GTP-binding elongation factor tu family protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GTP-binding protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X775_LEIDO

TriTrypDb:

LdBPK_332930.1 , LdCL_330036400 , LDHU3_33.4080

Length:

842

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X775

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X775

Function

Biological processes
Term	Name	Level	Count
GO:0006414	translational elongation	5	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	9
GO:0003746	translation elongation factor activity	4	9
GO:0003824	catalytic activity	1	12
GO:0003924	GTPase activity	7	12
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0008135	translation factor activity, RNA binding	3	9
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0019001	guanyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032561	guanyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0045182	translation regulator activity	1	9
GO:0090079	translation regulator activity, nucleic acid binding	2	9
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	546	550	PF00656	0.431
CLV_C14_Caspase3-7	83	87	PF00656	0.468
CLV_NRD_NRD_1	170	172	PF00675	0.431
CLV_NRD_NRD_1	246	248	PF00675	0.493
CLV_NRD_NRD_1	347	349	PF00675	0.507
CLV_NRD_NRD_1	572	574	PF00675	0.261
CLV_NRD_NRD_1	580	582	PF00675	0.244
CLV_NRD_NRD_1	623	625	PF00675	0.370
CLV_NRD_NRD_1	713	715	PF00675	0.371
CLV_NRD_NRD_1	827	829	PF00675	0.549
CLV_NRD_NRD_1	88	90	PF00675	0.580
CLV_PCSK_KEX2_1	153	155	PF00082	0.563
CLV_PCSK_KEX2_1	246	248	PF00082	0.493
CLV_PCSK_KEX2_1	346	348	PF00082	0.483
CLV_PCSK_KEX2_1	580	582	PF00082	0.271
CLV_PCSK_KEX2_1	709	711	PF00082	0.399
CLV_PCSK_KEX2_1	88	90	PF00082	0.579
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.563
CLV_PCSK_PC1ET2_1	709	711	PF00082	0.412
CLV_PCSK_SKI1_1	117	121	PF00082	0.509
CLV_PCSK_SKI1_1	163	167	PF00082	0.544
CLV_PCSK_SKI1_1	484	488	PF00082	0.243
CLV_PCSK_SKI1_1	496	500	PF00082	0.235
CLV_PCSK_SKI1_1	565	569	PF00082	0.242
CLV_PCSK_SKI1_1	796	800	PF00082	0.298
CLV_Separin_Metazoa	770	774	PF03568	0.431
DEG_SCF_TRCP1_1	250	256	PF00400	0.328
DEG_SCF_TRCP1_1	366	371	PF00400	0.431
DEG_SPOP_SBC_1	329	333	PF00917	0.632
DOC_ANK_TNKS_1	802	809	PF00023	0.442
DOC_CKS1_1	472	477	PF01111	0.529
DOC_CYCLIN_yCln2_LP_2	537	543	PF00134	0.431
DOC_CYCLIN_yCln2_LP_2	835	841	PF00134	0.526
DOC_MAPK_gen_1	525	535	PF00069	0.431
DOC_MAPK_gen_1	580	587	PF00069	0.446
DOC_MAPK_gen_1	714	720	PF00069	0.438
DOC_MAPK_gen_1	800	809	PF00069	0.498
DOC_MAPK_MEF2A_6	528	537	PF00069	0.431
DOC_MAPK_NFAT4_5	528	536	PF00069	0.442
DOC_MAPK_RevD_3	609	625	PF00069	0.501
DOC_PP1_RVXF_1	794	800	PF00149	0.535
DOC_PP2B_LxvP_1	537	540	PF13499	0.431
DOC_PP2B_LxvP_1	567	570	PF13499	0.431
DOC_PP2B_LxvP_1	835	838	PF13499	0.518
DOC_USP7_MATH_1	113	117	PF00917	0.630
DOC_USP7_MATH_1	211	215	PF00917	0.634
DOC_USP7_MATH_1	248	252	PF00917	0.333
DOC_USP7_MATH_1	308	312	PF00917	0.628
DOC_USP7_MATH_1	328	332	PF00917	0.740
DOC_USP7_MATH_1	457	461	PF00917	0.509
DOC_USP7_MATH_1	462	466	PF00917	0.475
DOC_USP7_MATH_1	479	483	PF00917	0.462
DOC_USP7_MATH_1	550	554	PF00917	0.407
DOC_USP7_UBL2_3	826	830	PF12436	0.582
DOC_WW_Pin1_4	207	212	PF00397	0.774
DOC_WW_Pin1_4	220	225	PF00397	0.761
DOC_WW_Pin1_4	322	327	PF00397	0.797
DOC_WW_Pin1_4	330	335	PF00397	0.661
DOC_WW_Pin1_4	471	476	PF00397	0.529
DOC_WW_Pin1_4	548	553	PF00397	0.431
DOC_WW_Pin1_4	61	66	PF00397	0.710
LIG_14-3-3_CanoR_1	403	408	PF00244	0.472
LIG_14-3-3_CanoR_1	496	505	PF00244	0.456
LIG_14-3-3_CanoR_1	759	767	PF00244	0.431
LIG_Actin_WH2_2	484	501	PF00022	0.431
LIG_Actin_WH2_2	760	775	PF00022	0.431
LIG_APCC_ABBA_1	105	110	PF00400	0.384
LIG_BIR_II_1	1	5	PF00653	0.545
LIG_BIR_III_2	549	553	PF00653	0.518
LIG_BRCT_BRCA1_1	640	644	PF00533	0.373
LIG_EVH1_2	725	729	PF00568	0.330
LIG_FHA_1	154	160	PF00498	0.589
LIG_FHA_1	254	260	PF00498	0.435
LIG_FHA_1	333	339	PF00498	0.590
LIG_FHA_1	371	377	PF00498	0.436
LIG_FHA_1	402	408	PF00498	0.431
LIG_FHA_1	42	48	PF00498	0.562
LIG_FHA_1	498	504	PF00498	0.435
LIG_FHA_1	64	70	PF00498	0.613
LIG_FHA_1	640	646	PF00498	0.360
LIG_FHA_1	655	661	PF00498	0.272
LIG_FHA_1	664	670	PF00498	0.312
LIG_FHA_1	802	808	PF00498	0.431
LIG_FHA_1	809	815	PF00498	0.431
LIG_FHA_2	429	435	PF00498	0.552
LIG_FHA_2	472	478	PF00498	0.483
LIG_FHA_2	485	491	PF00498	0.425
LIG_FHA_2	544	550	PF00498	0.440
LIG_FHA_2	621	627	PF00498	0.417
LIG_GBD_Chelix_1	166	174	PF00786	0.473
LIG_GBD_Chelix_1	531	539	PF00786	0.335
LIG_LIR_Gen_1	511	519	PF02991	0.431
LIG_LIR_Nem_3	255	260	PF02991	0.372
LIG_LIR_Nem_3	511	515	PF02991	0.432
LIG_LIR_Nem_3	672	677	PF02991	0.385
LIG_LIR_Nem_3	728	732	PF02991	0.445
LIG_LIR_Nem_3	746	752	PF02991	0.474
LIG_MLH1_MIPbox_1	640	644	PF16413	0.373
LIG_PCNA_yPIPBox_3	92	104	PF02747	0.449
LIG_Rb_pABgroove_1	483	491	PF01858	0.431
LIG_SH2_CRK	423	427	PF00017	0.498
LIG_SH2_CRK	512	516	PF00017	0.431
LIG_SH2_CRK	594	598	PF00017	0.477
LIG_SH2_NCK_1	196	200	PF00017	0.580
LIG_SH2_NCK_1	489	493	PF00017	0.431
LIG_SH2_NCK_1	594	598	PF00017	0.477
LIG_SH2_SRC	196	199	PF00017	0.629
LIG_SH2_SRC	749	752	PF00017	0.431
LIG_SH2_STAP1	512	516	PF00017	0.431
LIG_SH2_STAP1	594	598	PF00017	0.392
LIG_SH2_STAT3	14	17	PF00017	0.376
LIG_SH2_STAT3	766	769	PF00017	0.456
LIG_SH2_STAT5	423	426	PF00017	0.400
LIG_SH2_STAT5	497	500	PF00017	0.452
LIG_SH2_STAT5	766	769	PF00017	0.456
LIG_SH3_3	321	327	PF00018	0.637
LIG_SH3_3	434	440	PF00018	0.535
LIG_SUMO_SIM_anti_2	141	147	PF11976	0.575
LIG_SUMO_SIM_anti_2	735	740	PF11976	0.431
LIG_SUMO_SIM_par_1	482	490	PF11976	0.443
LIG_SUMO_SIM_par_1	678	684	PF11976	0.472
LIG_TRAF2_1	80	83	PF00917	0.448
LIG_TRAF2_2	48	53	PF00917	0.499
LIG_TYR_ITIM	421	426	PF00017	0.411
LIG_TYR_ITIM	592	597	PF00017	0.330
LIG_UBA3_1	566	574	PF00899	0.303
MOD_CDK_SPK_2	471	476	PF00069	0.309
MOD_CK1_1	219	225	PF00069	0.689
MOD_CK1_1	332	338	PF00069	0.668
MOD_CK1_1	367	373	PF00069	0.280
MOD_CK1_1	374	380	PF00069	0.266
MOD_CK1_1	405	411	PF00069	0.266
MOD_CK1_1	455	461	PF00069	0.489
MOD_CK1_1	59	65	PF00069	0.693
MOD_CK1_1	604	610	PF00069	0.266
MOD_CK2_1	231	237	PF00069	0.693
MOD_CK2_1	403	409	PF00069	0.266
MOD_CK2_1	428	434	PF00069	0.408
MOD_CK2_1	471	477	PF00069	0.479
MOD_CK2_1	88	94	PF00069	0.520
MOD_Cter_Amidation	86	89	PF01082	0.662
MOD_GlcNHglycan	176	179	PF01048	0.581
MOD_GlcNHglycan	2	5	PF01048	0.616
MOD_GlcNHglycan	250	253	PF01048	0.393
MOD_GlcNHglycan	305	308	PF01048	0.578
MOD_GlcNHglycan	310	313	PF01048	0.581
MOD_GlcNHglycan	366	369	PF01048	0.277
MOD_GlcNHglycan	414	417	PF01048	0.419
MOD_GlcNHglycan	449	452	PF01048	0.365
MOD_GlcNHglycan	454	457	PF01048	0.351
MOD_GlcNHglycan	459	462	PF01048	0.293
MOD_GlcNHglycan	464	467	PF01048	0.221
MOD_GlcNHglycan	517	520	PF01048	0.266
MOD_GlcNHglycan	58	61	PF01048	0.644
MOD_GlcNHglycan	760	763	PF01048	0.270
MOD_GSK3_1	207	214	PF00069	0.626
MOD_GSK3_1	216	223	PF00069	0.649
MOD_GSK3_1	231	238	PF00069	0.511
MOD_GSK3_1	318	325	PF00069	0.726
MOD_GSK3_1	328	335	PF00069	0.715
MOD_GSK3_1	364	371	PF00069	0.306
MOD_GSK3_1	398	405	PF00069	0.286
MOD_GSK3_1	462	469	PF00069	0.337
MOD_GSK3_1	480	487	PF00069	0.254
MOD_GSK3_1	59	66	PF00069	0.637
MOD_GSK3_1	639	646	PF00069	0.402
MOD_GSK3_1	739	746	PF00069	0.325
MOD_GSK3_1	754	761	PF00069	0.197
MOD_GSK3_1	771	778	PF00069	0.266
MOD_N-GLC_1	199	204	PF02516	0.729
MOD_N-GLC_1	316	321	PF02516	0.658
MOD_N-GLC_1	421	426	PF02516	0.279
MOD_N-GLC_1	604	609	PF02516	0.281
MOD_N-GLC_1	663	668	PF02516	0.425
MOD_NEK2_1	166	171	PF00069	0.421
MOD_NEK2_1	174	179	PF00069	0.454
MOD_NEK2_1	498	503	PF00069	0.280
MOD_NEK2_1	601	606	PF00069	0.281
MOD_NEK2_1	643	648	PF00069	0.432
MOD_NEK2_1	73	78	PF00069	0.575
MOD_NEK2_1	739	744	PF00069	0.281
MOD_NEK2_2	466	471	PF00069	0.287
MOD_PIKK_1	63	69	PF00454	0.570
MOD_PIKK_1	654	660	PF00454	0.302
MOD_PK_1	403	409	PF00069	0.284
MOD_PK_1	709	715	PF00069	0.495
MOD_PKA_1	153	159	PF00069	0.542
MOD_PKA_1	709	715	PF00069	0.412
MOD_PKA_1	88	94	PF00069	0.571
MOD_PKA_2	153	159	PF00069	0.423
MOD_PKA_2	402	408	PF00069	0.266
MOD_PKA_2	480	486	PF00069	0.388
MOD_PKA_2	524	530	PF00069	0.266
MOD_PKA_2	709	715	PF00069	0.452
MOD_PKA_2	758	764	PF00069	0.266
MOD_PKA_2	87	93	PF00069	0.578
MOD_Plk_1	238	244	PF00069	0.519
MOD_Plk_1	421	427	PF00069	0.314
MOD_Plk_1	556	562	PF00069	0.374
MOD_Plk_1	583	589	PF00069	0.364
MOD_Plk_1	639	645	PF00069	0.351
MOD_Plk_1	663	669	PF00069	0.420
MOD_Plk_1	775	781	PF00069	0.266
MOD_Plk_4	155	161	PF00069	0.564
MOD_Plk_4	202	208	PF00069	0.521
MOD_Plk_4	253	259	PF00069	0.440
MOD_Plk_4	334	340	PF00069	0.595
MOD_Plk_4	371	377	PF00069	0.290
MOD_Plk_4	421	427	PF00069	0.376
MOD_Plk_4	484	490	PF00069	0.276
MOD_Plk_4	498	504	PF00069	0.242
MOD_Plk_4	639	645	PF00069	0.370
MOD_Plk_4	647	653	PF00069	0.342
MOD_Plk_4	663	669	PF00069	0.341
MOD_Plk_4	725	731	PF00069	0.315
MOD_ProDKin_1	207	213	PF00069	0.774
MOD_ProDKin_1	220	226	PF00069	0.760
MOD_ProDKin_1	322	328	PF00069	0.797
MOD_ProDKin_1	330	336	PF00069	0.645
MOD_ProDKin_1	471	477	PF00069	0.403
MOD_ProDKin_1	548	554	PF00069	0.266
MOD_ProDKin_1	61	67	PF00069	0.705
MOD_SUMO_for_1	35	38	PF00179	0.460
MOD_SUMO_for_1	705	708	PF00179	0.389
TRG_DiLeu_BaEn_1	255	260	PF01217	0.431
TRG_DiLeu_BaEn_1	793	798	PF01217	0.331
TRG_DiLeu_BaEn_1	816	821	PF01217	0.500
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.610
TRG_DiLeu_LyEn_5	793	798	PF01217	0.331
TRG_ENDOCYTIC_2	423	426	PF00928	0.360
TRG_ENDOCYTIC_2	512	515	PF00928	0.266
TRG_ENDOCYTIC_2	594	597	PF00928	0.330
TRG_ENDOCYTIC_2	749	752	PF00928	0.411
TRG_ER_diArg_1	245	247	PF00400	0.488
TRG_ER_diArg_1	345	348	PF00400	0.497
TRG_ER_diArg_1	579	581	PF00400	0.322
TRG_NLS_Bipartite_1	153	175	PF00514	0.461
TRG_NLS_MonoExtC_3	827	833	PF00514	0.500
TRG_NLS_MonoExtN_4	826	832	PF00514	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4K5	Leptomonas seymouri	69%	100%
A0A0S4JM58	Bodo saltans	52%	100%
A0A1X0NRK6	Trypanosomatidae	47%	97%
A0A3R7MHD3	Trypanosoma rangeli	50%	100%
A4HLZ0	Leishmania braziliensis	84%	100%
A4I9C0	Leishmania infantum	100%	100%
C9ZJA2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9B4B9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	99%
Q4Q3Q6	Leishmania major	93%	100%
V5BF52	Trypanosoma cruzi	50%	99%