Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X7E6_LEIDO

TriTrypDb:

LdBPK_340450.1 , LdCL_340009600 , LDHU3_34.0620

Length:

269

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X7E6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7E6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	246	250	PF00656	0.550
CLV_C14_Caspase3-7	85	89	PF00656	0.720
CLV_NRD_NRD_1	134	136	PF00675	0.605
CLV_NRD_NRD_1	198	200	PF00675	0.443
CLV_PCSK_KEX2_1	179	181	PF00082	0.437
CLV_PCSK_KEX2_1	206	208	PF00082	0.498
CLV_PCSK_KEX2_1	261	263	PF00082	0.545
CLV_PCSK_KEX2_1	74	76	PF00082	0.712
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.437
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.498
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.545
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.713
CLV_PCSK_PC7_1	202	208	PF00082	0.475
DEG_APCC_DBOX_1	3	11	PF00400	0.406
DEG_Nend_UBRbox_3	1	3	PF02207	0.538
DOC_CDC14_PxL_1	13	21	PF14671	0.429
DOC_CYCLIN_RxL_1	3	11	PF00134	0.410
DOC_CYCLIN_yCln2_LP_2	120	126	PF00134	0.521
DOC_CYCLIN_yCln2_LP_2	47	53	PF00134	0.437
DOC_MAPK_gen_1	4	12	PF00069	0.403
DOC_MAPK_JIP1_4	43	49	PF00069	0.432
DOC_MAPK_MEF2A_6	4	12	PF00069	0.412
DOC_PP2B_LxvP_1	120	123	PF13499	0.577
DOC_PP2B_LxvP_1	47	50	PF13499	0.423
DOC_PP4_FxxP_1	22	25	PF00568	0.514
DOC_USP7_MATH_1	101	105	PF00917	0.577
DOC_USP7_MATH_1	137	141	PF00917	0.499
DOC_USP7_MATH_1	250	254	PF00917	0.593
DOC_USP7_MATH_1	29	33	PF00917	0.544
DOC_USP7_MATH_1	55	59	PF00917	0.425
DOC_USP7_UBL2_3	257	261	PF12436	0.644
DOC_WW_Pin1_4	135	140	PF00397	0.594
DOC_WW_Pin1_4	172	177	PF00397	0.501
DOC_WW_Pin1_4	21	26	PF00397	0.636
DOC_WW_Pin1_4	77	82	PF00397	0.667
LIG_14-3-3_CanoR_1	207	211	PF00244	0.597
LIG_14-3-3_CanoR_1	48	54	PF00244	0.409
LIG_BRCT_BRCA1_1	41	45	PF00533	0.519
LIG_Clathr_ClatBox_1	7	11	PF01394	0.398
LIG_FHA_2	215	221	PF00498	0.498
LIG_FHA_2	83	89	PF00498	0.725
LIG_LIR_Apic_2	11	17	PF02991	0.399
LIG_LIR_Gen_1	11	19	PF02991	0.405
LIG_LIR_Nem_3	11	15	PF02991	0.391
LIG_SH2_CRK	201	205	PF00017	0.455
LIG_SH2_GRB2like	166	169	PF00017	0.406
LIG_SH2_SRC	166	169	PF00017	0.406
LIG_SH2_STAP1	166	170	PF00017	0.401
LIG_SH2_STAT3	23	26	PF00017	0.634
LIG_SH2_STAT5	14	17	PF00017	0.435
LIG_SH2_STAT5	46	49	PF00017	0.496
LIG_SH2_STAT5	9	12	PF00017	0.420
LIG_SH3_3	120	126	PF00018	0.535
LIG_SH3_3	170	176	PF00018	0.395
LIG_SUMO_SIM_par_1	94	100	PF11976	0.685
LIG_TRAF2_1	252	255	PF00917	0.592
LIG_UBA3_1	15	20	PF00899	0.512
MOD_CDK_SPxxK_3	172	179	PF00069	0.504
MOD_CK1_1	138	144	PF00069	0.499
MOD_CK1_1	209	215	PF00069	0.525
MOD_CK1_1	58	64	PF00069	0.494
MOD_CK2_1	212	218	PF00069	0.513
MOD_CK2_1	245	251	PF00069	0.658
MOD_CK2_1	84	90	PF00069	0.667
MOD_Cter_Amidation	72	75	PF01082	0.646
MOD_GlcNHglycan	245	248	PF01048	0.585
MOD_GlcNHglycan	36	39	PF01048	0.672
MOD_GlcNHglycan	60	63	PF01048	0.499
MOD_GSK3_1	34	41	PF00069	0.597
MOD_GSK3_1	58	65	PF00069	0.548
MOD_GSK3_1	97	104	PF00069	0.622
MOD_NEK2_1	235	240	PF00069	0.518
MOD_NEK2_1	39	44	PF00069	0.563
MOD_NEK2_2	55	60	PF00069	0.433
MOD_PIKK_1	209	215	PF00454	0.512
MOD_PKA_1	206	212	PF00069	0.596
MOD_PKA_2	206	212	PF00069	0.596
MOD_Plk_1	129	135	PF00069	0.561
MOD_ProDKin_1	135	141	PF00069	0.594
MOD_ProDKin_1	172	178	PF00069	0.498
MOD_ProDKin_1	21	27	PF00069	0.641
MOD_ProDKin_1	77	83	PF00069	0.669
MOD_SUMO_for_1	260	263	PF00179	0.543
TRG_DiLeu_BaEn_1	11	16	PF01217	0.389
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.407
TRG_ENDOCYTIC_2	201	204	PF00928	0.451
TRG_ENDOCYTIC_2	46	49	PF00928	0.496
TRG_ENDOCYTIC_2	9	12	PF00928	0.420
TRG_ER_diArg_1	157	160	PF00400	0.514
TRG_ER_diArg_1	184	187	PF00400	0.434
TRG_ER_diArg_1	4	7	PF00400	0.418
TRG_Pf-PMV_PEXEL_1	6	11	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKH0	Leptomonas seymouri	51%	100%
A4HAF7	Leishmania braziliensis	74%	100%
E9B4L1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q3G5	Leishmania major	94%	100%