Fe2OG dioxygenase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X787_LEIDO

TriTrypDb:

LdBPK_333260.1 , LdCL_330040200 , LDHU3_33.4740

Length:

465

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X787

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X787

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.471
CLV_C14_Caspase3-7	379	383	PF00656	0.601
CLV_C14_Caspase3-7	401	405	PF00656	0.484
CLV_NRD_NRD_1	170	172	PF00675	0.484
CLV_NRD_NRD_1	212	214	PF00675	0.432
CLV_NRD_NRD_1	3	5	PF00675	0.649
CLV_NRD_NRD_1	444	446	PF00675	0.532
CLV_PCSK_KEX2_1	170	172	PF00082	0.530
CLV_PCSK_KEX2_1	211	213	PF00082	0.455
CLV_PCSK_KEX2_1	258	260	PF00082	0.638
CLV_PCSK_KEX2_1	3	5	PF00082	0.649
CLV_PCSK_KEX2_1	93	95	PF00082	0.480
CLV_PCSK_PC1ET2_1	258	260	PF00082	0.531
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.537
CLV_PCSK_SKI1_1	307	311	PF00082	0.701
CLV_PCSK_SKI1_1	373	377	PF00082	0.545
CLV_PCSK_SKI1_1	4	8	PF00082	0.631
CLV_PCSK_SKI1_1	69	73	PF00082	0.420
CLV_PCSK_SKI1_1	83	87	PF00082	0.487
DEG_APCC_DBOX_1	2	10	PF00400	0.629
DEG_Nend_Nbox_1	1	3	PF02207	0.592
DEG_SCF_FBW7_1	278	284	PF00400	0.721
DOC_CKS1_1	278	283	PF01111	0.727
DOC_MAPK_gen_1	170	176	PF00069	0.502
DOC_MAPK_gen_1	211	220	PF00069	0.515
DOC_MAPK_gen_1	3	9	PF00069	0.646
DOC_MAPK_MEF2A_6	213	222	PF00069	0.440
DOC_MAPK_MEF2A_6	69	78	PF00069	0.478
DOC_PP2B_LxvP_1	273	276	PF13499	0.697
DOC_USP7_MATH_1	15	19	PF00917	0.403
DOC_USP7_UBL2_3	402	406	PF12436	0.513
DOC_USP7_UBL2_3	411	415	PF12436	0.441
DOC_USP7_UBL2_3	452	456	PF12436	0.525
DOC_USP7_UBL2_3	89	93	PF12436	0.599
DOC_WW_Pin1_4	102	107	PF00397	0.405
DOC_WW_Pin1_4	277	282	PF00397	0.739
DOC_WW_Pin1_4	62	67	PF00397	0.494
LIG_14-3-3_CanoR_1	11	20	PF00244	0.538
LIG_14-3-3_CanoR_1	110	119	PF00244	0.426
LIG_14-3-3_CanoR_1	219	223	PF00244	0.362
LIG_14-3-3_CanoR_1	291	297	PF00244	0.523
LIG_14-3-3_CanoR_1	33	39	PF00244	0.420
LIG_CSL_BTD_1	103	106	PF09270	0.418
LIG_CtBP_PxDLS_1	437	441	PF00389	0.653
LIG_deltaCOP1_diTrp_1	187	194	PF00928	0.383
LIG_FHA_1	124	130	PF00498	0.393
LIG_FHA_1	146	152	PF00498	0.476
LIG_FHA_1	196	202	PF00498	0.527
LIG_FHA_1	278	284	PF00498	0.700
LIG_FHA_1	420	426	PF00498	0.663
LIG_FHA_2	157	163	PF00498	0.398
LIG_FHA_2	329	335	PF00498	0.659
LIG_FHA_2	63	69	PF00498	0.581
LIG_FHA_2	79	85	PF00498	0.476
LIG_LIR_Gen_1	148	156	PF02991	0.394
LIG_LIR_Gen_1	397	407	PF02991	0.485
LIG_LIR_Gen_1	42	52	PF02991	0.450
LIG_LIR_Nem_3	148	153	PF02991	0.415
LIG_LIR_Nem_3	30	35	PF02991	0.483
LIG_LIR_Nem_3	338	342	PF02991	0.497
LIG_LIR_Nem_3	347	353	PF02991	0.496
LIG_LIR_Nem_3	397	403	PF02991	0.488
LIG_LIR_Nem_3	42	48	PF02991	0.418
LIG_LIR_Nem_3	82	88	PF02991	0.502
LIG_MAD2	110	118	PF02301	0.496
LIG_PCNA_PIPBox_1	290	299	PF02747	0.526
LIG_Pex14_1	190	194	PF04695	0.408
LIG_SH2_CRK	350	354	PF00017	0.577
LIG_SH2_GRB2like	152	155	PF00017	0.401
LIG_SH2_STAP1	137	141	PF00017	0.443
