LeishMANIAdb
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ABC transporter family-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
ABC transporter family-like protein
Gene product:
ABC transporter family-like protein
Species:
Leishmania donovani
UniProt:
A0A3S7X7B4_LEIDO
TriTrypDb:
LdBPK_333410.1 * , LdCL_330041800 , LDHU3_33.4920
Length:
949

Annotations

LeishMANIAdb annotations

Publication identifier(s): 23716044
ABC superfamily protein. Involved in the efflux of toxic antimony species and porphyrin derivatives. Dimeric.. Most closely related to bacterial ABC transporters (e.g. A0A557ZZI4_9PSEU, A0A2Z6DZW4_HYDTE, G6XIG1_9PROT) with lipid flippase activity. Localization: Cell surface (experimental) / Mitochondrial (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6
GO:0005739 mitochondrion 5 1
GO:0005886 plasma membrane 3 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

A0A3S7X7B4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7B4

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0006811 monoatomic ion transport 4 1
GO:0006812 monoatomic cation transport 5 1
GO:0009987 cellular process 1 1
GO:0030001 metal ion transport 6 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0055085 transmembrane transport 2 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 8
GO:0005488 binding 1 8
GO:0005524 ATP binding 5 8
GO:0017076 purine nucleotide binding 4 8
GO:0030554 adenyl nucleotide binding 5 8
GO:0032553 ribonucleotide binding 3 8
GO:0032555 purine ribonucleotide binding 4 8
GO:0032559 adenyl ribonucleotide binding 5 8
GO:0035639 purine ribonucleoside triphosphate binding 4 8
GO:0036094 small molecule binding 2 8
GO:0043167 ion binding 2 8
GO:0043168 anion binding 3 8
GO:0097159 organic cyclic compound binding 2 8
GO:0097367 carbohydrate derivative binding 2 8
GO:1901265 nucleoside phosphate binding 3 8
GO:1901363 heterocyclic compound binding 2 8
GO:0005215 transporter activity 1 1
GO:0008324 monoatomic cation transmembrane transporter activity 4 1
GO:0015075 monoatomic ion transmembrane transporter activity 3 1
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 1
GO:0015399 primary active transmembrane transporter activity 4 1
GO:0022804 active transmembrane transporter activity 3 1
GO:0022857 transmembrane transporter activity 2 1
GO:0022890 inorganic cation transmembrane transporter activity 4 1
GO:0042626 ATPase-coupled transmembrane transporter activity 2 1
GO:0046873 metal ion transmembrane transporter activity 5 1
GO:0140657 ATP-dependent activity 1 1
GO:0003824 catalytic activity 1 1
GO:0016787 hydrolase activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 114 118 PF00656 0.623
CLV_C14_Caspase3-7 48 52 PF00656 0.625
CLV_C14_Caspase3-7 499 503 PF00656 0.483
CLV_NRD_NRD_1 164 166 PF00675 0.426
CLV_NRD_NRD_1 195 197 PF00675 0.489
CLV_NRD_NRD_1 276 278 PF00675 0.627
CLV_NRD_NRD_1 31 33 PF00675 0.488
CLV_NRD_NRD_1 539 541 PF00675 0.702
CLV_NRD_NRD_1 777 779 PF00675 0.263
CLV_NRD_NRD_1 83 85 PF00675 0.435
CLV_PCSK_KEX2_1 164 166 PF00082 0.502
CLV_PCSK_KEX2_1 276 278 PF00082 0.627
CLV_PCSK_KEX2_1 31 33 PF00082 0.514
CLV_PCSK_KEX2_1 539 541 PF00082 0.702
CLV_PCSK_KEX2_1 776 778 PF00082 0.263
CLV_PCSK_KEX2_1 83 85 PF00082 0.435
CLV_PCSK_PC7_1 773 779 PF00082 0.263
CLV_PCSK_SKI1_1 159 163 PF00082 0.343
CLV_PCSK_SKI1_1 180 184 PF00082 0.485
CLV_PCSK_SKI1_1 188 192 PF00082 0.443
CLV_PCSK_SKI1_1 20 24 PF00082 0.376
CLV_PCSK_SKI1_1 224 228 PF00082 0.333
CLV_PCSK_SKI1_1 492 496 PF00082 0.637
CLV_PCSK_SKI1_1 850 854 PF00082 0.377
CLV_PCSK_SKI1_1 893 897 PF00082 0.393
CLV_Separin_Metazoa 506 510 PF03568 0.465
CLV_Separin_Metazoa 836 840 PF03568 0.517
DEG_APCC_DBOX_1 393 401 PF00400 0.476
DEG_COP1_1 244 253 PF00400 0.481
DEG_Nend_UBRbox_1 1 4 PF02207 0.461
DEG_SPOP_SBC_1 575 579 PF00917 0.442
DOC_ANK_TNKS_1 539 546 PF00023 0.506
DOC_CKS1_1 183 188 PF01111 0.654
DOC_CKS1_1 683 688 PF01111 0.505
DOC_CYCLIN_RxL_1 185 193 PF00134 0.686
DOC_MAPK_FxFP_2 709 712 PF00069 0.363
DOC_MAPK_gen_1 891 900 PF00069 0.579
DOC_MAPK_JIP1_4 552 558 PF00069 0.415
DOC_MAPK_MEF2A_6 742 749 PF00069 0.360
DOC_MAPK_NFAT4_5 742 750 PF00069 0.360
DOC_PP2B_LxvP_1 172 175 PF13499 0.654
DOC_PP2B_LxvP_1 439 442 PF13499 0.433
DOC_PP4_FxxP_1 546 549 PF00568 0.477
DOC_PP4_FxxP_1 626 629 PF00568 0.458
DOC_PP4_FxxP_1 709 712 PF00568 0.363
DOC_PP4_FxxP_1 857 860 PF00568 0.483
DOC_PP4_FxxP_1 9 12 PF00568 0.376
DOC_USP7_MATH_1 137 141 PF00917 0.729
DOC_USP7_MATH_1 146 150 PF00917 0.652
DOC_USP7_MATH_1 175 179 PF00917 0.713
DOC_USP7_MATH_1 298 302 PF00917 0.444
DOC_USP7_MATH_1 464 468 PF00917 0.467
DOC_USP7_MATH_1 597 601 PF00917 0.465
DOC_USP7_MATH_1 740 744 PF00917 0.333
DOC_USP7_MATH_1 807 811 PF00917 0.545
DOC_USP7_MATH_1 829 833 PF00917 0.521
DOC_WW_Pin1_4 182 187 PF00397 0.690
DOC_WW_Pin1_4 217 222 PF00397 0.665
DOC_WW_Pin1_4 456 461 PF00397 0.478
DOC_WW_Pin1_4 480 485 PF00397 0.479
DOC_WW_Pin1_4 518 523 PF00397 0.469
DOC_WW_Pin1_4 682 687 PF00397 0.512
LIG_14-3-3_CanoR_1 2 9 PF00244 0.441
LIG_14-3-3_CanoR_1 20 28 PF00244 0.405
LIG_14-3-3_CanoR_1 240 250 PF00244 0.481
LIG_14-3-3_CanoR_1 289 299 PF00244 0.454
LIG_14-3-3_CanoR_1 347 355 PF00244 0.457
LIG_14-3-3_CanoR_1 376 381 PF00244 0.445
