Cysteine peptidase, Clan CA, family C51

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X756_LEIDO

TriTrypDb:

LdBPK_333010.1 , LdCL_330037200 , LDHU3_33.4200

Length:

484

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A0A3S7X756

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X756

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016874	ligase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	182	184	PF00675	0.301
CLV_NRD_NRD_1	21	23	PF00675	0.679
CLV_NRD_NRD_1	214	216	PF00675	0.445
CLV_NRD_NRD_1	362	364	PF00675	0.525
CLV_NRD_NRD_1	440	442	PF00675	0.531
CLV_PCSK_KEX2_1	182	184	PF00082	0.301
CLV_PCSK_KEX2_1	20	22	PF00082	0.682
CLV_PCSK_KEX2_1	214	216	PF00082	0.445
CLV_PCSK_KEX2_1	362	364	PF00082	0.525
CLV_PCSK_KEX2_1	440	442	PF00082	0.473
CLV_PCSK_SKI1_1	128	132	PF00082	0.348
CLV_PCSK_SKI1_1	188	192	PF00082	0.337
CLV_PCSK_SKI1_1	267	271	PF00082	0.393
CLV_PCSK_SKI1_1	335	339	PF00082	0.428
CLV_PCSK_SKI1_1	447	451	PF00082	0.392
DOC_CYCLIN_RxL_1	182	195	PF00134	0.529
DOC_CYCLIN_RxL_1	332	341	PF00134	0.625
DOC_CYCLIN_RxL_1	445	459	PF00134	0.549
DOC_CYCLIN_yCln2_LP_2	120	126	PF00134	0.590
DOC_MAPK_DCC_7	25	33	PF00069	0.505
DOC_MAPK_gen_1	214	225	PF00069	0.613
DOC_MAPK_gen_1	25	33	PF00069	0.511
DOC_MAPK_gen_1	445	454	PF00069	0.536
DOC_PP1_RVXF_1	307	314	PF00149	0.581
DOC_PP2B_LxvP_1	120	123	PF13499	0.584
DOC_PP2B_LxvP_1	231	234	PF13499	0.594
DOC_PP2B_PxIxI_1	87	93	PF00149	0.432
DOC_PP4_FxxP_1	232	235	PF00568	0.566
DOC_USP7_MATH_1	132	136	PF00917	0.628
DOC_USP7_MATH_1	280	284	PF00917	0.678
DOC_USP7_MATH_1	300	304	PF00917	0.669
DOC_WW_Pin1_4	128	133	PF00397	0.570
DOC_WW_Pin1_4	26	31	PF00397	0.519
DOC_WW_Pin1_4	347	352	PF00397	0.711
DOC_WW_Pin1_4	84	89	PF00397	0.449
LIG_14-3-3_CanoR_1	20	28	PF00244	0.551
LIG_14-3-3_CanoR_1	218	223	PF00244	0.716
LIG_14-3-3_CanoR_1	262	267	PF00244	0.553
LIG_14-3-3_CanoR_1	335	345	PF00244	0.647
LIG_14-3-3_CanoR_1	73	78	PF00244	0.550
LIG_BIR_II_1	1	5	PF00653	0.621
LIG_deltaCOP1_diTrp_1	396	404	PF00928	0.531
LIG_FHA_1	104	110	PF00498	0.339
LIG_FHA_1	448	454	PF00498	0.644
LIG_FHA_2	354	360	PF00498	0.776
LIG_FHA_2	409	415	PF00498	0.704
LIG_FHA_2	428	434	PF00498	0.605
LIG_GBD_Chelix_1	101	109	PF00786	0.339
LIG_Integrin_isoDGR_2	212	214	PF01839	0.406
