Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X786_LEIDO

TriTrypDb:

LdBPK_333330.1 , LdCL_330040900 , LDHU3_33.4810

Length:

612

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 4
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S7X786

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X786

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	260	266	PF00089	0.699
CLV_NRD_NRD_1	346	348	PF00675	0.562
CLV_NRD_NRD_1	533	535	PF00675	0.535
CLV_PCSK_KEX2_1	345	347	PF00082	0.567
CLV_PCSK_SKI1_1	2	6	PF00082	0.603
DEG_Kelch_Keap1_1	469	474	PF01344	0.768
DEG_Kelch_Keap1_1	515	520	PF01344	0.816
DEG_Nend_UBRbox_1	1	4	PF02207	0.829
DEG_SCF_FBW7_1	206	211	PF00400	0.442
DOC_ANK_TNKS_1	369	376	PF00023	0.778
DOC_CKS1_1	420	425	PF01111	0.809
DOC_MAPK_DCC_7	7	16	PF00069	0.551
DOC_MAPK_gen_1	279	288	PF00069	0.577
DOC_MAPK_MEF2A_6	213	220	PF00069	0.545
DOC_MAPK_MEF2A_6	7	16	PF00069	0.539
DOC_PP1_RVXF_1	328	335	PF00149	0.615
DOC_USP7_MATH_1	112	116	PF00917	0.537
DOC_USP7_MATH_1	39	43	PF00917	0.523
DOC_USP7_MATH_1	493	497	PF00917	0.881
DOC_USP7_MATH_1	79	83	PF00917	0.432
DOC_USP7_UBL2_3	233	237	PF12436	0.457
DOC_WW_Pin1_4	204	209	PF00397	0.434
DOC_WW_Pin1_4	222	227	PF00397	0.520
DOC_WW_Pin1_4	419	424	PF00397	0.867
DOC_WW_Pin1_4	6	11	PF00397	0.680
DOC_WW_Pin1_4	66	71	PF00397	0.464
LIG_14-3-3_CanoR_1	137	146	PF00244	0.525
LIG_14-3-3_CanoR_1	165	173	PF00244	0.540
LIG_14-3-3_CanoR_1	2	7	PF00244	0.814
LIG_14-3-3_CanoR_1	263	271	PF00244	0.499
LIG_14-3-3_CanoR_1	295	305	PF00244	0.604
LIG_14-3-3_CanoR_1	93	101	PF00244	0.532
LIG_BIR_III_4	364	368	PF00653	0.885
LIG_BIR_III_4	435	439	PF00653	0.821
LIG_EVH1_2	372	376	PF00568	0.901
LIG_FHA_1	114	120	PF00498	0.446
LIG_FHA_1	183	189	PF00498	0.444
LIG_FHA_1	3	9	PF00498	0.767
LIG_FHA_1	35	41	PF00498	0.618
LIG_FHA_1	590	596	PF00498	0.887
LIG_FHA_1	60	66	PF00498	0.572
LIG_FHA_1	67	73	PF00498	0.397
LIG_FHA_1	96	102	PF00498	0.565
LIG_FHA_2	205	211	PF00498	0.537
LIG_FHA_2	510	516	PF00498	0.793
LIG_FHA_2	562	568	PF00498	0.878
LIG_FHA_2	579	585	PF00498	0.839
LIG_LIR_Apic_2	157	163	PF02991	0.489
LIG_LIR_Apic_2	466	470	PF02991	0.782
LIG_LIR_Apic_2	512	516	PF02991	0.773
LIG_LIR_Apic_2	546	552	PF02991	0.825
LIG_LIR_Apic_2	559	563	PF02991	0.748
LIG_LIR_Gen_1	167	178	PF02991	0.535
LIG_LIR_Gen_1	225	235	PF02991	0.456
LIG_LIR_Gen_1	521	532	PF02991	0.808
LIG_LIR_Nem_3	115	120	PF02991	0.456
LIG_LIR_Nem_3	167	173	PF02991	0.539
LIG_LIR_Nem_3	225	230	PF02991	0.454
LIG_LIR_Nem_3	310	316	PF02991	0.572
LIG_LIR_Nem_3	508	513	PF02991	0.785
LIG_LIR_Nem_3	521	527	PF02991	0.773
