Dynein intermediate chain, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dynein intermediate chain, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X748_LEIDO

TriTrypDb:

LdBPK_332770.1 , LdCL_330034800 , LDHU3_33.3910

Length:

1084

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005858	axonemal dynein complex	4	1
GO:0005875	microtubule associated complex	2	1
GO:0005930	axoneme	2	1
GO:0030286	dynein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	2
GO:1902494	catalytic complex	2	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S7X748

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X748

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045503	dynein light chain binding	3	1
GO:0045504	dynein heavy chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1010	1014	PF00656	0.546
CLV_C14_Caspase3-7	418	422	PF00656	0.675
CLV_MEL_PAP_1	631	637	PF00089	0.523
CLV_NRD_NRD_1	10	12	PF00675	0.725
CLV_NRD_NRD_1	1027	1029	PF00675	0.410
CLV_NRD_NRD_1	1079	1081	PF00675	0.397
CLV_NRD_NRD_1	158	160	PF00675	0.756
CLV_NRD_NRD_1	190	192	PF00675	0.762
CLV_NRD_NRD_1	230	232	PF00675	0.692
CLV_NRD_NRD_1	273	275	PF00675	0.554
CLV_NRD_NRD_1	354	356	PF00675	0.616
CLV_NRD_NRD_1	653	655	PF00675	0.524
CLV_NRD_NRD_1	667	669	PF00675	0.506
CLV_NRD_NRD_1	677	679	PF00675	0.587
CLV_NRD_NRD_1	70	72	PF00675	0.670
CLV_NRD_NRD_1	862	864	PF00675	0.757
CLV_NRD_NRD_1	969	971	PF00675	0.494
CLV_PCSK_KEX2_1	10	12	PF00082	0.725
CLV_PCSK_KEX2_1	1027	1029	PF00082	0.414
CLV_PCSK_KEX2_1	158	160	PF00082	0.756
CLV_PCSK_KEX2_1	190	192	PF00082	0.717
CLV_PCSK_KEX2_1	229	231	PF00082	0.698
CLV_PCSK_KEX2_1	653	655	PF00082	0.532
CLV_PCSK_KEX2_1	666	668	PF00082	0.489
CLV_PCSK_KEX2_1	677	679	PF00082	0.591
CLV_PCSK_KEX2_1	689	691	PF00082	0.649
CLV_PCSK_KEX2_1	72	74	PF00082	0.671
CLV_PCSK_PC1ET2_1	689	691	PF00082	0.668
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.700
CLV_PCSK_SKI1_1	274	278	PF00082	0.655
CLV_PCSK_SKI1_1	461	465	PF00082	0.572
CLV_PCSK_SKI1_1	509	513	PF00082	0.447
CLV_PCSK_SKI1_1	545	549	PF00082	0.690
CLV_PCSK_SKI1_1	57	61	PF00082	0.707
DEG_SPOP_SBC_1	560	564	PF00917	0.576
DEG_SPOP_SBC_1	61	65	PF00917	0.657
DEG_SPOP_SBC_1	738	742	PF00917	0.450
DOC_ANK_TNKS_1	77	84	PF00023	0.738
DOC_CKS1_1	1037	1042	PF01111	0.507
DOC_CKS1_1	362	367	PF01111	0.486
DOC_CYCLIN_yCln2_LP_2	705	711	PF00134	0.393
DOC_MAPK_gen_1	1024	1034	PF00069	0.420
DOC_MAPK_gen_1	229	235	PF00069	0.685
DOC_MAPK_gen_1	274	282	PF00069	0.660
DOC_MAPK_gen_1	355	363	PF00069	0.545
DOC_MAPK_gen_1	653	661	PF00069	0.545
DOC_MAPK_gen_1	970	976	PF00069	0.530
DOC_MAPK_MEF2A_6	706	715	PF00069	0.514
DOC_PP1_RVXF_1	797	804	PF00149	0.395
DOC_PP1_RVXF_1	940	946	PF00149	0.371
DOC_PP4_FxxP_1	635	638	PF00568	0.422
DOC_USP7_MATH_1	311	315	PF00917	0.545
DOC_USP7_MATH_1	342	346	PF00917	0.566
DOC_USP7_MATH_1	679	683	PF00917	0.570
DOC_USP7_MATH_1	737	741	PF00917	0.507
DOC_USP7_UBL2_3	855	859	PF12436	0.689
DOC_USP7_UBL2_3	864	868	PF12436	0.604
DOC_WW_Pin1_4	1036	1041	PF00397	0.518
DOC_WW_Pin1_4	222	227	PF00397	0.642
DOC_WW_Pin1_4	28	33	PF00397	0.653
DOC_WW_Pin1_4	282	287	PF00397	0.552
DOC_WW_Pin1_4	361	366	PF00397	0.499
DOC_WW_Pin1_4	573	578	PF00397	0.637
DOC_WW_Pin1_4	634	639	PF00397	0.430
DOC_WW_Pin1_4	92	97	PF00397	0.631
DOC_WW_Pin1_4	943	948	PF00397	0.376
LIG_14-3-3_CanoR_1	102	106	PF00244	0.775
LIG_14-3-3_CanoR_1	1027	1034	PF00244	0.398
LIG_14-3-3_CanoR_1	158	163	PF00244	0.758
LIG_14-3-3_CanoR_1	190	197	PF00244	0.642
LIG_14-3-3_CanoR_1	214	222	PF00244	0.726
LIG_14-3-3_CanoR_1	250	254	PF00244	0.646
LIG_14-3-3_CanoR_1	274	282	PF00244	0.660
LIG_14-3-3_CanoR_1	312	319	PF00244	0.552
LIG_14-3-3_CanoR_1	50	54	PF00244	0.698
LIG_14-3-3_CanoR_1	509	514	PF00244	0.459
LIG_14-3-3_CanoR_1	545	554	PF00244	0.645
LIG_14-3-3_CanoR_1	624	632	PF00244	0.460
LIG_14-3-3_CanoR_1	666	671	PF00244	0.641
LIG_14-3-3_CanoR_1	677	686	PF00244	0.604
LIG_14-3-3_CanoR_1	975	980	PF00244	0.477
LIG_14-3-3_CterR_2	1080	1084	PF00244	0.424
LIG_BIR_II_1	1	5	PF00653	0.569
LIG_BIR_III_2	619	623	PF00653	0.511
LIG_BRCT_BRCA1_1	205	209	PF00533	0.731
LIG_FHA_1	1037	1043	PF00498	0.467
LIG_FHA_1	133	139	PF00498	0.688
LIG_FHA_1	275	281	PF00498	0.652
LIG_FHA_1	283	289	PF00498	0.544
LIG_FHA_1	305	311	PF00498	0.585
LIG_FHA_1	332	338	PF00498	0.616
LIG_FHA_1	468	474	PF00498	0.716
LIG_FHA_1	486	492	PF00498	0.387
LIG_FHA_1	560	566	PF00498	0.668
LIG_FHA_1	574	580	PF00498	0.547
LIG_FHA_1	740	746	PF00498	0.453
LIG_FHA_1	770	776	PF00498	0.436
LIG_FHA_1	871	877	PF00498	0.559
LIG_FHA_1	959	965	PF00498	0.491
LIG_FHA_1	990	996	PF00498	0.512
LIG_FHA_2	1008	1014	PF00498	0.534
LIG_FHA_2	1065	1071	PF00498	0.597
LIG_FHA_2	191	197	PF00498	0.579
LIG_FHA_2	250	256	PF00498	0.647
LIG_FHA_2	264	270	PF00498	0.478
LIG_FHA_2	384	390	PF00498	0.574
LIG_FHA_2	406	412	PF00498	0.620
LIG_FHA_2	63	69	PF00498	0.653
LIG_GBD_Chelix_1	481	489	PF00786	0.593
LIG_Integrin_RGD_1	1063	1065	PF01839	0.574
LIG_LIR_Apic_2	221	226	PF02991	0.642
LIG_LIR_Apic_2	256	262	PF02991	0.622
LIG_LIR_Gen_1	1007	1017	PF02991	0.468
LIG_LIR_Gen_1	314	323	PF02991	0.630
LIG_LIR_Gen_1	996	1002	PF02991	0.376
LIG_LIR_LC3C_4	1039	1044	PF02991	0.511
LIG_LIR_Nem_3	2	7	PF02991	0.669
LIG_LIR_Nem_3	314	319	PF02991	0.614
LIG_LIR_Nem_3	996	1000	PF02991	0.363
LIG_Rb_LxCxE_1	134	156	PF01857	0.647
LIG_RPA_C_Fungi	648	660	PF08784	0.474
LIG_SH2_CRK	223	227	PF00017	0.642
LIG_SH2_CRK	259	263	PF00017	0.617
LIG_SH2_CRK	508	512	PF00017	0.483
LIG_SH2_NCK_1	223	227	PF00017	0.642
LIG_SH2_NCK_1	259	263	PF00017	0.617
LIG_SH2_NCK_1	316	320	PF00017	0.623
LIG_SH2_NCK_1	948	952	PF00017	0.496
LIG_SH2_SRC	259	262	PF00017	0.637
LIG_SH2_STAP1	372	376	PF00017	0.520
LIG_SH2_STAP1	929	933	PF00017	0.422
LIG_SH2_STAP1	948	952	PF00017	0.378
LIG_SH2_STAT3	291	294	PF00017	0.547
LIG_SH2_STAT3	748	751	PF00017	0.528
LIG_SH2_STAT5	663	666	PF00017	0.563
LIG_SH2_STAT5	716	719	PF00017	0.555
LIG_SH2_STAT5	909	912	PF00017	0.368
LIG_SH2_STAT5	952	955	PF00017	0.353
LIG_SH3_3	258	264	PF00018	0.698
LIG_SH3_3	347	353	PF00018	0.682
LIG_SH3_3	547	553	PF00018	0.737
LIG_SH3_3	563	569	PF00018	0.530
LIG_SH3_3	705	711	PF00018	0.393
LIG_SH3_3	727	733	PF00018	0.354
LIG_SH3_3	751	757	PF00018	0.525
LIG_SUMO_SIM_anti_2	1038	1048	PF11976	0.531
LIG_SUMO_SIM_par_1	1038	1048	PF11976	0.531
LIG_SUMO_SIM_par_1	277	285	PF11976	0.555
LIG_SUMO_SIM_par_1	734	742	PF11976	0.511
LIG_TRAF2_1	1035	1038	PF00917	0.559
LIG_TRAF2_1	124	127	PF00917	0.669
LIG_TRAF2_1	128	131	PF00917	0.666
LIG_TRAF2_1	318	321	PF00917	0.636
LIG_TRAF2_1	386	389	PF00917	0.613
LIG_TRAF2_1	66	69	PF00917	0.736
LIG_TRAF2_1	884	887	PF00917	0.700
LIG_TYR_ITIM	506	511	PF00017	0.461
LIG_WRC_WIRS_1	1	6	PF05994	0.667
LIG_WRC_WIRS_1	513	518	PF05994	0.562
MOD_CDK_SPxxK_3	222	229	PF00069	0.642
MOD_CK1_1	104	110	PF00069	0.689
MOD_CK1_1	118	124	PF00069	0.635
MOD_CK1_1	157	163	PF00069	0.693
MOD_CK1_1	17	23	PF00069	0.647
MOD_CK1_1	175	181	PF00069	0.538
MOD_CK1_1	199	205	PF00069	0.632
MOD_CK1_1	216	222	PF00069	0.558
MOD_CK1_1	26	32	PF00069	0.644
MOD_CK1_1	3	9	PF00069	0.732
MOD_CK1_1	345	351	PF00069	0.566
MOD_CK1_1	44	50	PF00069	0.674
MOD_CK1_1	442	448	PF00069	0.788
MOD_CK1_1	467	473	PF00069	0.591
MOD_CK1_1	559	565	PF00069	0.615
MOD_CK1_1	63	69	PF00069	0.680
MOD_CK1_1	680	686	PF00069	0.546
MOD_CK1_1	946	952	PF00069	0.381
MOD_CK2_1	1064	1070	PF00069	0.493
MOD_CK2_1	121	127	PF00069	0.781
MOD_CK2_1	249	255	PF00069	0.721
MOD_CK2_1	263	269	PF00069	0.485
MOD_CK2_1	383	389	PF00069	0.571
MOD_CK2_1	405	411	PF00069	0.617
MOD_CK2_1	62	68	PF00069	0.675
MOD_CK2_1	738	744	PF00069	0.514
MOD_CK2_1	771	777	PF00069	0.486
MOD_CK2_1	921	927	PF00069	0.450
MOD_CK2_1	932	938	PF00069	0.415
MOD_Cter_Amidation	188	191	PF01082	0.711
MOD_Cter_Amidation	675	678	PF01082	0.496
MOD_GlcNHglycan	1029	1032	PF01048	0.472
MOD_GlcNHglycan	106	109	PF01048	0.613
MOD_GlcNHglycan	117	120	PF01048	0.739
MOD_GlcNHglycan	185	188	PF01048	0.785
MOD_GlcNHglycan	33	36	PF01048	0.664
MOD_GlcNHglycan	357	360	PF01048	0.614
MOD_GlcNHglycan	37	40	PF01048	0.619
MOD_GlcNHglycan	458	461	PF01048	0.736
MOD_GlcNHglycan	466	469	PF01048	0.584
MOD_GlcNHglycan	794	797	PF01048	0.398
MOD_GlcNHglycan	849	852	PF01048	0.703
MOD_GlcNHglycan	868	871	PF01048	0.599
MOD_GlcNHglycan	948	951	PF01048	0.426
MOD_GlcNHglycan	956	959	PF01048	0.317
MOD_GSK3_1	114	121	PF00069	0.643
MOD_GSK3_1	143	150	PF00069	0.688
MOD_GSK3_1	153	160	PF00069	0.613
MOD_GSK3_1	172	179	PF00069	0.640
MOD_GSK3_1	19	26	PF00069	0.690
MOD_GSK3_1	196	203	PF00069	0.661
MOD_GSK3_1	218	225	PF00069	0.647
MOD_GSK3_1	276	283	PF00069	0.685
MOD_GSK3_1	31	38	PF00069	0.707
MOD_GSK3_1	322	329	PF00069	0.682
MOD_GSK3_1	331	338	PF00069	0.560
MOD_GSK3_1	41	48	PF00069	0.686
MOD_GSK3_1	435	442	PF00069	0.658
MOD_GSK3_1	444	451	PF00069	0.679
MOD_GSK3_1	481	488	PF00069	0.555
MOD_GSK3_1	49	56	PF00069	0.564
MOD_GSK3_1	556	563	PF00069	0.684
MOD_GSK3_1	634	641	PF00069	0.541
MOD_GSK3_1	677	684	PF00069	0.570
MOD_GSK3_1	862	869	PF00069	0.719
MOD_GSK3_1	910	917	PF00069	0.388
MOD_GSK3_1	919	926	PF00069	0.430
MOD_GSK3_1	954	961	PF00069	0.365
MOD_GSK3_1	989	996	PF00069	0.375
MOD_N-GLC_1	22	27	PF02516	0.666
MOD_N-GLC_1	429	434	PF02516	0.678
MOD_N-GLC_1	92	97	PF02516	0.749
MOD_NEK2_1	1056	1061	PF00069	0.514
MOD_NEK2_1	115	120	PF00069	0.724
MOD_NEK2_1	143	148	PF00069	0.614
MOD_NEK2_1	152	157	PF00069	0.585
MOD_NEK2_1	200	205	PF00069	0.669
MOD_NEK2_1	331	336	PF00069	0.685
MOD_NEK2_1	41	46	PF00069	0.672
MOD_NEK2_1	456	461	PF00069	0.675
MOD_NEK2_1	481	486	PF00069	0.480
MOD_NEK2_1	5	10	PF00069	0.590
MOD_NEK2_1	790	795	PF00069	0.394
MOD_NEK2_1	847	852	PF00069	0.625
MOD_NEK2_1	919	924	PF00069	0.537
MOD_NEK2_2	1049	1054	PF00069	0.390
MOD_NEK2_2	335	340	PF00069	0.597
MOD_NEK2_2	556	561	PF00069	0.649
MOD_NEK2_2	701	706	PF00069	0.386
MOD_NEK2_2	872	877	PF00069	0.557
MOD_PIKK_1	126	132	PF00454	0.729
MOD_PIKK_1	170	176	PF00454	0.733
MOD_PIKK_1	326	332	PF00454	0.692
MOD_PIKK_1	383	389	PF00454	0.618
MOD_PIKK_1	857	863	PF00454	0.635
MOD_PIKK_1	921	927	PF00454	0.450
MOD_PK_1	158	164	PF00069	0.628
MOD_PK_1	218	224	PF00069	0.697
MOD_PK_1	229	235	PF00069	0.643
MOD_PK_1	975	981	PF00069	0.537
MOD_PKA_1	1027	1033	PF00069	0.396
MOD_PKA_1	158	164	PF00069	0.755
MOD_PKA_1	190	196	PF00069	0.603
MOD_PKA_1	229	235	PF00069	0.698
MOD_PKA_1	274	280	PF00069	0.656
MOD_PKA_1	355	361	PF00069	0.554
MOD_PKA_1	653	659	PF00069	0.491
MOD_PKA_1	666	672	PF00069	0.503
MOD_PKA_1	677	683	PF00069	0.493
MOD_PKA_1	863	869	PF00069	0.667
MOD_PKA_2	101	107	PF00069	0.772
MOD_PKA_2	1027	1033	PF00069	0.396
MOD_PKA_2	157	163	PF00069	0.757
MOD_PKA_2	17	23	PF00069	0.681
MOD_PKA_2	189	195	PF00069	0.687
MOD_PKA_2	213	219	PF00069	0.604
MOD_PKA_2	229	235	PF00069	0.630
MOD_PKA_2	249	255	PF00069	0.473
MOD_PKA_2	311	317	PF00069	0.530
MOD_PKA_2	49	55	PF00069	0.748
MOD_PKA_2	623	629	PF00069	0.548
MOD_PKA_2	653	659	PF00069	0.514
MOD_PKA_2	666	672	PF00069	0.567
MOD_PKA_2	677	683	PF00069	0.616
MOD_PKA_2	862	868	PF00069	0.585
MOD_Plk_1	1049	1055	PF00069	0.387
MOD_Plk_1	200	206	PF00069	0.756
MOD_Plk_1	216	222	PF00069	0.515
MOD_Plk_1	22	28	PF00069	0.648
MOD_Plk_1	255	261	PF00069	0.591
MOD_Plk_1	319	325	PF00069	0.595
MOD_Plk_1	680	686	PF00069	0.591
MOD_Plk_1	721	727	PF00069	0.495
MOD_Plk_2-3	1007	1013	PF00069	0.411
MOD_Plk_2-3	196	202	PF00069	0.743
MOD_Plk_4	101	107	PF00069	0.772
MOD_Plk_4	1049	1055	PF00069	0.387
MOD_Plk_4	143	149	PF00069	0.613
MOD_Plk_4	218	224	PF00069	0.613
MOD_Plk_4	249	255	PF00069	0.711
MOD_Plk_4	276	282	PF00069	0.542
MOD_Plk_4	284	290	PF00069	0.550
MOD_Plk_4	305	311	PF00069	0.506
MOD_Plk_4	436	442	PF00069	0.783
MOD_Plk_4	481	487	PF00069	0.479
MOD_Plk_4	681	687	PF00069	0.577
MOD_Plk_4	731	737	PF00069	0.409
MOD_Plk_4	771	777	PF00069	0.499
MOD_Plk_4	914	920	PF00069	0.460
MOD_ProDKin_1	1036	1042	PF00069	0.511
MOD_ProDKin_1	222	228	PF00069	0.641
MOD_ProDKin_1	28	34	PF00069	0.654
MOD_ProDKin_1	282	288	PF00069	0.551
MOD_ProDKin_1	361	367	PF00069	0.494
MOD_ProDKin_1	573	579	PF00069	0.641
MOD_ProDKin_1	634	640	PF00069	0.428
MOD_ProDKin_1	92	98	PF00069	0.633
MOD_ProDKin_1	943	949	PF00069	0.373
MOD_SUMO_rev_2	582	592	PF00179	0.616
TRG_DiLeu_BaEn_1	1038	1043	PF01217	0.530
TRG_DiLeu_BaEn_1	627	632	PF01217	0.545
TRG_DiLeu_BaEn_1	731	736	PF01217	0.415
TRG_DiLeu_BaEn_2	785	791	PF01217	0.477
TRG_ENDOCYTIC_2	316	319	PF00928	0.502
TRG_ENDOCYTIC_2	508	511	PF00928	0.474
TRG_ER_diArg_1	1027	1029	PF00400	0.414
TRG_ER_diArg_1	228	231	PF00400	0.696
TRG_ER_diArg_1	666	668	PF00400	0.570
TRG_ER_diArg_1	70	73	PF00400	0.679
TRG_ER_diArg_1	941	944	PF00400	0.381
TRG_NLS_MonoExtC_3	70	76	PF00514	0.704
TRG_Pf-PMV_PEXEL_1	668	672	PF00026	0.688

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HLX4	Leishmania braziliensis	73%	100%
A4I9A3	Leishmania infantum	99%	100%
C9ZJC3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B4A3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q3S3	Leishmania major	90%	100%