PrimPol-like protein 2, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PrimPol-like protein 2, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X7B7_LEIDO

TriTrypDb:

LdBPK_340110.1 , LdCL_340006200 , LDHU3_34.0160

Length:

693

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X7B7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7B7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0003887	DNA-directed DNA polymerase activity	5	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016779	nucleotidyltransferase activity	4	2
GO:0034061	DNA polymerase activity	4	2
GO:0140097	catalytic activity, acting on DNA	3	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	644	648	PF00656	0.543
CLV_NRD_NRD_1	213	215	PF00675	0.514
CLV_NRD_NRD_1	238	240	PF00675	0.521
CLV_NRD_NRD_1	683	685	PF00675	0.506
CLV_NRD_NRD_1	94	96	PF00675	0.548
CLV_PCSK_FUR_1	303	307	PF00082	0.571
CLV_PCSK_KEX2_1	213	215	PF00082	0.514
CLV_PCSK_KEX2_1	238	240	PF00082	0.577
CLV_PCSK_KEX2_1	305	307	PF00082	0.589
CLV_PCSK_KEX2_1	401	403	PF00082	0.519
CLV_PCSK_KEX2_1	539	541	PF00082	0.457
CLV_PCSK_KEX2_1	683	685	PF00082	0.506
CLV_PCSK_KEX2_1	94	96	PF00082	0.608
CLV_PCSK_PC1ET2_1	305	307	PF00082	0.557
CLV_PCSK_PC1ET2_1	401	403	PF00082	0.519
CLV_PCSK_PC1ET2_1	539	541	PF00082	0.393
CLV_PCSK_PC7_1	397	403	PF00082	0.441
CLV_PCSK_SKI1_1	203	207	PF00082	0.370
CLV_PCSK_SKI1_1	265	269	PF00082	0.457
CLV_PCSK_SKI1_1	397	401	PF00082	0.393
CLV_PCSK_SKI1_1	408	412	PF00082	0.337
CLV_PCSK_SKI1_1	421	425	PF00082	0.411
CLV_PCSK_SKI1_1	494	498	PF00082	0.761
CLV_PCSK_SKI1_1	539	543	PF00082	0.430
CLV_PCSK_SKI1_1	569	573	PF00082	0.460
CLV_PCSK_SKI1_1	669	673	PF00082	0.391
CLV_PCSK_SKI1_1	85	89	PF00082	0.535
CLV_Separin_Metazoa	680	684	PF03568	0.525
DEG_APCC_DBOX_1	264	272	PF00400	0.464
DEG_APCC_DBOX_1	396	404	PF00400	0.434
DEG_APCC_DBOX_1	407	415	PF00400	0.306
DEG_Nend_UBRbox_3	1	3	PF02207	0.564
DEG_SPOP_SBC_1	229	233	PF00917	0.386
DEG_SPOP_SBC_1	291	295	PF00917	0.621
DEG_SPOP_SBC_1	488	492	PF00917	0.590
DOC_CKS1_1	240	245	PF01111	0.557
DOC_CYCLIN_RxL_1	200	210	PF00134	0.463
DOC_CYCLIN_RxL_1	394	404	PF00134	0.406
DOC_CYCLIN_yCln2_LP_2	432	435	PF00134	0.414
DOC_MAPK_gen_1	599	607	PF00069	0.464
DOC_MAPK_MEF2A_6	85	92	PF00069	0.512
DOC_MAPK_NFAT4_5	85	93	PF00069	0.440
DOC_PP1_RVXF_1	251	257	PF00149	0.361
DOC_PP1_RVXF_1	316	323	PF00149	0.471
DOC_PP2B_LxvP_1	432	435	PF13499	0.414
DOC_PP2B_LxvP_1	56	59	PF13499	0.558
DOC_PP2B_LxvP_1	572	575	PF13499	0.511
DOC_PP2B_LxvP_1	672	675	PF13499	0.413
DOC_PP4_FxxP_1	331	334	PF00568	0.354
DOC_PP4_FxxP_1	409	412	PF00568	0.361
DOC_PP4_FxxP_1	428	431	PF00568	0.407
DOC_PP4_FxxP_1	518	521	PF00568	0.584
DOC_USP7_MATH_1	342	346	PF00917	0.650
DOC_USP7_MATH_1	347	351	PF00917	0.668
DOC_USP7_MATH_1	376	380	PF00917	0.457
DOC_USP7_MATH_1	442	446	PF00917	0.540
DOC_USP7_MATH_1	450	454	PF00917	0.451
DOC_USP7_MATH_1	488	492	PF00917	0.742
DOC_USP7_MATH_1	501	505	PF00917	0.600
DOC_USP7_MATH_1	507	511	PF00917	0.620
DOC_USP7_MATH_1	577	581	PF00917	0.590
DOC_WW_Pin1_4	239	244	PF00397	0.618
DOC_WW_Pin1_4	292	297	PF00397	0.585
DOC_WW_Pin1_4	427	432	PF00397	0.507
DOC_WW_Pin1_4	43	48	PF00397	0.691
DOC_WW_Pin1_4	446	451	PF00397	0.510
DOC_WW_Pin1_4	484	489	PF00397	0.546
DOC_WW_Pin1_4	513	518	PF00397	0.646
DOC_WW_Pin1_4	560	565	PF00397	0.667
LIG_14-3-3_CanoR_1	108	116	PF00244	0.651
LIG_14-3-3_CanoR_1	25	33	PF00244	0.593
LIG_14-3-3_CanoR_1	310	317	PF00244	0.429
LIG_14-3-3_CanoR_1	34	43	PF00244	0.632
LIG_14-3-3_CanoR_1	421	426	PF00244	0.575
LIG_14-3-3_CanoR_1	569	575	PF00244	0.621
LIG_Actin_WH2_2	205	223	PF00022	0.521
LIG_APCC_ABBA_1	158	163	PF00400	0.348
LIG_BRCT_BRCA1_1	489	493	PF00533	0.704
LIG_BRCT_BRCA1_1	514	518	PF00533	0.676
LIG_BRCT_BRCA1_1	99	103	PF00533	0.540
LIG_FHA_1	109	115	PF00498	0.522
LIG_FHA_1	229	235	PF00498	0.360
LIG_FHA_1	676	682	PF00498	0.606
LIG_FHA_1	685	691	PF00498	0.535
LIG_FHA_2	221	227	PF00498	0.506
LIG_FHA_2	240	246	PF00498	0.363
LIG_FHA_2	422	428	PF00498	0.469
LIG_FHA_2	69	75	PF00498	0.450
LIG_LIR_Apic_2	427	431	PF02991	0.510
LIG_LIR_Apic_2	515	521	PF02991	0.623
LIG_LIR_Apic_2	552	556	PF02991	0.456
LIG_LIR_Gen_1	100	107	PF02991	0.508
LIG_LIR_Gen_1	614	622	PF02991	0.457
LIG_LIR_Gen_1	7	17	PF02991	0.580
LIG_LIR_Nem_3	100	106	PF02991	0.507
LIG_LIR_Nem_3	13	19	PF02991	0.531
LIG_LIR_Nem_3	159	164	PF02991	0.366
LIG_LIR_Nem_3	321	325	PF02991	0.384
LIG_LIR_Nem_3	326	331	PF02991	0.450
LIG_LIR_Nem_3	404	410	PF02991	0.369
LIG_LIR_Nem_3	490	496	PF02991	0.655
LIG_LIR_Nem_3	544	549	PF02991	0.350
LIG_LIR_Nem_3	614	618	PF02991	0.384
LIG_LIR_Nem_3	621	625	PF02991	0.394
LIG_LIR_Nem_3	7	12	PF02991	0.543
LIG_Pex14_2	162	166	PF04695	0.488
LIG_Pex14_2	256	260	PF04695	0.332
LIG_PTB_Apo_2	667	674	PF02174	0.511
LIG_RPA_C_Fungi	90	102	PF08784	0.559
LIG_SH2_CRK	553	557	PF00017	0.490
LIG_SH2_GRB2like	630	633	PF00017	0.435
LIG_SH2_NCK_1	149	153	PF00017	0.506
LIG_SH2_SRC	587	590	PF00017	0.446
LIG_SH2_STAP1	587	591	PF00017	0.539
LIG_SH2_STAP1	662	666	PF00017	0.500
LIG_SH2_STAT3	393	396	PF00017	0.401
LIG_SH2_STAT3	595	598	PF00017	0.359
LIG_SH2_STAT5	161	164	PF00017	0.436
LIG_SH2_STAT5	325	328	PF00017	0.517
LIG_SH2_STAT5	398	401	PF00017	0.477
LIG_SH2_STAT5	595	598	PF00017	0.413
LIG_SH2_STAT5	603	606	PF00017	0.395
LIG_SH2_STAT5	619	622	PF00017	0.288
LIG_SH3_1	44	50	PF00018	0.639
LIG_SH3_3	154	160	PF00018	0.479
LIG_SH3_3	16	22	PF00018	0.553
LIG_SH3_3	237	243	PF00018	0.603
LIG_SH3_3	409	415	PF00018	0.339
LIG_SH3_3	428	434	PF00018	0.371
LIG_SH3_3	44	50	PF00018	0.672
LIG_SH3_3	441	447	PF00018	0.474
LIG_SH3_3	517	523	PF00018	0.586
LIG_SH3_3	55	61	PF00018	0.508
LIG_SH3_3	643	649	PF00018	0.509
LIG_SUMO_SIM_anti_2	176	183	PF11976	0.295
LIG_SUMO_SIM_anti_2	48	55	PF11976	0.552
LIG_SUMO_SIM_par_1	176	183	PF11976	0.295
LIG_SUMO_SIM_par_1	88	93	PF11976	0.499
LIG_TRAF2_1	483	486	PF00917	0.669
LIG_TRAF2_1	677	680	PF00917	0.501
LIG_WRC_WIRS_1	619	624	PF05994	0.503
MOD_CDC14_SPxK_1	300	303	PF00782	0.608
MOD_CDK_SPxK_1	297	303	PF00069	0.620
MOD_CK1_1	233	239	PF00069	0.462
MOD_CK1_1	297	303	PF00069	0.653
MOD_CK1_1	445	451	PF00069	0.617
MOD_CK1_1	487	493	PF00069	0.729
MOD_CK1_1	49	55	PF00069	0.636
MOD_CK1_1	563	569	PF00069	0.645
MOD_CK2_1	116	122	PF00069	0.613
MOD_CK2_1	180	186	PF00069	0.518
MOD_CK2_1	220	226	PF00069	0.528
MOD_CK2_1	239	245	PF00069	0.360
MOD_CK2_1	267	273	PF00069	0.514
MOD_CK2_1	421	427	PF00069	0.338
MOD_CK2_1	674	680	PF00069	0.524
MOD_CK2_1	68	74	PF00069	0.547
MOD_Cter_Amidation	236	239	PF01082	0.483
MOD_DYRK1A_RPxSP_1	239	243	PF00069	0.549
MOD_GlcNHglycan	118	121	PF01048	0.739
MOD_GlcNHglycan	122	126	PF01048	0.654
MOD_GlcNHglycan	130	133	PF01048	0.381
MOD_GlcNHglycan	137	140	PF01048	0.400
MOD_GlcNHglycan	196	199	PF01048	0.566
MOD_GlcNHglycan	312	315	PF01048	0.537
MOD_GlcNHglycan	345	348	PF01048	0.642
MOD_GlcNHglycan	349	352	PF01048	0.593
MOD_GlcNHglycan	37	40	PF01048	0.725
MOD_GlcNHglycan	421	424	PF01048	0.517
MOD_GlcNHglycan	443	447	PF01048	0.586
MOD_GlcNHglycan	452	455	PF01048	0.494
MOD_GlcNHglycan	458	461	PF01048	0.419
MOD_GlcNHglycan	503	506	PF01048	0.601
MOD_GlcNHglycan	509	512	PF01048	0.644
MOD_GlcNHglycan	572	575	PF01048	0.561
MOD_GlcNHglycan	650	653	PF01048	0.684
MOD_GlcNHglycan	95	98	PF01048	0.538
MOD_GSK3_1	215	222	PF00069	0.552
MOD_GSK3_1	229	236	PF00069	0.366
MOD_GSK3_1	241	248	PF00069	0.526
MOD_GSK3_1	276	283	PF00069	0.561
MOD_GSK3_1	290	297	PF00069	0.536
MOD_GSK3_1	343	350	PF00069	0.664
MOD_GSK3_1	376	383	PF00069	0.543
MOD_GSK3_1	415	422	PF00069	0.496
MOD_GSK3_1	442	449	PF00069	0.575
MOD_GSK3_1	45	52	PF00069	0.631
MOD_GSK3_1	471	478	PF00069	0.587
MOD_GSK3_1	484	491	PF00069	0.589
MOD_GSK3_1	507	514	PF00069	0.652
MOD_GSK3_1	64	71	PF00069	0.290
MOD_GSK3_1	93	100	PF00069	0.585
MOD_LATS_1	32	38	PF00433	0.678
MOD_N-GLC_2	632	634	PF02516	0.441
MOD_NEK2_1	180	185	PF00069	0.517
MOD_NEK2_1	220	225	PF00069	0.459
MOD_NEK2_1	228	233	PF00069	0.343
MOD_NEK2_1	252	257	PF00069	0.543
MOD_NEK2_1	618	623	PF00069	0.375
MOD_NEK2_1	64	69	PF00069	0.443
MOD_NEK2_2	587	592	PF00069	0.535
MOD_PIKK_1	27	33	PF00454	0.564
MOD_PIKK_1	577	583	PF00454	0.295
MOD_PKA_2	107	113	PF00069	0.492
MOD_PKA_2	27	33	PF00069	0.563
MOD_PKA_2	343	349	PF00069	0.646
MOD_PKA_2	93	99	PF00069	0.651
MOD_Plk_1	164	170	PF00069	0.532
MOD_Plk_1	470	476	PF00069	0.614
MOD_Plk_1	587	593	PF00069	0.526
MOD_Plk_2-3	245	251	PF00069	0.448
MOD_Plk_4	204	210	PF00069	0.468
MOD_Plk_4	376	382	PF00069	0.413
MOD_Plk_4	4	10	PF00069	0.588
MOD_Plk_4	49	55	PF00069	0.653
MOD_Plk_4	555	561	PF00069	0.514
MOD_Plk_4	64	70	PF00069	0.405
MOD_ProDKin_1	239	245	PF00069	0.617
MOD_ProDKin_1	292	298	PF00069	0.592
MOD_ProDKin_1	427	433	PF00069	0.502
MOD_ProDKin_1	43	49	PF00069	0.689
MOD_ProDKin_1	446	452	PF00069	0.508
MOD_ProDKin_1	484	490	PF00069	0.541
MOD_ProDKin_1	513	519	PF00069	0.647
MOD_ProDKin_1	560	566	PF00069	0.663
MOD_SUMO_rev_2	183	190	PF00179	0.530
MOD_SUMO_rev_2	215	223	PF00179	0.494
MOD_SUMO_rev_2	534	541	PF00179	0.496
TRG_DiLeu_BaEn_1	537	542	PF01217	0.483
TRG_DiLeu_BaEn_2	272	278	PF01217	0.398
TRG_DiLeu_BaLyEn_6	491	496	PF01217	0.702
TRG_DiLeu_LyEn_5	537	542	PF01217	0.466
TRG_ENDOCYTIC_2	149	152	PF00928	0.382
TRG_ENDOCYTIC_2	161	164	PF00928	0.358
TRG_ENDOCYTIC_2	594	597	PF00928	0.468
TRG_ENDOCYTIC_2	619	622	PF00928	0.400
TRG_ENDOCYTIC_2	662	665	PF00928	0.393
TRG_ER_diArg_1	212	214	PF00400	0.506
TRG_ER_diArg_1	238	240	PF00400	0.513
TRG_ER_diArg_1	281	284	PF00400	0.484
TRG_ER_diArg_1	529	532	PF00400	0.617
TRG_ER_diArg_1	682	684	PF00400	0.492
TRG_NES_CRM1_1	250	264	PF08389	0.479
TRG_NES_CRM1_1	355	370	PF08389	0.533
TRG_Pf-PMV_PEXEL_1	494	498	PF00026	0.695
TRG_Pf-PMV_PEXEL_1	540	544	PF00026	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZS4	Leptomonas seymouri	53%	89%
A0A1X0P8G3	Trypanosomatidae	32%	93%
A0A3R7N6P4	Trypanosoma rangeli	37%	94%
A4HAC4	Leishmania braziliensis	82%	100%
A4I9H9	Leishmania infantum	99%	100%
D0A1T6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	95%
E9B4H7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q3J8	Leishmania major	93%	100%