LeishMANIAdb
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DnaJ_domain_containing_protein_putative/Pfam:PF00 226

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DnaJ_domain_containing_protein_putative/Pfam:PF00 226
Gene product:
DnaJ domain containing protein, putative
Species:
Leishmania donovani
UniProt:
A0A3S7X796_LEIDO
TriTrypDb:
LdBPK_340040.1 , LdCL_340005500 , LDHU3_34.0060
Length:
679

Annotations

LeishMANIAdb annotations

A protein unique to Kinetoplastids, combining a TM domain with J-domain. Only expanded in the T. cruzi lineage.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

A0A3S7X796
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X796

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 452 456 PF00656 0.667
CLV_NRD_NRD_1 200 202 PF00675 0.448
CLV_NRD_NRD_1 258 260 PF00675 0.590
CLV_NRD_NRD_1 323 325 PF00675 0.570
CLV_NRD_NRD_1 477 479 PF00675 0.411
CLV_NRD_NRD_1 48 50 PF00675 0.370
CLV_NRD_NRD_1 564 566 PF00675 0.477
CLV_NRD_NRD_1 580 582 PF00675 0.426
CLV_PCSK_KEX2_1 120 122 PF00082 0.489
CLV_PCSK_KEX2_1 258 260 PF00082 0.627
CLV_PCSK_KEX2_1 50 52 PF00082 0.403
CLV_PCSK_KEX2_1 582 584 PF00082 0.525
CLV_PCSK_PC1ET2_1 120 122 PF00082 0.511
CLV_PCSK_PC1ET2_1 50 52 PF00082 0.436
CLV_PCSK_PC1ET2_1 582 584 PF00082 0.525
CLV_PCSK_PC7_1 116 122 PF00082 0.493
CLV_PCSK_SKI1_1 170 174 PF00082 0.645
CLV_PCSK_SKI1_1 202 206 PF00082 0.341
CLV_PCSK_SKI1_1 267 271 PF00082 0.633
CLV_PCSK_SKI1_1 344 348 PF00082 0.605
CLV_PCSK_SKI1_1 50 54 PF00082 0.383
CLV_PCSK_SKI1_1 565 569 PF00082 0.485
DEG_APCC_DBOX_1 564 572 PF00400 0.641
DEG_Nend_UBRbox_1 1 4 PF02207 0.661
DEG_ODPH_VHL_1 493 505 PF01847 0.596
DOC_ANK_TNKS_1 580 587 PF00023 0.637
DOC_CKS1_1 388 393 PF01111 0.635
DOC_CYCLIN_RxL_1 164 174 PF00134 0.415
DOC_MAPK_gen_1 11 20 PF00069 0.640
DOC_MAPK_gen_1 140 149 PF00069 0.327
DOC_MAPK_gen_1 201 208 PF00069 0.629
DOC_MAPK_gen_1 324 330 PF00069 0.303
DOC_MAPK_gen_1 550 559 PF00069 0.724
DOC_MAPK_HePTP_8 10 22 PF00069 0.684
DOC_MAPK_MEF2A_6 13 22 PF00069 0.689
DOC_MAPK_MEF2A_6 207 216 PF00069 0.561
DOC_MAPK_MEF2A_6 66 74 PF00069 0.382
DOC_PP1_RVXF_1 468 475 PF00149 0.568
DOC_PP2B_LxvP_1 100 103 PF13499 0.317
DOC_PP2B_LxvP_1 70 73 PF13499 0.366
DOC_PP4_FxxP_1 384 387 PF00568 0.430
DOC_USP7_MATH_1 106 110 PF00917 0.282
DOC_USP7_MATH_1 168 172 PF00917 0.463
DOC_USP7_MATH_1 200 204 PF00917 0.659
DOC_USP7_MATH_1 245 249 PF00917 0.444
DOC_USP7_MATH_1 413 417 PF00917 0.786
DOC_USP7_MATH_1 433 437 PF00917 0.544
DOC_USP7_MATH_1 515 519 PF00917 0.710
DOC_USP7_MATH_1 531 535 PF00917 0.508