LIG_Pex14_1	314	318	PF04695	0.413
LIG_Pex14_2	318	322	PF04695	0.480
LIG_Pex14_2	329	333	PF04695	0.683
LIG_SH2_CRK	160	164	PF00017	0.514
LIG_SH2_CRK	170	174	PF00017	0.551
LIG_SH2_CRK	227	231	PF00017	0.467
LIG_SH2_CRK	524	528	PF00017	0.737
LIG_SH2_CRK	549	553	PF00017	0.798
LIG_SH2_GRB2like	467	470	PF00017	0.821
LIG_SH2_GRB2like	549	552	PF00017	0.818
LIG_SH2_NCK_1	524	528	PF00017	0.876
LIG_SH2_NCK_1	549	553	PF00017	0.798
LIG_SH2_NCK_1	607	611	PF00017	0.878
LIG_SH2_PTP2	467	470	PF00017	0.767
LIG_SH2_PTP2	513	516	PF00017	0.772
LIG_SH2_PTP2	538	541	PF00017	0.728
LIG_SH2_PTP2	560	563	PF00017	0.760
LIG_SH2_PTP2	596	599	PF00017	0.787
LIG_SH2_SRC	172	175	PF00017	0.632
LIG_SH2_SRC	467	470	PF00017	0.783
LIG_SH2_SRC	513	516	PF00017	0.772
LIG_SH2_SRC	536	539	PF00017	0.841
LIG_SH2_SRC	547	550	PF00017	0.776
LIG_SH2_SRC	558	561	PF00017	0.755
LIG_SH2_SRC	596	599	PF00017	0.787
LIG_SH2_STAP1	399	403	PF00017	0.761
LIG_SH2_STAP1	571	575	PF00017	0.814
LIG_SH2_STAT5	118	121	PF00017	0.493
LIG_SH2_STAT5	172	175	PF00017	0.590
LIG_SH2_STAT5	187	190	PF00017	0.368
LIG_SH2_STAT5	198	201	PF00017	0.521
LIG_SH2_STAT5	202	205	PF00017	0.500
LIG_SH2_STAT5	227	230	PF00017	0.513
LIG_SH2_STAT5	245	248	PF00017	0.473
LIG_SH2_STAT5	331	334	PF00017	0.664
LIG_SH2_STAT5	431	434	PF00017	0.776
LIG_SH2_STAT5	467	470	PF00017	0.781
LIG_SH2_STAT5	478	481	PF00017	0.842
LIG_SH2_STAT5	513	516	PF00017	0.785
LIG_SH2_STAT5	524	527	PF00017	0.795
LIG_SH2_STAT5	538	541	PF00017	0.717
LIG_SH2_STAT5	560	563	PF00017	0.776
LIG_SH2_STAT5	571	574	PF00017	0.812
LIG_SH2_STAT5	596	599	PF00017	0.787
LIG_SH3_3	215	221	PF00018	0.549
LIG_TRAF2_1	485	488	PF00917	0.908
LIG_TRFH_1	187	191	PF08558	0.524
MOD_CK1_1	104	110	PF00069	0.429
MOD_CK1_1	130	136	PF00069	0.407
MOD_CK1_1	149	155	PF00069	0.423
MOD_CK1_1	222	228	PF00069	0.600
MOD_CK1_1	298	304	PF00069	0.640
MOD_CK1_1	34	40	PF00069	0.574
MOD_CK1_1	448	454	PF00069	0.898
MOD_CK1_1	66	72	PF00069	0.451
MOD_CK1_1	82	88	PF00069	0.470
MOD_CK1_1	95	101	PF00069	0.549
MOD_CK2_1	204	210	PF00069	0.530
MOD_CK2_1	286	292	PF00069	0.477
MOD_CK2_1	493	499	PF00069	0.846
MOD_CK2_1	514	520	PF00069	0.816
MOD_CK2_1	561	567	PF00069	0.877
MOD_CK2_1	578	584	PF00069	0.787
MOD_GlcNHglycan	139	142	PF01048	0.655
MOD_GlcNHglycan	33	36	PF01048	0.749
MOD_GlcNHglycan	434	439	PF01048	0.611
MOD_GlcNHglycan	49	52	PF01048	0.633
MOD_GlcNHglycan	65	68	PF01048	0.618
MOD_GlcNHglycan	77	80	PF01048	0.751
MOD_GlcNHglycan	81	84	PF01048	0.700
MOD_GSK3_1	101	108	PF00069	0.502
MOD_GSK3_1	125	132	PF00069	0.552
MOD_GSK3_1	137	144	PF00069	0.535
MOD_GSK3_1	145	152	PF00069	0.467
MOD_GSK3_1	164	171	PF00069	0.579
MOD_GSK3_1	2	9	PF00069	0.771
MOD_GSK3_1	204	211	PF00069	0.532
MOD_GSK3_1	27	34	PF00069	0.545
MOD_GSK3_1	287	294	PF00069	0.517
MOD_GSK3_1	297	304	PF00069	0.636
MOD_GSK3_1	35	42	PF00069	0.547
MOD_GSK3_1	472	479	PF00069	0.872
MOD_GSK3_1	489	496	PF00069	0.795
MOD_GSK3_1	514	521	PF00069	0.828
MOD_GSK3_1	53	60	PF00069	0.413
MOD_GSK3_1	561	568	PF00069	0.848
MOD_GSK3_1	68	75	PF00069	0.433
MOD_N-GLC_1	113	118	PF02516	0.754
MOD_N-GLC_1	126	131	PF02516	0.681
MOD_N-GLC_1	45	50	PF02516	0.632
MOD_N-GLC_1	577	582	PF02516	0.675
MOD_N-GLC_1	72	77	PF02516	0.739
MOD_NEK2_1	101	106	PF00069	0.525
MOD_NEK2_1	146	151	PF00069	0.532
MOD_NEK2_1	153	158	PF00069	0.491
MOD_NEK2_1	376	381	PF00069	0.898
MOD_NEK2_1	45	50	PF00069	0.444
MOD_NEK2_2	182	187	PF00069	0.515
MOD_NEK2_2	208	213	PF00069	0.510
MOD_PIKK_1	118	124	PF00454	0.464
MOD_PIKK_1	445	451	PF00454	0.908
MOD_PIKK_1	522	528	PF00454	0.829
MOD_PKA_2	136	142	PF00069	0.523
MOD_PKA_2	164	170	PF00069	0.624
MOD_PKA_2	212	218	PF00069	0.501
MOD_PKA_2	301	307	PF00069	0.682
MOD_PKA_2	92	98	PF00069	0.545
MOD_PKB_1	335	343	PF00069	0.748
MOD_Plk_1	113	119	PF00069	0.550
MOD_Plk_1	126	132	PF00069	0.482
MOD_Plk_1	27	33	PF00069	0.630
MOD_Plk_1	291	297	PF00069	0.559
MOD_Plk_1	376	382	PF00069	0.796
MOD_Plk_1	45	51	PF00069	0.386
MOD_Plk_1	493	499	PF00069	0.852
MOD_Plk_1	72	78	PF00069	0.545
MOD_Plk_1	95	101	PF00069	0.481
MOD_Plk_4	101	107	PF00069	0.525
MOD_Plk_4	113	119	PF00069	0.375
MOD_Plk_4	168	174	PF00069	0.555
MOD_Plk_4	182	188	PF00069	0.455
MOD_Plk_4	212	218	PF00069	0.519
MOD_Plk_4	225	231	PF00069	0.428
MOD_Plk_4	463	469	PF00069	0.771
MOD_Plk_4	509	515	PF00069	0.778
MOD_ProDKin_1	204	210	PF00069	0.437
MOD_ProDKin_1	222	228	PF00069	0.511
MOD_ProDKin_1	419	425	PF00069	0.867
MOD_ProDKin_1	6	12	PF00069	0.680
MOD_ProDKin_1	66	72	PF00069	0.458
TRG_ENDOCYTIC_2	117	120	PF00928	0.460
TRG_ENDOCYTIC_2	170	173	PF00928	0.549
TRG_ENDOCYTIC_2	227	230	PF00928	0.429
TRG_ENDOCYTIC_2	280	283	PF00928	0.502
TRG_ENDOCYTIC_2	313	316	PF00928	0.575
TRG_ENDOCYTIC_2	331	334	PF00928	0.625
TRG_ENDOCYTIC_2	524	527	PF00928	0.764
TRG_ENDOCYTIC_2	536	539	PF00928	0.745
TRG_ENDOCYTIC_2	558	561	PF00928	0.781
TRG_ER_diArg_1	334	337	PF00400	0.773
TRG_ER_diArg_1	345	347	PF00400	0.757

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Z7	Leptomonas seymouri	43%	100%
A4HM25	Leishmania braziliensis	62%	97%
A4I9F9	Leishmania infantum	100%	100%
E9B4F7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	76%
Q4Q3L8	Leishmania major	88%	100%