LIG_14-3-3_CanoR_1 438 442 PF00244 0.459
LIG_14-3-3_CanoR_1 462 471 PF00244 0.399
LIG_14-3-3_CanoR_1 496 505 PF00244 0.489
LIG_14-3-3_CanoR_1 596 605 PF00244 0.426
LIG_14-3-3_CanoR_1 632 637 PF00244 0.476
LIG_14-3-3_CanoR_1 659 665 PF00244 0.397
LIG_14-3-3_CanoR_1 897 907 PF00244 0.519
LIG_14-3-3_CanoR_1 91 96 PF00244 0.602
LIG_Actin_WH2_2 21 39 PF00022 0.552
LIG_APCC_ABBA_1 866 871 PF00400 0.506
LIG_BIR_III_4 51 55 PF00653 0.567
LIG_BRCT_BRCA1_1 300 304 PF00533 0.441
LIG_BRCT_BRCA1_1 638 642 PF00533 0.512
LIG_deltaCOP1_diTrp_1 398 404 PF00928 0.443
LIG_DLG_GKlike_1 91 99 PF00625 0.619
LIG_eIF4E_1 448 454 PF01652 0.464
LIG_FHA_1 21 27 PF00498 0.359
LIG_FHA_1 255 261 PF00498 0.491
LIG_FHA_1 323 329 PF00498 0.482
LIG_FHA_1 409 415 PF00498 0.458
LIG_FHA_1 489 495 PF00498 0.495
LIG_FHA_1 599 605 PF00498 0.493
LIG_FHA_1 644 650 PF00498 0.497
LIG_FHA_1 71 77 PF00498 0.625
LIG_FHA_1 721 727 PF00498 0.357
LIG_FHA_1 742 748 PF00498 0.302
LIG_FHA_1 787 793 PF00498 0.506
LIG_FHA_1 813 819 PF00498 0.517
LIG_FHA_1 871 877 PF00498 0.475
LIG_FHA_1 926 932 PF00498 0.534
LIG_FHA_2 112 118 PF00498 0.626
LIG_FHA_2 330 336 PF00498 0.436
LIG_FHA_2 712 718 PF00498 0.399
LIG_FHA_2 72 78 PF00498 0.695
LIG_FHA_2 823 829 PF00498 0.422
LIG_LIR_Apic_2 339 345 PF02991 0.459
LIG_LIR_Apic_2 379 384 PF02991 0.450
LIG_LIR_Apic_2 544 550 PF02991 0.480
LIG_LIR_Apic_2 708 712 PF02991 0.312
LIG_LIR_Gen_1 122 131 PF02991 0.575
LIG_LIR_Gen_1 332 340 PF02991 0.434
LIG_LIR_Gen_1 359 367 PF02991 0.476
LIG_LIR_Gen_1 703 712 PF02991 0.352
LIG_LIR_Gen_1 926 931 PF02991 0.537
LIG_LIR_Gen_1 936 947 PF02991 0.493
LIG_LIR_Nem_3 122 127 PF02991 0.571
LIG_LIR_Nem_3 274 278 PF02991 0.483
LIG_LIR_Nem_3 332 337 PF02991 0.464
LIG_LIR_Nem_3 359 363 PF02991 0.474
LIG_LIR_Nem_3 5 11 PF02991 0.311
LIG_LIR_Nem_3 703 707 PF02991 0.307
LIG_LIR_Nem_3 926 930 PF02991 0.562
LIG_LIR_Nem_3 936 942 PF02991 0.544
LIG_NRBOX 225 231 PF00104 0.376
LIG_NRBOX 449 455 PF00104 0.411
LIG_NRBOX 744 750 PF00104 0.300
LIG_Pex14_1 700 704 PF04695 0.301
LIG_PTB_Apo_2 231 238 PF02174 0.376
LIG_PTB_Apo_2 354 361 PF02174 0.463
LIG_PTB_Apo_2 570 577 PF02174 0.440
LIG_PTB_Phospho_1 231 237 PF10480 0.376
LIG_Rb_pABgroove_1 97 105 PF01858 0.628
LIG_RPA_C_Fungi 898 910 PF08784 0.390
LIG_SH2_CRK 349 353 PF00017 0.556
LIG_SH2_CRK 425 429 PF00017 0.495
LIG_SH2_CRK 512 516 PF00017 0.598
LIG_SH2_CRK 683 687 PF00017 0.644
LIG_SH2_CRK 803 807 PF00017 0.336
LIG_SH2_NCK_1 683 687 PF00017 0.644
LIG_SH2_SRC 651 654 PF00017 0.576
LIG_SH2_STAP1 256 260 PF00017 0.598
LIG_SH2_STAP1 657 661 PF00017 0.602
LIG_SH2_STAT3 448 451 PF00017 0.575
LIG_SH2_STAT3 943 946 PF00017 0.452
