Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X783_LEIDO

TriTrypDb:

LdBPK_333080.1 , LdCL_330038100 , LDHU3_33.4460

Length:

306

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X783

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X783

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	170	172	PF00675	0.674
CLV_NRD_NRD_1	195	197	PF00675	0.640
CLV_NRD_NRD_1	200	202	PF00675	0.618
CLV_NRD_NRD_1	217	219	PF00675	0.536
CLV_NRD_NRD_1	94	96	PF00675	0.751
CLV_PCSK_KEX2_1	170	172	PF00082	0.726
CLV_PCSK_KEX2_1	195	197	PF00082	0.640
CLV_PCSK_KEX2_1	200	202	PF00082	0.618
CLV_PCSK_KEX2_1	217	219	PF00082	0.536
CLV_PCSK_PC1ET2_1	217	219	PF00082	0.668
CLV_PCSK_PC7_1	166	172	PF00082	0.744
CLV_PCSK_PC7_1	196	202	PF00082	0.663
CLV_PCSK_SKI1_1	195	199	PF00082	0.790
CLV_PCSK_SKI1_1	206	210	PF00082	0.674
CLV_PCSK_SKI1_1	84	88	PF00082	0.712
DOC_ANK_TNKS_1	199	206	PF00023	0.682
DOC_MAPK_gen_1	129	137	PF00069	0.702
DOC_PP4_FxxP_1	86	89	PF00568	0.610
DOC_USP7_MATH_1	107	111	PF00917	0.785
DOC_USP7_MATH_1	177	181	PF00917	0.770
DOC_USP7_MATH_1	257	261	PF00917	0.696
DOC_USP7_MATH_1	79	83	PF00917	0.745
LIG_14-3-3_CanoR_1	140	146	PF00244	0.642
LIG_14-3-3_CanoR_1	243	248	PF00244	0.756
LIG_14-3-3_CanoR_1	95	101	PF00244	0.676
LIG_BIR_II_1	1	5	PF00653	0.686
LIG_BRCT_BRCA1_1	122	126	PF00533	0.687
LIG_BRCT_BRCA1_1	289	293	PF00533	0.707
LIG_BRCT_BRCA1_1	82	86	PF00533	0.779
LIG_FHA_1	101	107	PF00498	0.729
LIG_Integrin_RGD_1	182	184	PF01839	0.690
LIG_LIR_Apic_2	260	265	PF02991	0.780
LIG_LIR_Apic_2	83	89	PF02991	0.619
LIG_LIR_Gen_1	150	160	PF02991	0.490
LIG_LIR_Gen_1	285	293	PF02991	0.690
LIG_LIR_Nem_3	150	156	PF02991	0.489
LIG_LIR_Nem_3	2	6	PF02991	0.682
LIG_LIR_Nem_3	209	214	PF02991	0.654
LIG_LIR_Nem_3	226	231	PF02991	0.531
LIG_LIR_Nem_3	285	289	PF02991	0.672
LIG_MLH1_MIPbox_1	122	126	PF16413	0.687
LIG_REV1ctd_RIR_1	123	133	PF16727	0.690
LIG_SH2_CRK	211	215	PF00017	0.612
LIG_SH2_CRK	262	266	PF00017	0.710
LIG_SH2_CRK	286	290	PF00017	0.679
LIG_SH2_CRK	67	71	PF00017	0.597
LIG_SH2_GRB2like	286	289	PF00017	0.689
LIG_SH2_NCK_1	286	290	PF00017	0.654
LIG_SH2_SRC	62	65	PF00017	0.721
LIG_SH2_STAT3	21	24	PF00017	0.700
LIG_SH2_STAT5	21	24	PF00017	0.765
LIG_SH2_STAT5	67	70	PF00017	0.638
LIG_SH3_3	188	194	PF00018	0.629
LIG_SH3_3	249	255	PF00018	0.656
LIG_SH3_3	269	275	PF00018	0.647
LIG_SH3_3	42	48	PF00018	0.790
LIG_TYR_ITSM	207	214	PF00017	0.667
MOD_CK1_1	105	111	PF00069	0.647
MOD_CK1_1	287	293	PF00069	0.695
MOD_CK1_1	52	58	PF00069	0.669
MOD_CK1_1	82	88	PF00069	0.655
MOD_CK1_1	98	104	PF00069	0.712
MOD_CK2_1	289	295	PF00069	0.700
MOD_GlcNHglycan	206	209	PF01048	0.727
MOD_GlcNHglycan	51	54	PF01048	0.719
MOD_GlcNHglycan	89	92	PF01048	0.651
MOD_GSK3_1	287	294	PF00069	0.654
MOD_GSK3_1	75	82	PF00069	0.649
MOD_GSK3_1	96	103	PF00069	0.703
MOD_N-GLC_1	287	292	PF02516	0.700
MOD_NEK2_1	80	85	PF00069	0.694
MOD_NEK2_2	141	146	PF00069	0.690
MOD_PIKK_1	130	136	PF00454	0.700
MOD_PIKK_1	65	71	PF00454	0.751
MOD_PK_1	120	126	PF00069	0.758
MOD_PK_1	96	102	PF00069	0.667
MOD_PKA_1	195	201	PF00069	0.717
MOD_PKA_1	95	101	PF00069	0.715
MOD_PKA_2	108	114	PF00069	0.665
MOD_PKA_2	130	136	PF00069	0.700
MOD_PKA_2	195	201	PF00069	0.717
MOD_Plk_1	19	25	PF00069	0.689
MOD_Plk_2-3	291	297	PF00069	0.779
MOD_Plk_4	120	126	PF00069	0.690
MOD_Plk_4	257	263	PF00069	0.768
MOD_SUMO_rev_2	90	98	PF00179	0.700
TRG_DiLeu_BaEn_4	151	157	PF01217	0.606
TRG_ENDOCYTIC_2	160	163	PF00928	0.579
TRG_ENDOCYTIC_2	211	214	PF00928	0.612
TRG_ENDOCYTIC_2	286	289	PF00928	0.697
TRG_ENDOCYTIC_2	40	43	PF00928	0.713
TRG_ER_diArg_1	170	172	PF00400	0.746
TRG_ER_diArg_1	194	196	PF00400	0.647
TRG_ER_diArg_1	233	236	PF00400	0.637
TRG_NLS_Bipartite_1	200	221	PF00514	0.747
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.673

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYS4	Leptomonas seymouri	54%	98%
A0A1X0NRB6	Trypanosomatidae	30%	100%
A4HM03	Leishmania braziliensis	66%	100%
A4I9D4	Leishmania infantum	100%	100%
E9B4D4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q3P3	Leishmania major	93%	100%