Cysteine peptidase, Clan CA, family C51, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cysteine peptidase, Clan CA, family C51, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X769_LEIDO

TriTrypDb:

LdBPK_332970.1 , LdCL_330036800 , LDHU3_33.4120

Length:

236

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 29
NetGPI	no	yes: 0, no: 30

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	21
GO:0110165	cellular anatomical entity	1	22
GO:0005737	cytoplasm	2	2

Expansion

Sequence features

A0A3S7X769

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X769

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016874	ligase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	207	209	PF00675	0.530
CLV_NRD_NRD_1	95	97	PF00675	0.426
CLV_PCSK_KEX2_1	207	209	PF00082	0.561
CLV_PCSK_KEX2_1	95	97	PF00082	0.422
DEG_Nend_Nbox_1	1	3	PF02207	0.445
DEG_SCF_FBW7_1	28	35	PF00400	0.608
DOC_PP1_RVXF_1	226	233	PF00149	0.356
DOC_PP2B_LxvP_1	149	152	PF13499	0.190
DOC_PP2B_LxvP_1	63	66	PF13499	0.449
DOC_USP7_MATH_1	144	148	PF00917	0.230
DOC_WW_Pin1_4	100	105	PF00397	0.233
DOC_WW_Pin1_4	28	33	PF00397	0.603
LIG_APCC_ABBA_1	209	214	PF00400	0.362
LIG_APCC_ABBAyCdc20_2	208	214	PF00400	0.361
LIG_BRCT_BRCA1_1	78	82	PF00533	0.448
LIG_deltaCOP1_diTrp_1	117	123	PF00928	0.248
LIG_deltaCOP1_diTrp_1	190	198	PF00928	0.413
LIG_FHA_1	144	150	PF00498	0.298
LIG_FHA_1	215	221	PF00498	0.507
LIG_FHA_1	70	76	PF00498	0.660
LIG_FHA_2	219	225	PF00498	0.525
LIG_FHA_2	62	68	PF00498	0.407
LIG_LIR_Gen_1	122	127	PF02991	0.258
LIG_LIR_Gen_1	31	40	PF02991	0.379
LIG_LIR_Gen_1	57	68	PF02991	0.515
LIG_LIR_Nem_3	122	126	PF02991	0.267
LIG_LIR_Nem_3	200	205	PF02991	0.571
LIG_LIR_Nem_3	31	36	PF02991	0.497
LIG_LIR_Nem_3	57	63	PF02991	0.589
LIG_Pex14_1	119	123	PF04695	0.298
LIG_Pex14_1	198	202	PF04695	0.431
LIG_Pex14_2	40	44	PF04695	0.411
LIG_PTB_Apo_2	117	124	PF02174	0.204
LIG_PTB_Apo_2	38	45	PF02174	0.495
LIG_SH2_CRK	213	217	PF00017	0.530
LIG_SH2_CRK	3	7	PF00017	0.558
LIG_SH2_CRK	83	87	PF00017	0.273
LIG_SH2_GRB2like	202	205	PF00017	0.458
LIG_SH2_GRB2like	46	49	PF00017	0.560
LIG_SH2_GRB2like	60	63	PF00017	0.489
LIG_SH2_PTP2	60	63	PF00017	0.722
LIG_SH2_STAP1	205	209	PF00017	0.464
LIG_SH2_STAP1	93	97	PF00017	0.196
LIG_SH2_STAT3	160	163	PF00017	0.226
LIG_SH2_STAT3	97	100	PF00017	0.337
LIG_SH2_STAT5	108	111	PF00017	0.295
LIG_SH2_STAT5	187	190	PF00017	0.296
LIG_SH2_STAT5	53	56	PF00017	0.601
LIG_SH2_STAT5	60	63	PF00017	0.653
LIG_SH2_STAT5	77	80	PF00017	0.592
LIG_SH2_STAT5	83	86	PF00017	0.285
LIG_SH3_3	22	28	PF00018	0.671
LIG_SUMO_SIM_par_1	217	224	PF11976	0.646
LIG_TYR_ITIM	211	216	PF00017	0.588
LIG_TYR_ITIM	58	63	PF00017	0.694
MOD_CK1_1	128	134	PF00069	0.344
MOD_CK1_1	19	25	PF00069	0.712
MOD_CK1_1	218	224	PF00069	0.438
MOD_CK1_1	52	58	PF00069	0.540
MOD_CK2_1	61	67	PF00069	0.416
MOD_GlcNHglycan	100	103	PF01048	0.526
MOD_GlcNHglycan	18	21	PF01048	0.663
MOD_GlcNHglycan	199	202	PF01048	0.421
MOD_GSK3_1	12	19	PF00069	0.628
MOD_GSK3_1	174	181	PF00069	0.290
MOD_GSK3_1	214	221	PF00069	0.513
MOD_GSK3_1	28	35	PF00069	0.552
MOD_GSK3_1	49	56	PF00069	0.575
MOD_GSK3_1	69	76	PF00069	0.629
MOD_N-GLC_1	10	15	PF02516	0.648
MOD_N-GLC_1	119	124	PF02516	0.538
MOD_N-GLC_1	128	133	PF02516	0.393
MOD_N-GLC_1	203	208	PF02516	0.462
MOD_N-GLC_1	49	54	PF02516	0.548
MOD_N-GLC_1	61	66	PF02516	0.464
MOD_N-GLC_1	69	74	PF02516	0.663
MOD_NEK2_1	1	6	PF00069	0.621
MOD_NEK2_1	127	132	PF00069	0.259
MOD_NEK2_1	215	220	PF00069	0.518
MOD_NEK2_1	44	49	PF00069	0.518
MOD_Plk_1	119	125	PF00069	0.325
MOD_Plk_1	128	134	PF00069	0.309
MOD_Plk_1	49	55	PF00069	0.645
MOD_Plk_1	61	67	PF00069	0.464
MOD_Plk_4	119	125	PF00069	0.310
MOD_Plk_4	32	38	PF00069	0.463
MOD_Plk_4	49	55	PF00069	0.673
MOD_Plk_4	73	79	PF00069	0.590
MOD_ProDKin_1	100	106	PF00069	0.233
MOD_ProDKin_1	28	34	PF00069	0.602
TRG_DiLeu_BaLyEn_6	122	127	PF01217	0.309
TRG_ENDOCYTIC_2	169	172	PF00928	0.262
TRG_ENDOCYTIC_2	212	215	PF00928	0.538
TRG_ENDOCYTIC_2	3	6	PF00928	0.561
TRG_ENDOCYTIC_2	60	63	PF00928	0.624
TRG_ENDOCYTIC_2	83	86	PF00928	0.270
TRG_ER_diArg_1	207	209	PF00400	0.559
TRG_ER_diArg_1	95	97	PF00400	0.224

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I309	Leptomonas seymouri	28%	79%
A0A0N1PB04	Leptomonas seymouri	40%	66%
A0A0S4IP47	Bodo saltans	28%	69%
A0A0S4ITA7	Bodo saltans	39%	76%
A0A0S4IVA9	Bodo saltans	31%	78%
A0A1X0NR96	Trypanosomatidae	49%	83%
A0A1X0NR98	Trypanosomatidae	47%	80%
A0A1X0NRB4	Trypanosomatidae	32%	69%
A0A1X0NY88	Trypanosomatidae	24%	84%
A0A1X0NYK9	Trypanosomatidae	25%	80%
A0A3R7KMG1	Trypanosoma rangeli	23%	72%
A0A3R7LYQ4	Trypanosoma rangeli	43%	76%
A0A3S5IRC8	Trypanosoma rangeli	44%	84%
A0A3S7WZA9	Leishmania donovani	27%	100%
A0A422NKH5	Trypanosoma rangeli	31%	72%
A4HEJ1	Leishmania braziliensis	27%	100%
A4HLZ4	Leishmania braziliensis	64%	100%
A4I1M7	Leishmania infantum	27%	100%
C9ZJ94	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	86%
C9ZJ95	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	84%
C9ZK72	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	82%
D0A867	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	86%
E9AXR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B4C3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q3Q2	Leishmania major	83%	98%
Q4Q9R0	Leishmania major	27%	100%
V5BF57	Trypanosoma cruzi	30%	72%
V5DB66	Trypanosoma cruzi	41%	76%
V5DIU8	Trypanosoma cruzi	27%	80%