LIG_SH2_STAT5 138 141 PF00017 0.553
LIG_SH2_STAT5 237 240 PF00017 0.698
LIG_SH2_STAT5 256 259 PF00017 0.491
LIG_SH2_STAT5 349 352 PF00017 0.559
LIG_SH2_STAT5 425 428 PF00017 0.492
LIG_SH3_3 478 484 PF00018 0.556
LIG_SH3_3 547 553 PF00018 0.615
LIG_SH3_3 624 630 PF00018 0.572
LIG_SH3_3 749 755 PF00018 0.378
LIG_SUMO_SIM_anti_2 257 263 PF11976 0.581
LIG_SUMO_SIM_anti_2 743 750 PF11976 0.360
LIG_SUMO_SIM_anti_2 911 917 PF11976 0.339
LIG_SUMO_SIM_par_1 325 332 PF11976 0.527
LIG_SUMO_SIM_par_1 72 81 PF11976 0.509
LIG_SUMO_SIM_par_1 743 750 PF11976 0.364
LIG_TYR_ITIM 801 806 PF00017 0.360
LIG_WRC_WIRS_1 316 321 PF05994 0.451
LIG_WRC_WIRS_1 410 415 PF05994 0.525
LIG_WRC_WIRS_1 637 642 PF05994 0.644
LIG_WW_3 185 189 PF00397 0.610
LIG_WW_3 770 774 PF00397 0.360
MOD_CDC14_SPxK_1 459 462 PF00782 0.474
MOD_CDK_SPK_2 480 485 PF00069 0.580
MOD_CDK_SPxK_1 182 188 PF00069 0.619
MOD_CDK_SPxK_1 456 462 PF00069 0.472
MOD_CDK_SPxxK_3 217 224 PF00069 0.516
MOD_CK1_1 246 252 PF00069 0.660
MOD_CK1_1 465 471 PF00069 0.600
MOD_CK1_1 600 606 PF00069 0.646
MOD_CK1_1 660 666 PF00069 0.658
MOD_CK1_1 841 847 PF00069 0.376
MOD_CK2_1 303 309 PF00069 0.518
MOD_CK2_1 518 524 PF00069 0.627
MOD_CK2_1 822 828 PF00069 0.413
MOD_CK2_1 841 847 PF00069 0.269
MOD_CK2_1 875 881 PF00069 0.475
MOD_Cter_Amidation 162 165 PF01082 0.450
MOD_GlcNHglycan 139 142 PF01048 0.602
MOD_GlcNHglycan 246 249 PF01048 0.735
MOD_GlcNHglycan 251 254 PF01048 0.617
MOD_GlcNHglycan 284 287 PF01048 0.660
MOD_GlcNHglycan 292 295 PF01048 0.528
MOD_GlcNHglycan 305 308 PF01048 0.414
MOD_GlcNHglycan 464 467 PF01048 0.598
MOD_GlcNHglycan 541 544 PF01048 0.588
MOD_GlcNHglycan 553 556 PF01048 0.590
MOD_GlcNHglycan 621 624 PF01048 0.703
MOD_GlcNHglycan 737 740 PF01048 0.324
MOD_GlcNHglycan 809 812 PF01048 0.368
MOD_GlcNHglycan 831 834 PF01048 0.367
MOD_GlcNHglycan 842 846 PF01048 0.259
MOD_GSK3_1 146 153 PF00069 0.560
MOD_GSK3_1 242 249 PF00069 0.583
MOD_GSK3_1 315 322 PF00069 0.502
MOD_GSK3_1 456 463 PF00069 0.599
MOD_GSK3_1 599 606 PF00069 0.609
MOD_GSK3_1 632 639 PF00069 0.637
MOD_GSK3_1 65 72 PF00069 0.660
MOD_GSK3_1 934 941 PF00069 0.449
MOD_N-GLC_1 146 151 PF02516 0.555
MOD_N-GLC_1 233 238 PF02516 0.409
MOD_N-GLC_1 26 31 PF02516 0.587
MOD_N-GLC_1 356 361 PF02516 0.550
MOD_N-GLC_1 69 74 PF02516 0.551
MOD_N-GLC_1 693 698 PF02516 0.549
MOD_N-GLC_1 78 83 PF02516 0.492
MOD_N-GLC_1 893 898 PF02516 0.459
MOD_N-GLC_2 217 219 PF02516 0.523
MOD_NEK2_1 176 181 PF00069 0.622
MOD_NEK2_1 241 246 PF00069 0.670
MOD_NEK2_1 290 295 PF00069 0.591
MOD_NEK2_1 303 308 PF00069 0.431
MOD_NEK2_1 319 324 PF00069 0.500
MOD_NEK2_1 329 334 PF00069 0.544
MOD_NEK2_1 409 414 PF00069 0.482
MOD_NEK2_1 488 493 PF00069 0.529
MOD_NEK2_1 576 581 PF00069 0.603
MOD_NEK2_1 636 641 PF00069 0.658
MOD_NEK2_1 747 752 PF00069 0.328
MOD_NEK2_1 78 83 PF00069 0.525
MOD_NEK2_1 938 943 PF00069 0.451
MOD_NEK2_2 534 539 PF00069 0.614
MOD_NEK2_2 934 939 PF00069 0.428
MOD_PIKK_1 85 91 PF00454 0.391
MOD_PIKK_1 925 931 PF00454 0.542
MOD_PK_1 903 909 PF00069 0.464
MOD_PKA_1 539 545 PF00069 0.589
MOD_PKA_2 1 7 PF00069 0.576
MOD_PKA_2 254 260 PF00069 0.574
MOD_PKA_2 437 443 PF00069 0.634
MOD_PKA_2 488 494 PF00069 0.571
MOD_PKA_2 539 545 PF00069 0.763
MOD_PKA_2 551 557 PF00069 0.504
MOD_PKA_2 786 792 PF00069 0.377
MOD_PKA_2 829 835 PF00069 0.350
MOD_PKA_2 838 844 PF00069 0.375
MOD_PKA_2 923 929 PF00069 0.439
MOD_PKB_1 35 43 PF00069 0.546
MOD_PKB_1 691 699 PF00069 0.482
MOD_PKB_1 891 899 PF00069 0.428
MOD_Plk_1 233 239 PF00069 0.376
MOD_Plk_1 356 362 PF00069 0.548
MOD_Plk_1 475 481 PF00069 0.557
MOD_Plk_1 720 726 PF00069 0.340
MOD_Plk_1 893 899 PF00069 0.454
MOD_Plk_1 934 940 PF00069 0.445
MOD_Plk_2-3 45 51 PF00069 0.452
MOD_Plk_2-3 793 799 PF00069 0.360
MOD_Plk_4 233 239 PF00069 0.388
MOD_Plk_4 324 330 PF00069 0.563
MOD_Plk_4 376 382 PF00069 0.409
MOD_Plk_4 409 415 PF00069 0.509
MOD_Plk_4 45 51 PF00069 0.508
MOD_Plk_4 660 666 PF00069 0.625
MOD_Plk_4 685 691 PF00069 0.628
MOD_Plk_4 71 77 PF00069 0.483
MOD_Plk_4 741 747 PF00069 0.337
MOD_Plk_4 934 940 PF00069 0.429
MOD_ProDKin_1 182 188 PF00069 0.619
MOD_ProDKin_1 217 223 PF00069 0.578
MOD_ProDKin_1 456 462 PF00069 0.605
MOD_ProDKin_1 480 486 PF00069 0.600
MOD_ProDKin_1 518 524 PF00069 0.591
MOD_ProDKin_1 682 688 PF00069 0.644
MOD_SUMO_rev_2 877 885 PF00179 0.495
TRG_DiLeu_BaEn_1 847 852 PF01217 0.376
TRG_DiLeu_BaLyEn_6 177 182 PF01217 0.583
TRG_DiLeu_BaLyEn_6 362 367 PF01217 0.576
TRG_ENDOCYTIC_2 349 352 PF00928 0.558
TRG_ENDOCYTIC_2 512 515 PF00928 0.594
TRG_ENDOCYTIC_2 803 806 PF00928 0.360
TRG_ER_diArg_1 164 166 PF00400 0.528
TRG_ER_diArg_1 275 277 PF00400 0.547
TRG_ER_diArg_1 34 37 PF00400 0.580
TRG_ER_diArg_1 508 511 PF00400 0.584
TRG_ER_diArg_1 538 540 PF00400 0.641
TRG_ER_diArg_1 690 693 PF00400 0.531
TRG_ER_diArg_1 775 778 PF00400 0.300
TRG_ER_diArg_1 83 85 PF00400 0.534
TRG_Pf-PMV_PEXEL_1 188 193 PF00026 0.614
TRG_Pf-PMV_PEXEL_1 887 892 PF00026 0.432

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I508 Leptomonas seymouri 44% 99%
A0A3R7LPT9 Trypanosoma rangeli 27% 100%
A4HM34 Leishmania braziliensis 77% 100%
A4I9G7 Leishmania infantum 99% 100%
E9B4G5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q3L0 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS