOD_PIKK_1	229	235	PF00454	0.624
MOD_PIKK_1	53	59	PF00454	0.581
MOD_PIKK_1	601	607	PF00454	0.535
MOD_PIKK_1	78	84	PF00454	0.792
MOD_PK_1	688	694	PF00069	0.750
MOD_PKA_2	138	144	PF00069	0.608
MOD_PKA_2	374	380	PF00069	0.641
MOD_PKA_2	45	51	PF00069	0.703
MOD_PKA_2	466	472	PF00069	0.603
MOD_PKA_2	500	506	PF00069	0.695
MOD_PKA_2	568	574	PF00069	0.581
MOD_PKA_2	655	661	PF00069	0.835
MOD_PKA_2	668	674	PF00069	0.689
MOD_PKA_2	708	714	PF00069	0.733
MOD_PKA_2	768	774	PF00069	0.632
MOD_PKB_1	461	469	PF00069	0.552
MOD_Plk_1	118	124	PF00069	0.631
MOD_Plk_1	341	347	PF00069	0.532
MOD_Plk_1	490	496	PF00069	0.822
MOD_Plk_1	823	829	PF00069	0.655
MOD_Plk_2-3	394	400	PF00069	0.640
MOD_Plk_2-3	760	766	PF00069	0.619
MOD_Plk_2-3	781	787	PF00069	0.459
MOD_Plk_4	145	151	PF00069	0.621
MOD_Plk_4	199	205	PF00069	0.629
MOD_ProDKin_1	102	108	PF00069	0.794
MOD_ProDKin_1	17	23	PF00069	0.728
MOD_ProDKin_1	192	198	PF00069	0.754
MOD_ProDKin_1	546	552	PF00069	0.676
MOD_ProDKin_1	557	563	PF00069	0.784
MOD_ProDKin_1	569	575	PF00069	0.633
MOD_ProDKin_1	592	598	PF00069	0.757
MOD_ProDKin_1	608	614	PF00069	0.581
MOD_ProDKin_1	622	628	PF00069	0.821
MOD_ProDKin_1	632	638	PF00069	0.688
MOD_ProDKin_1	682	688	PF00069	0.776
MOD_ProDKin_1	795	801	PF00069	0.713
MOD_SUMO_for_1	347	350	PF00179	0.522
MOD_SUMO_for_1	410	413	PF00179	0.489
MOD_SUMO_for_1	450	453	PF00179	0.535
MOD_SUMO_rev_2	47	56	PF00179	0.709
MOD_SUMO_rev_2	781	790	PF00179	0.693
MOD_SUMO_rev_2	96	101	PF00179	0.833
TRG_DiLeu_BaEn_1	342	347	PF01217	0.532
TRG_DiLeu_BaEn_2	275	281	PF01217	0.634
TRG_DiLeu_BaEn_4	167	173	PF01217	0.644
TRG_DiLeu_BaEn_4	453	459	PF01217	0.519
TRG_DiLeu_BaLyEn_6	325	330	PF01217	0.562
TRG_ENDOCYTIC_2	308	311	PF00928	0.469
TRG_ENDOCYTIC_2	327	330	PF00928	0.551
TRG_ENDOCYTIC_2	513	516	PF00928	0.572
TRG_ER_diArg_1	138	140	PF00400	0.591
TRG_ER_diArg_1	287	289	PF00400	0.567
TRG_ER_diArg_1	353	356	PF00400	0.629
TRG_ER_diArg_1	372	375	PF00400	0.542
TRG_ER_diArg_1	432	434	PF00400	0.547
TRG_ER_diArg_1	437	439	PF00400	0.546
TRG_ER_diArg_1	457	460	PF00400	0.300
TRG_ER_diArg_1	461	464	PF00400	0.542
TRG_ER_diArg_1	777	780	PF00400	0.504
TRG_NES_CRM1_1	336	350	PF08389	0.628
TRG_NES_CRM1_1	453	468	PF08389	0.637
TRG_NES_CRM1_1	53	65	PF08389	0.596
TRG_NLS_MonoExtC_3	787	793	PF00514	0.727
TRG_Pf-PMV_PEXEL_1	287	291	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	328	332	PF00026	0.563
TRG_Pf-PMV_PEXEL_1	403	408	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	438	443	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	52	57	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	780	785	PF00026	0.494
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.741

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5X2	Leptomonas seymouri	65%	97%
A4HAH0	Leishmania braziliensis	72%	99%
A4I9N0	Leishmania infantum	100%	100%
E9B4M9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	97%
Q4Q3E7	Leishmania major	91%	100%