ZIP Zinc transporter family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cation transporter, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X7B0_LEIDO

TriTrypDb:

LdBPK_333350.1 , LdCL_330041100 , LDHU3_33.4830

Length:

334

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 27
NetGPI	no	yes: 0, no: 27

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	28
GO:0110165	cellular anatomical entity	1	28
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A0A3S7X7B0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7B0

Function

Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	1
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006829	zinc ion transport	8	1
GO:0009987	cellular process	1	1
GO:0030001	metal ion transport	6	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1
GO:0071577	zinc ion transmembrane transport	6	1
GO:0098655	monoatomic cation transmembrane transport	4	1
GO:0098660	inorganic ion transmembrane transport	4	1
GO:0098662	inorganic cation transmembrane transport	5	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	28
GO:0008324	monoatomic cation transmembrane transporter activity	4	28
GO:0015075	monoatomic ion transmembrane transporter activity	3	28
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	28
GO:0022857	transmembrane transporter activity	2	28
GO:0022890	inorganic cation transmembrane transporter activity	4	28
GO:0046873	metal ion transmembrane transporter activity	5	28
GO:0005385	zinc ion transmembrane transporter activity	7	1
GO:0046915	transition metal ion transmembrane transporter activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	45	51	PF00089	0.172
CLV_PCSK_KEX2_1	47	49	PF00082	0.273
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.273
CLV_PCSK_SKI1_1	122	126	PF00082	0.329
CLV_PCSK_SKI1_1	310	314	PF00082	0.240
DEG_APCC_DBOX_1	309	317	PF00400	0.504
DOC_PP1_RVXF_1	120	126	PF00149	0.204
DOC_PP2B_LxvP_1	243	246	PF13499	0.426
DOC_PP4_FxxP_1	52	55	PF00568	0.526
DOC_PP4_FxxP_1	98	101	PF00568	0.276
DOC_USP7_MATH_1	113	117	PF00917	0.336
DOC_USP7_MATH_1	135	139	PF00917	0.618
DOC_USP7_MATH_1	161	165	PF00917	0.506
DOC_USP7_MATH_1	219	223	PF00917	0.289
DOC_USP7_MATH_1	322	326	PF00917	0.230
DOC_USP7_MATH_1	82	86	PF00917	0.309
DOC_WW_Pin1_4	3	8	PF00397	0.384
DOC_WW_Pin1_4	305	310	PF00397	0.524
LIG_14-3-3_CanoR_1	48	55	PF00244	0.393
LIG_Actin_WH2_2	66	82	PF00022	0.449
LIG_AP2alpha_1	124	128	PF02296	0.366
LIG_APCC_ABBA_1	121	126	PF00400	0.385
LIG_CSL_BTD_1	7	10	PF09270	0.327
LIG_eIF4E_1	285	291	PF01652	0.270
LIG_FHA_1	231	237	PF00498	0.536
LIG_FHA_1	269	275	PF00498	0.310
LIG_FHA_1	65	71	PF00498	0.320
LIG_FHA_2	13	19	PF00498	0.434
LIG_LIR_Apic_2	50	55	PF02991	0.376
LIG_LIR_Gen_1	201	211	PF02991	0.353
LIG_LIR_Gen_1	21	32	PF02991	0.208
LIG_LIR_Gen_1	294	303	PF02991	0.522
LIG_LIR_Nem_3	126	131	PF02991	0.471
LIG_LIR_Nem_3	187	192	PF02991	0.311
LIG_LIR_Nem_3	21	27	PF02991	0.256
LIG_LIR_Nem_3	210	214	PF02991	0.282
LIG_PCNA_PIPBox_1	289	298	PF02747	0.230
LIG_Pex14_2	124	128	PF04695	0.376
LIG_Pex14_2	211	215	PF04695	0.321
LIG_PTAP_UEV_1	156	161	PF05743	0.348
LIG_SH2_SRC	57	60	PF00017	0.478
LIG_SH2_STAP1	20	24	PF00017	0.352
LIG_SH2_STAP1	57	61	PF00017	0.399
LIG_SH2_STAT5	104	107	PF00017	0.261
LIG_SH2_STAT5	203	206	PF00017	0.318
LIG_SH2_STAT5	235	238	PF00017	0.409
LIG_SH2_STAT5	268	271	PF00017	0.281
LIG_SH2_STAT5	285	288	PF00017	0.231
LIG_SH3_3	154	160	PF00018	0.533
LIG_SH3_3	303	309	PF00018	0.480
LIG_SH3_3	4	10	PF00018	0.511
LIG_UBA3_1	75	80	PF00899	0.439
MOD_CDK_SPK_2	305	310	PF00069	0.371
MOD_CK1_1	138	144	PF00069	0.402
MOD_CK1_1	164	170	PF00069	0.366
MOD_CK1_1	184	190	PF00069	0.339
MOD_CK1_1	64	70	PF00069	0.350
MOD_CK1_1	85	91	PF00069	0.253
MOD_CK2_1	12	18	PF00069	0.439
MOD_Cter_Amidation	45	48	PF01082	0.334
MOD_GlcNHglycan	137	140	PF01048	0.403
MOD_GlcNHglycan	145	148	PF01048	0.263
MOD_GlcNHglycan	157	160	PF01048	0.250
MOD_GlcNHglycan	167	170	PF01048	0.209
MOD_GlcNHglycan	174	177	PF01048	0.234
MOD_GlcNHglycan	21	24	PF01048	0.458
MOD_GlcNHglycan	243	246	PF01048	0.319
MOD_GlcNHglycan	49	52	PF01048	0.346
MOD_GlcNHglycan	92	95	PF01048	0.528
MOD_GSK3_1	161	168	PF00069	0.390
MOD_GSK3_1	33	40	PF00069	0.258
MOD_GSK3_1	8	15	PF00069	0.364
MOD_N-GLC_1	18	23	PF02516	0.436
MOD_N-GLC_1	3	8	PF02516	0.527
MOD_N-GLC_1	82	87	PF02516	0.449
MOD_N-GLC_1	96	101	PF02516	0.428
MOD_NEK2_1	145	150	PF00069	0.410
MOD_NEK2_1	181	186	PF00069	0.286
MOD_NEK2_1	241	246	PF00069	0.289
MOD_NEK2_1	299	304	PF00069	0.524
MOD_NEK2_1	33	38	PF00069	0.259
MOD_NEK2_2	207	212	PF00069	0.445
MOD_NEK2_2	227	232	PF00069	0.395
MOD_PIKK_1	138	144	PF00454	0.504
MOD_PIKK_1	145	151	PF00454	0.467
MOD_PIKK_1	268	274	PF00454	0.255
MOD_PKA_1	47	53	PF00069	0.376
MOD_PKA_2	47	53	PF00069	0.376
MOD_Plk_1	82	88	PF00069	0.265
MOD_Plk_4	184	190	PF00069	0.285
MOD_Plk_4	201	207	PF00069	0.234
MOD_Plk_4	263	269	PF00069	0.267
MOD_Plk_4	322	328	PF00069	0.324
MOD_Plk_4	33	39	PF00069	0.286
MOD_ProDKin_1	3	9	PF00069	0.378
MOD_ProDKin_1	305	311	PF00069	0.524
TRG_DiLeu_BaEn_1	140	145	PF01217	0.399
TRG_DiLeu_BaEn_1	201	206	PF01217	0.213
TRG_ENDOCYTIC_2	203	206	PF00928	0.312
TRG_ENDOCYTIC_2	285	288	PF00928	0.251
TRG_ENDOCYTIC_2	296	299	PF00928	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2E9	Leptomonas seymouri	32%	100%
A0A0N0P5K7	Leptomonas seymouri	63%	100%
A0A1X0NR51	Trypanosomatidae	42%	90%
A0A1X0NSB9	Trypanosomatidae	36%	82%
A0A1X0NSI7	Trypanosomatidae	35%	88%
A0A3R7LZX6	Trypanosoma rangeli	38%	95%
A0A3S7X1N7	Leishmania donovani	35%	100%
A0A422MUI2	Trypanosoma rangeli	33%	90%
A4HGP7	Leishmania braziliensis	36%	99%
A4HJU6	Leishmania braziliensis	44%	100%
A4HJU9	Leishmania braziliensis	33%	100%
A4HJV0	Leishmania braziliensis	33%	100%
A4HM27	Leishmania braziliensis	76%	100%
A4I3R9	Leishmania infantum	35%	100%
A4I9G1	Leishmania infantum	100%	100%
D0A885	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	85%
D0A886	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	85%
D0A887	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	85%
D0A888	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	85%
D0A889	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	87%
E9B012	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9B4F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
O23039	Arabidopsis thaliana	25%	93%
O64738	Arabidopsis thaliana	25%	98%
O81123	Arabidopsis thaliana	29%	94%
O81850	Arabidopsis thaliana	27%	95%
O82643	Arabidopsis thaliana	26%	97%
O94639	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	82%
P32804	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	89%
Q38856	Arabidopsis thaliana	28%	96%
Q4Q3L6	Leishmania major	90%	100%
Q6L8G0	Oryza sativa subsp. japonica	31%	95%
Q6L8G1	Oryza sativa subsp. japonica	28%	90%
Q6ZJ91	Oryza sativa subsp. japonica	25%	84%
Q75HB1	Oryza sativa subsp. japonica	28%	89%
Q7XLD4	Oryza sativa subsp. japonica	27%	92%
Q852F6	Oryza sativa subsp. japonica	24%	93%
Q8S3W4	Arabidopsis thaliana	26%	96%
Q8W245	Arabidopsis thaliana	29%	92%
Q8W246	Arabidopsis thaliana	24%	92%
Q9FIS2	Arabidopsis thaliana	27%	94%
Q9SLG3	Arabidopsis thaliana	26%	99%
V5AWN3	Trypanosoma cruzi	36%	90%
V5BC34	Trypanosoma cruzi	34%	90%
V5DCU2	Trypanosoma cruzi	42%	90%