J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X763_LEIDO

TriTrypDb:

LdBPK_333170.1 , LdCL_330039000 , LDHU3_33.4630

Length:

1052

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X763

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X763

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.729
CLV_C14_Caspase3-7	139	143	PF00656	0.657
CLV_C14_Caspase3-7	380	384	PF00656	0.648
CLV_C14_Caspase3-7	451	455	PF00656	0.442
CLV_C14_Caspase3-7	704	708	PF00656	0.542
CLV_NRD_NRD_1	1020	1022	PF00675	0.479
CLV_NRD_NRD_1	148	150	PF00675	0.719
CLV_NRD_NRD_1	400	402	PF00675	0.600
CLV_NRD_NRD_1	41	43	PF00675	0.569
CLV_NRD_NRD_1	435	437	PF00675	0.530
CLV_NRD_NRD_1	445	447	PF00675	0.535
CLV_NRD_NRD_1	456	458	PF00675	0.506
CLV_NRD_NRD_1	477	479	PF00675	0.574
CLV_NRD_NRD_1	502	504	PF00675	0.694
CLV_NRD_NRD_1	526	528	PF00675	0.628
CLV_NRD_NRD_1	55	57	PF00675	0.570
CLV_NRD_NRD_1	586	588	PF00675	0.652
CLV_NRD_NRD_1	956	958	PF00675	0.492
CLV_PCSK_FUR_1	524	528	PF00082	0.611
CLV_PCSK_FUR_1	969	973	PF00082	0.332
CLV_PCSK_KEX2_1	1020	1022	PF00082	0.468
CLV_PCSK_KEX2_1	148	150	PF00082	0.719
CLV_PCSK_KEX2_1	400	402	PF00082	0.600
CLV_PCSK_KEX2_1	41	43	PF00082	0.569
CLV_PCSK_KEX2_1	434	436	PF00082	0.526
CLV_PCSK_KEX2_1	458	460	PF00082	0.595
CLV_PCSK_KEX2_1	476	478	PF00082	0.554
CLV_PCSK_KEX2_1	483	485	PF00082	0.457
CLV_PCSK_KEX2_1	526	528	PF00082	0.628
CLV_PCSK_KEX2_1	55	57	PF00082	0.570
CLV_PCSK_KEX2_1	971	973	PF00082	0.358
CLV_PCSK_KEX2_1	994	996	PF00082	0.396
CLV_PCSK_PC1ET2_1	458	460	PF00082	0.571
CLV_PCSK_PC1ET2_1	476	478	PF00082	0.554
CLV_PCSK_PC1ET2_1	483	485	PF00082	0.457
CLV_PCSK_PC1ET2_1	971	973	PF00082	0.343
CLV_PCSK_PC1ET2_1	994	996	PF00082	0.396
CLV_PCSK_PC7_1	396	402	PF00082	0.599
CLV_PCSK_PC7_1	472	478	PF00082	0.520
CLV_PCSK_PC7_1	522	528	PF00082	0.634
CLV_PCSK_SKI1_1	256	260	PF00082	0.589
CLV_PCSK_SKI1_1	447	451	PF00082	0.556
CLV_PCSK_SKI1_1	786	790	PF00082	0.411
CLV_PCSK_SKI1_1	818	822	PF00082	0.394
CLV_PCSK_SKI1_1	971	975	PF00082	0.330
CLV_PCSK_SKI1_1	995	999	PF00082	0.408
DEG_APCC_DBOX_1	40	48	PF00400	0.583
DEG_SPOP_SBC_1	211	215	PF00917	0.696
DEG_SPOP_SBC_1	328	332	PF00917	0.674
DEG_SPOP_SBC_1	862	866	PF00917	0.490
DOC_CDC14_PxL_1	263	271	PF14671	0.647
DOC_CYCLIN_RxL_1	691	704	PF00134	0.508
DOC_CYCLIN_RxL_1	783	793	PF00134	0.393
DOC_MAPK_gen_1	969	976	PF00069	0.321
DOC_MAPK_gen_1	994	1002	PF00069	0.475
DOC_PP4_FxxP_1	773	776	PF00568	0.389
DOC_USP7_MATH_1	147	151	PF00917	0.610
DOC_USP7_MATH_1	185	189	PF00917	0.667
DOC_USP7_MATH_1	211	215	PF00917	0.668
DOC_USP7_MATH_1	327	331	PF00917	0.673
DOC_USP7_MATH_1	356	360	PF00917	0.610
DOC_USP7_MATH_1	620	624	PF00917	0.718
DOC_USP7_MATH_1	647	651	PF00917	0.692
DOC_USP7_MATH_1	667	671	PF00917	0.541
DOC_USP7_MATH_1	684	688	PF00917	0.600
DOC_USP7_MATH_1	752	756	PF00917	0.447
DOC_USP7_MATH_1	826	830	PF00917	0.427
DOC_USP7_MATH_1	83	87	PF00917	0.690
DOC_USP7_MATH_1	918	922	PF00917	0.418
DOC_USP7_MATH_1	94	98	PF00917	0.587
DOC_USP7_UBL2_3	159	163	PF12436	0.683
DOC_USP7_UBL2_3	814	818	PF12436	0.466
DOC_USP7_UBL2_3	994	998	PF12436	0.397
DOC_WW_Pin1_4	162	167	PF00397	0.647
DOC_WW_Pin1_4	221	226	PF00397	0.643
DOC_WW_Pin1_4	283	288	PF00397	0.632
DOC_WW_Pin1_4	306	311	PF00397	0.682
DOC_WW_Pin1_4	598	603	PF00397	0.689
DOC_WW_Pin1_4	608	613	PF00397	0.588
DOC_WW_Pin1_4	625	630	PF00397	0.650
DOC_WW_Pin1_4	658	663	PF00397	0.710
DOC_WW_Pin1_4	772	777	PF00397	0.423
DOC_WW_Pin1_4	835	840	PF00397	0.415
LIG_14-3-3_CanoR_1	362	367	PF00244	0.618
LIG_14-3-3_CanoR_1	46	53	PF00244	0.575
LIG_14-3-3_CanoR_1	587	591	PF00244	0.694
LIG_14-3-3_CanoR_1	596	602	PF00244	0.645
LIG_14-3-3_CanoR_1	606	612	PF00244	0.551
LIG_14-3-3_CanoR_1	619	629	PF00244	0.613
LIG_14-3-3_CanoR_1	783	789	PF00244	0.380
LIG_14-3-3_CanoR_1	869	876	PF00244	0.494
LIG_Actin_WH2_2	692	708	PF00022	0.461
LIG_Actin_WH2_2	973	991	PF00022	0.384
LIG_BRCT_BRCA1_1	53	57	PF00533	0.564
LIG_BRCT_BRCA1_1	62	66	PF00533	0.513
LIG_Clathr_ClatBox_1	699	703	PF01394	0.468
LIG_deltaCOP1_diTrp_1	58	66	PF00928	0.547
LIG_FHA_1	253	259	PF00498	0.658
LIG_FHA_1	287	293	PF00498	0.648
LIG_FHA_1	587	593	PF00498	0.590
LIG_FHA_1	696	702	PF00498	0.394
LIG_FHA_1	723	729	PF00498	0.451
LIG_FHA_1	862	868	PF00498	0.471
LIG_FHA_1	878	884	PF00498	0.295
LIG_FHA_2	26	32	PF00498	0.533
LIG_FHA_2	449	455	PF00498	0.531
LIG_FHA_2	508	514	PF00498	0.530
LIG_FHA_2	553	559	PF00498	0.637
LIG_FHA_2	609	615	PF00498	0.673
LIG_FHA_2	731	737	PF00498	0.461
LIG_FHA_2	820	826	PF00498	0.540
LIG_FHA_2	909	915	PF00498	0.493
LIG_FHA_2	924	930	PF00498	0.347
LIG_LIR_Apic_2	14	19	PF02991	0.603
LIG_LIR_Gen_1	775	785	PF02991	0.361
LIG_LIR_Gen_1	827	837	PF02991	0.442
LIG_LIR_Gen_1	849	858	PF02991	0.571
LIG_LIR_Gen_1	929	938	PF02991	0.381
LIG_LIR_LC3C_4	905	909	PF02991	0.433
LIG_LIR_Nem_3	1036	1041	PF02991	0.379
LIG_LIR_Nem_3	58	64	PF02991	0.523
LIG_LIR_Nem_3	775	781	PF02991	0.364
LIG_LIR_Nem_3	827	833	PF02991	0.473
LIG_LIR_Nem_3	849	853	PF02991	0.562
LIG_LIR_Nem_3	857	862	PF02991	0.445
LIG_LIR_Nem_3	929	933	PF02991	0.401
LIG_PCNA_yPIPBox_3	782	795	PF02747	0.346
LIG_PCNA_yPIPBox_3	967	979	PF02747	0.414
LIG_Pex14_2	53	57	PF04695	0.564
LIG_PTB_Apo_2	844	851	PF02174	0.402
LIG_PTB_Phospho_1	844	850	PF10480	0.399
LIG_SH2_CRK	1038	1042	PF00017	0.436
LIG_SH2_CRK	850	854	PF00017	0.524
LIG_SH2_CRK	930	934	PF00017	0.376
LIG_SH2_NCK_1	16	20	PF00017	0.621
LIG_SH2_NCK_1	850	854	PF00017	0.406
LIG_SH2_NCK_1	930	934	PF00017	0.376
LIG_SH2_PTP2	999	1002	PF00017	0.478
LIG_SH2_STAP1	930	934	PF00017	0.376
LIG_SH2_STAT3	721	724	PF00017	0.452
LIG_SH2_STAT5	1026	1029	PF00017	0.414
LIG_SH2_STAT5	811	814	PF00017	0.401
LIG_SH2_STAT5	903	906	PF00017	0.374
LIG_SH2_STAT5	999	1002	PF00017	0.436
LIG_SH3_1	276	282	PF00018	0.682
LIG_SH3_3	276	282	PF00018	0.746
LIG_SH3_3	289	295	PF00018	0.588
LIG_SH3_3	345	351	PF00018	0.670
LIG_SH3_3	366	372	PF00018	0.659
LIG_SH3_3	538	544	PF00018	0.625
LIG_SH3_3	650	656	PF00018	0.612
LIG_SH3_3	761	767	PF00018	0.440
LIG_SH3_3	850	856	PF00018	0.386
LIG_SUMO_SIM_anti_2	698	704	PF11976	0.476
LIG_SUMO_SIM_par_1	697	704	PF11976	0.480
LIG_SUMO_SIM_par_1	724	730	PF11976	0.513
LIG_SUMO_SIM_par_1	760	765	PF11976	0.538
LIG_TRAF2_1	28	31	PF00917	0.539
LIG_TRAF2_1	296	299	PF00917	0.594
LIG_TRAF2_1	965	968	PF00917	0.481
LIG_TRAF2_2	541	546	PF00917	0.613
LIG_TYR_ITIM	848	853	PF00017	0.398
LIG_TYR_ITIM	997	1002	PF00017	0.478
LIG_UBA3_1	449	458	PF00899	0.530
LIG_UBA3_1	87	93	PF00899	0.654
LIG_UBA3_1	947	955	PF00899	0.319
MOD_CDK_SPxxK_3	306	313	PF00069	0.599
MOD_CK1_1	158	164	PF00069	0.731
MOD_CK1_1	193	199	PF00069	0.655
MOD_CK1_1	304	310	PF00069	0.632
MOD_CK1_1	312	318	PF00069	0.643
MOD_CK1_1	330	336	PF00069	0.525
MOD_CK1_1	361	367	PF00069	0.619
MOD_CK1_1	623	629	PF00069	0.725
MOD_CK1_1	658	664	PF00069	0.663
MOD_CK1_1	670	676	PF00069	0.757
MOD_CK1_1	680	686	PF00069	0.594
MOD_CK1_1	687	693	PF00069	0.511
MOD_CK1_1	868	874	PF00069	0.423
MOD_CK1_1	921	927	PF00069	0.422
MOD_CK1_1	97	103	PF00069	0.628
MOD_CK2_1	115	121	PF00069	0.707
MOD_CK2_1	185	191	PF00069	0.717
MOD_CK2_1	25	31	PF00069	0.540
MOD_CK2_1	364	370	PF00069	0.594
MOD_CK2_1	386	392	PF00069	0.520
MOD_CK2_1	507	513	PF00069	0.550
MOD_CK2_1	608	614	PF00069	0.676
MOD_CK2_1	730	736	PF00069	0.514
MOD_CK2_1	819	825	PF00069	0.517
MOD_CK2_1	854	860	PF00069	0.377
MOD_CK2_1	875	881	PF00069	0.397
MOD_CK2_1	923	929	PF00069	0.422
MOD_CK2_1	962	968	PF00069	0.623
MOD_DYRK1A_RPxSP_1	625	629	PF00069	0.727
MOD_GlcNHglycan	117	120	PF01048	0.613
MOD_GlcNHglycan	125	128	PF01048	0.617
MOD_GlcNHglycan	149	152	PF01048	0.718
MOD_GlcNHglycan	160	163	PF01048	0.608
MOD_GlcNHglycan	172	175	PF01048	0.661
MOD_GlcNHglycan	202	205	PF01048	0.684
MOD_GlcNHglycan	303	306	PF01048	0.617
MOD_GlcNHglycan	48	51	PF01048	0.584
MOD_GlcNHglycan	518	521	PF01048	0.725
MOD_GlcNHglycan	563	566	PF01048	0.597
MOD_GlcNHglycan	637	640	PF01048	0.688
MOD_GlcNHglycan	643	646	PF01048	0.687
MOD_GlcNHglycan	649	652	PF01048	0.595
MOD_GlcNHglycan	677	682	PF01048	0.746
MOD_GlcNHglycan	754	757	PF01048	0.461
MOD_GlcNHglycan	80	83	PF01048	0.707
MOD_GlcNHglycan	822	825	PF01048	0.527
MOD_GlcNHglycan	855	859	PF01048	0.396
MOD_GlcNHglycan	90	93	PF01048	0.609
MOD_GlcNHglycan	911	914	PF01048	0.366
MOD_GlcNHglycan	920	923	PF01048	0.480
MOD_GlcNHglycan	980	983	PF01048	0.420
MOD_GlcNHglycan	989	992	PF01048	0.343
MOD_GSK3_1	158	165	PF00069	0.690
MOD_GSK3_1	186	193	PF00069	0.665
MOD_GSK3_1	196	203	PF00069	0.769
MOD_GSK3_1	212	219	PF00069	0.707
MOD_GSK3_1	252	259	PF00069	0.688
MOD_GSK3_1	300	307	PF00069	0.642
MOD_GSK3_1	32	39	PF00069	0.550
MOD_GSK3_1	327	334	PF00069	0.667
MOD_GSK3_1	358	365	PF00069	0.651
MOD_GSK3_1	5	12	PF00069	0.621
MOD_GSK3_1	518	525	PF00069	0.656
MOD_GSK3_1	527	534	PF00069	0.661
MOD_GSK3_1	56	63	PF00069	0.538
MOD_GSK3_1	641	648	PF00069	0.646
MOD_GSK3_1	680	687	PF00069	0.729
MOD_GSK3_1	722	729	PF00069	0.464
MOD_GSK3_1	772	779	PF00069	0.417
MOD_GSK3_1	861	868	PF00069	0.415
MOD_GSK3_1	909	916	PF00069	0.337
MOD_GSK3_1	97	104	PF00069	0.664
MOD_N-GLC_1	196	201	PF02516	0.653
MOD_N-GLC_1	334	339	PF02516	0.647
MOD_N-GLC_1	667	672	PF02516	0.684
MOD_N-GLC_1	846	851	PF02516	0.485
MOD_N-GLC_1	88	93	PF02516	0.654
MOD_NEK2_1	561	566	PF00069	0.630
MOD_NEK2_1	695	700	PF00069	0.415
MOD_NEK2_1	705	710	PF00069	0.488
MOD_NEK2_1	72	77	PF00069	0.721
MOD_NEK2_1	803	808	PF00069	0.432
MOD_NEK2_1	863	868	PF00069	0.412
MOD_NEK2_1	88	93	PF00069	0.601
MOD_NEK2_1	9	14	PF00069	0.602
MOD_NEK2_2	11	16	PF00069	0.585
MOD_NEK2_2	5	10	PF00069	0.634
MOD_NEK2_2	941	946	PF00069	0.338
MOD_PIKK_1	212	218	PF00454	0.725
MOD_PIKK_1	249	255	PF00454	0.592
MOD_PIKK_1	620	626	PF00454	0.722
MOD_PIKK_1	661	667	PF00454	0.699
MOD_PIKK_1	670	676	PF00454	0.781
MOD_PK_1	715	721	PF00069	0.376
MOD_PK_1	989	995	PF00069	0.382
MOD_PKA_1	526	532	PF00069	0.651
MOD_PKA_2	101	107	PF00069	0.615
MOD_PKA_2	147	153	PF00069	0.716
MOD_PKA_2	337	343	PF00069	0.651
MOD_PKA_2	361	367	PF00069	0.619
MOD_PKA_2	526	532	PF00069	0.687
MOD_PKA_2	586	592	PF00069	0.783
MOD_PKA_2	595	601	PF00069	0.605
MOD_PKA_2	705	711	PF00069	0.472
MOD_PKA_2	843	849	PF00069	0.424
MOD_PKA_2	868	874	PF00069	0.499
MOD_PKA_2	893	899	PF00069	0.442
MOD_PKB_1	524	532	PF00069	0.655
MOD_Plk_1	715	721	PF00069	0.449
MOD_Plk_1	826	832	PF00069	0.460
MOD_Plk_1	846	852	PF00069	0.487
MOD_Plk_1	872	878	PF00069	0.425
MOD_Plk_1	913	919	PF00069	0.413
MOD_Plk_1	962	968	PF00069	0.518
MOD_Plk_4	364	370	PF00069	0.615
MOD_Plk_4	5	11	PF00069	0.634
MOD_Plk_4	695	701	PF00069	0.402
MOD_Plk_4	72	78	PF00069	0.639
MOD_Plk_4	741	747	PF00069	0.421
MOD_Plk_4	83	89	PF00069	0.589
MOD_Plk_4	903	909	PF00069	0.364
MOD_Plk_4	929	935	PF00069	0.384
MOD_ProDKin_1	162	168	PF00069	0.647
MOD_ProDKin_1	221	227	PF00069	0.646
MOD_ProDKin_1	283	289	PF00069	0.633
MOD_ProDKin_1	306	312	PF00069	0.681
MOD_ProDKin_1	598	604	PF00069	0.690
MOD_ProDKin_1	608	614	PF00069	0.590
MOD_ProDKin_1	625	631	PF00069	0.646
MOD_ProDKin_1	658	664	PF00069	0.712
MOD_ProDKin_1	772	778	PF00069	0.418
MOD_ProDKin_1	835	841	PF00069	0.413
MOD_SUMO_for_1	296	299	PF00179	0.633
MOD_SUMO_rev_2	214	224	PF00179	0.700
MOD_SUMO_rev_2	248	258	PF00179	0.632
MOD_SUMO_rev_2	475	485	PF00179	0.521
MOD_SUMO_rev_2	486	491	PF00179	0.581
MOD_SUMO_rev_2	508	517	PF00179	0.601
MOD_SUMO_rev_2	673	681	PF00179	0.734
MOD_SUMO_rev_2	727	733	PF00179	0.510
MOD_SUMO_rev_2	895	900	PF00179	0.465
MOD_SUMO_rev_2	952	956	PF00179	0.356
TRG_DiLeu_BaEn_1	1029	1034	PF01217	0.390
TRG_DiLeu_BaLyEn_6	1036	1041	PF01217	0.455
TRG_DiLeu_BaLyEn_6	264	269	PF01217	0.647
TRG_DiLeu_LyEn_5	1029	1034	PF01217	0.390
TRG_ENDOCYTIC_2	1038	1041	PF00928	0.386
TRG_ENDOCYTIC_2	850	853	PF00928	0.429
TRG_ENDOCYTIC_2	930	933	PF00928	0.380
TRG_ENDOCYTIC_2	999	1002	PF00928	0.478
TRG_ER_diArg_1	351	354	PF00400	0.650
TRG_ER_diArg_1	434	436	PF00400	0.516
TRG_ER_diArg_1	477	479	PF00400	0.574
TRG_ER_diArg_1	524	527	PF00400	0.646
TRG_ER_diArg_1	55	57	PF00400	0.570
TRG_Pf-PMV_PEXEL_1	1025	1029	PF00026	0.423
TRG_Pf-PMV_PEXEL_1	1032	1036	PF00026	0.389
TRG_Pf-PMV_PEXEL_1	1039	1043	PF00026	0.400
TRG_Pf-PMV_PEXEL_1	483	487	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	503	508	PF00026	0.389
TRG_Pf-PMV_PEXEL_1	786	791	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILP3	Leptomonas seymouri	49%	100%
A4HM11	Leishmania braziliensis	68%	100%
A4I9E2	Leishmania infantum	100%	100%
E9B4E2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q4Q3N5	Leishmania major	90%	99%