Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7X7D2_LEIDO

TriTrypDb:

LdBPK_340020.1 , LdCL_340005300 , LDHU3_34.0040

Length:

449

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	18
GO:0042995	cell projection	2	18
GO:0043226	organelle	2	18
GO:0043227	membrane-bounded organelle	3	18
GO:0110165	cellular anatomical entity	1	18
GO:0120025	plasma membrane bounded cell projection	3	18
GO:0000151	ubiquitin ligase complex	3	1
GO:0019005	SCF ubiquitin ligase complex	5	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1
GO:0005743	mitochondrial inner membrane	5	2
GO:0016020	membrane	2	2
GO:0019866	organelle inner membrane	4	2
GO:0031090	organelle membrane	3	2
GO:0031966	mitochondrial membrane	4	2

Expansion

Sequence features

A0A3S7X7D2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7D2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	5
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	5
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	7	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:0006793	phosphorus metabolic process	3	4
GO:0006796	phosphate-containing compound metabolic process	4	4
GO:0016310	phosphorylation	5	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0016301	kinase activity	4	4
GO:0016740	transferase activity	2	4
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	4
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.353
CLV_C14_Caspase3-7	194	198	PF00656	0.276
CLV_C14_Caspase3-7	403	407	PF00656	0.459
CLV_NRD_NRD_1	240	242	PF00675	0.289
CLV_NRD_NRD_1	25	27	PF00675	0.709
CLV_NRD_NRD_1	255	257	PF00675	0.505
CLV_NRD_NRD_1	36	38	PF00675	0.717
CLV_PCSK_KEX2_1	24	26	PF00082	0.689
CLV_PCSK_KEX2_1	255	257	PF00082	0.437
CLV_PCSK_KEX2_1	323	325	PF00082	0.328
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.249
CLV_PCSK_SKI1_1	126	130	PF00082	0.342
CLV_PCSK_SKI1_1	210	214	PF00082	0.429
CLV_PCSK_SKI1_1	255	259	PF00082	0.459
CLV_PCSK_SKI1_1	26	30	PF00082	0.452
CLV_PCSK_SKI1_1	302	306	PF00082	0.401
CLV_PCSK_SKI1_1	38	42	PF00082	0.477
DEG_APCC_DBOX_1	125	133	PF00400	0.334
DEG_APCC_DBOX_1	25	33	PF00400	0.449
DEG_ODPH_VHL_1	154	166	PF01847	0.331
DEG_SCF_FBW7_1	259	266	PF00400	0.280
DOC_CYCLIN_RxL_1	22	33	PF00134	0.450
DOC_CYCLIN_RxL_1	252	262	PF00134	0.444
DOC_CYCLIN_RxL_1	299	310	PF00134	0.285
DOC_CYCLIN_RxL_1	34	44	PF00134	0.426
DOC_MAPK_gen_1	241	248	PF00069	0.279
DOC_MAPK_gen_1	323	330	PF00069	0.458
DOC_MAPK_MEF2A_6	344	353	PF00069	0.263
DOC_USP7_MATH_1	204	208	PF00917	0.318
DOC_USP7_MATH_1	263	267	PF00917	0.450
DOC_USP7_UBL2_3	146	150	PF12436	0.361
DOC_USP7_UBL2_3	323	327	PF12436	0.247
DOC_WW_Pin1_4	16	21	PF00397	0.465
DOC_WW_Pin1_4	259	264	PF00397	0.314
DOC_WW_Pin1_4	30	35	PF00397	0.401
LIG_14-3-3_CanoR_1	18	28	PF00244	0.465
LIG_14-3-3_CanoR_1	229	233	PF00244	0.476
LIG_14-3-3_CanoR_1	382	389	PF00244	0.427
LIG_14-3-3_CanoR_1	396	401	PF00244	0.370
LIG_APCC_ABBAyCdc20_2	411	417	PF00400	0.275
LIG_BIR_II_1	1	5	PF00653	0.449
LIG_BIR_III_4	406	410	PF00653	0.300
LIG_BRCT_BRCA1_1	189	193	PF00533	0.493
LIG_BRCT_BRCA1_1	49	53	PF00533	0.591
LIG_FHA_1	203	209	PF00498	0.484
LIG_FHA_1	232	238	PF00498	0.489
LIG_FHA_1	243	249	PF00498	0.448
LIG_FHA_1	34	40	PF00498	0.603
LIG_FHA_1	382	388	PF00498	0.413
LIG_FHA_1	419	425	PF00498	0.343
LIG_FHA_1	79	85	PF00498	0.400
LIG_FHA_2	108	114	PF00498	0.363
LIG_FHA_2	180	186	PF00498	0.310
LIG_FHA_2	204	210	PF00498	0.294
LIG_FHA_2	401	407	PF00498	0.421
LIG_GBD_Chelix_1	345	353	PF00786	0.284
LIG_LIR_Gen_1	394	405	PF02991	0.280
LIG_LIR_Nem_3	394	400	PF02991	0.460
LIG_NRBOX	253	259	PF00104	0.283
LIG_NRBOX	344	350	PF00104	0.300
LIG_SH2_STAT5	130	133	PF00017	0.291
LIG_SH2_STAT5	444	447	PF00017	0.503
LIG_SH3_3	153	159	PF00018	0.450
LIG_SH3_3	402	408	PF00018	0.256
LIG_SH3_3	66	72	PF00018	0.461
LIG_SUMO_SIM_anti_2	234	239	PF11976	0.271
LIG_SUMO_SIM_anti_2	371	379	PF11976	0.245
LIG_SUMO_SIM_par_1	185	191	PF11976	0.292
LIG_SUMO_SIM_par_1	2	8	PF11976	0.453
LIG_SUMO_SIM_par_1	233	239	PF11976	0.259
LIG_Vh1_VBS_1	366	384	PF01044	0.480
MOD_CDK_SPxxK_3	30	37	PF00069	0.429
MOD_CK1_1	160	166	PF00069	0.484
MOD_CK1_1	178	184	PF00069	0.447
MOD_CK1_1	19	25	PF00069	0.462
MOD_CK1_1	196	202	PF00069	0.447
MOD_CK1_1	231	237	PF00069	0.430
MOD_CK1_1	33	39	PF00069	0.408
MOD_CK1_1	368	374	PF00069	0.365
MOD_CK2_1	107	113	PF00069	0.374
MOD_CK2_1	179	185	PF00069	0.537
MOD_CK2_1	218	224	PF00069	0.413
MOD_CK2_1	358	364	PF00069	0.445
MOD_CK2_1	368	374	PF00069	0.385
MOD_GlcNHglycan	177	180	PF01048	0.403
MOD_GlcNHglycan	360	363	PF01048	0.390
MOD_GlcNHglycan	78	81	PF01048	0.541
MOD_GSK3_1	16	23	PF00069	0.481
MOD_GSK3_1	175	182	PF00069	0.398
MOD_GSK3_1	187	194	PF00069	0.441
MOD_GSK3_1	199	206	PF00069	0.529
MOD_GSK3_1	259	266	PF00069	0.407
MOD_GSK3_1	352	359	PF00069	0.384
MOD_GSK3_1	396	403	PF00069	0.392
MOD_GSK3_1	76	83	PF00069	0.541
MOD_N-GLC_1	60	65	PF02516	0.613
MOD_NEK2_1	213	218	PF00069	0.530
MOD_NEK2_1	28	33	PF00069	0.449
MOD_NEK2_1	306	311	PF00069	0.431
MOD_NEK2_1	353	358	PF00069	0.407
MOD_NEK2_1	424	429	PF00069	0.459
MOD_NEK2_1	60	65	PF00069	0.591
MOD_NEK2_2	228	233	PF00069	0.518
MOD_NEK2_2	391	396	PF00069	0.326
MOD_NEK2_2	49	54	PF00069	0.443
MOD_PKA_2	107	113	PF00069	0.371
MOD_PKA_2	228	234	PF00069	0.286
MOD_PKA_2	381	387	PF00069	0.447
MOD_PKA_2	76	82	PF00069	0.393
MOD_Plk_1	196	202	PF00069	0.517
MOD_Plk_1	307	313	PF00069	0.500
MOD_Plk_1	60	66	PF00069	0.681
MOD_Plk_2-3	113	119	PF00069	0.545
MOD_Plk_2-3	191	197	PF00069	0.265
MOD_Plk_4	162	168	PF00069	0.381
MOD_Plk_4	218	224	PF00069	0.439
MOD_Plk_4	233	239	PF00069	0.427
MOD_Plk_4	368	374	PF00069	0.466
MOD_Plk_4	396	402	PF00069	0.417
MOD_ProDKin_1	16	22	PF00069	0.464
MOD_ProDKin_1	259	265	PF00069	0.315
MOD_ProDKin_1	30	36	PF00069	0.399
TRG_DiLeu_BaLyEn_6	253	258	PF01217	0.396
TRG_ER_diArg_1	24	26	PF00400	0.689
TRG_ER_diArg_1	254	256	PF00400	0.499
TRG_NES_CRM1_1	138	153	PF08389	0.322
TRG_NES_CRM1_1	185	197	PF08389	0.283
TRG_Pf-PMV_PEXEL_1	299	303	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F9	Leptomonas seymouri	23%	86%
A0A0S4IRL6	Bodo saltans	22%	100%
A0A0S4IRN7	Bodo saltans	25%	100%
A0A0S4J6D7	Bodo saltans	27%	100%
A0A0S4JR29	Bodo saltans	24%	88%
A0A0S4JR64	Bodo saltans	23%	69%
A0A1X0P4M6	Trypanosomatidae	26%	77%
A0A3S5H5M6	Leishmania donovani	25%	84%
A4H4H0	Leishmania braziliensis	26%	84%
A4HSP5	Leishmania infantum	25%	84%
A4I9H0	Leishmania infantum	100%	100%
D0A0X4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	66%
E9AKN0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	84%
E9B4G8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
P23799	Trypanosoma brucei brucei	25%	71%
P26337	Trypanosoma equiperdum	25%	71%
Q4Q3K7	Leishmania major	86%	100%
V5BMQ2	Trypanosoma cruzi	25%	80%