Methyltranfer_dom domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X7D8_LEIDO

TriTrypDb:

LdBPK_340200.1 , LdCL_340007100 , LDHU3_34.0300

Length:

765

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X7D8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7D8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	351	355	PF00656	0.711
CLV_C14_Caspase3-7	402	406	PF00656	0.570
CLV_C14_Caspase3-7	501	505	PF00656	0.458
CLV_NRD_NRD_1	156	158	PF00675	0.556
CLV_NRD_NRD_1	187	189	PF00675	0.526
CLV_NRD_NRD_1	279	281	PF00675	0.509
CLV_NRD_NRD_1	294	296	PF00675	0.727
CLV_NRD_NRD_1	326	328	PF00675	0.537
CLV_NRD_NRD_1	387	389	PF00675	0.607
CLV_NRD_NRD_1	513	515	PF00675	0.425
CLV_NRD_NRD_1	546	548	PF00675	0.600
CLV_NRD_NRD_1	578	580	PF00675	0.357
CLV_NRD_NRD_1	586	588	PF00675	0.501
CLV_NRD_NRD_1	718	720	PF00675	0.559
CLV_NRD_NRD_1	722	724	PF00675	0.545
CLV_PCSK_FUR_1	323	327	PF00082	0.613
CLV_PCSK_FUR_1	715	719	PF00082	0.564
CLV_PCSK_KEX2_1	155	157	PF00082	0.602
CLV_PCSK_KEX2_1	279	281	PF00082	0.510
CLV_PCSK_KEX2_1	294	296	PF00082	0.641
CLV_PCSK_KEX2_1	301	303	PF00082	0.572
CLV_PCSK_KEX2_1	323	325	PF00082	0.542
CLV_PCSK_KEX2_1	326	328	PF00082	0.532
CLV_PCSK_KEX2_1	387	389	PF00082	0.571
CLV_PCSK_KEX2_1	512	514	PF00082	0.417
CLV_PCSK_KEX2_1	546	548	PF00082	0.646
CLV_PCSK_KEX2_1	586	588	PF00082	0.612
CLV_PCSK_KEX2_1	717	719	PF00082	0.560
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.565
CLV_PCSK_PC7_1	542	548	PF00082	0.571
CLV_PCSK_PC7_1	582	588	PF00082	0.598
CLV_PCSK_SKI1_1	157	161	PF00082	0.512
CLV_PCSK_SKI1_1	653	657	PF00082	0.581
CLV_PCSK_SKI1_1	724	728	PF00082	0.588
CLV_PCSK_SKI1_1	740	744	PF00082	0.441
CLV_TASPASE1	502	508	PF01112	0.498
DEG_APCC_DBOX_1	718	726	PF00400	0.657
DEG_SPOP_SBC_1	214	218	PF00917	0.571
DEG_SPOP_SBC_1	313	317	PF00917	0.683
DOC_CDC14_PxL_1	489	497	PF14671	0.427
DOC_CYCLIN_RxL_1	717	731	PF00134	0.643
DOC_CYCLIN_yCln2_LP_2	408	414	PF00134	0.517
DOC_MAPK_gen_1	717	727	PF00069	0.532
DOC_PP2B_LxvP_1	408	411	PF13499	0.502
DOC_PP2B_LxvP_1	473	476	PF13499	0.418
DOC_PP2B_LxvP_1	490	493	PF13499	0.389
DOC_PP4_FxxP_1	159	162	PF00568	0.492
DOC_USP7_MATH_1	21	25	PF00917	0.498
DOC_USP7_MATH_1	214	218	PF00917	0.566
DOC_USP7_MATH_1	290	294	PF00917	0.720
DOC_USP7_MATH_1	355	359	PF00917	0.587
DOC_USP7_MATH_1	428	432	PF00917	0.482
DOC_USP7_MATH_1	451	455	PF00917	0.749
DOC_USP7_MATH_1	458	462	PF00917	0.621
DOC_USP7_MATH_1	521	525	PF00917	0.722
DOC_USP7_MATH_1	526	530	PF00917	0.687
DOC_USP7_MATH_1	625	629	PF00917	0.625
DOC_USP7_MATH_1	96	100	PF00917	0.666
DOC_USP7_MATH_2	341	347	PF00917	0.651
DOC_USP7_UBL2_3	757	761	PF12436	0.584
DOC_WW_Pin1_4	103	108	PF00397	0.595
DOC_WW_Pin1_4	193	198	PF00397	0.642
DOC_WW_Pin1_4	293	298	PF00397	0.698
DOC_WW_Pin1_4	449	454	PF00397	0.673
DOC_WW_Pin1_4	645	650	PF00397	0.599
DOC_WW_Pin1_4	676	681	PF00397	0.741
DOC_WW_Pin1_4	725	730	PF00397	0.590
LIG_14-3-3_CanoR_1	188	194	PF00244	0.638
LIG_14-3-3_CanoR_1	387	391	PF00244	0.593
LIG_14-3-3_CanoR_1	579	585	PF00244	0.529
LIG_BIR_III_2	101	105	PF00653	0.578
LIG_BIR_III_2	247	251	PF00653	0.541
LIG_BRCT_BRCA1_1	215	219	PF00533	0.559
LIG_BRCT_BRCA1_1	702	706	PF00533	0.619
LIG_deltaCOP1_diTrp_1	77	81	PF00928	0.543
LIG_eIF4E_1	230	236	PF01652	0.339
LIG_eIF4E_1	479	485	PF01652	0.486
LIG_eIF4E_1	736	742	PF01652	0.457
LIG_FHA_1	405	411	PF00498	0.396
LIG_FHA_1	479	485	PF00498	0.462
LIG_FHA_1	591	597	PF00498	0.617
LIG_FHA_1	630	636	PF00498	0.543
LIG_FHA_1	690	696	PF00498	0.750
LIG_FHA_2	196	202	PF00498	0.596
LIG_FHA_2	257	263	PF00498	0.426
LIG_GBD_Chelix_1	42	50	PF00786	0.476
LIG_LIR_Apic_2	363	369	PF02991	0.484
LIG_LIR_Apic_2	643	649	PF02991	0.600
LIG_LIR_Apic_2	669	675	PF02991	0.710
LIG_LIR_Gen_1	112	120	PF02991	0.411
LIG_LIR_Gen_1	389	399	PF02991	0.449
LIG_LIR_Gen_1	467	476	PF02991	0.344
LIG_LIR_Gen_1	504	511	PF02991	0.388
LIG_LIR_Gen_1	569	578	PF02991	0.441
LIG_LIR_Gen_1	628	638	PF02991	0.489
LIG_LIR_Gen_1	703	714	PF02991	0.619
LIG_LIR_Gen_1	78	89	PF02991	0.496
LIG_LIR_Nem_3	112	116	PF02991	0.381
LIG_LIR_Nem_3	122	126	PF02991	0.360
LIG_LIR_Nem_3	216	222	PF02991	0.426
LIG_LIR_Nem_3	26	32	PF02991	0.447
LIG_LIR_Nem_3	389	395	PF02991	0.509
LIG_LIR_Nem_3	467	473	PF02991	0.349
LIG_LIR_Nem_3	504	510	PF02991	0.392
LIG_LIR_Nem_3	569	575	PF02991	0.421
LIG_LIR_Nem_3	612	618	PF02991	0.468
LIG_LIR_Nem_3	628	634	PF02991	0.429
LIG_LIR_Nem_3	637	641	PF02991	0.414
LIG_LIR_Nem_3	703	709	PF02991	0.623
LIG_LIR_Nem_3	78	84	PF02991	0.540
LIG_NRBOX	45	51	PF00104	0.461
LIG_Pex14_1	609	613	PF04695	0.563
LIG_Pex14_2	159	163	PF04695	0.495
LIG_Pex14_2	706	710	PF04695	0.581
LIG_PTAP_UEV_1	296	301	PF05743	0.645
LIG_SH2_CRK	335	339	PF00017	0.709
LIG_SH2_CRK	507	511	PF00017	0.442
LIG_SH2_CRK	672	676	PF00017	0.717
LIG_SH2_NCK_1	646	650	PF00017	0.586
LIG_SH2_PTP2	178	181	PF00017	0.375
LIG_SH2_PTP2	366	369	PF00017	0.476
LIG_SH2_PTP2	470	473	PF00017	0.434
LIG_SH2_SRC	178	181	PF00017	0.468
LIG_SH2_SRC	366	369	PF00017	0.476
LIG_SH2_STAP1	479	483	PF00017	0.491
LIG_SH2_STAP1	507	511	PF00017	0.364
LIG_SH2_STAT5	158	161	PF00017	0.398
LIG_SH2_STAT5	178	181	PF00017	0.320
LIG_SH2_STAT5	230	233	PF00017	0.458
LIG_SH2_STAT5	277	280	PF00017	0.511
LIG_SH2_STAT5	366	369	PF00017	0.476
LIG_SH2_STAT5	412	415	PF00017	0.505
LIG_SH2_STAT5	470	473	PF00017	0.326
LIG_SH2_STAT5	640	643	PF00017	0.453
LIG_SH2_STAT5	736	739	PF00017	0.464
LIG_SH3_1	294	300	PF00018	0.753
LIG_SH3_2	297	302	PF14604	0.745
LIG_SH3_3	101	107	PF00018	0.701
LIG_SH3_3	208	214	PF00018	0.500
LIG_SH3_3	294	300	PF00018	0.789
LIG_SH3_3	34	40	PF00018	0.448
LIG_SH3_3	408	414	PF00018	0.517
LIG_SH3_3	655	661	PF00018	0.635
LIG_SH3_3	85	91	PF00018	0.600
LIG_SUMO_SIM_anti_2	574	579	PF11976	0.372
LIG_SUMO_SIM_par_1	20	28	PF11976	0.404
LIG_TRAF2_1	328	331	PF00917	0.663
LIG_TRAF2_1	341	344	PF00917	0.532
LIG_TRAF2_1	567	570	PF00917	0.461
LIG_TRFH_1	158	162	PF08558	0.364
LIG_UBA3_1	751	757	PF00899	0.564
LIG_WRC_WIRS_1	110	115	PF05994	0.413
MOD_CDK_SPK_2	676	681	PF00069	0.660
MOD_CK1_1	135	141	PF00069	0.615
MOD_CK1_1	215	221	PF00069	0.459
MOD_CK1_1	293	299	PF00069	0.592
MOD_CK1_1	336	342	PF00069	0.748
MOD_CK1_1	371	377	PF00069	0.538
MOD_CK1_1	553	559	PF00069	0.534
MOD_CK1_1	663	669	PF00069	0.675
MOD_CK2_1	14	20	PF00069	0.526
MOD_CK2_1	188	194	PF00069	0.661
MOD_CK2_1	195	201	PF00069	0.561
MOD_CK2_1	21	27	PF00069	0.490
MOD_CK2_1	256	262	PF00069	0.422
MOD_CK2_1	316	322	PF00069	0.667
MOD_CK2_1	345	351	PF00069	0.670
MOD_CK2_1	428	434	PF00069	0.550
MOD_CK2_1	451	457	PF00069	0.691
MOD_CK2_1	564	570	PF00069	0.573
MOD_CK2_1	636	642	PF00069	0.452
MOD_CK2_1	725	731	PF00069	0.565
MOD_CMANNOS	76	79	PF00535	0.525
MOD_GlcNHglycan	137	140	PF01048	0.665
MOD_GlcNHglycan	227	230	PF01048	0.339
MOD_GlcNHglycan	297	300	PF01048	0.786
MOD_GlcNHglycan	316	319	PF01048	0.627
MOD_GlcNHglycan	335	338	PF01048	0.661
MOD_GlcNHglycan	347	350	PF01048	0.677
MOD_GlcNHglycan	351	354	PF01048	0.576
MOD_GlcNHglycan	356	360	PF01048	0.571
MOD_GlcNHglycan	370	373	PF01048	0.297
MOD_GlcNHglycan	430	433	PF01048	0.481
MOD_GlcNHglycan	446	450	PF01048	0.399
MOD_GlcNHglycan	453	456	PF01048	0.703
MOD_GlcNHglycan	460	463	PF01048	0.565
MOD_GlcNHglycan	521	524	PF01048	0.669
MOD_GlcNHglycan	552	555	PF01048	0.639
MOD_GlcNHglycan	64	67	PF01048	0.638
MOD_GlcNHglycan	649	652	PF01048	0.565
MOD_GlcNHglycan	662	665	PF01048	0.663
MOD_GlcNHglycan	702	705	PF01048	0.604
MOD_GlcNHglycan	744	747	PF01048	0.501
MOD_GSK3_1	189	196	PF00069	0.701
MOD_GSK3_1	225	232	PF00069	0.378
MOD_GSK3_1	312	319	PF00069	0.687
MOD_GSK3_1	339	346	PF00069	0.715
MOD_GSK3_1	445	452	PF00069	0.596
MOD_GSK3_1	549	556	PF00069	0.428
MOD_GSK3_1	620	627	PF00069	0.554
MOD_GSK3_1	696	703	PF00069	0.556
MOD_GSK3_1	713	720	PF00069	0.556
MOD_GSK3_1	80	87	PF00069	0.527
MOD_N-GLC_1	395	400	PF02516	0.477
MOD_NEK2_1	1	6	PF00069	0.521
MOD_NEK2_1	111	116	PF00069	0.380
MOD_NEK2_1	386	391	PF00069	0.539
MOD_NEK2_1	404	409	PF00069	0.555
MOD_NEK2_1	50	55	PF00069	0.616
MOD_NEK2_1	578	583	PF00069	0.498
MOD_NEK2_1	741	746	PF00069	0.554
MOD_PIKK_1	111	117	PF00454	0.407
MOD_PIKK_1	498	504	PF00454	0.394
MOD_PK_1	189	195	PF00069	0.571
MOD_PKA_1	188	194	PF00069	0.624
MOD_PKA_1	717	723	PF00069	0.650
MOD_PKA_2	135	141	PF00069	0.666
MOD_PKA_2	285	291	PF00069	0.593
MOD_PKA_2	386	392	PF00069	0.580
MOD_PKA_2	549	555	PF00069	0.440
MOD_PKA_2	564	570	PF00069	0.428
MOD_PKA_2	578	584	PF00069	0.327
MOD_PKA_2	620	626	PF00069	0.610
MOD_PKA_2	717	723	PF00069	0.645
MOD_PKB_1	715	723	PF00069	0.644
MOD_Plk_1	256	262	PF00069	0.422
MOD_Plk_1	343	349	PF00069	0.656
MOD_Plk_1	395	401	PF00069	0.430
MOD_Plk_1	404	410	PF00069	0.440
MOD_Plk_1	609	615	PF00069	0.441
MOD_Plk_1	696	702	PF00069	0.650
MOD_Plk_4	371	377	PF00069	0.486
MOD_Plk_4	404	410	PF00069	0.590
MOD_Plk_4	636	642	PF00069	0.471
MOD_Plk_4	705	711	PF00069	0.560
MOD_ProDKin_1	103	109	PF00069	0.582
MOD_ProDKin_1	193	199	PF00069	0.637
MOD_ProDKin_1	293	299	PF00069	0.697
MOD_ProDKin_1	449	455	PF00069	0.677
MOD_ProDKin_1	645	651	PF00069	0.600
MOD_ProDKin_1	676	682	PF00069	0.742
MOD_ProDKin_1	725	731	PF00069	0.587
MOD_SUMO_for_1	747	750	PF00179	0.449
MOD_SUMO_rev_2	65	73	PF00179	0.577
MOD_SUMO_rev_2	734	742	PF00179	0.468
TRG_DiLeu_BaEn_1	28	33	PF01217	0.495
TRG_ENDOCYTIC_2	178	181	PF00928	0.375
TRG_ENDOCYTIC_2	335	338	PF00928	0.707
TRG_ENDOCYTIC_2	470	473	PF00928	0.326
TRG_ENDOCYTIC_2	506	509	PF00928	0.378
TRG_ENDOCYTIC_2	638	641	PF00928	0.465
TRG_ER_diArg_1	154	157	PF00400	0.597
TRG_ER_diArg_1	323	326	PF00400	0.535
TRG_ER_diArg_1	386	388	PF00400	0.572
TRG_ER_diArg_1	511	514	PF00400	0.445
TRG_ER_diArg_1	546	548	PF00400	0.646
TRG_ER_diArg_1	714	717	PF00400	0.535
TRG_NES_CRM1_1	13	28	PF08389	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY62	Leptomonas seymouri	50%	88%
A0A1X0P9D5	Trypanosomatidae	29%	100%
A0A422N292	Trypanosoma rangeli	32%	100%
A4HAD6	Leishmania braziliensis	79%	100%
A4I9I8	Leishmania infantum	100%	100%
D0A1U4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	94%
E9B4I6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q3J0	Leishmania major	91%	100%
V5BM66	Trypanosoma cruzi	29%	100%