Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X7D6_LEIDO

TriTrypDb:

LdBPK_340440.1 , LdCL_340009500 , LDHU3_34.0610

Length:

418

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X7D6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7D6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	169	173	PF00656	0.577
CLV_MEL_PAP_1	194	200	PF00089	0.416
CLV_NRD_NRD_1	287	289	PF00675	0.447
CLV_NRD_NRD_1	406	408	PF00675	0.418
CLV_NRD_NRD_1	98	100	PF00675	0.673
CLV_PCSK_FUR_1	285	289	PF00082	0.437
CLV_PCSK_KEX2_1	285	287	PF00082	0.437
CLV_PCSK_KEX2_1	406	408	PF00082	0.418
CLV_PCSK_KEX2_1	98	100	PF00082	0.660
CLV_PCSK_SKI1_1	180	184	PF00082	0.631
CLV_PCSK_SKI1_1	224	228	PF00082	0.478
CLV_PCSK_SKI1_1	340	344	PF00082	0.374
CLV_Separin_Metazoa	366	370	PF03568	0.405
DEG_APCC_DBOX_1	196	204	PF00400	0.447
DOC_CKS1_1	68	73	PF01111	0.622
DOC_CKS1_1	85	90	PF01111	0.527
DOC_MAPK_gen_1	246	254	PF00069	0.437
DOC_MAPK_gen_1	389	396	PF00069	0.549
DOC_MAPK_MEF2A_6	192	200	PF00069	0.420
DOC_MAPK_MEF2A_6	248	256	PF00069	0.411
DOC_PP1_RVXF_1	367	373	PF00149	0.412
DOC_PP2B_LxvP_1	256	259	PF13499	0.446
DOC_USP7_MATH_1	117	121	PF00917	0.555
DOC_USP7_MATH_1	122	126	PF00917	0.469
DOC_USP7_MATH_1	145	149	PF00917	0.539
DOC_USP7_MATH_1	174	178	PF00917	0.546
DOC_USP7_MATH_1	196	200	PF00917	0.370
DOC_USP7_MATH_1	210	214	PF00917	0.445
DOC_USP7_MATH_1	322	326	PF00917	0.551
DOC_USP7_MATH_1	349	353	PF00917	0.422
DOC_WW_Pin1_4	107	112	PF00397	0.592
DOC_WW_Pin1_4	113	118	PF00397	0.628
DOC_WW_Pin1_4	170	175	PF00397	0.627
DOC_WW_Pin1_4	271	276	PF00397	0.559
DOC_WW_Pin1_4	67	72	PF00397	0.591
DOC_WW_Pin1_4	84	89	PF00397	0.767
DOC_WW_Pin1_4	9	14	PF00397	0.512
LIG_14-3-3_CanoR_1	197	201	PF00244	0.443
LIG_14-3-3_CanoR_1	271	275	PF00244	0.596
LIG_14-3-3_CanoR_1	288	298	PF00244	0.283
LIG_14-3-3_CanoR_1	321	328	PF00244	0.555
LIG_14-3-3_CanoR_1	395	402	PF00244	0.520
LIG_14-3-3_CanoR_1	411	418	PF00244	0.417
LIG_Actin_WH2_2	187	203	PF00022	0.423
LIG_BRCT_BRCA1_1	29	33	PF00533	0.445
LIG_Clathr_ClatBox_1	157	161	PF01394	0.457
LIG_FHA_1	144	150	PF00498	0.539
LIG_FHA_1	227	233	PF00498	0.379
LIG_FHA_1	37	43	PF00498	0.500
LIG_FHA_2	167	173	PF00498	0.558
LIG_FHA_2	183	189	PF00498	0.301
LIG_FHA_2	374	380	PF00498	0.568
LIG_FHA_2	383	389	PF00498	0.513
LIG_GBD_Chelix_1	132	140	PF00786	0.410
LIG_HP1_1	196	200	PF01393	0.429
LIG_LIR_Apic_2	12	17	PF02991	0.515
LIG_LIR_Gen_1	181	190	PF02991	0.583
LIG_LIR_Nem_3	181	186	PF02991	0.604
LIG_SH2_PTP2	14	17	PF00017	0.601
LIG_SH2_SRC	14	17	PF00017	0.677
LIG_SH2_STAT3	231	234	PF00017	0.425
LIG_SH2_STAT5	14	17	PF00017	0.614
LIG_SH2_STAT5	231	234	PF00017	0.425
LIG_SH2_STAT5	38	41	PF00017	0.464
LIG_SH3_1	10	16	PF00018	0.542
LIG_SH3_1	168	174	PF00018	0.583
LIG_SH3_3	10	16	PF00018	0.582
LIG_SH3_3	168	174	PF00018	0.623
LIG_SH3_3	230	236	PF00018	0.369
LIG_SH3_3	82	88	PF00018	0.667
LIG_SH3_3	91	97	PF00018	0.610
LIG_SUMO_SIM_anti_2	249	255	PF11976	0.410
LIG_SUMO_SIM_par_1	156	161	PF11976	0.448
LIG_SUMO_SIM_par_1	249	255	PF11976	0.402
LIG_SUMO_SIM_par_1	352	359	PF11976	0.399
LIG_TRAF2_1	112	115	PF00917	0.584
LIG_WRC_WIRS_1	4	9	PF05994	0.557
MOD_CDK_SPxK_1	67	73	PF00069	0.595
MOD_CK1_1	163	169	PF00069	0.530
MOD_CK1_1	269	275	PF00069	0.608
MOD_CK1_1	276	282	PF00069	0.543
MOD_CK1_1	356	362	PF00069	0.487
MOD_CK1_1	390	396	PF00069	0.586
MOD_CK2_1	2	8	PF00069	0.614
MOD_CK2_1	373	379	PF00069	0.552
MOD_CK2_1	382	388	PF00069	0.515
MOD_GlcNHglycan	124	127	PF01048	0.475
MOD_GlcNHglycan	324	327	PF01048	0.714
MOD_GlcNHglycan	413	416	PF01048	0.518
MOD_GlcNHglycan	50	54	PF01048	0.736
MOD_GlcNHglycan	88	91	PF01048	0.646
MOD_GSK3_1	113	120	PF00069	0.618
MOD_GSK3_1	145	152	PF00069	0.508
MOD_GSK3_1	166	173	PF00069	0.584
MOD_GSK3_1	242	249	PF00069	0.422
MOD_GSK3_1	262	269	PF00069	0.524
MOD_GSK3_1	276	283	PF00069	0.470
MOD_GSK3_1	329	336	PF00069	0.564
MOD_GSK3_1	343	350	PF00069	0.360
MOD_GSK3_1	378	385	PF00069	0.607
MOD_GSK3_1	390	397	PF00069	0.481
MOD_N-GLC_1	143	148	PF02516	0.482
MOD_NEK2_1	121	126	PF00069	0.525
MOD_NEK2_1	160	165	PF00069	0.492
MOD_NEK2_1	182	187	PF00069	0.580
MOD_NEK2_1	226	231	PF00069	0.382
MOD_NEK2_1	254	259	PF00069	0.415
MOD_NEK2_1	263	268	PF00069	0.387
MOD_NEK2_1	270	275	PF00069	0.558
MOD_NEK2_1	343	348	PF00069	0.368
MOD_NEK2_1	355	360	PF00069	0.421
MOD_NEK2_1	394	399	PF00069	0.528
MOD_NEK2_2	196	201	PF00069	0.442
MOD_OFUCOSY	35	40	PF10250	0.480
MOD_PIKK_1	289	295	PF00454	0.370
MOD_PIKK_1	304	310	PF00454	0.361
MOD_PIKK_1	349	355	PF00454	0.421
MOD_PIKK_1	394	400	PF00454	0.488
MOD_PK_1	246	252	PF00069	0.388
MOD_PKA_2	196	202	PF00069	0.443
MOD_PKA_2	270	276	PF00069	0.593
MOD_PKA_2	320	326	PF00069	0.554
MOD_PKA_2	390	396	PF00069	0.545
MOD_PKA_2	64	70	PF00069	0.633
MOD_Plk_1	254	260	PF00069	0.404
MOD_Plk_4	160	166	PF00069	0.538
MOD_Plk_4	227	233	PF00069	0.513
MOD_ProDKin_1	107	113	PF00069	0.590
MOD_ProDKin_1	170	176	PF00069	0.622
MOD_ProDKin_1	271	277	PF00069	0.564
MOD_ProDKin_1	67	73	PF00069	0.592
MOD_ProDKin_1	84	90	PF00069	0.768
MOD_ProDKin_1	9	15	PF00069	0.515
MOD_SUMO_for_1	281	284	PF00179	0.494
MOD_SUMO_rev_2	274	283	PF00179	0.601
TRG_DiLeu_BaEn_1	366	371	PF01217	0.402
TRG_DiLeu_BaLyEn_6	198	203	PF01217	0.440
TRG_DiLeu_LyEn_5	366	371	PF01217	0.402
TRG_ER_diArg_1	285	288	PF00400	0.465
TRG_ER_diArg_1	406	408	PF00400	0.418
TRG_ER_diArg_1	97	99	PF00400	0.616
TRG_Pf-PMV_PEXEL_1	180	184	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	288	293	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	406	410	PF00026	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDW8	Leptomonas seymouri	39%	72%
A4HAF6	Leishmania braziliensis	70%	98%
A4I9L2	Leishmania infantum	99%	100%
E9B4L0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q3G6	Leishmania major	91%	100%