Cleft lip and palate transmembrane protein 1 (CLPTM1), putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cleft lip and palate transmembrane protein 1 (CLPTM1), putative

Species:

Leishmania donovani

UniProt:

A0A3S7X7A7_LEIDO

TriTrypDb:

LdBPK_340050.1 , LdCL_340005600 , LDHU3_34.0070

Length:

584

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A0A3S7X7A7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7A7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.604
CLV_C14_Caspase3-7	562	566	PF00656	0.654
CLV_NRD_NRD_1	330	332	PF00675	0.256
CLV_PCSK_KEX2_1	289	291	PF00082	0.424
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.424
CLV_PCSK_SKI1_1	159	163	PF00082	0.526
CLV_PCSK_SKI1_1	21	25	PF00082	0.273
CLV_PCSK_SKI1_1	26	30	PF00082	0.335
CLV_PCSK_SKI1_1	260	264	PF00082	0.466
CLV_PCSK_SKI1_1	289	293	PF00082	0.438
CLV_PCSK_SKI1_1	380	384	PF00082	0.315
CLV_PCSK_SKI1_1	386	390	PF00082	0.315
DEG_SPOP_SBC_1	240	244	PF00917	0.259
DEG_SPOP_SBC_1	392	396	PF00917	0.504
DOC_CKS1_1	485	490	PF01111	0.343
DOC_CYCLIN_RxL_1	156	166	PF00134	0.315
DOC_CYCLIN_RxL_1	257	265	PF00134	0.303
DOC_CYCLIN_RxL_1	287	297	PF00134	0.303
DOC_CYCLIN_yCln2_LP_2	89	95	PF00134	0.315
DOC_MAPK_FxFP_2	197	200	PF00069	0.303
DOC_MAPK_gen_1	289	295	PF00069	0.303
DOC_MAPK_gen_1	329	339	PF00069	0.438
DOC_MAPK_gen_1	380	390	PF00069	0.503
DOC_MAPK_gen_1	430	439	PF00069	0.441
DOC_MAPK_MEF2A_6	182	191	PF00069	0.224
DOC_MAPK_MEF2A_6	298	305	PF00069	0.303
DOC_PP1_RVXF_1	129	135	PF00149	0.309
DOC_PP2B_PxIxI_1	487	493	PF00149	0.472
DOC_PP4_FxxP_1	197	200	PF00568	0.238
DOC_PP4_FxxP_1	218	221	PF00568	0.303
DOC_SPAK_OSR1_1	78	82	PF12202	0.315
DOC_USP7_MATH_1	175	179	PF00917	0.301
DOC_USP7_MATH_1	404	408	PF00917	0.503
DOC_USP7_MATH_1	45	49	PF00917	0.346
DOC_USP7_MATH_1	576	580	PF00917	0.683
DOC_WW_Pin1_4	189	194	PF00397	0.233
DOC_WW_Pin1_4	206	211	PF00397	0.224
DOC_WW_Pin1_4	251	256	PF00397	0.254
DOC_WW_Pin1_4	484	489	PF00397	0.343
DOC_WW_Pin1_4	56	61	PF00397	0.276
LIG_14-3-3_CanoR_1	131	137	PF00244	0.322
LIG_14-3-3_CanoR_1	335	340	PF00244	0.480
LIG_14-3-3_CanoR_1	464	470	PF00244	0.307
LIG_14-3-3_CanoR_1	78	82	PF00244	0.205
LIG_BRCT_BRCA1_1	344	348	PF00533	0.390
LIG_BRCT_BRCA1_1	349	353	PF00533	0.398
LIG_BRCT_BRCA1_1	479	483	PF00533	0.391
LIG_CaM_NSCaTE_8	466	473	PF13499	0.277
LIG_CtBP_PxDLS_1	552	556	PF00389	0.624
LIG_eIF4E_1	30	36	PF01652	0.353
LIG_FHA_1	111	117	PF00498	0.255
LIG_FHA_1	125	131	PF00498	0.217
LIG_FHA_1	138	144	PF00498	0.242
LIG_FHA_1	207	213	PF00498	0.315
LIG_FHA_1	248	254	PF00498	0.256
LIG_FHA_1	304	310	PF00498	0.305
LIG_FHA_1	382	388	PF00498	0.479
LIG_FHA_1	393	399	PF00498	0.462
LIG_FHA_1	4	10	PF00498	0.733
LIG_FHA_1	485	491	PF00498	0.345
LIG_FHA_1	50	56	PF00498	0.328
LIG_FHA_2	263	269	PF00498	0.315
LIG_FHA_2	394	400	PF00498	0.529
LIG_FHA_2	512	518	PF00498	0.466
LIG_GBD_Chelix_1	304	312	PF00786	0.377
LIG_LIR_Apic_2	198	202	PF02991	0.257
LIG_LIR_Gen_1	314	321	PF02991	0.278
LIG_LIR_Gen_1	345	356	PF02991	0.281
LIG_LIR_Gen_1	361	372	PF02991	0.199
LIG_LIR_Gen_1	454	460	PF02991	0.266
LIG_LIR_Gen_1	480	491	PF02991	0.391
LIG_LIR_Gen_1	517	527	PF02991	0.489
LIG_LIR_Gen_1	538	546	PF02991	0.479
LIG_LIR_Gen_1	77	87	PF02991	0.262
LIG_LIR_Nem_3	178	184	PF02991	0.247
LIG_LIR_Nem_3	207	211	PF02991	0.247
LIG_LIR_Nem_3	314	319	PF02991	0.295
LIG_LIR_Nem_3	333	337	PF02991	0.343
LIG_LIR_Nem_3	345	351	PF02991	0.269
LIG_LIR_Nem_3	361	367	PF02991	0.199
LIG_LIR_Nem_3	377	381	PF02991	0.289
LIG_LIR_Nem_3	451	456	PF02991	0.315
LIG_LIR_Nem_3	506	512	PF02991	0.471
LIG_LIR_Nem_3	517	523	PF02991	0.479
LIG_LIR_Nem_3	538	544	PF02991	0.474
LIG_LIR_Nem_3	77	82	PF02991	0.270
LIG_MLH1_MIPbox_1	344	348	PF16413	0.376
LIG_PCNA_PIPBox_1	17	26	PF02747	0.568
LIG_PCNA_yPIPBox_3	10	24	PF02747	0.664
LIG_PCNA_yPIPBox_3	510	520	PF02747	0.470
LIG_Pex14_2	375	379	PF04695	0.316
LIG_Pex14_2	477	481	PF04695	0.267
LIG_PTB_Apo_2	135	142	PF02174	0.280
LIG_REV1ctd_RIR_1	148	156	PF16727	0.303
LIG_SH2_CRK	30	34	PF00017	0.328
LIG_SH2_CRK	444	448	PF00017	0.337
LIG_SH2_CRK	456	460	PF00017	0.215
LIG_SH2_CRK	467	471	PF00017	0.201
LIG_SH2_CRK	509	513	PF00017	0.469
LIG_SH2_GRB2like	224	227	PF00017	0.224
LIG_SH2_SRC	419	422	PF00017	0.503
LIG_SH2_STAP1	139	143	PF00017	0.271
LIG_SH2_STAP1	444	448	PF00017	0.327
LIG_SH2_STAP1	456	460	PF00017	0.220
LIG_SH2_STAP1	467	471	PF00017	0.228
LIG_SH2_STAT5	139	142	PF00017	0.253
LIG_SH2_STAT5	160	163	PF00017	0.298
LIG_SH2_STAT5	184	187	PF00017	0.224
LIG_SH2_STAT5	224	227	PF00017	0.279
LIG_SH2_STAT5	264	267	PF00017	0.238
LIG_SH2_STAT5	347	350	PF00017	0.285
