Ribosomal S13/S15 N-terminal domain family protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

40S ribosomal protein S13, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X790_LEIDO

TriTrypDb:

LdBPK_333300.1 , LdCL_330040600 , LDHU3_19.0440 , LDHU3_33.4780

Length:

151

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 40S ribosomal S13

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 12

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	15
GO:0032991	protein-containing complex	1	15
GO:0043226	organelle	2	16
GO:0043228	non-membrane-bounded organelle	3	16
GO:0043229	intracellular organelle	3	16
GO:0043232	intracellular non-membrane-bounded organelle	4	16
GO:0110165	cellular anatomical entity	1	16
GO:1990904	ribonucleoprotein complex	2	15
GO:0005730	nucleolus	5	1
GO:0015935	small ribosomal subunit	4	1
GO:0022627	cytosolic small ribosomal subunit	5	1
GO:0035869	ciliary transition zone	2	1
GO:0044391	ribosomal subunit	3	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S7X790

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X790

PDB structure(s): 6az1_T

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	16
GO:0006518	peptide metabolic process	4	16
GO:0006807	nitrogen compound metabolic process	2	16
GO:0008152	metabolic process	1	16
GO:0009058	biosynthetic process	2	16
GO:0009059	macromolecule biosynthetic process	4	16
GO:0009987	cellular process	1	16
GO:0019538	protein metabolic process	3	16
GO:0034641	cellular nitrogen compound metabolic process	3	16
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	16
GO:0043043	peptide biosynthetic process	5	16
GO:0043170	macromolecule metabolic process	3	16
GO:0043603	amide metabolic process	3	16
GO:0043604	amide biosynthetic process	4	16
GO:0044237	cellular metabolic process	2	16
GO:0044238	primary metabolic process	2	16
GO:0044249	cellular biosynthetic process	3	16
GO:0044260	obsolete cellular macromolecule metabolic process	3	16
GO:0044271	cellular nitrogen compound biosynthetic process	4	16
GO:0071704	organic substance metabolic process	2	16
GO:1901564	organonitrogen compound metabolic process	3	16
GO:1901566	organonitrogen compound biosynthetic process	4	16
GO:1901576	organic substance biosynthetic process	3	16

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	16
GO:0005198	structural molecule activity	1	16
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0019843	rRNA binding	5	1
GO:0070181	small ribosomal subunit rRNA binding	6	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	53	57	PF00656	0.523
CLV_NRD_NRD_1	19	21	PF00675	0.420
CLV_NRD_NRD_1	41	43	PF00675	0.472
CLV_NRD_NRD_1	68	70	PF00675	0.490
CLV_NRD_NRD_1	98	100	PF00675	0.385
CLV_PCSK_KEX2_1	130	132	PF00082	0.407
CLV_PCSK_KEX2_1	19	21	PF00082	0.420
CLV_PCSK_KEX2_1	93	95	PF00082	0.385
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.435
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.385
CLV_PCSK_SKI1_1	114	118	PF00082	0.395
CLV_PCSK_SKI1_1	130	134	PF00082	0.395
CLV_PCSK_SKI1_1	64	68	PF00082	0.472
CLV_PCSK_SKI1_1	69	73	PF00082	0.487
CLV_PCSK_SKI1_1	93	97	PF00082	0.407
DEG_APCC_DBOX_1	68	76	PF00400	0.479
DEG_ODPH_VHL_1	80	92	PF01847	0.523
DOC_MAPK_gen_1	109	118	PF00069	0.408
DOC_USP7_UBL2_3	35	39	PF12436	0.402
DOC_WW_Pin1_4	18	23	PF00397	0.378
LIG_14-3-3_CanoR_1	104	113	PF00244	0.523
LIG_14-3-3_CanoR_1	9	18	PF00244	0.523
LIG_14-3-3_CanoR_1	94	102	PF00244	0.407
LIG_Clathr_ClatBox_1	115	119	PF01394	0.395
LIG_FHA_2	105	111	PF00498	0.523
LIG_Integrin_isoDGR_2	7	9	PF01839	0.523
LIG_LIR_Nem_3	110	116	PF02991	0.384
LIG_LIR_Nem_3	86	92	PF02991	0.380
LIG_SH2_CRK	113	117	PF00017	0.514
LIG_SH2_CRK	129	133	PF00017	0.232
LIG_SH2_STAT5	89	92	PF00017	0.385
LIG_SH3_3	79	85	PF00018	0.385
LIG_SUMO_SIM_par_1	114	120	PF11976	0.395
LIG_TYR_ITSM	109	116	PF00017	0.523
LIG_UBA3_1	71	76	PF00899	0.469
MOD_CK1_1	144	150	PF00069	0.532
MOD_Cter_Amidation	67	70	PF01082	0.486
MOD_GlcNHglycan	13	16	PF01048	0.403
MOD_GlcNHglycan	146	149	PF01048	0.546
MOD_GlcNHglycan	77	80	PF01048	0.320
MOD_GSK3_1	104	111	PF00069	0.511
MOD_GSK3_1	140	147	PF00069	0.407
MOD_N-GLC_1	64	69	PF02516	0.475
MOD_NEK2_1	117	122	PF00069	0.386
MOD_NEK2_1	54	59	PF00069	0.385
MOD_NEK2_1	75	80	PF00069	0.320
MOD_PIKK_1	45	51	PF00454	0.505
MOD_PIKK_1	93	99	PF00454	0.472
MOD_PKA_1	93	99	PF00069	0.407
MOD_PKA_2	103	109	PF00069	0.407
MOD_PKA_2	54	60	PF00069	0.385
MOD_PKA_2	93	99	PF00069	0.407
MOD_ProDKin_1	18	24	PF00069	0.378
TRG_DiLeu_BaEn_2	85	91	PF01217	0.523
TRG_DiLeu_BaLyEn_6	111	116	PF01217	0.395
TRG_ENDOCYTIC_2	113	116	PF00928	0.514
TRG_ENDOCYTIC_2	129	132	PF00928	0.232
TRG_ENDOCYTIC_2	89	92	PF00928	0.376
TRG_ER_diArg_1	18	20	PF00400	0.420
TRG_NLS_MonoExtN_4	127	134	PF00514	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYB7	Leptomonas seymouri	95%	100%
A0A0S4IT71	Bodo saltans	78%	100%
A0A0S4J1V6	Bodo saltans	80%	100%
A0A1D8PPE0	Candida albicans (strain SC5314 / ATCC MYA-2876)	64%	100%
A0A1X0NRE5	Trypanosomatidae	85%	100%
A0A3R7M2N1	Trypanosoma rangeli	74%	100%
A0A3R7P3J7	Trypanosoma rangeli	83%	100%
A0A3S7WVA6	Leishmania donovani	99%	100%
A0B5E6	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	33%	89%
A0RTT1	Cenarchaeum symbiosum (strain A)	36%	100%
A1RSM4	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	45%	100%
A1RXJ1	Thermofilum pendens (strain DSM 2475 / Hrk 5)	51%	100%
A2BJY6	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	40%	94%
A2SQ60	Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)	39%	99%
A3CSL3	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	39%	99%
A3DMT2	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	43%	98%
A3MVD1	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	43%	100%
A4G0Z3	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	36%	100%
A4H9Z7	Leishmania braziliensis	99%	100%
A4HY61	Leishmania infantum	100%	100%
A4WMA2	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	43%	98%
A4YIY3	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	40%	99%
A5UMH1	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	41%	100%
A6UQM4	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	40%	100%
A6UUL9	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	42%	100%
A6VHG7	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	37%	100%
A7IAI8	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	38%	99%
A8AAU0	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	43%	95%
A8MCD3	Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)	46%	100%
A9A4V0	Nitrosopumilus maritimus (strain SCM1)	39%	100%
C9ZJT0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	83%	76%
D0A0I0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	83%	100%
E9ARZ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
O27474	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	41%	100%
O29457	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	45%	99%
O57805	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	45%	96%
O77303	Lumbricus rubellus	64%	100%
P05756	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	61%	100%
P05762	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	33%	97%
P27072	Musca domestica	66%	100%
P28189	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	66%	100%
P33192	Candida maltosa	64%	100%
P46298	Pisum sativum	69%	100%
P47772	Ictalurus punctatus	64%	100%
P49393	Xenopus laevis	64%	100%
P51404	Caenorhabditis elegans	61%	100%
P52811	Anopheles gambiae	63%	100%
P54012	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	44%	99%
P59223	Arabidopsis thaliana	66%	100%
P59224	Arabidopsis thaliana	66%	100%
P62277	Homo sapiens	64%	100%
P62278	Rattus norvegicus	64%	100%
P62279	Sus scrofa	60%	100%
P62299	Brugia pahangi	66%	100%
P62300	Wuchereria bancrofti	66%	100%
P62301	Mus musculus	64%	100%
P62302	Glycine max	69%	100%
P78571	Agaricus bisporus	62%	100%
Q03334	Drosophila melanogaster	62%	100%
Q05761	Zea mays	69%	100%
Q0W938	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	38%	99%
Q12TM7	Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)	39%	99%
Q18HQ4	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	36%	96%
Q2FS30	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	40%	99%
Q2NIA9	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	43%	100%
Q3IQA3	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	36%	98%
Q46BC9	Methanosarcina barkeri (strain Fusaro / DSM 804)	40%	99%
Q4JAI3	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	40%	99%
Q4Q3M1	Leishmania major	99%	100%
Q54PH8	Dictyostelium discoideum	58%	100%
Q56JX8	Bos taurus	64%	100%
Q5JGJ4	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	46%	100%
Q69UI1	Oryza sativa subsp. japonica	70%	100%
Q69UI2	Oryza sativa subsp. japonica	68%	100%
Q6ITC7	Gallus gallus	64%	100%
Q6L2H3	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	35%	100%
Q6LWX5	Methanococcus maripaludis (strain S2 / LL)	36%	100%
Q74MB8	Nanoarchaeum equitans (strain Kin4-M)	39%	98%
Q8I7D6	Ciona intestinalis	63%	100%
Q8I7U0	Plutella xylostella	64%	100%
Q8MUR2	Choristoneura parallela	64%	100%
Q8PVA5	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	43%	99%
Q8SRB3	Encephalitozoon cuniculi (strain GB-M1)	42%	100%
Q8TS56	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	42%	99%
Q8TV08	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	47%	100%
Q8TZD9	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	44%	96%
Q8ZT11	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	43%	100%
Q962R6	Spodoptera frugiperda	64%	100%
Q975N5	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	44%	99%
Q979D0	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	35%	100%
Q980A8	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	40%	99%
Q9DFR6	Gillichthys mirabilis	63%	100%
Q9HJ42	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	36%	100%
Q9HRA2	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	34%	97%
Q9V2K9	Pyrococcus abyssi (strain GE5 / Orsay)	45%	96%
Q9WVH0	Cricetulus griseus	65%	100%
Q9YCX3	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	39%	100%
V5BSE4	Trypanosoma cruzi	81%	100%