DOC_USP7_MATH_1 573 577 PF00917 0.752
DOC_USP7_MATH_1 619 623 PF00917 0.530
DOC_USP7_MATH_1 9 13 PF00917 0.677
DOC_USP7_MATH_2 292 298 PF00917 0.300
DOC_WW_Pin1_4 104 109 PF00397 0.350
DOC_WW_Pin1_4 311 316 PF00397 0.326
DOC_WW_Pin1_4 363 368 PF00397 0.359
DOC_WW_Pin1_4 387 392 PF00397 0.634
DOC_WW_Pin1_4 550 555 PF00397 0.722
DOC_WW_Pin1_4 584 589 PF00397 0.739
DOC_WW_Pin1_4 612 617 PF00397 0.452
LIG_14-3-3_CanoR_1 170 176 PF00244 0.422
LIG_14-3-3_CanoR_1 201 207 PF00244 0.596
LIG_14-3-3_CanoR_1 258 263 PF00244 0.440
LIG_14-3-3_CanoR_1 324 329 PF00244 0.358
LIG_14-3-3_CanoR_1 339 343 PF00244 0.343
LIG_14-3-3_CanoR_1 344 354 PF00244 0.250
LIG_14-3-3_CanoR_1 363 367 PF00244 0.223
LIG_14-3-3_CanoR_1 420 430 PF00244 0.693
LIG_Actin_WH2_2 3 21 PF00022 0.570
LIG_BRCT_BRCA1_1 296 300 PF00533 0.387
LIG_BRCT_BRCA1_1 336 340 PF00533 0.421
LIG_Clathr_ClatBox_1 536 540 PF01394 0.676
LIG_Clathr_ClatBox_1 88 92 PF01394 0.374
LIG_EVH1_2 643 647 PF00568 0.486
LIG_FHA_1 136 142 PF00498 0.320
LIG_FHA_1 203 209 PF00498 0.578
LIG_FHA_1 221 227 PF00498 0.229
LIG_FHA_1 345 351 PF00498 0.369
LIG_FHA_1 359 365 PF00498 0.275
LIG_FHA_1 388 394 PF00498 0.682
LIG_FHA_1 643 649 PF00498 0.474
LIG_FHA_2 105 111 PF00498 0.350
LIG_FHA_2 217 223 PF00498 0.335
LIG_FHA_2 231 237 PF00498 0.386
LIG_FHA_2 329 335 PF00498 0.399
LIG_FHA_2 423 429 PF00498 0.767
LIG_FHA_2 442 448 PF00498 0.532
LIG_FHA_2 450 456 PF00498 0.634
LIG_Integrin_isoDGR_2 394 396 PF01839 0.446
LIG_LIR_Gen_1 143 149 PF02991 0.332
LIG_LIR_Gen_1 227 237 PF02991 0.356
LIG_LIR_Gen_1 261 271 PF02991 0.364
LIG_LIR_Gen_1 331 340 PF02991 0.386
LIG_LIR_Gen_1 341 350 PF02991 0.319
LIG_LIR_Gen_1 460 469 PF02991 0.608
LIG_LIR_Nem_3 143 148 PF02991 0.332
LIG_LIR_Nem_3 174 178 PF02991 0.343
LIG_LIR_Nem_3 227 232 PF02991 0.356
LIG_LIR_Nem_3 236 242 PF02991 0.417
LIG_LIR_Nem_3 261 266 PF02991 0.360
LIG_LIR_Nem_3 268 273 PF02991 0.344
LIG_LIR_Nem_3 341 345 PF02991 0.346
LIG_LIR_Nem_3 365 371 PF02991 0.361
LIG_LIR_Nem_3 460 464 PF02991 0.605
LIG_LIR_Nem_3 466 472 PF02991 0.575
LIG_LIR_Nem_3 563 567 PF02991 0.627
LIG_LIR_Nem_3 589 595 PF02991 0.736
LIG_LIR_Nem_3 94 100 PF02991 0.275
LIG_NRBOX 168 174 PF00104 0.433
LIG_PCNA_PIPBox_1 351 360 PF02747 0.391
LIG_Pex14_2 225 229 PF04695 0.407
LIG_Pex14_2 309 313 PF04695 0.354
LIG_Pex14_2 384 388 PF04695 0.394
LIG_Pex14_2 53 57 PF04695 0.621
LIG_SH2_CRK 145 149 PF00017 0.352
LIG_SH2_CRK 301 305 PF00017 0.378
LIG_SH2_CRK 368 372 PF00017 0.350
LIG_SH2_CRK 469 473 PF00017 0.630
LIG_SH2_CRK 564 568 PF00017 0.600
LIG_SH2_GRB2like 318 321 PF00017 0.405
