Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X7C6_LEIDO

TriTrypDb:

LdBPK_340340.1 , LdCL_340008500 , LDHU3_34.0500

Length:

358

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X7C6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7C6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0008289	lipid binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	7	11	PF00656	0.616
CLV_NRD_NRD_1	247	249	PF00675	0.361
CLV_NRD_NRD_1	284	286	PF00675	0.362
CLV_NRD_NRD_1	346	348	PF00675	0.585
CLV_PCSK_KEX2_1	201	203	PF00082	0.450
CLV_PCSK_KEX2_1	284	286	PF00082	0.362
CLV_PCSK_KEX2_1	346	348	PF00082	0.675
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.450
CLV_PCSK_SKI1_1	122	126	PF00082	0.380
CLV_PCSK_SKI1_1	284	288	PF00082	0.348
CLV_PCSK_SKI1_1	305	309	PF00082	0.593
CLV_PCSK_SKI1_1	346	350	PF00082	0.562
CLV_PCSK_SKI1_1	81	85	PF00082	0.626
CLV_PCSK_SKI1_1	96	100	PF00082	0.268
DEG_Nend_Nbox_1	1	3	PF02207	0.526
DOC_PIKK_1	161	169	PF02985	0.433
DOC_PP1_RVXF_1	120	127	PF00149	0.473
DOC_PP1_RVXF_1	351	358	PF00149	0.561
DOC_PP1_RVXF_1	82	89	PF00149	0.568
DOC_PP4_FxxP_1	98	101	PF00568	0.405
DOC_USP7_MATH_1	22	26	PF00917	0.634
DOC_USP7_MATH_1	297	301	PF00917	0.714
DOC_USP7_MATH_1	314	318	PF00917	0.458
DOC_USP7_UBL2_3	14	18	PF12436	0.627
DOC_WW_Pin1_4	116	121	PF00397	0.358
DOC_WW_Pin1_4	256	261	PF00397	0.385
LIG_14-3-3_CanoR_1	110	116	PF00244	0.491
LIG_14-3-3_CanoR_1	183	187	PF00244	0.496
LIG_14-3-3_CanoR_1	248	252	PF00244	0.426
LIG_APCC_ABBAyCdc20_2	284	290	PF00400	0.385
LIG_BRCT_BRCA1_1	104	108	PF00533	0.466
LIG_FHA_1	110	116	PF00498	0.417
LIG_FHA_1	220	226	PF00498	0.552
LIG_FHA_1	264	270	PF00498	0.451
LIG_FHA_1	46	52	PF00498	0.435
LIG_FHA_2	213	219	PF00498	0.441
LIG_FHA_2	71	77	PF00498	0.641
LIG_FHA_2	87	93	PF00498	0.598
LIG_LIR_Apic_2	310	314	PF02991	0.485
LIG_LIR_Gen_1	105	115	PF02991	0.476
LIG_LIR_Gen_1	194	203	PF02991	0.325
LIG_LIR_Gen_1	54	63	PF02991	0.503
LIG_LIR_Nem_3	105	111	PF02991	0.434
LIG_LIR_Nem_3	180	184	PF02991	0.420
LIG_LIR_Nem_3	194	198	PF02991	0.301
LIG_LIR_Nem_3	250	254	PF02991	0.347
LIG_LIR_Nem_3	54	59	PF02991	0.509
LIG_Pex14_1	177	181	PF04695	0.445
LIG_Pex14_1	263	267	PF04695	0.407
LIG_Pex14_2	239	243	PF04695	0.341
LIG_Pex14_2	267	271	PF04695	0.389
LIG_PTB_Apo_2	50	57	PF02174	0.463
LIG_PTB_Phospho_1	50	56	PF10480	0.508
LIG_SH2_CRK	145	149	PF00017	0.481
LIG_SH2_CRK	184	188	PF00017	0.517
LIG_SH2_CRK	311	315	PF00017	0.543
LIG_SH2_CRK	56	60	PF00017	0.489
LIG_SH2_GRB2like	138	141	PF00017	0.444
LIG_SH2_NCK_1	145	149	PF00017	0.481
LIG_SH2_NCK_1	184	188	PF00017	0.517
LIG_SH2_NCK_1	56	60	PF00017	0.282
LIG_SH2_SRC	211	214	PF00017	0.287
LIG_SH2_SRC	288	291	PF00017	0.559
LIG_SH2_STAP1	138	142	PF00017	0.363
LIG_SH2_STAP1	145	149	PF00017	0.350
LIG_SH2_STAT5	158	161	PF00017	0.473
LIG_SH2_STAT5	197	200	PF00017	0.376
LIG_SH2_STAT5	203	206	PF00017	0.367
LIG_SH2_STAT5	211	214	PF00017	0.287
LIG_SH2_STAT5	251	254	PF00017	0.349
LIG_SH2_STAT5	303	306	PF00017	0.480
LIG_SH3_3	149	155	PF00018	0.510
LIG_SH3_3	25	31	PF00018	0.416
LIG_SUMO_SIM_par_1	111	117	PF11976	0.348
LIG_TRAF2_1	131	134	PF00917	0.445
LIG_TYR_ITIM	286	291	PF00017	0.449
LIG_WRC_WIRS_1	123	128	PF05994	0.379
MOD_CDC14_SPxK_1	119	122	PF00782	0.392
MOD_CDK_SPxK_1	116	122	PF00069	0.475
MOD_CK1_1	256	262	PF00069	0.473
MOD_CK1_1	293	299	PF00069	0.647
MOD_CK1_1	329	335	PF00069	0.699
MOD_CK1_1	72	78	PF00069	0.494
MOD_CK2_1	128	134	PF00069	0.396
MOD_CK2_1	86	92	PF00069	0.418
MOD_Cter_Amidation	246	249	PF01082	0.358
MOD_GlcNHglycan	184	187	PF01048	0.448
MOD_GlcNHglycan	332	335	PF01048	0.699
MOD_GSK3_1	219	226	PF00069	0.558
MOD_GSK3_1	293	300	PF00069	0.643
MOD_GSK3_1	325	332	PF00069	0.697
MOD_N-GLC_1	325	330	PF02516	0.771
MOD_N-GLC_1	52	57	PF02516	0.500
MOD_N-GLC_2	141	143	PF02516	0.455
MOD_NEK2_1	4	9	PF00069	0.647
MOD_NEK2_1	52	57	PF00069	0.476
MOD_NEK2_1	69	74	PF00069	0.594
MOD_NEK2_2	314	319	PF00069	0.557
MOD_OFUCOSY	252	257	PF10250	0.447
MOD_PKA_2	109	115	PF00069	0.491
MOD_PKA_2	136	142	PF00069	0.447
MOD_PKA_2	182	188	PF00069	0.500
MOD_PKA_2	219	225	PF00069	0.520
MOD_PKA_2	247	253	PF00069	0.431
MOD_Plk_1	52	58	PF00069	0.495
MOD_Plk_2-3	61	67	PF00069	0.527
MOD_Plk_4	122	128	PF00069	0.379
MOD_Plk_4	250	256	PF00069	0.315
MOD_Plk_4	263	269	PF00069	0.375
MOD_ProDKin_1	116	122	PF00069	0.359
MOD_ProDKin_1	256	262	PF00069	0.394
MOD_SUMO_for_1	341	344	PF00179	0.619
MOD_SUMO_rev_2	345	355	PF00179	0.550
TRG_DiLeu_BaEn_1	344	349	PF01217	0.646
TRG_DiLeu_BaEn_4	344	350	PF01217	0.722
TRG_DiLeu_BaLyEn_6	65	70	PF01217	0.592
TRG_DiLeu_LyEn_5	344	349	PF01217	0.646
TRG_ENDOCYTIC_2	145	148	PF00928	0.486
TRG_ENDOCYTIC_2	288	291	PF00928	0.559
TRG_ENDOCYTIC_2	56	59	PF00928	0.503
TRG_ER_diArg_1	135	138	PF00400	0.490
TRG_ER_diArg_1	284	286	PF00400	0.362
TRG_ER_diArg_1	346	348	PF00400	0.541
TRG_NES_CRM1_1	164	176	PF08389	0.497
TRG_Pf-PMV_PEXEL_1	285	289	PF00026	0.381
TRG_Pf-PMV_PEXEL_1	346	350	PF00026	0.669
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4J3	Leptomonas seymouri	70%	100%
A0A0S4KHG7	Bodo saltans	38%	100%
A0A1X0P8H6	Trypanosomatidae	42%	100%
A0A3R7MF23	Trypanosoma rangeli	40%	100%
A4H7D8	Leishmania braziliensis	77%	100%
A4I9K2	Leishmania infantum	100%	100%
D0A1W1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B4K0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q3H6	Leishmania major	95%	100%
V5DIM4	Trypanosoma cruzi	42%	100%