Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7X7F2_LEIDO

TriTrypDb:

LdBPK_340410.1 , LdCL_340009200 , LDHU3_34.0580

Length:

572

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 6
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X7F2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7F2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	23	27	PF00656	0.634
CLV_NRD_NRD_1	32	34	PF00675	0.443
CLV_NRD_NRD_1	51	53	PF00675	0.317
CLV_NRD_NRD_1	517	519	PF00675	0.643
CLV_PCSK_FUR_1	515	519	PF00082	0.620
CLV_PCSK_KEX2_1	32	34	PF00082	0.443
CLV_PCSK_KEX2_1	517	519	PF00082	0.614
CLV_PCSK_SKI1_1	167	171	PF00082	0.371
CLV_PCSK_SKI1_1	217	221	PF00082	0.443
CLV_Separin_Metazoa	29	33	PF03568	0.640
CLV_Separin_Metazoa	411	415	PF03568	0.390
DOC_CKS1_1	406	411	PF01111	0.500
DOC_CKS1_1	421	426	PF01111	0.352
DOC_MAPK_DCC_7	199	209	PF00069	0.484
DOC_MAPK_MEF2A_6	125	133	PF00069	0.489
DOC_PP4_FxxP_1	337	340	PF00568	0.401
DOC_PP4_FxxP_1	357	360	PF00568	0.340
DOC_USP7_MATH_1	105	109	PF00917	0.708
DOC_USP7_MATH_1	118	122	PF00917	0.696
DOC_USP7_MATH_1	193	197	PF00917	0.757
DOC_USP7_MATH_1	263	267	PF00917	0.467
DOC_USP7_MATH_1	290	294	PF00917	0.326
DOC_USP7_MATH_1	340	344	PF00917	0.367
DOC_USP7_MATH_1	358	362	PF00917	0.359
DOC_USP7_MATH_1	396	400	PF00917	0.439
DOC_USP7_MATH_1	407	411	PF00917	0.459
DOC_USP7_MATH_1	72	76	PF00917	0.606
DOC_WW_Pin1_4	242	247	PF00397	0.349
DOC_WW_Pin1_4	356	361	PF00397	0.381
DOC_WW_Pin1_4	405	410	PF00397	0.410
DOC_WW_Pin1_4	420	425	PF00397	0.333
LIG_14-3-3_CanoR_1	156	163	PF00244	0.550
LIG_14-3-3_CanoR_1	217	226	PF00244	0.341
LIG_14-3-3_CanoR_1	324	334	PF00244	0.402
LIG_14-3-3_CanoR_1	338	348	PF00244	0.326
LIG_14-3-3_CanoR_1	448	455	PF00244	0.405
LIG_APCC_ABBA_1	368	373	PF00400	0.302
LIG_BRCT_BRCA1_1	167	171	PF00533	0.538
LIG_deltaCOP1_diTrp_1	519	527	PF00928	0.412
LIG_FHA_1	196	202	PF00498	0.667
LIG_FHA_1	208	214	PF00498	0.328
LIG_FHA_1	220	226	PF00498	0.350
LIG_FHA_1	239	245	PF00498	0.304
LIG_FHA_1	42	48	PF00498	0.624
LIG_FHA_1	420	426	PF00498	0.338
LIG_FHA_1	432	438	PF00498	0.360
LIG_FHA_1	449	455	PF00498	0.469
LIG_FHA_1	483	489	PF00498	0.310
LIG_FHA_2	21	27	PF00498	0.525
LIG_FHA_2	361	367	PF00498	0.375
LIG_FHA_2	406	412	PF00498	0.439
LIG_LIR_Gen_1	297	302	PF02991	0.336
LIG_LIR_Gen_1	380	385	PF02991	0.405
LIG_LIR_Gen_1	415	424	PF02991	0.369
LIG_LIR_Gen_1	495	502	PF02991	0.346
LIG_LIR_Nem_3	168	174	PF02991	0.487
LIG_LIR_Nem_3	297	301	PF02991	0.346
LIG_LIR_Nem_3	35	40	PF02991	0.663
LIG_LIR_Nem_3	380	384	PF02991	0.402
LIG_LIR_Nem_3	415	419	PF02991	0.394
LIG_LIR_Nem_3	452	458	PF02991	0.414
LIG_LIR_Nem_3	480	486	PF02991	0.328
LIG_LIR_Nem_3	495	500	PF02991	0.436
LIG_LIR_Nem_3	536	542	PF02991	0.347
LIG_LYPXL_yS_3	483	486	PF13949	0.323
LIG_PCNA_yPIPBox_3	375	389	PF02747	0.381
LIG_SH2_CRK	101	105	PF00017	0.572
LIG_SH2_CRK	298	302	PF00017	0.354
LIG_SH2_CRK	416	420	PF00017	0.393
LIG_SH2_GRB2like	22	25	PF00017	0.490
LIG_SH2_NCK_1	542	546	PF00017	0.353
LIG_SH2_PTP2	381	384	PF00017	0.412
LIG_SH2_STAP1	157	161	PF00017	0.553
LIG_SH2_STAP1	298	302	PF00017	0.316
LIG_SH2_STAP1	450	454	PF00017	0.368
LIG_SH2_STAP1	97	101	PF00017	0.495
LIG_SH2_STAT3	97	100	PF00017	0.569
LIG_SH2_STAT5	150	153	PF00017	0.515
LIG_SH2_STAT5	17	20	PF00017	0.337
LIG_SH2_STAT5	214	217	PF00017	0.344
LIG_SH2_STAT5	22	25	PF00017	0.567
LIG_SH2_STAT5	381	384	PF00017	0.437
LIG_SH2_STAT5	39	42	PF00017	0.728
LIG_SH2_STAT5	450	453	PF00017	0.440
LIG_SH2_STAT5	524	527	PF00017	0.414
LIG_SH2_STAT5	533	536	PF00017	0.357
LIG_SH2_STAT5	542	545	PF00017	0.287
LIG_SH2_STAT5	561	564	PF00017	0.321
LIG_SH3_1	418	424	PF00018	0.365
LIG_SH3_3	175	181	PF00018	0.575
LIG_SH3_3	252	258	PF00018	0.420
LIG_SH3_3	403	409	PF00018	0.390
LIG_SH3_3	418	424	PF00018	0.368
LIG_SH3_3	481	487	PF00018	0.330
LIG_SUMO_SIM_anti_2	235	241	PF11976	0.281
LIG_SUMO_SIM_par_1	205	211	PF11976	0.327
LIG_TYR_ITIM	296	301	PF00017	0.340
LIG_UBA3_1	170	176	PF00899	0.511
LIG_WRC_WIRS_1	341	346	PF05994	0.368
LIG_WW_3	29	33	PF00397	0.640
MOD_CK1_1	232	238	PF00069	0.340
MOD_CK1_1	316	322	PF00069	0.416
MOD_CK1_1	399	405	PF00069	0.428
MOD_CK1_1	550	556	PF00069	0.314
MOD_CK1_1	564	570	PF00069	0.342
MOD_CK2_1	340	346	PF00069	0.335
MOD_CK2_1	360	366	PF00069	0.383
MOD_CK2_1	405	411	PF00069	0.498
MOD_CK2_1	532	538	PF00069	0.406
MOD_CK2_1	90	96	PF00069	0.557
MOD_Cter_Amidation	515	518	PF01082	0.592
MOD_GlcNHglycan	142	145	PF01048	0.377
MOD_GlcNHglycan	167	170	PF01048	0.343
MOD_GlcNHglycan	195	198	PF01048	0.413
MOD_GlcNHglycan	217	220	PF01048	0.370
MOD_GlcNHglycan	360	363	PF01048	0.693
MOD_GlcNHglycan	554	557	PF01048	0.506
MOD_GlcNHglycan	563	566	PF01048	0.604
MOD_GlcNHglycan	74	77	PF01048	0.392
MOD_GSK3_1	213	220	PF00069	0.354
MOD_GSK3_1	234	241	PF00069	0.325
MOD_GSK3_1	263	270	PF00069	0.477
MOD_GSK3_1	290	297	PF00069	0.319
MOD_GSK3_1	312	319	PF00069	0.409
MOD_GSK3_1	356	363	PF00069	0.372
MOD_GSK3_1	396	403	PF00069	0.630
MOD_GSK3_1	543	550	PF00069	0.449
MOD_N-GLC_1	138	143	PF02516	0.361
MOD_N-GLC_1	193	198	PF02516	0.473
MOD_N-GLC_1	326	331	PF02516	0.587
MOD_N-GLC_1	41	46	PF02516	0.433
MOD_N-GLC_1	509	514	PF02516	0.632
MOD_NEK2_1	149	154	PF00069	0.568
MOD_NEK2_1	155	160	PF00069	0.682
MOD_NEK2_1	20	25	PF00069	0.686
MOD_NEK2_1	207	212	PF00069	0.321
MOD_NEK2_1	238	243	PF00069	0.380
MOD_NEK2_1	325	330	PF00069	0.408
MOD_NEK2_2	263	268	PF00069	0.391
MOD_NEK2_2	360	365	PF00069	0.347
MOD_PIKK_1	105	111	PF00454	0.589
MOD_PIKK_1	41	47	PF00454	0.619
MOD_PIKK_1	432	438	PF00454	0.382
MOD_PKA_2	155	161	PF00069	0.534
MOD_PKA_2	540	546	PF00069	0.338
MOD_PKA_2	547	553	PF00069	0.279
MOD_Plk_1	312	318	PF00069	0.370
MOD_Plk_1	326	332	PF00069	0.394
MOD_Plk_1	462	468	PF00069	0.369
MOD_Plk_4	234	240	PF00069	0.280
MOD_Plk_4	297	303	PF00069	0.314
MOD_Plk_4	327	333	PF00069	0.357
MOD_Plk_4	564	570	PF00069	0.345
MOD_ProDKin_1	242	248	PF00069	0.355
MOD_ProDKin_1	356	362	PF00069	0.381
MOD_ProDKin_1	405	411	PF00069	0.415
MOD_ProDKin_1	420	426	PF00069	0.334
MOD_SUMO_rev_2	386	390	PF00179	0.461
TRG_DiLeu_BaEn_1	43	48	PF01217	0.620
TRG_ENDOCYTIC_2	101	104	PF00928	0.566
TRG_ENDOCYTIC_2	142	145	PF00928	0.589
TRG_ENDOCYTIC_2	17	20	PF00928	0.411
TRG_ENDOCYTIC_2	298	301	PF00928	0.352
TRG_ENDOCYTIC_2	37	40	PF00928	0.590
TRG_ENDOCYTIC_2	381	384	PF00928	0.412
TRG_ENDOCYTIC_2	416	419	PF00928	0.404
TRG_ENDOCYTIC_2	483	486	PF00928	0.323
TRG_ENDOCYTIC_2	497	500	PF00928	0.311
TRG_ER_diArg_1	31	33	PF00400	0.647
TRG_ER_diArg_1	321	324	PF00400	0.436
TRG_ER_diArg_1	515	518	PF00400	0.423
TRG_NES_CRM1_1	468	482	PF08389	0.352

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW70	Leptomonas seymouri	63%	98%
A0A1X0PA87	Trypanosomatidae	42%	100%
A0A3Q8IF83	Leishmania donovani	26%	100%
A4HAF2	Leishmania braziliensis	24%	100%
A4HAF3	Leishmania braziliensis	77%	100%
A4I9K8	Leishmania infantum	26%	100%
A4I9K9	Leishmania infantum	99%	100%
Q4Q3G9	Leishmania major	92%	99%