Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7X7I2_LEIDO

TriTrypDb:

LdBPK_340660.1 , LdCL_340012200 , LDHU3_34.1090

Length:

586

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	4
GO:0016020	membrane	2	4
GO:0042995	cell projection	2	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0110165	cellular anatomical entity	1	4
GO:0120025	plasma membrane bounded cell projection	3	4

Expansion

Sequence features

A0A3S7X7I2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7I2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.499
CLV_C14_Caspase3-7	221	225	PF00656	0.443
CLV_C14_Caspase3-7	335	339	PF00656	0.450
CLV_NRD_NRD_1	143	145	PF00675	0.629
CLV_NRD_NRD_1	361	363	PF00675	0.715
CLV_NRD_NRD_1	435	437	PF00675	0.675
CLV_NRD_NRD_1	581	583	PF00675	0.728
CLV_NRD_NRD_1	84	86	PF00675	0.544
CLV_PCSK_FUR_1	141	145	PF00082	0.656
CLV_PCSK_KEX2_1	143	145	PF00082	0.741
CLV_PCSK_KEX2_1	435	437	PF00082	0.675
CLV_PCSK_KEX2_1	84	86	PF00082	0.544
CLV_PCSK_PC7_1	80	86	PF00082	0.521
CLV_PCSK_SKI1_1	19	23	PF00082	0.506
CLV_PCSK_SKI1_1	233	237	PF00082	0.527
DEG_APCC_DBOX_1	143	151	PF00400	0.398
DEG_APCC_DBOX_1	373	381	PF00400	0.441
DEG_APCC_DBOX_1	487	495	PF00400	0.453
DEG_APCC_DBOX_1	83	91	PF00400	0.503
DEG_MDM2_SWIB_1	21	29	PF02201	0.418
DEG_Nend_Nbox_1	1	3	PF02207	0.651
DEG_SCF_FBW7_1	110	116	PF00400	0.478
DEG_SPOP_SBC_1	113	117	PF00917	0.519
DOC_CDC14_PxL_1	40	48	PF14671	0.488
DOC_CDC14_PxL_1	506	514	PF14671	0.452
DOC_CKS1_1	110	115	PF01111	0.465
DOC_CKS1_1	481	486	PF01111	0.470
DOC_CYCLIN_RxL_1	255	264	PF00134	0.468
DOC_CYCLIN_yCln2_LP_2	283	289	PF00134	0.445
DOC_MAPK_gen_1	435	442	PF00069	0.430
DOC_MAPK_gen_1	531	541	PF00069	0.456
DOC_MAPK_gen_1	84	92	PF00069	0.313
DOC_MAPK_MEF2A_6	19	26	PF00069	0.392
DOC_MAPK_MEF2A_6	435	444	PF00069	0.480
DOC_MAPK_MEF2A_6	534	543	PF00069	0.449
DOC_PP2B_LxvP_1	283	286	PF13499	0.329
DOC_PP4_FxxP_1	194	197	PF00568	0.400
DOC_PP4_MxPP_1	111	114	PF00568	0.405
DOC_USP7_MATH_1	114	118	PF00917	0.532
DOC_USP7_MATH_1	195	199	PF00917	0.441
DOC_USP7_MATH_1	218	222	PF00917	0.452
DOC_USP7_MATH_1	329	333	PF00917	0.510
DOC_USP7_MATH_1	421	425	PF00917	0.494
DOC_WW_Pin1_4	109	114	PF00397	0.447
DOC_WW_Pin1_4	193	198	PF00397	0.399
DOC_WW_Pin1_4	249	254	PF00397	0.502
DOC_WW_Pin1_4	434	439	PF00397	0.529
DOC_WW_Pin1_4	480	485	PF00397	0.479
DOC_WW_Pin1_4	520	525	PF00397	0.477
LIG_14-3-3_CanoR_1	531	537	PF00244	0.412
LIG_14-3-3_CanoR_1	542	550	PF00244	0.326
LIG_14-3-3_CterR_2	582	586	PF00244	0.437
LIG_Actin_WH2_2	175	191	PF00022	0.475
LIG_Actin_WH2_2	32	49	PF00022	0.652
LIG_BRCT_BRCA1_1	539	543	PF00533	0.440
LIG_Clathr_ClatBox_1	343	347	PF01394	0.485
LIG_FHA_1	174	180	PF00498	0.474
LIG_FHA_1	261	267	PF00498	0.363
LIG_FHA_1	313	319	PF00498	0.490
LIG_FHA_1	381	387	PF00498	0.446
LIG_FHA_1	435	441	PF00498	0.496
LIG_FHA_1	512	518	PF00498	0.450
LIG_FHA_1	536	542	PF00498	0.336
LIG_FHA_1	98	104	PF00498	0.448
LIG_FHA_2	113	119	PF00498	0.530
LIG_FHA_2	276	282	PF00498	0.396
LIG_FHA_2	286	292	PF00498	0.322
LIG_FHA_2	521	527	PF00498	0.477
LIG_GBD_Chelix_1	103	111	PF00786	0.662
LIG_LIR_Apic_2	192	197	PF02991	0.413
LIG_LIR_Gen_1	545	554	PF02991	0.460
LIG_LIR_Gen_1	563	572	PF02991	0.268
LIG_LIR_Gen_1	73	82	PF02991	0.477
LIG_LIR_Nem_3	545	550	PF02991	0.457
LIG_LIR_Nem_3	563	567	PF02991	0.268
LIG_MYND_3	509	513	PF01753	0.451
LIG_NRBOX	279	285	PF00104	0.443
LIG_PCNA_yPIPBox_3	33	47	PF02747	0.476
LIG_Pex14_2	21	25	PF04695	0.418
LIG_Pex14_2	543	547	PF04695	0.458
LIG_SH2_CRK	234	238	PF00017	0.449
LIG_SH2_CRK	4	8	PF00017	0.655
LIG_SH2_STAP1	234	238	PF00017	0.449
LIG_SH2_STAP1	303	307	PF00017	0.459
LIG_SH2_STAP1	572	576	PF00017	0.490
LIG_SH2_STAT3	276	279	PF00017	0.451
LIG_SH2_STAT5	276	279	PF00017	0.451
LIG_SH2_STAT5	289	292	PF00017	0.243
LIG_SH2_STAT5	384	387	PF00017	0.456
LIG_SH2_STAT5	496	499	PF00017	0.472
LIG_SH2_STAT5	570	573	PF00017	0.454
LIG_SH3_1	320	326	PF00018	0.525
LIG_SH3_3	107	113	PF00018	0.487
LIG_SH3_3	244	250	PF00018	0.483
LIG_SH3_3	320	326	PF00018	0.525
LIG_SH3_3	39	45	PF00018	0.537
LIG_SUMO_SIM_par_1	174	181	PF11976	0.450
LIG_SUMO_SIM_par_1	182	187	PF11976	0.397
LIG_SUMO_SIM_par_1	308	316	PF11976	0.479
LIG_SUMO_SIM_par_1	342	349	PF11976	0.406
LIG_SUMO_SIM_par_1	513	521	PF11976	0.462
LIG_SUMO_SIM_par_1	67	73	PF11976	0.526
LIG_TYR_ITIM	2	7	PF00017	0.558
LIG_WRC_WIRS_1	561	566	PF05994	0.562
MOD_CDK_SPxxK_3	434	441	PF00069	0.633
MOD_CK1_1	109	115	PF00069	0.560
MOD_CK1_1	332	338	PF00069	0.608
MOD_CK1_1	424	430	PF00069	0.806
MOD_CK1_1	452	458	PF00069	0.553
MOD_CK1_1	532	538	PF00069	0.568
MOD_CK1_1	8	14	PF00069	0.722
MOD_CK2_1	112	118	PF00069	0.717
MOD_CK2_1	166	172	PF00069	0.665
MOD_CK2_1	275	281	PF00069	0.462
MOD_CK2_1	458	464	PF00069	0.500
MOD_CK2_1	520	526	PF00069	0.588
MOD_Cter_Amidation	82	85	PF01082	0.372
MOD_GlcNHglycan	172	176	PF01048	0.631
MOD_GlcNHglycan	197	200	PF01048	0.506
MOD_GlcNHglycan	224	227	PF01048	0.543
MOD_GlcNHglycan	263	266	PF01048	0.573
MOD_GlcNHglycan	306	310	PF01048	0.567
MOD_GlcNHglycan	423	427	PF01048	0.799
MOD_GlcNHglycan	429	432	PF01048	0.734
MOD_GlcNHglycan	453	457	PF01048	0.548
MOD_GlcNHglycan	469	472	PF01048	0.323
MOD_GlcNHglycan	53	56	PF01048	0.822
MOD_GlcNHglycan	72	75	PF01048	0.288
MOD_GSK3_1	109	116	PF00069	0.576
MOD_GSK3_1	156	163	PF00069	0.588
MOD_GSK3_1	189	196	PF00069	0.662
MOD_GSK3_1	218	225	PF00069	0.547
MOD_GSK3_1	249	256	PF00069	0.628
MOD_GSK3_1	329	336	PF00069	0.629
MOD_GSK3_1	421	428	PF00069	0.652
MOD_GSK3_1	516	523	PF00069	0.572
MOD_GSK3_1	53	60	PF00069	0.730
MOD_LATS_1	370	376	PF00433	0.566
MOD_N-GLC_1	403	408	PF02516	0.454
MOD_N-GLC_1	57	62	PF02516	0.721
MOD_NEK2_1	182	187	PF00069	0.568
MOD_NEK2_1	260	265	PF00069	0.554
MOD_NEK2_1	31	36	PF00069	0.506
MOD_NEK2_1	313	318	PF00069	0.423
MOD_NEK2_1	380	385	PF00069	0.422
MOD_NEK2_1	386	391	PF00069	0.407
MOD_NEK2_1	403	408	PF00069	0.466
MOD_NEK2_1	492	497	PF00069	0.539
MOD_NEK2_1	530	535	PF00069	0.587
MOD_NEK2_1	90	95	PF00069	0.591
MOD_NEK2_2	166	171	PF00069	0.663
MOD_NEK2_2	253	258	PF00069	0.630
MOD_NEK2_2	387	392	PF00069	0.552
MOD_PIKK_1	135	141	PF00454	0.576
MOD_PIKK_1	241	247	PF00454	0.574
MOD_PIKK_1	275	281	PF00454	0.462
MOD_PIKK_1	403	409	PF00454	0.550
MOD_PIKK_1	5	11	PF00454	0.558
MOD_PKA_2	46	52	PF00069	0.721
MOD_PKA_2	5	11	PF00069	0.733
MOD_PKA_2	530	536	PF00069	0.460
MOD_PKA_2	97	103	PF00069	0.548
MOD_Plk_1	166	172	PF00069	0.665
MOD_Plk_1	305	311	PF00069	0.573
MOD_Plk_1	380	386	PF00069	0.535
MOD_Plk_1	492	498	PF00069	0.548
MOD_Plk_4	106	112	PF00069	0.582
MOD_Plk_4	211	217	PF00069	0.564
MOD_Plk_4	31	37	PF00069	0.422
MOD_Plk_4	511	517	PF00069	0.550
MOD_ProDKin_1	109	115	PF00069	0.560
MOD_ProDKin_1	193	199	PF00069	0.467
MOD_ProDKin_1	249	255	PF00069	0.604
MOD_ProDKin_1	434	440	PF00069	0.646
MOD_ProDKin_1	480	486	PF00069	0.583
MOD_ProDKin_1	520	526	PF00069	0.588
MOD_SUMO_rev_2	521	530	PF00179	0.592
TRG_ENDOCYTIC_2	234	237	PF00928	0.545
TRG_ENDOCYTIC_2	4	7	PF00928	0.562
TRG_ENDOCYTIC_2	572	575	PF00928	0.588
TRG_ER_diArg_1	140	143	PF00400	0.515
TRG_ER_diArg_1	434	436	PF00400	0.631
TRG_ER_diLys_1	583	586	PF00400	0.727
TRG_NES_CRM1_1	485	498	PF08389	0.443
TRG_NES_CRM1_1	508	521	PF08389	0.562
TRG_Pf-PMV_PEXEL_1	363	367	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	569	573	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E9B4N3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q3E3	Leishmania major	93%	100%