Signal recognition particle receptor subunit beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

signal recognition particle receptor beta subunit, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X750_LEIDO

TriTrypDb:

LdBPK_332760.1 , LdCL_330034700 , LDHU3_33.3900

Length:

492

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	6
GO:0016020	membrane	2	7
GO:0031090	organelle membrane	3	6
GO:0110165	cellular anatomical entity	1	7
GO:0005785	signal recognition particle receptor complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1

Expansion

Sequence features

A0A3S7X750

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X750

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0045047	protein targeting to ER	6	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0070972	protein localization to endoplasmic reticulum	6	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003676	nucleic acid binding	3	2
GO:0003746	translation elongation factor activity	4	2
GO:0005488	binding	1	7
GO:0005525	GTP binding	5	7
GO:0008135	translation factor activity, RNA binding	3	2
GO:0017076	purine nucleotide binding	4	7
GO:0019001	guanyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032561	guanyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0045182	translation regulator activity	1	2
GO:0090079	translation regulator activity, nucleic acid binding	2	2
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	321	325	PF00656	0.469
CLV_C14_Caspase3-7	394	398	PF00656	0.459
CLV_C14_Caspase3-7	425	429	PF00656	0.629
CLV_NRD_NRD_1	133	135	PF00675	0.773
CLV_NRD_NRD_1	230	232	PF00675	0.411
CLV_NRD_NRD_1	350	352	PF00675	0.316
CLV_NRD_NRD_1	370	372	PF00675	0.271
CLV_NRD_NRD_1	384	386	PF00675	0.357
CLV_NRD_NRD_1	418	420	PF00675	0.521
CLV_PCSK_KEX2_1	229	231	PF00082	0.416
CLV_PCSK_KEX2_1	350	352	PF00082	0.300
CLV_PCSK_KEX2_1	358	360	PF00082	0.243
CLV_PCSK_KEX2_1	418	420	PF00082	0.463
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.269
CLV_PCSK_SKI1_1	108	112	PF00082	0.649
CLV_PCSK_SKI1_1	18	22	PF00082	0.624
CLV_PCSK_SKI1_1	246	250	PF00082	0.413
CLV_PCSK_SKI1_1	350	354	PF00082	0.274
CLV_PCSK_SKI1_1	371	375	PF00082	0.275
CLV_PCSK_SKI1_1	419	423	PF00082	0.457
CLV_PCSK_SKI1_1	86	90	PF00082	0.685
DEG_SPOP_SBC_1	232	236	PF00917	0.516
DOC_CKS1_1	93	98	PF01111	0.472
DOC_CYCLIN_RxL_1	348	357	PF00134	0.469
DOC_CYCLIN_RxL_1	368	375	PF00134	0.383
DOC_CYCLIN_yCln2_LP_2	459	465	PF00134	0.538
DOC_MAPK_gen_1	134	141	PF00069	0.399
DOC_MAPK_gen_1	229	239	PF00069	0.469
DOC_MAPK_gen_1	418	424	PF00069	0.657
DOC_MAPK_MEF2A_6	233	241	PF00069	0.476
DOC_MAPK_MEF2A_6	246	253	PF00069	0.528
DOC_PP1_RVXF_1	217	224	PF00149	0.531
DOC_PP1_RVXF_1	348	355	PF00149	0.472
DOC_PP2B_LxvP_1	459	462	PF13499	0.545
DOC_USP7_MATH_1	120	124	PF00917	0.427
DOC_USP7_MATH_1	183	187	PF00917	0.410
DOC_USP7_MATH_1	447	451	PF00917	0.684
DOC_USP7_MATH_1	63	67	PF00917	0.440
DOC_USP7_MATH_1	98	102	PF00917	0.466
DOC_USP7_UBL2_3	368	372	PF12436	0.455
DOC_WW_Pin1_4	148	153	PF00397	0.468
DOC_WW_Pin1_4	177	182	PF00397	0.449
DOC_WW_Pin1_4	340	345	PF00397	0.490
DOC_WW_Pin1_4	89	94	PF00397	0.520
LIG_14-3-3_CanoR_1	108	117	PF00244	0.413
LIG_14-3-3_CanoR_1	190	195	PF00244	0.410
LIG_14-3-3_CanoR_1	230	239	PF00244	0.480
LIG_14-3-3_CanoR_1	263	267	PF00244	0.516
LIG_14-3-3_CanoR_1	281	291	PF00244	0.396
LIG_14-3-3_CanoR_1	419	425	PF00244	0.595
LIG_14-3-3_CanoR_1	69	74	PF00244	0.442
LIG_14-3-3_CanoR_1	86	93	PF00244	0.488
LIG_14-3-3_CanoR_1	97	106	PF00244	0.413
LIG_BIR_II_1	1	5	PF00653	0.442
LIG_BIR_III_2	172	176	PF00653	0.441
LIG_BRCT_BRCA1_1	342	346	PF00533	0.469
LIG_BRCT_BRCA1_1	452	456	PF00533	0.586
LIG_deltaCOP1_diTrp_1	198	201	PF00928	0.316
LIG_EH1_1	346	354	PF00400	0.469
LIG_eIF4E_1	347	353	PF01652	0.469
LIG_FHA_1	149	155	PF00498	0.436
LIG_FHA_1	203	209	PF00498	0.369
LIG_FHA_1	232	238	PF00498	0.472
LIG_FHA_1	283	289	PF00498	0.534
LIG_FHA_2	10	16	PF00498	0.417
LIG_FHA_2	319	325	PF00498	0.555
LIG_FHA_2	355	361	PF00498	0.474
LIG_GBD_Chelix_1	333	341	PF00786	0.269
LIG_HCF-1_HBM_1	476	479	PF13415	0.578
LIG_LIR_Gen_1	122	132	PF02991	0.427
LIG_LIR_Gen_1	196	207	PF02991	0.279
LIG_LIR_Gen_1	247	254	PF02991	0.516
LIG_LIR_Gen_1	335	346	PF02991	0.469
LIG_LIR_Gen_1	453	464	PF02991	0.547
LIG_LIR_Nem_3	122	128	PF02991	0.426
LIG_LIR_Nem_3	196	202	PF02991	0.310
LIG_LIR_Nem_3	247	253	PF02991	0.469
LIG_LIR_Nem_3	335	341	PF02991	0.491
LIG_LIR_Nem_3	343	349	PF02991	0.453
LIG_LIR_Nem_3	453	459	PF02991	0.544
LIG_MAD2	289	297	PF02301	0.516
LIG_SH2_SRC	210	213	PF00017	0.292
LIG_SH2_STAP1	365	369	PF00017	0.455
LIG_SH2_STAP1	479	483	PF00017	0.598
LIG_SH2_STAT5	210	213	PF00017	0.304
LIG_SH2_STAT5	24	27	PF00017	0.571
LIG_SH3_3	288	294	PF00018	0.469
LIG_SH3_3	90	96	PF00018	0.468
LIG_SUMO_SIM_anti_2	480	486	PF11976	0.589
LIG_SUMO_SIM_par_1	312	319	PF11976	0.469
LIG_SUMO_SIM_par_1	420	425	PF11976	0.584
LIG_TRAF2_1	41	44	PF00917	0.444
LIG_TYR_ITIM	208	213	PF00017	0.321
LIG_UBA3_1	238	246	PF00899	0.479
LIG_WRC_WIRS_1	191	196	PF05994	0.443
LIG_WW_3	436	440	PF00397	0.692
MOD_CDK_SPK_2	92	97	PF00069	0.439
MOD_CK1_1	192	198	PF00069	0.446
MOD_CK1_1	244	250	PF00069	0.481
MOD_CK1_1	262	268	PF00069	0.469
MOD_CK1_1	282	288	PF00069	0.387
MOD_CK1_1	32	38	PF00069	0.548
MOD_CK1_1	364	370	PF00069	0.462
MOD_CK1_1	381	387	PF00069	0.469
MOD_CK1_1	450	456	PF00069	0.596
MOD_CK2_1	192	198	PF00069	0.432
MOD_CK2_1	262	268	PF00069	0.455
MOD_CK2_1	38	44	PF00069	0.497
MOD_CK2_1	9	15	PF00069	0.416
MOD_Cter_Amidation	416	419	PF01082	0.479
MOD_GlcNHglycan	100	103	PF01048	0.661
MOD_GlcNHglycan	129	132	PF01048	0.660
MOD_GlcNHglycan	195	198	PF01048	0.576
MOD_GlcNHglycan	202	205	PF01048	0.314
MOD_GlcNHglycan	243	246	PF01048	0.287
MOD_GlcNHglycan	268	272	PF01048	0.310
MOD_GlcNHglycan	31	34	PF01048	0.763
MOD_GlcNHglycan	413	416	PF01048	0.505
MOD_GlcNHglycan	449	452	PF01048	0.431
MOD_GlcNHglycan	49	52	PF01048	0.669
MOD_GSK3_1	148	155	PF00069	0.534
MOD_GSK3_1	189	196	PF00069	0.424
MOD_GSK3_1	65	72	PF00069	0.451
MOD_LATS_1	279	285	PF00433	0.469
MOD_LATS_1	84	90	PF00433	0.487
MOD_N-GLC_1	108	113	PF02516	0.636
MOD_N-GLC_1	282	287	PF02516	0.269
MOD_N-GLC_1	9	14	PF02516	0.651
MOD_NEK2_1	202	207	PF00069	0.383
MOD_NEK2_1	259	264	PF00069	0.469
MOD_NEK2_1	354	359	PF00069	0.476
MOD_NEK2_1	47	52	PF00069	0.425
MOD_PK_1	391	397	PF00069	0.459
MOD_PKA_2	189	195	PF00069	0.401
MOD_PKA_2	232	238	PF00069	0.476
MOD_PKA_2	262	268	PF00069	0.479
MOD_PKB_1	229	237	PF00069	0.577
MOD_Plk_1	108	114	PF00069	0.421
MOD_Plk_1	9	15	PF00069	0.450
MOD_Plk_2-3	318	324	PF00069	0.469
MOD_Plk_4	120	126	PF00069	0.421
MOD_Plk_4	202	208	PF00069	0.338
MOD_Plk_4	233	239	PF00069	0.469
MOD_Plk_4	9	15	PF00069	0.412
MOD_ProDKin_1	148	154	PF00069	0.470
MOD_ProDKin_1	177	183	PF00069	0.446
MOD_ProDKin_1	340	346	PF00069	0.490
MOD_ProDKin_1	89	95	PF00069	0.515
MOD_SUMO_rev_2	470	480	PF00179	0.624
TRG_DiLeu_BaEn_1	43	48	PF01217	0.435
TRG_DiLeu_BaLyEn_6	348	353	PF01217	0.469
TRG_ENDOCYTIC_2	210	213	PF00928	0.321
TRG_ER_diArg_1	229	231	PF00400	0.616
TRG_ER_diArg_1	349	351	PF00400	0.516
TRG_ER_diArg_1	418	420	PF00400	0.647
TRG_Pf-PMV_PEXEL_1	305	309	PF00026	0.284
TRG_Pf-PMV_PEXEL_1	371	375	PF00026	0.269

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2X6	Leptomonas seymouri	53%	100%
A4HLX3	Leishmania braziliensis	69%	100%
A4I9A2	Leishmania infantum	100%	100%
E9B4A2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q3S4	Leishmania major	92%	100%