LIG_SH2_STAP1 145 149 PF00017 0.350
LIG_SH2_STAP1 240 244 PF00017 0.478
LIG_SH2_STAP1 318 322 PF00017 0.411
LIG_SH2_STAT5 133 136 PF00017 0.338
LIG_SH2_STAT5 262 265 PF00017 0.337
LIG_SH2_STAT5 305 308 PF00017 0.283
LIG_SH2_STAT5 332 335 PF00017 0.293
LIG_SH2_STAT5 373 376 PF00017 0.396
LIG_SH2_STAT5 442 445 PF00017 0.734
LIG_SH2_STAT5 46 49 PF00017 0.621
LIG_SH3_1 582 588 PF00018 0.611
LIG_SH3_3 17 23 PF00018 0.680
LIG_SH3_3 406 412 PF00018 0.717
LIG_SH3_3 525 531 PF00018 0.645
LIG_SH3_3 545 551 PF00018 0.488
LIG_SH3_3 582 588 PF00018 0.634
LIG_SH3_3 608 614 PF00018 0.427
LIG_SUMO_SIM_anti_2 211 217 PF11976 0.433
LIG_SUMO_SIM_anti_2 230 236 PF11976 0.163
LIG_SUMO_SIM_par_1 230 236 PF11976 0.404
LIG_SUMO_SIM_par_1 87 94 PF11976 0.384
LIG_TRAF2_1 253 256 PF00917 0.415
LIG_TRAF2_1 292 295 PF00917 0.439
LIG_TRAF2_1 444 447 PF00917 0.636
LIG_TYR_ITIM 237 242 PF00017 0.391
LIG_TYR_ITIM 467 472 PF00017 0.642
LIG_WRC_WIRS_1 172 177 PF05994 0.434
LIG_WRC_WIRS_1 306 311 PF05994 0.374
LIG_WW_3 22 26 PF00397 0.639
MOD_CDC14_SPxK_1 366 369 PF00782 0.372
MOD_CDK_SPxK_1 363 369 PF00069 0.345
MOD_CK1_1 109 115 PF00069 0.323
MOD_CK1_1 171 177 PF00069 0.438
MOD_CK1_1 227 233 PF00069 0.366
MOD_CK1_1 277 283 PF00069 0.463
MOD_CK1_1 416 422 PF00069 0.774
MOD_CK1_1 424 430 PF00069 0.712
MOD_CK1_1 441 447 PF00069 0.685
MOD_CK2_1 104 110 PF00069 0.317
MOD_CK2_1 216 222 PF00069 0.369
MOD_CK2_1 230 236 PF00069 0.386
MOD_CK2_1 250 256 PF00069 0.254
MOD_CK2_1 441 447 PF00069 0.621
MOD_CMANNOS 79 82 PF00535 0.440
MOD_Cter_Amidation 476 479 PF01082 0.450
MOD_DYRK1A_RPxSP_1 550 554 PF00069 0.676
MOD_GlcNHglycan 180 183 PF01048 0.388
MOD_GlcNHglycan 198 201 PF01048 0.464
MOD_GlcNHglycan 202 205 PF01048 0.419
MOD_GlcNHglycan 226 229 PF01048 0.325
MOD_GlcNHglycan 247 250 PF01048 0.597
MOD_GlcNHglycan 336 339 PF01048 0.630
MOD_GlcNHglycan 397 400 PF01048 0.517
MOD_GlcNHglycan 413 416 PF01048 0.585
MOD_GlcNHglycan 486 489 PF01048 0.477
MOD_GlcNHglycan 575 578 PF01048 0.538
MOD_GlcNHglycan 588 591 PF01048 0.439
MOD_GlcNHglycan 651 654 PF01048 0.662
MOD_GSK3_1 102 109 PF00069 0.339
MOD_GSK3_1 196 203 PF00069 0.673
MOD_GSK3_1 216 223 PF00069 0.419
MOD_GSK3_1 324 331 PF00069 0.375
MOD_GSK3_1 334 341 PF00069 0.372
MOD_GSK3_1 358 365 PF00069 0.383
MOD_GSK3_1 429 436 PF00069 0.708
MOD_GSK3_1 449 456 PF00069 0.576
MOD_GSK3_1 9 16 PF00069 0.643
MOD_NEK2_1 147 152 PF00069 0.302
MOD_NEK2_1 208 213 PF00069 0.387
MOD_NEK2_1 224 229 PF00069 0.259
MOD_NEK2_1 238 243 PF00069 0.341
MOD_NEK2_1 300 305 PF00069 0.328
MOD_NEK2_1 333 338 PF00069 0.422
MOD_NEK2_1 340 345 PF00069 0.431
MOD_NEK2_1 358 363 PF00069 0.223
MOD_NEK2_1 438 443 PF00069 0.692
MOD_PIKK_1 515 521 PF00454 0.755
MOD_PKA_1 258 264 PF00069 0.387
MOD_PKA_1 324 330 PF00069 0.303
MOD_PKA_2 200 206 PF00069 0.635
MOD_PKA_2 258 264 PF00069 0.436
MOD_PKA_2 338 344 PF00069 0.389
MOD_PKA_2 362 368 PF00069 0.361
MOD_PKA_2 395 401 PF00069 0.724
MOD_PKA_2 620 626 PF00069 0.563
MOD_Plk_1 294 300 PF00069 0.374
MOD_Plk_1 433 439 PF00069 0.726
MOD_Plk_1 531 537 PF00069 0.667
MOD_Plk_1 626 632 PF00069 0.483
MOD_Plk_2-3 449 455 PF00069 0.680
MOD_Plk_2-3 457 463 PF00069 0.619
MOD_Plk_4 162 168 PF00069 0.443
MOD_Plk_4 208 214 PF00069 0.437
MOD_Plk_4 220 226 PF00069 0.286
MOD_Plk_4 230 236 PF00069 0.372
MOD_Plk_4 258 264 PF00069 0.397
MOD_Plk_4 300 306 PF00069 0.350
MOD_Plk_4 328 334 PF00069 0.374
MOD_Plk_4 438 444 PF00069 0.723
MOD_Plk_4 457 463 PF00069 0.509
MOD_Plk_4 594 600 PF00069 0.363
MOD_ProDKin_1 104 110 PF00069 0.350
MOD_ProDKin_1 311 317 PF00069 0.328
MOD_ProDKin_1 363 369 PF00069 0.356
MOD_ProDKin_1 387 393 PF00069 0.640
MOD_ProDKin_1 550 556 PF00069 0.718
MOD_ProDKin_1 584 590 PF00069 0.737
MOD_ProDKin_1 612 618 PF00069 0.455
MOD_SUMO_rev_2 407 412 PF00179 0.702
MOD_SUMO_rev_2 45 52 PF00179 0.648
TRG_DiLeu_BaEn_1 349 354 PF01217 0.366
TRG_DiLeu_BaEn_1 532 537 PF01217 0.667
TRG_ENDOCYTIC_2 115 118 PF00928 0.317
TRG_ENDOCYTIC_2 145 148 PF00928 0.333
TRG_ENDOCYTIC_2 239 242 PF00928 0.473
TRG_ENDOCYTIC_2 262 265 PF00928 0.351
TRG_ENDOCYTIC_2 301 304 PF00928 0.380
TRG_ENDOCYTIC_2 318 321 PF00928 0.297
TRG_ENDOCYTIC_2 332 335 PF00928 0.269
TRG_ENDOCYTIC_2 368 371 PF00928 0.350
TRG_ENDOCYTIC_2 469 472 PF00928 0.631
TRG_ENDOCYTIC_2 564 567 PF00928 0.600
TRG_ENDOCYTIC_2 97 100 PF00928 0.317
TRG_ER_diArg_1 257 259 PF00400 0.387
TRG_ER_diArg_1 283 286 PF00400 0.320
TRG_ER_diArg_1 418 421 PF00400 0.723
TRG_ER_diArg_1 49 52 PF00400 0.573
TRG_ER_diArg_1 57 60 PF00400 0.574
TRG_ER_diArg_1 580 583 PF00400 0.711
TRG_NLS_Bipartite_1 565 585 PF00514 0.691
TRG_NLS_MonoExtC_3 580 585 PF00514 0.751
TRG_Pf-PMV_PEXEL_1 50 54 PF00026 0.427
TRG_Pf-PMV_PEXEL_1 86 90 PF00026 0.645

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PET9 Leptomonas seymouri 58% 100%
A0A0S4IPM5 Bodo saltans 29% 87%
A0A1X0P8F9 Trypanosomatidae 32% 94%
A0A3R7RAC5 Trypanosoma rangeli 35% 100%
A4HAC9 Leishmania braziliensis 78% 100%
A4I9H2 Leishmania infantum 100% 100%
D0A1S7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
E9B4H0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q3K5 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS