Trafficking protein Mon1, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Trafficking protein Mon1, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X7E3_LEIDO

TriTrypDb:

LdBPK_340310.1 , LdCL_340008200 , LDHU3_34.0450

Length:

679

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S7X7E3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7E3

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	10
GO:0006623	protein targeting to vacuole	5	10
GO:0006810	transport	3	10
GO:0006886	intracellular protein transport	4	10
GO:0007034	vacuolar transport	4	10
GO:0008104	protein localization	4	10
GO:0009987	cellular process	1	10
GO:0015031	protein transport	4	10
GO:0016192	vesicle-mediated transport	4	10
GO:0033036	macromolecule localization	2	10
GO:0033365	protein localization to organelle	5	10
GO:0045184	establishment of protein localization	3	10
GO:0046907	intracellular transport	3	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10
GO:0051641	cellular localization	2	10
GO:0051649	establishment of localization in cell	3	10
GO:0070727	cellular macromolecule localization	3	10
GO:0071702	organic substance transport	4	10
GO:0071705	nitrogen compound transport	4	10
GO:0072594	establishment of protein localization to organelle	4	10
GO:0072665	protein localization to vacuole	6	10
GO:0072666	establishment of protein localization to vacuole	5	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	257	261	PF00656	0.649
CLV_NRD_NRD_1	244	246	PF00675	0.448
CLV_NRD_NRD_1	407	409	PF00675	0.399
CLV_NRD_NRD_1	665	667	PF00675	0.650
CLV_PCSK_KEX2_1	243	245	PF00082	0.449
CLV_PCSK_KEX2_1	407	409	PF00082	0.399
CLV_PCSK_KEX2_1	665	667	PF00082	0.650
CLV_PCSK_PC1ET2_1	243	245	PF00082	0.554
CLV_PCSK_SKI1_1	213	217	PF00082	0.588
CLV_PCSK_SKI1_1	249	253	PF00082	0.523
CLV_PCSK_SKI1_1	31	35	PF00082	0.433
CLV_PCSK_SKI1_1	41	45	PF00082	0.456
CLV_PCSK_SKI1_1	510	514	PF00082	0.728
DEG_APCC_DBOX_1	212	220	PF00400	0.589
DEG_APCC_DBOX_1	96	104	PF00400	0.439
DEG_SPOP_SBC_1	547	551	PF00917	0.641
DOC_CKS1_1	432	437	PF01111	0.577
DOC_CKS1_1	570	575	PF01111	0.641
DOC_MAPK_gen_1	18	25	PF00069	0.574
DOC_PP1_RVXF_1	508	514	PF00149	0.687
DOC_PP2B_LxvP_1	187	190	PF13499	0.586
DOC_PP2B_LxvP_1	413	416	PF13499	0.538
DOC_PP4_FxxP_1	583	586	PF00568	0.707
DOC_PP4_FxxP_1	590	593	PF00568	0.662
DOC_SPAK_OSR1_1	610	614	PF12202	0.528
DOC_USP7_MATH_1	169	173	PF00917	0.594
DOC_USP7_MATH_1	294	298	PF00917	0.639
DOC_USP7_MATH_1	505	509	PF00917	0.698
DOC_USP7_MATH_1	547	551	PF00917	0.625
DOC_USP7_MATH_1	614	618	PF00917	0.717
DOC_USP7_MATH_1	90	94	PF00917	0.688
DOC_WW_Pin1_4	196	201	PF00397	0.627
DOC_WW_Pin1_4	431	436	PF00397	0.575
DOC_WW_Pin1_4	450	455	PF00397	0.602
DOC_WW_Pin1_4	51	56	PF00397	0.597
DOC_WW_Pin1_4	515	520	PF00397	0.642
DOC_WW_Pin1_4	569	574	PF00397	0.617
DOC_WW_Pin1_4	582	587	PF00397	0.545
DOC_WW_Pin1_4	643	648	PF00397	0.529
LIG_14-3-3_CanoR_1	107	115	PF00244	0.668
LIG_14-3-3_CanoR_1	324	330	PF00244	0.444
LIG_14-3-3_CanoR_1	345	353	PF00244	0.408
LIG_14-3-3_CanoR_1	559	568	PF00244	0.637
LIG_14-3-3_CanoR_1	610	614	PF00244	0.689
LIG_14-3-3_CanoR_1	619	624	PF00244	0.585
LIG_14-3-3_CanoR_1	665	671	PF00244	0.498
LIG_Actin_WH2_2	528	546	PF00022	0.679
LIG_APCC_ABBA_1	64	69	PF00400	0.554
LIG_BIR_II_1	1	5	PF00653	0.753
LIG_CSL_BTD_1	337	340	PF09270	0.485
LIG_EABR_CEP55_1	282	291	PF12180	0.597
LIG_EH_1	587	591	PF12763	0.737
LIG_EH1_1	652	660	PF00400	0.607
LIG_EH1_1	668	676	PF00400	0.653
LIG_eIF4E_1	133	139	PF01652	0.457
LIG_eIF4E_1	275	281	PF01652	0.558
LIG_FHA_1	226	232	PF00498	0.605
LIG_FHA_1	234	240	PF00498	0.502
LIG_FHA_1	347	353	PF00498	0.344
LIG_FHA_1	437	443	PF00498	0.672
LIG_FHA_1	459	465	PF00498	0.670
LIG_FHA_1	497	503	PF00498	0.691
LIG_FHA_1	622	628	PF00498	0.634
LIG_FHA_2	207	213	PF00498	0.564
LIG_FHA_2	381	387	PF00498	0.407
LIG_LIR_Apic_2	429	435	PF02991	0.538
LIG_LIR_Apic_2	581	586	PF02991	0.699
LIG_LIR_Gen_1	272	281	PF02991	0.471
LIG_LIR_Gen_1	406	417	PF02991	0.453
LIG_LIR_Nem_3	129	134	PF02991	0.408
LIG_LIR_Nem_3	272	276	PF02991	0.417
LIG_LIR_Nem_3	336	341	PF02991	0.344
LIG_LIR_Nem_3	373	378	PF02991	0.446
LIG_LIR_Nem_3	397	402	PF02991	0.362
LIG_LIR_Nem_3	406	412	PF02991	0.328
LIG_LIR_Nem_3	420	426	PF02991	0.459
LIG_LIR_Nem_3	531	535	PF02991	0.622
LIG_NRBOX	59	65	PF00104	0.594
LIG_NRP_CendR_1	678	679	PF00754	0.635
LIG_SH2_CRK	432	436	PF00017	0.555
LIG_SH2_CRK	468	472	PF00017	0.625
LIG_SH2_NCK_1	208	212	PF00017	0.617
LIG_SH2_SRC	414	417	PF00017	0.516
LIG_SH2_STAP1	325	329	PF00017	0.444
LIG_SH2_STAP1	355	359	PF00017	0.444
LIG_SH2_STAP1	362	366	PF00017	0.444
LIG_SH2_STAP1	623	627	PF00017	0.624
LIG_SH2_STAT3	539	542	PF00017	0.643
LIG_SH2_STAT5	133	136	PF00017	0.417
LIG_SH2_STAT5	140	143	PF00017	0.400
LIG_SH2_STAT5	208	211	PF00017	0.574
LIG_SH2_STAT5	275	278	PF00017	0.575
LIG_SH2_STAT5	279	282	PF00017	0.514
LIG_SH2_STAT5	351	354	PF00017	0.344
LIG_SH2_STAT5	623	626	PF00017	0.574
LIG_SH3_3	146	152	PF00018	0.609
LIG_SH3_3	260	266	PF00018	0.679
LIG_SH3_3	281	287	PF00018	0.529
LIG_SH3_3	295	301	PF00018	0.700
LIG_SH3_3	338	344	PF00018	0.401
LIG_SH3_3	565	571	PF00018	0.565
LIG_SH3_3	583	589	PF00018	0.653
LIG_SH3_3	77	83	PF00018	0.739
LIG_SUMO_SIM_anti_2	383	389	PF11976	0.404
LIG_SUMO_SIM_anti_2	637	642	PF11976	0.504
LIG_SUMO_SIM_par_1	185	191	PF11976	0.572
LIG_SUMO_SIM_par_1	235	240	PF11976	0.557
LIG_SUMO_SIM_par_1	32	37	PF11976	0.473
LIG_TYR_ITIM	466	471	PF00017	0.638
LIG_UBA3_1	270	277	PF00899	0.495
LIG_UBA3_1	63	70	PF00899	0.560
LIG_WRC_WIRS_1	270	275	PF05994	0.415
MOD_CDK_SPK_2	450	455	PF00069	0.481
MOD_CDK_SPK_2	582	587	PF00069	0.702
MOD_CK1_1	108	114	PF00069	0.627
MOD_CK1_1	143	149	PF00069	0.507
MOD_CK1_1	222	228	PF00069	0.642
MOD_CK1_1	403	409	PF00069	0.444
MOD_CK1_1	445	451	PF00069	0.646
MOD_CK1_1	488	494	PF00069	0.786
MOD_CK1_1	515	521	PF00069	0.554
MOD_CK2_1	156	162	PF00069	0.733
MOD_CK2_1	642	648	PF00069	0.536
MOD_CK2_1	69	75	PF00069	0.559
MOD_Cter_Amidation	16	19	PF01082	0.559
MOD_GlcNHglycan	111	114	PF01048	0.568
MOD_GlcNHglycan	159	162	PF01048	0.644
MOD_GlcNHglycan	209	212	PF01048	0.511
MOD_GlcNHglycan	298	301	PF01048	0.714
MOD_GlcNHglycan	392	395	PF01048	0.444
MOD_GlcNHglycan	505	508	PF01048	0.674
MOD_GlcNHglycan	550	553	PF01048	0.646
MOD_GlcNHglycan	561	564	PF01048	0.632
MOD_GlcNHglycan	71	74	PF01048	0.634
MOD_GlcNHglycan	92	95	PF01048	0.759
MOD_GSK3_1	105	112	PF00069	0.641
MOD_GSK3_1	143	150	PF00069	0.608
MOD_GSK3_1	233	240	PF00069	0.549
MOD_GSK3_1	436	443	PF00069	0.593
MOD_GSK3_1	485	492	PF00069	0.736
MOD_GSK3_1	74	81	PF00069	0.766
MOD_N-GLC_1	346	351	PF02516	0.344
MOD_N-GLC_1	357	362	PF02516	0.344
MOD_NEK2_1	1	6	PF00069	0.704
MOD_NEK2_1	219	224	PF00069	0.544
MOD_NEK2_1	34	39	PF00069	0.484
MOD_NEK2_1	346	351	PF00069	0.444
MOD_NEK2_1	390	395	PF00069	0.444
MOD_NEK2_1	402	407	PF00069	0.444
MOD_NEK2_1	441	446	PF00069	0.635
MOD_NEK2_1	447	452	PF00069	0.665
MOD_NEK2_1	512	517	PF00069	0.656
MOD_NEK2_1	642	647	PF00069	0.486
MOD_NEK2_2	140	145	PF00069	0.481
MOD_NEK2_2	505	510	PF00069	0.705
MOD_OFUCOSY	253	258	PF10250	0.520
MOD_PIKK_1	392	398	PF00454	0.369
MOD_PIKK_1	42	48	PF00454	0.622
MOD_PIKK_1	512	518	PF00454	0.672
MOD_PIKK_1	78	84	PF00454	0.818
MOD_PKA_2	108	114	PF00069	0.549
MOD_PKA_2	403	409	PF00069	0.444
MOD_PKA_2	609	615	PF00069	0.656
MOD_PKA_2	664	670	PF00069	0.596
MOD_PKB_1	107	115	PF00069	0.506
MOD_Plk_1	225	231	PF00069	0.669
MOD_Plk_1	357	363	PF00069	0.369
MOD_Plk_1	397	403	PF00069	0.401
MOD_Plk_1	475	481	PF00069	0.531
MOD_Plk_1	636	642	PF00069	0.594
MOD_Plk_2-3	380	386	PF00069	0.459
MOD_Plk_4	126	132	PF00069	0.460
MOD_Plk_4	191	197	PF00069	0.454
MOD_Plk_4	418	424	PF00069	0.544
MOD_Plk_4	475	481	PF00069	0.531
MOD_Plk_4	636	642	PF00069	0.593
MOD_ProDKin_1	196	202	PF00069	0.624
MOD_ProDKin_1	431	437	PF00069	0.586
MOD_ProDKin_1	450	456	PF00069	0.602
MOD_ProDKin_1	51	57	PF00069	0.588
MOD_ProDKin_1	515	521	PF00069	0.642
MOD_ProDKin_1	569	575	PF00069	0.614
MOD_ProDKin_1	582	588	PF00069	0.549
MOD_ProDKin_1	643	649	PF00069	0.532
MOD_SUMO_rev_2	288	297	PF00179	0.663
MOD_SUMO_rev_2	486	491	PF00179	0.695
TRG_DiLeu_BaEn_1	137	142	PF01217	0.321
TRG_DiLeu_BaEn_1	30	35	PF01217	0.578
TRG_DiLeu_BaEn_4	380	386	PF01217	0.408
TRG_DiLeu_BaLyEn_6	507	512	PF01217	0.686
TRG_DiLeu_BaLyEn_6	516	521	PF01217	0.664
TRG_ENDOCYTIC_2	423	426	PF00928	0.455
TRG_ENDOCYTIC_2	468	471	PF00928	0.625
TRG_ER_diArg_1	106	109	PF00400	0.637
TRG_ER_diArg_1	244	246	PF00400	0.452
TRG_ER_diArg_1	407	409	PF00400	0.399
TRG_Pf-PMV_PEXEL_1	217	221	PF00026	0.600
TRG_Pf-PMV_PEXEL_1	332	336	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	364	368	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	510	514	PF00026	0.700
TRG_Pf-PMV_PEXEL_1	672	677	PF00026	0.611

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKG6	Leptomonas seymouri	54%	95%
A0A1X0P9E4	Trypanosomatidae	27%	94%
A0A422N7B5	Trypanosoma rangeli	24%	95%
A4H7E1	Leishmania braziliensis	78%	100%
A4I9J9	Leishmania infantum	100%	100%
E9B4J7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q3H9	Leishmania major	89%	100%
V5BM77	Trypanosoma cruzi	25%	93%