Cysteine peptidase, Clan CA, family C51, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cysteine peptidase, Clan CA, family C51, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X774_LEIDO

TriTrypDb:

LdBPK_333000.1 , LdCL_330037100 , LDHU3_33.4180

Length:

404

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	2

Expansion

Sequence features

A0A3S7X774

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X774

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016874	ligase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	209	213	PF00656	0.433
CLV_C14_Caspase3-7	265	269	PF00656	0.316
CLV_C14_Caspase3-7	329	333	PF00656	0.446
CLV_NRD_NRD_1	234	236	PF00675	0.462
CLV_NRD_NRD_1	69	71	PF00675	0.491
CLV_NRD_NRD_1	98	100	PF00675	0.473
CLV_PCSK_KEX2_1	234	236	PF00082	0.462
CLV_PCSK_KEX2_1	97	99	PF00082	0.475
CLV_PCSK_SKI1_1	208	212	PF00082	0.596
CLV_PCSK_SKI1_1	219	223	PF00082	0.522
DEG_APCC_DBOX_1	342	350	PF00400	0.304
DEG_Nend_UBRbox_1	1	4	PF02207	0.619
DEG_SPOP_SBC_1	140	144	PF00917	0.451
DEG_SPOP_SBC_1	334	338	PF00917	0.375
DEG_SPOP_SBC_1	49	53	PF00917	0.660
DOC_CKS1_1	145	150	PF01111	0.418
DOC_CYCLIN_RxL_1	364	376	PF00134	0.323
DOC_MAPK_gen_1	104	113	PF00069	0.458
DOC_MAPK_gen_1	341	349	PF00069	0.349
DOC_MAPK_MEF2A_6	104	113	PF00069	0.515
DOC_MAPK_MEF2A_6	196	203	PF00069	0.303
DOC_MAPK_MEF2A_6	368	375	PF00069	0.323
DOC_PP2B_LxvP_1	211	214	PF13499	0.433
DOC_PP2B_PxIxI_1	108	114	PF00149	0.325
DOC_PP4_FxxP_1	19	22	PF00568	0.627
DOC_PP4_FxxP_1	247	250	PF00568	0.214
DOC_USP7_MATH_1	22	26	PF00917	0.644
DOC_USP7_MATH_1	326	330	PF00917	0.437
DOC_USP7_MATH_1	334	338	PF00917	0.373
DOC_USP7_MATH_1	49	53	PF00917	0.652
DOC_USP7_MATH_1	56	60	PF00917	0.661
DOC_WW_Pin1_4	105	110	PF00397	0.614
DOC_WW_Pin1_4	144	149	PF00397	0.431
DOC_WW_Pin1_4	241	246	PF00397	0.270
LIG_14-3-3_CanoR_1	219	227	PF00244	0.356
LIG_Actin_WH2_2	120	137	PF00022	0.491
LIG_BIR_III_4	302	306	PF00653	0.214
LIG_Clathr_ClatBox_1	372	376	PF01394	0.314
LIG_deltaCOP1_diTrp_1	351	359	PF00928	0.337
LIG_FHA_1	118	124	PF00498	0.336
LIG_FHA_1	140	146	PF00498	0.517
LIG_FHA_1	190	196	PF00498	0.285
LIG_FHA_1	215	221	PF00498	0.429
LIG_FHA_1	270	276	PF00498	0.289
LIG_FHA_2	141	147	PF00498	0.451
LIG_FHA_2	207	213	PF00498	0.435
LIG_FHA_2	263	269	PF00498	0.316
LIG_FHA_2	320	326	PF00498	0.397
LIG_FHA_2	384	390	PF00498	0.324
LIG_FHA_2	91	97	PF00498	0.612
LIG_HP1_1	371	375	PF01393	0.321
LIG_IBAR_NPY_1	361	363	PF08397	0.340
LIG_LIR_Apic_2	244	250	PF02991	0.232
LIG_LIR_Apic_2	356	362	PF02991	0.399
LIG_LIR_Gen_1	256	266	PF02991	0.299
LIG_LIR_Gen_1	7	16	PF02991	0.592
LIG_LIR_LC3C_4	120	125	PF02991	0.325
LIG_LIR_LC3C_4	369	374	PF02991	0.322
LIG_LIR_Nem_3	168	173	PF02991	0.342
LIG_LIR_Nem_3	256	261	PF02991	0.280
LIG_LIR_Nem_3	304	309	PF02991	0.215
LIG_LIR_Nem_3	7	13	PF02991	0.620
LIG_NRBOX	111	117	PF00104	0.360
LIG_Pex14_1	359	363	PF04695	0.328
LIG_Pex14_2	10	14	PF04695	0.595
LIG_SH2_GRB2like	183	186	PF00017	0.384
LIG_SH2_GRB2like	363	366	PF00017	0.337
LIG_SH2_STAP1	366	370	PF00017	0.340
LIG_SH2_STAP1	84	88	PF00017	0.634
LIG_SH2_STAT5	160	163	PF00017	0.401
LIG_SH2_STAT5	348	351	PF00017	0.392
LIG_SH2_STAT5	385	388	PF00017	0.363
LIG_SH3_3	142	148	PF00018	0.446
LIG_SH3_3	199	205	PF00018	0.398
LIG_SUMO_SIM_anti_2	120	125	PF11976	0.229
LIG_SUMO_SIM_par_1	369	377	PF11976	0.322
LIG_TRAF2_1	92	95	PF00917	0.586
LIG_TYR_ITIM	124	129	PF00017	0.462
MOD_CK1_1	144	150	PF00069	0.435
MOD_CK1_1	47	53	PF00069	0.727
MOD_CK1_1	73	79	PF00069	0.636
MOD_CK2_1	140	146	PF00069	0.555
MOD_CK2_1	319	325	PF00069	0.367
MOD_CK2_1	90	96	PF00069	0.601
MOD_GlcNHglycan	288	291	PF01048	0.454
MOD_GlcNHglycan	29	32	PF01048	0.485
MOD_GlcNHglycan	355	358	PF01048	0.504
MOD_GlcNHglycan	376	379	PF01048	0.543
MOD_GlcNHglycan	47	50	PF01048	0.464
MOD_GlcNHglycan	52	55	PF01048	0.472
MOD_GlcNHglycan	72	75	PF01048	0.362
MOD_GSK3_1	140	147	PF00069	0.504
MOD_GSK3_1	181	188	PF00069	0.353
MOD_GSK3_1	215	222	PF00069	0.374
MOD_GSK3_1	383	390	PF00069	0.408
MOD_GSK3_1	40	47	PF00069	0.673
MOD_GSK3_1	5	12	PF00069	0.790
MOD_N-GLC_1	268	273	PF02516	0.510
MOD_N-GLC_1	364	369	PF02516	0.546
MOD_NEK2_1	181	186	PF00069	0.363
MOD_NEK2_1	220	225	PF00069	0.304
MOD_NEK2_1	45	50	PF00069	0.650
MOD_OFUCOSY	186	191	PF10250	0.531
MOD_PIKK_1	147	153	PF00454	0.403
MOD_PKA_1	70	76	PF00069	0.661
MOD_PKA_2	45	51	PF00069	0.612
MOD_PKB_1	68	76	PF00069	0.645
MOD_Plk_1	129	135	PF00069	0.414
MOD_Plk_1	140	146	PF00069	0.380
MOD_Plk_1	326	332	PF00069	0.452
MOD_Plk_1	387	393	PF00069	0.393
MOD_Plk_2-3	141	147	PF00069	0.407
MOD_Plk_4	107	113	PF00069	0.541
MOD_Plk_4	190	196	PF00069	0.380
MOD_Plk_4	262	268	PF00069	0.319
MOD_Plk_4	326	332	PF00069	0.404
MOD_Plk_4	40	46	PF00069	0.666
MOD_Plk_4	5	11	PF00069	0.623
MOD_Plk_4	56	62	PF00069	0.613
MOD_ProDKin_1	105	111	PF00069	0.483
MOD_ProDKin_1	144	150	PF00069	0.422
MOD_ProDKin_1	241	247	PF00069	0.270
TRG_DiLeu_BaLyEn_6	271	276	PF01217	0.275
TRG_ENDOCYTIC_2	126	129	PF00928	0.386
TRG_ENDOCYTIC_2	16	19	PF00928	0.625
TRG_ENDOCYTIC_2	236	239	PF00928	0.274
TRG_ENDOCYTIC_2	309	312	PF00928	0.248
TRG_ER_diArg_1	103	106	PF00400	0.712
TRG_ER_diArg_1	133	136	PF00400	0.397
TRG_ER_diArg_1	23	26	PF00400	0.719
TRG_ER_diArg_1	234	236	PF00400	0.264
TRG_ER_diArg_1	340	343	PF00400	0.443
TRG_ER_diArg_1	67	70	PF00400	0.649
TRG_ER_diArg_1	97	99	PF00400	0.685

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB04	Leptomonas seymouri	59%	100%
A0A1X0NR96	Trypanosomatidae	43%	100%
A0A3S7WZA9	Leishmania donovani	27%	100%
A4HLZ4	Leishmania braziliensis	38%	100%
A4HLZ6	Leishmania braziliensis	68%	100%
A4I1M7	Leishmania infantum	27%	100%
A4I9C6	Leishmania infantum	100%	100%
C9ZJ94	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AXR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B4C6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q3Q0	Leishmania major	86%	100%
Q4Q9R0	Leishmania major	28%	100%