LIG_SH2_STAT3	342	345	PF00017	0.524
LIG_SH2_STAT5	152	155	PF00017	0.323
LIG_SH2_STAT5	204	207	PF00017	0.536
LIG_SH2_STAT5	75	78	PF00017	0.372
LIG_SH3_3	112	118	PF00018	0.462
LIG_SH3_3	138	144	PF00018	0.544
LIG_SH3_3	17	23	PF00018	0.375
LIG_SH3_3	171	177	PF00018	0.391
LIG_SH3_3	269	275	PF00018	0.638
LIG_SH3_3	286	292	PF00018	0.700
LIG_SUMO_SIM_par_1	34	42	PF11976	0.490
LIG_TYR_ITIM	43	48	PF00017	0.451
LIG_UBA3_1	352	357	PF00899	0.531
LIG_WRC_WIRS_1	293	298	PF05994	0.657
MOD_CDK_SPxxK_3	62	69	PF00069	0.482
MOD_CK1_1	18	24	PF00069	0.436
MOD_CK2_1	34	40	PF00069	0.413
MOD_CK2_1	391	397	PF00069	0.636
MOD_CK2_1	61	67	PF00069	0.551
MOD_CK2_1	78	84	PF00069	0.461
MOD_Cter_Amidation	168	171	PF01082	0.557
MOD_GlcNHglycan	13	16	PF01048	0.470
MOD_GlcNHglycan	184	187	PF01048	0.374
MOD_GlcNHglycan	304	307	PF01048	0.759
MOD_GlcNHglycan	322	325	PF01048	0.735
MOD_GlcNHglycan	361	364	PF01048	0.618
MOD_GSK3_1	11	18	PF00069	0.564
MOD_GSK3_1	277	284	PF00069	0.719
MOD_GSK3_1	373	380	PF00069	0.652
MOD_GSK3_1	457	464	PF00069	0.629
MOD_N-GLC_1	207	212	PF02516	0.553
MOD_N-GLC_1	302	307	PF02516	0.741
MOD_NEK2_1	156	161	PF00069	0.370
MOD_NEK2_1	218	223	PF00069	0.362
MOD_NEK2_1	359	364	PF00069	0.559
MOD_NEK2_1	375	380	PF00069	0.582
MOD_NEK2_1	391	396	PF00069	0.400
MOD_NEK2_1	424	429	PF00069	0.614
MOD_NEK2_1	440	445	PF00069	0.532
MOD_PIKK_1	430	436	PF00454	0.638
MOD_PKA_1	373	379	PF00069	0.633
MOD_PKA_2	218	224	PF00069	0.376
MOD_PKA_2	440	446	PF00069	0.615
MOD_PKB_1	211	219	PF00069	0.521
MOD_Plk_1	15	21	PF00069	0.414
MOD_Plk_1	241	247	PF00069	0.509
MOD_Plk_1	376	382	PF00069	0.642
MOD_Plk_1	46	52	PF00069	0.508
MOD_Plk_2-3	377	383	PF00069	0.627
MOD_Plk_4	104	110	PF00069	0.376
MOD_Plk_4	15	21	PF00069	0.369
MOD_Plk_4	156	162	PF00069	0.378
MOD_Plk_4	200	206	PF00069	0.451
MOD_Plk_4	292	298	PF00069	0.671
MOD_Plk_4	56	62	PF00069	0.524
MOD_ProDKin_1	102	108	PF00069	0.398
MOD_ProDKin_1	277	283	PF00069	0.743
MOD_ProDKin_1	62	68	PF00069	0.491
MOD_SUMO_rev_2	401	407	PF00179	0.482
MOD_SUMO_rev_2	64	71	PF00179	0.568
TRG_DiLeu_BaLyEn_6	232	237	PF01217	0.620
TRG_ENDOCYTIC_2	152	155	PF00928	0.342
TRG_ENDOCYTIC_2	350	353	PF00928	0.574
TRG_ENDOCYTIC_2	45	48	PF00928	0.498
TRG_ENDOCYTIC_2	75	78	PF00928	0.372
TRG_ER_diArg_1	2	4	PF00400	0.658
TRG_ER_diArg_1	211	213	PF00400	0.449
TRG_NES_CRM1_1	251	263	PF08389	0.423
TRG_NLS_MonoExtC_3	371	377	PF00514	0.507
TRG_Pf-PMV_PEXEL_1	11	16	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	50	55	PF00026	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD27	Leptomonas seymouri	76%	99%
A0A0S4JDR9	Bodo saltans	40%	75%
A0A1X0NSW5	Trypanosomatidae	53%	100%
A4HM19	Leishmania braziliensis	88%	100%
A4I9F2	Leishmania infantum	100%	100%
C9ZJS8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	90%
E9B4F0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q3M6	Leishmania major	95%	100%
V5AFA6	Trypanosoma cruzi	55%	100%