LIG_LIR_Apic_2	229	235	PF02991	0.544
LIG_LIR_Apic_2	457	461	PF02991	0.555
LIG_LIR_Gen_1	159	169	PF02991	0.553
LIG_LIR_Gen_1	173	181	PF02991	0.514
LIG_LIR_Gen_1	226	235	PF02991	0.555
LIG_LIR_Gen_1	402	410	PF02991	0.676
LIG_LIR_Nem_3	113	118	PF02991	0.339
LIG_LIR_Nem_3	131	136	PF02991	0.556
LIG_LIR_Nem_3	159	164	PF02991	0.545
LIG_LIR_Nem_3	173	178	PF02991	0.521
LIG_LIR_Nem_3	192	196	PF02991	0.623
LIG_LIR_Nem_3	226	231	PF02991	0.627
LIG_LIR_Nem_3	310	316	PF02991	0.605
LIG_LIR_Nem_3	36	42	PF02991	0.595
LIG_LIR_Nem_3	386	392	PF02991	0.528
LIG_LIR_Nem_3	402	407	PF02991	0.696
LIG_NRBOX	100	106	PF00104	0.391
LIG_NRBOX	186	192	PF00104	0.617
LIG_PCNA_yPIPBox_3	471	479	PF02747	0.531
LIG_PDZ_Class_1	479	484	PF00595	0.560
LIG_Pex14_1	399	403	PF04695	0.523
LIG_Pex14_2	114	118	PF04695	0.466
LIG_SH2_CRK	228	232	PF00017	0.627
LIG_SH2_CRK	458	462	PF00017	0.597
LIG_SH2_GRB2like	146	149	PF00017	0.626
LIG_SH2_GRB2like	228	231	PF00017	0.530
LIG_SH2_GRB2like	458	461	PF00017	0.653
LIG_SH2_STAP1	180	184	PF00017	0.500
LIG_SH2_STAP1	228	232	PF00017	0.537
LIG_SH2_STAT5	115	118	PF00017	0.353
LIG_SH2_STAT5	170	173	PF00017	0.503
LIG_SH2_STAT5	228	231	PF00017	0.514
LIG_SH2_STAT5	409	412	PF00017	0.714
LIG_SH3_3	191	197	PF00018	0.544
LIG_SH3_3	2	8	PF00018	0.566
LIG_SH3_3	294	300	PF00018	0.557
LIG_SH3_3	323	329	PF00018	0.673
LIG_SH3_3	346	352	PF00018	0.723
LIG_SH3_CIN85_PxpxPR_1	30	35	PF14604	0.574
LIG_SUMO_SIM_anti_2	106	113	PF11976	0.466
LIG_SUMO_SIM_anti_2	450	457	PF11976	0.530
LIG_SUMO_SIM_par_1	106	113	PF11976	0.399
LIG_SUMO_SIM_par_1	450	457	PF11976	0.530
LIG_TYR_ITIM	387	392	PF00017	0.520
LIG_WRC_WIRS_1	111	116	PF05994	0.466
MOD_CDK_SPxK_1	347	353	PF00069	0.697
MOD_CK1_1	189	195	PF00069	0.527
MOD_CK1_1	408	414	PF00069	0.629
MOD_CK1_1	420	426	PF00069	0.691
MOD_CK2_1	370	376	PF00069	0.766
MOD_CK2_1	399	405	PF00069	0.599
MOD_CK2_1	427	433	PF00069	0.695
MOD_Cter_Amidation	18	21	PF01082	0.686
MOD_Cter_Amidation	212	215	PF01082	0.415
MOD_GlcNHglycan	120	123	PF01048	0.384
MOD_GlcNHglycan	257	260	PF01048	0.485
MOD_GlcNHglycan	287	290	PF01048	0.453
MOD_GlcNHglycan	365	368	PF01048	0.583
MOD_GlcNHglycan	372	375	PF01048	0.518
MOD_GlcNHglycan	433	437	PF01048	0.517
MOD_GlcNHglycan	61	64	PF01048	0.725
MOD_GlcNHglycan	70	73	PF01048	0.624
MOD_GSK3_1	128	135	PF00069	0.566
MOD_GSK3_1	353	360	PF00069	0.776
MOD_GSK3_1	427	434	PF00069	0.702
MOD_GSK3_1	68	75	PF00069	0.509
MOD_GSK3_1	80	87	PF00069	0.424
MOD_N-GLC_1	239	244	PF02516	0.506
MOD_N-GLC_1	255	260	PF02516	0.279
MOD_N-GLC_1	317	322	PF02516	0.444
MOD_N-GLC_1	353	358	PF02516	0.576
MOD_N-GLC_1	370	375	PF02516	0.448
MOD_N-GLC_1	427	432	PF02516	0.489
MOD_N-GLC_1	447	452	PF02516	0.440
MOD_NEK2_1	110	115	PF00069	0.339
MOD_NEK2_1	118	123	PF00069	0.457
MOD_NEK2_1	137	142	PF00069	0.542
MOD_NEK2_1	204	209	PF00069	0.551
MOD_NEK2_1	257	262	PF00069	0.677
MOD_NEK2_1	466	471	PF00069	0.542
MOD_PIKK_1	336	342	PF00454	0.730
MOD_PIKK_1	417	423	PF00454	0.652
MOD_PK_1	218	224	PF00069	0.691
MOD_PK_1	317	323	PF00069	0.668
MOD_PKA_1	20	26	PF00069	0.477
MOD_PKA_1	362	368	PF00069	0.706
MOD_PKA_2	20	26	PF00069	0.476
MOD_PKA_2	217	223	PF00069	0.646
MOD_PKA_2	226	232	PF00069	0.501
MOD_PKA_2	362	368	PF00069	0.706
MOD_PKA_2	478	484	PF00069	0.559
MOD_PKA_2	59	65	PF00069	0.615
MOD_PKA_2	72	78	PF00069	0.442
MOD_PKB_1	445	453	PF00069	0.597
MOD_Plk_1	317	323	PF00069	0.716
MOD_Plk_1	399	405	PF00069	0.528
MOD_Plk_1	447	453	PF00069	0.637
MOD_Plk_4	103	109	PF00069	0.339
MOD_Plk_4	110	116	PF00069	0.339
MOD_Plk_4	132	138	PF00069	0.551
MOD_Plk_4	186	192	PF00069	0.510
MOD_Plk_4	218	224	PF00069	0.634
MOD_Plk_4	383	389	PF00069	0.569
MOD_Plk_4	399	405	PF00069	0.543
MOD_ProDKin_1	128	134	PF00069	0.569
MOD_ProDKin_1	26	32	PF00069	0.519
MOD_ProDKin_1	347	353	PF00069	0.713
MOD_ProDKin_1	84	90	PF00069	0.447
TRG_DiLeu_BaEn_2	309	315	PF01217	0.693
TRG_DiLeu_BaLyEn_6	332	337	PF01217	0.630
TRG_ENDOCYTIC_2	115	118	PF00928	0.339
TRG_ENDOCYTIC_2	184	187	PF00928	0.599
TRG_ENDOCYTIC_2	228	231	PF00928	0.531
TRG_ENDOCYTIC_2	389	392	PF00928	0.515
TRG_ENDOCYTIC_2	39	42	PF00928	0.508
TRG_ER_diArg_1	182	184	PF00400	0.501
TRG_ER_diArg_1	20	22	PF00400	0.516
TRG_ER_diArg_1	261	264	PF00400	0.648
TRG_ER_diArg_1	362	364	PF00400	0.725
TRG_NES_CRM1_1	156	167	PF08389	0.563
TRG_Pf-PMV_PEXEL_1	335	340	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRT1	Leptomonas seymouri	52%	100%
A4HLZ7	Leishmania braziliensis	71%	98%
A4I9C7	Leishmania infantum	99%	100%
E9B4C7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q3P9	Leishmania major	88%	100%