Emp24/gp25L/p24_family/GOLD_putative/Pfam:PF01105

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

emp24/gp25L/p24 family/GOLD, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X7B6_LEIDO

TriTrypDb:

LdBPK_340240.1 , LdCL_340007500 , LDHU3_34.0370

Length:

335

Annotations

Annotations by Jardim et al.

Transporters, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 1
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005783	endoplasmic reticulum	5	1
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	5	1
GO:0005794	Golgi apparatus	5	1
GO:0030134	COPII-coated ER to Golgi transport vesicle	8	1
GO:0030135	coated vesicle	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

A0A3S7X7B6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7B6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	1
GO:0006996	organelle organization	4	1
GO:0007030	Golgi organization	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0016192	vesicle-mediated transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.753
CLV_NRD_NRD_1	124	126	PF00675	0.502
CLV_NRD_NRD_1	246	248	PF00675	0.330
CLV_NRD_NRD_1	290	292	PF00675	0.308
CLV_PCSK_FUR_1	288	292	PF00082	0.308
CLV_PCSK_KEX2_1	124	126	PF00082	0.502
CLV_PCSK_KEX2_1	290	292	PF00082	0.308
CLV_PCSK_SKI1_1	235	239	PF00082	0.292
CLV_PCSK_SKI1_1	247	251	PF00082	0.292
CLV_PCSK_SKI1_1	273	277	PF00082	0.271
CLV_PCSK_SKI1_1	8	12	PF00082	0.640
DEG_APCC_DBOX_1	301	309	PF00400	0.451
DEG_MDM2_SWIB_1	300	308	PF02201	0.492
DEG_Nend_Nbox_1	1	3	PF02207	0.595
DOC_CYCLIN_RxL_1	232	242	PF00134	0.576
DOC_USP7_MATH_1	209	213	PF00917	0.499
DOC_USP7_MATH_1	255	259	PF00917	0.474
DOC_USP7_MATH_1	74	78	PF00917	0.688
DOC_USP7_MATH_1	95	99	PF00917	0.675
DOC_USP7_UBL2_3	42	46	PF12436	0.517
LIG_14-3-3_CanoR_1	136	144	PF00244	0.686
LIG_14-3-3_CanoR_1	195	205	PF00244	0.576
LIG_14-3-3_CanoR_1	239	249	PF00244	0.576
LIG_14-3-3_CanoR_1	291	300	PF00244	0.501
LIG_14-3-3_CanoR_1	72	82	PF00244	0.652
LIG_Clathr_ClatBox_1	60	64	PF01394	0.345
LIG_FHA_1	135	141	PF00498	0.697
LIG_FHA_1	308	314	PF00498	0.318
LIG_FHA_1	323	329	PF00498	0.295
LIG_FHA_1	4	10	PF00498	0.590
LIG_FHA_2	177	183	PF00498	0.451
LIG_FHA_2	220	226	PF00498	0.451
LIG_LIR_Gen_1	178	189	PF02991	0.576
LIG_LIR_Gen_1	229	238	PF02991	0.496
LIG_LIR_Gen_1	297	308	PF02991	0.542
LIG_LIR_Gen_1	47	52	PF02991	0.561
LIG_LIR_Nem_3	178	184	PF02991	0.576
LIG_LIR_Nem_3	297	303	PF02991	0.504
LIG_LIR_Nem_3	317	322	PF02991	0.338
LIG_LIR_Nem_3	32	38	PF02991	0.563
LIG_LIR_Nem_3	47	51	PF02991	0.578
LIG_NRBOX	11	17	PF00104	0.629
LIG_NRBOX	245	251	PF00104	0.492
LIG_PCNA_PIPBox_1	272	281	PF02747	0.492
LIG_PCNA_yPIPBox_3	269	279	PF02747	0.492
LIG_Pex14_2	300	304	PF04695	0.505
LIG_PTB_Apo_2	278	285	PF02174	0.508
LIG_PTB_Phospho_1	278	284	PF10480	0.508
LIG_RPA_C_Fungi	131	143	PF08784	0.662
LIG_RPA_C_Fungi	223	235	PF08784	0.358
LIG_SH2_CRK	48	52	PF00017	0.718
LIG_SH2_SRC	181	184	PF00017	0.389
LIG_SH2_SRC	284	287	PF00017	0.323
LIG_SH2_STAP1	160	164	PF00017	0.335
LIG_SH2_STAP1	230	234	PF00017	0.335
LIG_SH2_STAP1	324	328	PF00017	0.358
LIG_SH2_STAP1	75	79	PF00017	0.557
LIG_SH2_STAT5	201	204	PF00017	0.335
LIG_SH2_STAT5	284	287	PF00017	0.421
LIG_SH2_STAT5	324	327	PF00017	0.453
LIG_SH2_STAT5	38	41	PF00017	0.568
LIG_SH3_3	30	36	PF00018	0.630
LIG_SUMO_SIM_anti_2	101	106	PF11976	0.669
LIG_SUMO_SIM_anti_2	310	315	PF11976	0.308
LIG_SUMO_SIM_par_1	59	64	PF11976	0.335
LIG_TRAF2_1	118	121	PF00917	0.630
LIG_TRAF2_1	257	260	PF00917	0.335
LIG_TYR_ITSM	177	184	PF00017	0.278
MOD_CK1_1	135	141	PF00069	0.758
MOD_CK1_1	197	203	PF00069	0.342
MOD_CK1_1	240	246	PF00069	0.303
MOD_CK1_1	77	83	PF00069	0.673
MOD_CK1_1	98	104	PF00069	0.585
MOD_CK2_1	115	121	PF00069	0.633
MOD_CK2_1	176	182	PF00069	0.278
MOD_CK2_1	219	225	PF00069	0.310
MOD_CK2_1	254	260	PF00069	0.335
MOD_CK2_1	41	47	PF00069	0.714
MOD_GlcNHglycan	117	120	PF01048	0.599
MOD_GlcNHglycan	19	22	PF01048	0.569
MOD_GlcNHglycan	242	245	PF01048	0.278
MOD_GlcNHglycan	43	46	PF01048	0.570
MOD_GlcNHglycan	55	58	PF01048	0.218
MOD_GlcNHglycan	95	98	PF01048	0.549
MOD_GSK3_1	111	118	PF00069	0.637
MOD_GSK3_1	134	141	PF00069	0.639
MOD_GSK3_1	190	197	PF00069	0.352
MOD_GSK3_1	233	240	PF00069	0.480
MOD_GSK3_1	292	299	PF00069	0.348
MOD_GSK3_1	314	321	PF00069	0.355
MOD_GSK3_1	73	80	PF00069	0.610
MOD_GSK3_1	89	96	PF00069	0.462
MOD_N-GLC_1	77	82	PF02516	0.671
MOD_NEK2_1	1	6	PF00069	0.583
MOD_NEK2_1	11	16	PF00069	0.491
MOD_NEK2_1	166	171	PF00069	0.453
MOD_NEK2_1	233	238	PF00069	0.380
MOD_NEK2_1	314	319	PF00069	0.444
MOD_NEK2_1	322	327	PF00069	0.370
MOD_NEK2_1	73	78	PF00069	0.536
MOD_NEK2_1	89	94	PF00069	0.548
MOD_NEK2_2	304	309	PF00069	0.278
MOD_PIKK_1	176	182	PF00454	0.278
MOD_PIKK_1	209	215	PF00454	0.310
MOD_PIKK_1	3	9	PF00454	0.542
MOD_PKA_2	135	141	PF00069	0.807
MOD_PKA_2	194	200	PF00069	0.453
MOD_PKA_2	238	244	PF00069	0.335
MOD_PKA_2	292	298	PF00069	0.375
MOD_Plk_1	296	302	PF00069	0.335
MOD_Plk_4	11	17	PF00069	0.600
MOD_Plk_4	197	203	PF00069	0.305
MOD_Plk_4	304	310	PF00069	0.299
MOD_Plk_4	314	320	PF00069	0.422
MOD_Plk_4	324	330	PF00069	0.353
MOD_SUMO_rev_2	177	186	PF00179	0.389
MOD_SUMO_rev_2	254	263	PF00179	0.421
MOD_SUMO_rev_2	34	44	PF00179	0.670
TRG_DiLeu_BaEn_4	266	272	PF01217	0.358
TRG_DiLeu_BaLyEn_6	162	167	PF01217	0.299
TRG_ENDOCYTIC_2	181	184	PF00928	0.453
TRG_ENDOCYTIC_2	230	233	PF00928	0.335
TRG_ENDOCYTIC_2	279	282	PF00928	0.395
TRG_ENDOCYTIC_2	48	51	PF00928	0.719
TRG_ER_diArg_1	124	127	PF00400	0.634
TRG_ER_diArg_1	289	291	PF00400	0.308
TRG_ER_diLys_1	331	335	PF00400	0.502
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.335
TRG_Pf-PMV_PEXEL_1	269	274	PF00026	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCV9	Leptomonas seymouri	52%	100%
A4HAE0	Leishmania braziliensis	69%	100%
A4I9J2	Leishmania infantum	100%	100%
E9B4J0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q3I6	Leishmania major	91%	100%