LIG_SH2_STAT5	355	358	PF00017	0.284
LIG_SH2_STAT5	441	444	PF00017	0.281
LIG_SH2_STAT5	453	456	PF00017	0.295
LIG_SH3_3	109	115	PF00018	0.303
LIG_SH3_3	363	369	PF00018	0.394
LIG_SH3_3	44	50	PF00018	0.291
LIG_SH3_3	54	60	PF00018	0.283
LIG_SUMO_SIM_anti_2	34	39	PF11976	0.209
LIG_SUMO_SIM_par_1	291	297	PF11976	0.311
LIG_SUMO_SIM_par_1	300	306	PF11976	0.231
LIG_TRAF2_1	566	569	PF00917	0.670
LIG_TYR_ITIM	28	33	PF00017	0.362
LIG_TYR_ITIM	442	447	PF00017	0.400
LIG_UBA3_1	37	43	PF00899	0.335
LIG_UBA3_1	89	94	PF00899	0.303
LIG_ULM_U2AF65_1	410	415	PF00076	0.459
LIG_WRC_WIRS_1	20	25	PF05994	0.544
LIG_WRC_WIRS_1	478	483	PF05994	0.394
MOD_CDK_SPxxK_3	251	258	PF00069	0.303
MOD_CK1_1	22	28	PF00069	0.332
MOD_CK1_1	241	247	PF00069	0.346
MOD_CK1_1	280	286	PF00069	0.256
MOD_CK1_1	338	344	PF00069	0.267
MOD_CK1_1	359	365	PF00069	0.314
MOD_CK1_1	426	432	PF00069	0.522
MOD_CK1_1	511	517	PF00069	0.556
MOD_CK1_1	64	70	PF00069	0.294
MOD_CK2_1	139	145	PF00069	0.183
MOD_CK2_1	163	169	PF00069	0.232
MOD_CK2_1	262	268	PF00069	0.299
MOD_CK2_1	280	286	PF00069	0.229
MOD_CK2_1	311	317	PF00069	0.394
MOD_CK2_1	393	399	PF00069	0.529
MOD_Cter_Amidation	329	332	PF01082	0.315
MOD_GlcNHglycan	169	172	PF01048	0.517
MOD_GlcNHglycan	369	372	PF01048	0.286
MOD_GlcNHglycan	406	409	PF01048	0.303
MOD_GlcNHglycan	456	459	PF01048	0.280
MOD_GlcNHglycan	561	564	PF01048	0.487
MOD_GSK3_1	137	144	PF00069	0.299
MOD_GSK3_1	163	170	PF00069	0.278
MOD_GSK3_1	247	254	PF00069	0.264
MOD_GSK3_1	273	280	PF00069	0.315
MOD_GSK3_1	303	310	PF00069	0.267
MOD_GSK3_1	338	345	PF00069	0.376
MOD_GSK3_1	356	363	PF00069	0.433
MOD_GSK3_1	45	52	PF00069	0.257
MOD_GSK3_1	465	472	PF00069	0.279
MOD_GSK3_1	61	68	PF00069	0.257
MOD_N-GLC_1	108	113	PF02516	0.462
MOD_N-GLC_1	124	129	PF02516	0.364
MOD_N-GLC_1	137	142	PF02516	0.424
MOD_N-GLC_1	238	243	PF02516	0.424
MOD_N-GLC_1	247	252	PF02516	0.424
MOD_NEK2_1	110	115	PF00069	0.294
MOD_NEK2_1	151	156	PF00069	0.287
MOD_NEK2_1	238	243	PF00069	0.244
MOD_NEK2_1	247	252	PF00069	0.201
MOD_NEK2_1	262	267	PF00069	0.224
MOD_NEK2_1	293	298	PF00069	0.239
MOD_NEK2_1	303	308	PF00069	0.268
MOD_NEK2_1	381	386	PF00069	0.424
MOD_NEK2_1	459	464	PF00069	0.390
MOD_NEK2_1	469	474	PF00069	0.295
MOD_NEK2_1	477	482	PF00069	0.212
MOD_NEK2_2	126	131	PF00069	0.251
MOD_PIKK_1	241	247	PF00454	0.303
MOD_PIKK_1	262	268	PF00454	0.315
MOD_PIKK_1	270	276	PF00454	0.315
MOD_PIKK_1	356	362	PF00454	0.420
MOD_PIKK_1	428	434	PF00454	0.515
MOD_PIKK_1	470	476	PF00454	0.267
MOD_PIKK_1	82	88	PF00454	0.338
MOD_PK_1	335	341	PF00069	0.480
MOD_PK_1	495	501	PF00069	0.522
MOD_PKA_2	151	157	PF00069	0.267
MOD_PKA_2	404	410	PF00069	0.526
MOD_PKA_2	77	83	PF00069	0.346
MOD_Plk_1	108	114	PF00069	0.275
MOD_Plk_1	124	130	PF00069	0.160
MOD_Plk_1	137	143	PF00069	0.238
MOD_Plk_1	152	158	PF00069	0.265
MOD_Plk_1	187	193	PF00069	0.266
MOD_Plk_1	247	253	PF00069	0.237
MOD_Plk_1	267	273	PF00069	0.118
MOD_Plk_1	360	366	PF00069	0.227
MOD_Plk_1	553	559	PF00069	0.636
MOD_Plk_4	219	225	PF00069	0.352
MOD_Plk_4	307	313	PF00069	0.295
MOD_Plk_4	31	37	PF00069	0.347
MOD_Plk_4	347	353	PF00069	0.267
MOD_Plk_4	451	457	PF00069	0.271
MOD_Plk_4	465	471	PF00069	0.228
MOD_Plk_4	511	517	PF00069	0.465
MOD_ProDKin_1	189	195	PF00069	0.233
MOD_ProDKin_1	206	212	PF00069	0.224
MOD_ProDKin_1	251	257	PF00069	0.254
MOD_ProDKin_1	484	490	PF00069	0.341
MOD_ProDKin_1	56	62	PF00069	0.276
MOD_SUMO_for_1	388	391	PF00179	0.503
MOD_SUMO_for_1	93	96	PF00179	0.303
MOD_SUMO_rev_2	111	120	PF00179	0.351
MOD_SUMO_rev_2	283	291	PF00179	0.224
MOD_SUMO_rev_2	322	327	PF00179	0.438
TRG_AP2beta_CARGO_1	538	548	PF09066	0.478
TRG_DiLeu_BaEn_3	286	292	PF01217	0.259
TRG_ENDOCYTIC_2	264	267	PF00928	0.238
TRG_ENDOCYTIC_2	30	33	PF00928	0.324
TRG_ENDOCYTIC_2	444	447	PF00928	0.334
TRG_ENDOCYTIC_2	456	459	PF00928	0.235
TRG_ENDOCYTIC_2	467	470	PF00928	0.233
TRG_ENDOCYTIC_2	509	512	PF00928	0.474
TRG_ER_diLys_1	581	584	PF00400	0.730
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	70	75	PF00026	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6I8	Leptomonas seymouri	66%	97%
A0A1X0P8S5	Trypanosomatidae	44%	100%
A0A422MZT4	Trypanosoma rangeli	46%	99%
A4HAD0	Leishmania braziliensis	84%	100%
A4I9H3	Leishmania infantum	99%	100%
D0A1S8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B4H1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O96005	Homo sapiens	40%	87%
Q2NL17	Bos taurus	39%	87%
Q4Q3K4	Leishmania major	95%	100%
Q54RJ1	Dictyostelium discoideum	41%	94%
Q5ZKJ0	Gallus gallus	36%	100%
Q6DEL2	Danio rerio	31%	93%
Q8BXA5	Mus musculus	36%	100%
Q8VBZ3	Mus musculus	39%	88%
V5DIK4	Trypanosoma cruzi	43%	99%