WD domain, G-beta repeat, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X7G1_LEIDO

TriTrypDb:

LdBPK_340320.1 , LdCL_340008300 , LDHU3_34.0470

Length:

762

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0030684	preribosome	3	1
GO:0032040	small-subunit processome	4	1
GO:0032991	protein-containing complex	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3S7X7G1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7G1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0030515	snoRNA binding	5	11
GO:0034511	U3 snoRNA binding	6	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.496
CLV_C14_Caspase3-7	630	634	PF00656	0.736
CLV_NRD_NRD_1	112	114	PF00675	0.607
CLV_NRD_NRD_1	18	20	PF00675	0.541
CLV_NRD_NRD_1	205	207	PF00675	0.516
CLV_NRD_NRD_1	276	278	PF00675	0.291
CLV_NRD_NRD_1	328	330	PF00675	0.499
CLV_NRD_NRD_1	37	39	PF00675	0.473
CLV_NRD_NRD_1	412	414	PF00675	0.418
CLV_NRD_NRD_1	467	469	PF00675	0.558
CLV_NRD_NRD_1	525	527	PF00675	0.729
CLV_NRD_NRD_1	566	568	PF00675	0.520
CLV_NRD_NRD_1	589	591	PF00675	0.495
CLV_NRD_NRD_1	692	694	PF00675	0.707
CLV_PCSK_KEX2_1	112	114	PF00082	0.607
CLV_PCSK_KEX2_1	18	20	PF00082	0.596
CLV_PCSK_KEX2_1	204	206	PF00082	0.595
CLV_PCSK_KEX2_1	412	414	PF00082	0.418
CLV_PCSK_KEX2_1	467	469	PF00082	0.558
CLV_PCSK_KEX2_1	511	513	PF00082	0.741
CLV_PCSK_KEX2_1	566	568	PF00082	0.486
CLV_PCSK_KEX2_1	692	694	PF00082	0.686
CLV_PCSK_KEX2_1	734	736	PF00082	0.675
CLV_PCSK_KEX2_1	758	760	PF00082	0.704
CLV_PCSK_KEX2_1	9	11	PF00082	0.562
CLV_PCSK_PC1ET2_1	511	513	PF00082	0.705
CLV_PCSK_PC1ET2_1	692	694	PF00082	0.712
CLV_PCSK_PC1ET2_1	734	736	PF00082	0.671
CLV_PCSK_PC1ET2_1	758	760	PF00082	0.673
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.641
CLV_PCSK_SKI1_1	206	210	PF00082	0.414
CLV_PCSK_SKI1_1	234	238	PF00082	0.529
CLV_PCSK_SKI1_1	270	274	PF00082	0.505
CLV_PCSK_SKI1_1	278	282	PF00082	0.342
CLV_PCSK_SKI1_1	365	369	PF00082	0.628
CLV_PCSK_SKI1_1	6	10	PF00082	0.637
CLV_PCSK_SKI1_1	61	65	PF00082	0.716
CLV_PCSK_SKI1_1	725	729	PF00082	0.686
CLV_PCSK_SKI1_1	731	735	PF00082	0.675
CLV_PCSK_SKI1_1	755	759	PF00082	0.637
DEG_APCC_DBOX_1	412	420	PF00400	0.468
DEG_APCC_DBOX_1	589	597	PF00400	0.646
DEG_Nend_Nbox_1	1	3	PF02207	0.560
DEG_SPOP_SBC_1	44	48	PF00917	0.555
DOC_CYCLIN_RxL_1	204	211	PF00134	0.499
DOC_CYCLIN_yCln2_LP_2	209	215	PF00134	0.439
DOC_MAPK_gen_1	176	185	PF00069	0.460
DOC_MAPK_gen_1	204	210	PF00069	0.549
DOC_MAPK_gen_1	277	285	PF00069	0.526
DOC_MAPK_gen_1	412	419	PF00069	0.386
DOC_MAPK_gen_1	675	682	PF00069	0.673
DOC_MAPK_gen_1	705	715	PF00069	0.687
DOC_MAPK_MEF2A_6	179	187	PF00069	0.483
DOC_MAPK_MEF2A_6	412	419	PF00069	0.479
DOC_MAPK_MEF2A_6	526	535	PF00069	0.591
DOC_MAPK_MEF2A_6	577	585	PF00069	0.498
DOC_PP2B_LxvP_1	581	584	PF13499	0.492
DOC_PP4_FxxP_1	54	57	PF00568	0.584
DOC_USP7_MATH_1	192	196	PF00917	0.609
DOC_USP7_MATH_1	363	367	PF00917	0.629
DOC_USP7_MATH_1	42	46	PF00917	0.643
DOC_USP7_MATH_1	486	490	PF00917	0.467
DOC_USP7_MATH_1	521	525	PF00917	0.811
DOC_USP7_MATH_1	57	61	PF00917	0.524
DOC_USP7_MATH_1	627	631	PF00917	0.746
DOC_USP7_MATH_1	632	636	PF00917	0.748
DOC_USP7_MATH_1	687	691	PF00917	0.733
DOC_USP7_MATH_1	716	720	PF00917	0.724
DOC_USP7_MATH_1	72	76	PF00917	0.502
DOC_USP7_UBL2_3	5	9	PF12436	0.617
DOC_USP7_UBL2_3	691	695	PF12436	0.594
DOC_USP7_UBL2_3	754	758	PF12436	0.645
DOC_WW_Pin1_4	365	370	PF00397	0.703
DOC_WW_Pin1_4	372	377	PF00397	0.742
LIG_BIR_III_2	520	524	PF00653	0.651
LIG_BIR_III_4	618	622	PF00653	0.773
LIG_BIR_III_4	640	644	PF00653	0.726
LIG_BRCT_BRCA1_1	546	550	PF00533	0.323
LIG_Clathr_ClatBox_1	607	611	PF01394	0.686
LIG_FHA_1	143	149	PF00498	0.473
LIG_FHA_1	166	172	PF00498	0.512
LIG_FHA_1	287	293	PF00498	0.526
LIG_FHA_1	298	304	PF00498	0.421
LIG_FHA_1	320	326	PF00498	0.460
LIG_FHA_2	230	236	PF00498	0.624
LIG_FHA_2	238	244	PF00498	0.608
LIG_FHA_2	333	339	PF00498	0.350
LIG_FHA_2	430	436	PF00498	0.498
LIG_FHA_2	97	103	PF00498	0.482
LIG_LIR_Apic_2	52	57	PF02991	0.591
LIG_LIR_Gen_1	260	268	PF02991	0.470
LIG_LIR_Nem_3	260	265	PF02991	0.465
LIG_LIR_Nem_3	459	463	PF02991	0.537
LIG_LIR_Nem_3	487	493	PF02991	0.471
LIG_MAD2	207	215	PF02301	0.522
LIG_PCNA_PIPBox_1	309	318	PF02747	0.517
LIG_Rb_pABgroove_1	660	668	PF01858	0.637
LIG_RPA_C_Fungi	116	128	PF08784	0.612
LIG_SH2_CRK	425	429	PF00017	0.435
LIG_SH2_CRK	490	494	PF00017	0.334
LIG_SH2_SRC	357	360	PF00017	0.525
LIG_SH2_SRC	481	484	PF00017	0.419
LIG_SH2_STAP1	481	485	PF00017	0.308
LIG_SH2_STAT5	138	141	PF00017	0.512
LIG_SH2_STAT5	181	184	PF00017	0.427
LIG_SH2_STAT5	249	252	PF00017	0.322
LIG_SH3_3	209	215	PF00018	0.418
LIG_SH3_3	373	379	PF00018	0.736
LIG_SH3_3	414	420	PF00018	0.551
LIG_SUMO_SIM_anti_2	555	560	PF11976	0.405
LIG_SUMO_SIM_par_1	181	186	PF11976	0.506
LIG_SUMO_SIM_par_1	308	313	PF11976	0.478
LIG_SUMO_SIM_par_1	532	538	PF11976	0.431
LIG_TRAF2_1	614	617	PF00917	0.700
LIG_TRAF2_1	620	623	PF00917	0.743
LIG_TYR_ITIM	479	484	PF00017	0.334
LIG_UBA3_1	272	278	PF00899	0.516
LIG_ULM_U2AF65_1	566	571	PF00076	0.540
MOD_CK1_1	186	192	PF00069	0.636
MOD_CK1_1	224	230	PF00069	0.511
MOD_CK1_1	245	251	PF00069	0.389
MOD_CK1_1	45	51	PF00069	0.678
MOD_CK1_1	459	465	PF00069	0.732
MOD_CK1_1	711	717	PF00069	0.670
MOD_CK2_1	257	263	PF00069	0.457
MOD_CK2_1	291	297	PF00069	0.315
MOD_CK2_1	332	338	PF00069	0.366
MOD_CK2_1	429	435	PF00069	0.488
MOD_CK2_1	645	651	PF00069	0.654
MOD_Cter_Amidation	509	512	PF01082	0.665
MOD_Cter_Amidation	588	591	PF01082	0.530
MOD_GlcNHglycan	13	16	PF01048	0.559
MOD_GlcNHglycan	175	179	PF01048	0.376
MOD_GlcNHglycan	189	192	PF01048	0.582
MOD_GlcNHglycan	215	218	PF01048	0.444
MOD_GlcNHglycan	574	577	PF01048	0.414
MOD_GlcNHglycan	587	590	PF01048	0.435
MOD_GlcNHglycan	640	644	PF01048	0.702
MOD_GlcNHglycan	65	68	PF01048	0.716
MOD_GlcNHglycan	697	700	PF01048	0.735
MOD_GlcNHglycan	718	721	PF01048	0.760
MOD_GlcNHglycan	728	731	PF01048	0.771
MOD_GlcNHglycan	74	77	PF01048	0.562
MOD_GSK3_1	183	190	PF00069	0.544
MOD_GSK3_1	213	220	PF00069	0.402
MOD_GSK3_1	238	245	PF00069	0.545
MOD_GSK3_1	25	32	PF00069	0.555
MOD_GSK3_1	257	264	PF00069	0.374
MOD_GSK3_1	288	295	PF00069	0.357
MOD_GSK3_1	522	529	PF00069	0.674
MOD_GSK3_1	59	66	PF00069	0.722
MOD_GSK3_1	704	711	PF00069	0.679
MOD_LATS_1	276	282	PF00433	0.419
MOD_N-GLC_1	391	396	PF02516	0.439
MOD_NEK2_1	131	136	PF00069	0.468
MOD_NEK2_1	187	192	PF00069	0.593
MOD_NEK2_1	237	242	PF00069	0.532
MOD_NEK2_1	34	39	PF00069	0.565
MOD_NEK2_1	391	396	PF00069	0.439
MOD_NEK2_1	585	590	PF00069	0.491
MOD_NEK2_1	704	709	PF00069	0.545
MOD_NEK2_1	743	748	PF00069	0.650
MOD_NEK2_1	750	755	PF00069	0.617
MOD_NEK2_1	83	88	PF00069	0.495
MOD_OFUCOSY	157	162	PF10250	0.441
MOD_PIKK_1	25	31	PF00454	0.591
MOD_PIKK_1	348	354	PF00454	0.400
MOD_PKA_1	329	335	PF00069	0.512
MOD_PKA_1	526	532	PF00069	0.452
MOD_PKA_1	708	714	PF00069	0.632
MOD_PKA_2	229	235	PF00069	0.520
MOD_PKA_2	704	710	PF00069	0.702
MOD_PKA_2	716	722	PF00069	0.651
MOD_Plk_1	183	189	PF00069	0.568
MOD_Plk_1	237	243	PF00069	0.543
MOD_Plk_1	363	369	PF00069	0.564
MOD_Plk_1	391	397	PF00069	0.435
MOD_Plk_1	711	717	PF00069	0.693
MOD_Plk_1	96	102	PF00069	0.482
MOD_Plk_2-3	238	244	PF00069	0.569
MOD_Plk_4	245	251	PF00069	0.400
MOD_Plk_4	288	294	PF00069	0.276
MOD_Plk_4	379	385	PF00069	0.564
MOD_Plk_4	391	397	PF00069	0.393
MOD_ProDKin_1	365	371	PF00069	0.701
MOD_ProDKin_1	372	378	PF00069	0.740
MOD_SUMO_for_1	738	741	PF00179	0.690
MOD_SUMO_rev_2	52	60	PF00179	0.561
TRG_ENDOCYTIC_2	425	428	PF00928	0.435
TRG_ENDOCYTIC_2	481	484	PF00928	0.319
TRG_ENDOCYTIC_2	490	493	PF00928	0.292
TRG_ER_diArg_1	17	19	PF00400	0.639
TRG_ER_diArg_1	204	206	PF00400	0.595
TRG_ER_diArg_1	565	567	PF00400	0.508
TRG_NES_CRM1_1	671	685	PF08389	0.489
TRG_NLS_MonoCore_2	690	695	PF00514	0.634
TRG_NLS_MonoExtC_3	37	43	PF00514	0.687
TRG_NLS_MonoExtC_3	690	695	PF00514	0.591
TRG_NLS_MonoExtC_3	730	735	PF00514	0.681
TRG_NLS_MonoExtN_4	57	62	PF00514	0.613
TRG_NLS_MonoExtN_4	691	698	PF00514	0.616
TRG_NLS_MonoExtN_4	755	762	PF00514	0.582
TRG_Pf-PMV_PEXEL_1	207	211	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5A4	Leptomonas seymouri	68%	100%
A0A1X0P8I5	Trypanosomatidae	43%	100%
A0A3S5IQN4	Trypanosoma rangeli	44%	100%
A4H7E0	Leishmania braziliensis	79%	99%
A4I9K0	Leishmania infantum	100%	100%
D0A1V8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B4J8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q3H8	Leishmania major	91%	99%
V5BRS0	Trypanosoma cruzi	42%	100%