LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X784_LEIDO
TriTrypDb:
LdBPK_333030.1 , LdCL_330037400 , LDHU3_33.4220
Length:
414

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X784
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X784

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 274 278 PF00656 0.741
CLV_C14_Caspase3-7 401 405 PF00656 0.655
CLV_NRD_NRD_1 110 112 PF00675 0.710
CLV_NRD_NRD_1 136 138 PF00675 0.654
CLV_NRD_NRD_1 227 229 PF00675 0.654
CLV_NRD_NRD_1 25 27 PF00675 0.593
CLV_NRD_NRD_1 317 319 PF00675 0.752
CLV_NRD_NRD_1 383 385 PF00675 0.637
CLV_NRD_NRD_1 386 388 PF00675 0.675
CLV_NRD_NRD_1 389 391 PF00675 0.693
CLV_PCSK_FUR_1 384 388 PF00082 0.707
CLV_PCSK_KEX2_1 136 138 PF00082 0.616
CLV_PCSK_KEX2_1 187 189 PF00082 0.640
CLV_PCSK_KEX2_1 194 196 PF00082 0.660
CLV_PCSK_KEX2_1 229 231 PF00082 0.707
CLV_PCSK_KEX2_1 317 319 PF00082 0.752
CLV_PCSK_KEX2_1 334 336 PF00082 0.551
CLV_PCSK_KEX2_1 382 384 PF00082 0.630
CLV_PCSK_KEX2_1 386 388 PF00082 0.667
CLV_PCSK_KEX2_1 389 391 PF00082 0.684
CLV_PCSK_PC1ET2_1 187 189 PF00082 0.685
CLV_PCSK_PC1ET2_1 194 196 PF00082 0.678
CLV_PCSK_PC1ET2_1 229 231 PF00082 0.689
CLV_PCSK_PC1ET2_1 334 336 PF00082 0.604
CLV_PCSK_PC7_1 382 388 PF00082 0.654
CLV_PCSK_SKI1_1 261 265 PF00082 0.666
CLV_PCSK_SKI1_1 298 302 PF00082 0.489
CLV_Separin_Metazoa 179 183 PF03568 0.626
CLV_Separin_Metazoa 262 266 PF03568 0.686
DOC_ANK_TNKS_1 388 395 PF00023 0.660
DOC_PP1_RVXF_1 332 339 PF00149 0.588
DOC_PP4_FxxP_1 385 388 PF00568 0.716
DOC_USP7_MATH_1 120 124 PF00917 0.658
DOC_USP7_MATH_1 193 197 PF00917 0.703
DOC_USP7_MATH_1 2 6 PF00917 0.789
DOC_USP7_MATH_1 200 204 PF00917 0.648
DOC_USP7_MATH_1 220 224 PF00917 0.651
DOC_USP7_MATH_1 316 320 PF00917 0.733
DOC_USP7_MATH_1 355 359 PF00917 0.664
DOC_USP7_MATH_1 64 68 PF00917 0.611
DOC_USP7_MATH_1 9 13 PF00917 0.668
DOC_USP7_UBL2_3 190 194 PF12436 0.690
DOC_WW_Pin1_4 11 16 PF00397 0.774
DOC_WW_Pin1_4 122 127 PF00397 0.712
DOC_WW_Pin1_4 91 96 PF00397 0.735
LIG_14-3-3_CanoR_1 317 323 PF00244 0.745
LIG_BIR_II_1 1 5 PF00653 0.671
LIG_BIR_III_3 1 5 PF00653 0.792
LIG_BIR_III_4 146 150 PF00653 0.633
LIG_FHA_1 302 308 PF00498 0.697
LIG_FHA_1 79 85 PF00498 0.718
LIG_FHA_1 86 92 PF00498 0.583
LIG_FHA_2 242 248 PF00498 0.637
LIG_FHA_2 255 261 PF00498 0.662
LIG_LIR_Gen_1 67 77 PF02991 0.627
LIG_LIR_Nem_3 158 164 PF02991 0.567
LIG_LIR_Nem_3 57 62 PF02991 0.550
LIG_LIR_Nem_3 67 72 PF02991 0.508
LIG_LIR_Nem_3 94 99 PF02991 0.661
LIG_LYPXL_yS_3 59 62 PF13949 0.614
LIG_PCNA_PIPBox_1 326 335 PF02747 0.610
LIG_PCNA_yPIPBox_3 167 181 PF02747 0.613
LIG_PCNA_yPIPBox_3 326 337 PF02747 0.620
LIG_RPA_C_Fungi 132 144 PF08784 0.638
LIG_SH2_CRK 69 73 PF00017 0.584
LIG_SH2_NCK_1 104 108 PF00017 0.703
LIG_SH2_NCK_1 253 257 PF00017 0.700
LIG_SH2_NCK_1 37 41 PF00017 0.689
LIG_SH2_SRC 104 107 PF00017 0.652
LIG_SH2_STAT5 243 246 PF00017 0.662
LIG_SH2_STAT5 332 335 PF00017 0.546
LIG_SH3_3 112 118 PF00018 0.739
LIG_SH3_3 153 159 PF00018 0.576
LIG_SH3_3 39 45 PF00018 0.611
LIG_Sin3_3 140 147 PF02671 0.634
LIG_SUMO_SIM_par_1 297 306 PF11976 0.630
LIG_TRAF2_1 256 259 PF00917 0.664
LIG_TRAF2_1 290 293 PF00917 0.779
LIG_TRAF2_1 319 322 PF00917 0.740
LIG_ULM_U2AF65_1 334 339 PF00076 0.590
LIG_WW_3 14 18 PF00397 0.760
MOD_CDC14_SPxK_1 14 17 PF00782 0.762
MOD_CDK_SPxK_1 11 17 PF00069 0.771
MOD_CK1_1 11 17 PF00069 0.684
MOD_CK1_1 125 131 PF00069 0.665
MOD_CK1_1 254 260 PF00069 0.668
MOD_CK1_1 272 278 PF00069 0.741
MOD_CK1_1 291 297 PF00069 0.626
MOD_CK1_1 358 364 PF00069 0.629
MOD_CK2_1 241 247 PF00069 0.634
MOD_CK2_1 254 260 PF00069 0.615
MOD_CK2_1 316 322 PF00069 0.753
MOD_Cter_Amidation 226 229 PF01082 0.527
MOD_GlcNHglycan 11 14 PF01048 0.639
MOD_GlcNHglycan 122 125 PF01048 0.686
MOD_GlcNHglycan 2 5 PF01048 0.780
MOD_GlcNHglycan 247 250 PF01048 0.638
MOD_GlcNHglycan 253 256 PF01048 0.675
MOD_GlcNHglycan 273 277 PF01048 0.482
MOD_GlcNHglycan 312 315 PF01048 0.716
MOD_GlcNHglycan 357 360 PF01048 0.738
MOD_GSK3_1 125 132 PF00069 0.686
MOD_GSK3_1 241 248 PF00069 0.657
MOD_GSK3_1 338 345 PF00069 0.576
MOD_GSK3_1 44 51 PF00069 0.696
MOD_GSK3_1 7 14 PF00069 0.700
MOD_GSK3_1 80 87 PF00069 0.701
MOD_N-GLC_1 211 216 PF02516 0.747
MOD_NEK2_1 251 256 PF00069 0.661
MOD_NEK2_1 264 269 PF00069 0.688
MOD_NEK2_1 301 306 PF00069 0.554
MOD_NEK2_1 84 89 PF00069 0.719
MOD_NEK2_2 64 69 PF00069 0.685
MOD_PIKK_1 254 260 PF00454 0.662
MOD_PIKK_1 288 294 PF00454 0.780
MOD_PIKK_1 338 344 PF00454 0.590
MOD_PKA_1 194 200 PF00069 0.678
MOD_PKA_2 194 200 PF00069 0.714
MOD_PKA_2 264 270 PF00069 0.612
MOD_PKA_2 316 322 PF00069 0.753
MOD_Plk_1 220 226 PF00069 0.678
MOD_ProDKin_1 11 17 PF00069 0.771
MOD_ProDKin_1 122 128 PF00069 0.705
MOD_ProDKin_1 91 97 PF00069 0.735
MOD_SUMO_for_1 371 374 PF00179 0.623
MOD_SUMO_rev_2 254 263 PF00179 0.666
TRG_DiLeu_BaEn_4 259 265 PF01217 0.619
TRG_DiLeu_BaLyEn_6 57 62 PF01217 0.620
TRG_ENDOCYTIC_2 104 107 PF00928 0.706
TRG_ENDOCYTIC_2 243 246 PF00928 0.652
TRG_ENDOCYTIC_2 37 40 PF00928 0.680
TRG_ENDOCYTIC_2 59 62 PF00928 0.561
TRG_ENDOCYTIC_2 69 72 PF00928 0.563
TRG_ER_diArg_1 228 231 PF00400 0.696
TRG_ER_diArg_1 335 338 PF00400 0.556
TRG_ER_diArg_1 382 384 PF00400 0.637
TRG_ER_diArg_1 385 387 PF00400 0.671
TRG_ER_diArg_1 388 390 PF00400 0.699
TRG_NLS_Bipartite_1 317 338 PF00514 0.699
TRG_NLS_MonoExtC_3 227 233 PF00514 0.656

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2L6 Leptomonas seymouri 57% 100%
A4HLZ9 Leishmania braziliensis 79% 100%
A4I9C9 Leishmania infantum 100% 100%
E9B4C9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q4Q3P7 Leishmania major 90% 100%
V5BJN0 Trypanosoma cruzi 27% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS