Metallo-peptidase_Clan_MF_Family_M17/GeneDB:LmjF. 33.2570

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo-peptidase, Clan MF, Family M17

Species:

Leishmania donovani

UniProt:

A0A3S7X742_LEIDO

TriTrypDb:

LdBPK_332700.1 , LdCL_330034100 , LDHU3_33.3840

Length:

527

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	16
GO:0110165	cellular anatomical entity	1	16
GO:0005654	nucleoplasm	2	1

Expansion

Sequence features

A0A3S7X742

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X742

PDB structure(s): 5nth_A

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	16
GO:0006807	nitrogen compound metabolic process	2	16
GO:0008152	metabolic process	1	16
GO:0019538	protein metabolic process	3	16
GO:0043170	macromolecule metabolic process	3	16
GO:0044238	primary metabolic process	2	16
GO:0071704	organic substance metabolic process	2	16
GO:1901564	organonitrogen compound metabolic process	3	16

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	16
GO:0004177	aminopeptidase activity	5	16
GO:0005488	binding	1	16
GO:0008233	peptidase activity	3	16
GO:0008235	metalloexopeptidase activity	5	16
GO:0008237	metallopeptidase activity	4	16
GO:0008238	exopeptidase activity	4	16
GO:0016787	hydrolase activity	2	16
GO:0030145	manganese ion binding	6	16
GO:0043167	ion binding	2	16
GO:0043169	cation binding	3	16
GO:0046872	metal ion binding	4	16
GO:0046914	transition metal ion binding	5	16
GO:0070006	metalloaminopeptidase activity	6	16
GO:0140096	catalytic activity, acting on a protein	2	16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	164	166	PF00675	0.477
CLV_PCSK_KEX2_1	164	166	PF00082	0.393
CLV_PCSK_KEX2_1	170	172	PF00082	0.378
CLV_PCSK_KEX2_1	5	7	PF00082	0.511
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.412
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.511
CLV_PCSK_SKI1_1	165	169	PF00082	0.435
CLV_PCSK_SKI1_1	288	292	PF00082	0.336
CLV_PCSK_SKI1_1	380	384	PF00082	0.327
CLV_PCSK_SKI1_1	41	45	PF00082	0.599
DOC_CYCLIN_yCln2_LP_2	334	340	PF00134	0.340
DOC_CYCLIN_yCln2_LP_2	443	449	PF00134	0.370
DOC_MAPK_gen_1	233	241	PF00069	0.444
DOC_MAPK_gen_1	363	372	PF00069	0.366
DOC_MAPK_MEF2A_6	363	372	PF00069	0.429
DOC_MAPK_MEF2A_6	94	103	PF00069	0.502
DOC_PP2B_LxvP_1	334	337	PF13499	0.419
DOC_PP2B_LxvP_1	501	504	PF13499	0.460
DOC_PP2B_PxIxI_1	397	403	PF00149	0.429
DOC_USP7_MATH_1	16	20	PF00917	0.532
DOC_USP7_MATH_1	42	46	PF00917	0.643
DOC_USP7_MATH_1	475	479	PF00917	0.329
DOC_USP7_MATH_2	337	343	PF00917	0.381
DOC_WW_Pin1_4	394	399	PF00397	0.357
LIG_14-3-3_CanoR_1	164	168	PF00244	0.504
LIG_14-3-3_CanoR_1	380	388	PF00244	0.461
LIG_14-3-3_CanoR_1	41	50	PF00244	0.684
LIG_14-3-3_CanoR_1	466	470	PF00244	0.354
LIG_14-3-3_CanoR_1	6	13	PF00244	0.527
LIG_Actin_WH2_2	219	237	PF00022	0.500
LIG_BIR_III_4	376	380	PF00653	0.327
LIG_CaM_NSCaTE_8	230	237	PF13499	0.392
LIG_CtBP_PxDLS_1	248	254	PF00389	0.370
LIG_FHA_1	192	198	PF00498	0.584
LIG_FHA_1	213	219	PF00498	0.361
LIG_FHA_1	298	304	PF00498	0.383
LIG_FHA_1	367	373	PF00498	0.327
LIG_FHA_1	395	401	PF00498	0.340
LIG_FHA_1	45	51	PF00498	0.612
LIG_FHA_1	94	100	PF00498	0.432
LIG_FHA_2	220	226	PF00498	0.327
LIG_FHA_2	373	379	PF00498	0.327
LIG_FHA_2	422	428	PF00498	0.439
LIG_FHA_2	504	510	PF00498	0.460
LIG_FHA_2	82	88	PF00498	0.540
LIG_LIR_Gen_1	175	185	PF02991	0.590
LIG_LIR_Gen_1	220	231	PF02991	0.336
LIG_LIR_Gen_1	33	42	PF02991	0.633
LIG_LIR_Gen_1	493	504	PF02991	0.412
LIG_LIR_Nem_3	175	181	PF02991	0.560
LIG_LIR_Nem_3	220	226	PF02991	0.336
LIG_LIR_Nem_3	253	259	PF02991	0.372
LIG_LIR_Nem_3	3	7	PF02991	0.665
LIG_LIR_Nem_3	33	37	PF02991	0.519
LIG_LIR_Nem_3	442	448	PF02991	0.327
LIG_LIR_Nem_3	493	499	PF02991	0.365
LIG_PDZ_Class_3	522	527	PF00595	0.546
LIG_PTB_Apo_2	452	459	PF02174	0.451
LIG_RPA_C_Fungi	427	439	PF08784	0.326
LIG_SH2_CRK	256	260	PF00017	0.376
LIG_SH2_CRK	4	8	PF00017	0.515
LIG_SH2_GRB2like	178	181	PF00017	0.529
LIG_SH2_GRB2like	423	426	PF00017	0.386
LIG_SH2_NCK_1	13	17	PF00017	0.444
LIG_SH2_NCK_1	74	78	PF00017	0.500
LIG_SH2_SRC	13	16	PF00017	0.543
LIG_SH2_SRC	178	181	PF00017	0.529
LIG_SH2_STAP1	28	32	PF00017	0.393
LIG_SH2_STAP1	74	78	PF00017	0.429
LIG_SH2_STAT5	146	149	PF00017	0.400
LIG_SH2_STAT5	178	181	PF00017	0.481
LIG_SH2_STAT5	396	399	PF00017	0.386
LIG_SH2_STAT5	423	426	PF00017	0.400
LIG_SH2_STAT5	449	452	PF00017	0.370
LIG_SH3_3	178	184	PF00018	0.464
LIG_SH3_3	208	214	PF00018	0.375
LIG_SH3_3	445	451	PF00018	0.429
LIG_SUMO_SIM_anti_2	287	293	PF11976	0.486
LIG_SUMO_SIM_anti_2	52	59	PF11976	0.390
LIG_SUMO_SIM_par_1	271	276	PF11976	0.357
LIG_SUMO_SIM_par_1	336	342	PF11976	0.381
LIG_SUMO_SIM_par_1	52	59	PF11976	0.427
LIG_TRAF2_1	12	15	PF00917	0.569
LIG_TRAF2_1	247	250	PF00917	0.460
LIG_UBA3_1	361	365	PF00899	0.370
MOD_CK1_1	108	114	PF00069	0.399
MOD_CK1_1	191	197	PF00069	0.519
MOD_CK1_1	30	36	PF00069	0.514
MOD_CK1_1	366	372	PF00069	0.327
MOD_CK1_1	426	432	PF00069	0.492
MOD_CK1_1	468	474	PF00069	0.401
MOD_CK2_1	146	152	PF00069	0.404
MOD_CK2_1	219	225	PF00069	0.327
MOD_CK2_1	372	378	PF00069	0.327
MOD_CK2_1	421	427	PF00069	0.398
MOD_CK2_1	503	509	PF00069	0.405
MOD_CK2_1	8	14	PF00069	0.497
MOD_CK2_1	81	87	PF00069	0.489
MOD_GlcNHglycan	10	13	PF01048	0.542
MOD_GlcNHglycan	148	151	PF01048	0.369
MOD_GlcNHglycan	18	21	PF01048	0.403
MOD_GlcNHglycan	190	193	PF01048	0.607
MOD_GlcNHglycan	240	244	PF01048	0.476
MOD_GlcNHglycan	365	368	PF01048	0.327
MOD_GlcNHglycan	459	462	PF01048	0.527
MOD_GSK3_1	159	166	PF00069	0.456
MOD_GSK3_1	217	224	PF00069	0.345
MOD_GSK3_1	392	399	PF00069	0.401
MOD_GSK3_1	81	88	PF00069	0.523
MOD_N-GLC_1	30	35	PF02516	0.464
MOD_N-GLC_1	372	377	PF02516	0.336
MOD_N-GLC_1	486	491	PF02516	0.455
MOD_NEK2_1	21	26	PF00069	0.368
MOD_NEK2_1	217	222	PF00069	0.339
MOD_NEK2_1	259	264	PF00069	0.369
MOD_NEK2_1	465	470	PF00069	0.302
MOD_NEK2_2	310	315	PF00069	0.424
MOD_PIKK_1	352	358	PF00454	0.427
MOD_PIKK_1	6	12	PF00454	0.441
MOD_PK_1	105	111	PF00069	0.534
MOD_PKA_2	163	169	PF00069	0.504
MOD_PKA_2	465	471	PF00069	0.354
MOD_PKB_1	6	14	PF00069	0.503
MOD_Plk_1	14	20	PF00069	0.443
MOD_Plk_1	151	157	PF00069	0.493
MOD_Plk_1	30	36	PF00069	0.405
MOD_Plk_1	338	344	PF00069	0.500
MOD_Plk_1	392	398	PF00069	0.429
MOD_Plk_2-3	219	225	PF00069	0.370
MOD_Plk_4	339	345	PF00069	0.429
MOD_Plk_4	396	402	PF00069	0.392
MOD_Plk_4	49	55	PF00069	0.425
MOD_ProDKin_1	394	400	PF00069	0.357
TRG_DiLeu_BaLyEn_6	97	102	PF01217	0.500
TRG_ENDOCYTIC_2	178	181	PF00928	0.582
TRG_ENDOCYTIC_2	256	259	PF00928	0.367
TRG_ENDOCYTIC_2	4	7	PF00928	0.656
TRG_NES_CRM1_1	359	371	PF08389	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6B6	Leptomonas seymouri	34%	97%
A0A0N0P8E6	Leptomonas seymouri	77%	100%
A0A0N1PAS4	Leptomonas seymouri	43%	98%
A0A0S4IQ79	Bodo saltans	54%	100%
A0A1X0NWR5	Trypanosomatidae	51%	100%
A0A1X0P4M9	Trypanosomatidae	48%	100%
A0A3R7JY84	Trypanosoma rangeli	51%	100%
A0A3R7N130	Trypanosoma rangeli	58%	94%
A0A3S7WRP1	Leishmania donovani	44%	99%
A0K9N9	Burkholderia cenocepacia (strain HI2424)	30%	100%
A1SRZ1	Psychromonas ingrahamii (strain 37)	31%	100%
A2BSQ4	Prochlorococcus marinus (strain AS9601)	30%	100%
A3PEG6	Prochlorococcus marinus (strain MIT 9301)	30%	100%
A4H6I8	Leishmania braziliensis	44%	98%
A4HCW4	Leishmania braziliensis	34%	100%
A4HLW7	Leishmania braziliensis	86%	100%
A4HUX3	Leishmania infantum	44%	99%
A4I996	Leishmania infantum	100%	100%
A4JGZ2	Burkholderia vietnamiensis (strain G4 / LMG 22486)	29%	100%
A5GV03	Synechococcus sp. (strain RCC307)	30%	100%
A6TWW9	Alkaliphilus metalliredigens (strain QYMF)	31%	100%
A6X259	Brucella anthropi (strain ATCC 49188 / DSM 6882 / CCUG 24695 / JCM 21032 / LMG 3331 / NBRC 15819 / NCTC 12168 / Alc 37)	33%	100%
A8G6E3	Prochlorococcus marinus (strain MIT 9215)	30%	100%
A8LI79	Dinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)	34%	100%
A9AHG9	Burkholderia multivorans (strain ATCC 17616 / 249)	29%	100%
B0U1L5	Xylella fastidiosa (strain M12)	29%	100%
B1JWV2	Burkholderia cenocepacia (strain MC0-3)	30%	100%
B1V932	Phytoplasma australiense	32%	100%
B1YUW5	Burkholderia ambifaria (strain MC40-6)	30%	100%
B2I6L3	Xylella fastidiosa (strain M23)	29%	100%
B2JET5	Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 / STM815)	29%	100%
B2T146	Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN)	27%	100%
B4E8G9	Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610)	30%	100%
B4F2N1	Proteus mirabilis (strain HI4320)	33%	100%
B5ZWY7	Rhizobium leguminosarum bv. trifolii (strain WSM2304)	33%	100%
B8GTX6	Thioalkalivibrio sulfidiphilus (strain HL-EbGR7)	30%	100%
C0QC86	Desulforapulum autotrophicum (strain ATCC 43914 / DSM 3382 / VKM B-1955 / HRM2)	30%	100%
C4LA51	Tolumonas auensis (strain DSM 9187 / TA4)	30%	100%
C5CCM4	Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230)	35%	100%
C9ZV91	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	79%
D0A654	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	93%
D0A7H3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9ANK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	98%
E9B496	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O06865	Synechococcus elongatus (strain PCC 7942 / FACHB-805)	32%	100%
Q0BCQ2	Burkholderia ambifaria (strain ATCC BAA-244 / AMMD)	30%	100%
Q1BUE7	Burkholderia cenocepacia (strain AU 1054)	30%	100%
Q215R8	Rhodopseudomonas palustris (strain BisB18)	32%	100%
Q21KZ5	Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)	30%	100%
Q39DS5	Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)	30%	100%
Q488M4	Colwellia psychrerythraea (strain 34H / ATCC BAA-681)	30%	100%
Q4Q3T0	Leishmania major	97%	100%
Q4QH17	Leishmania major	44%	99%
Q5FFZ5	Ehrlichia ruminantium (strain Gardel)	31%	100%
Q5N569	Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1)	32%	100%
Q5QY05	Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)	31%	100%
Q65SA3	Mannheimia succiniciproducens (strain MBEL55E)	28%	100%
Q6NSR8	Mus musculus	45%	100%
Q7V0D4	Prochlorococcus marinus subsp. pastoris (strain CCMP1986 / NIES-2087 / MED4)	27%	100%
Q7VAP4	Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)	31%	100%
Q87F32	Xylella fastidiosa (strain Temecula1 / ATCC 700964)	29%	100%
Q92QY7	Rhizobium meliloti (strain 1021)	36%	100%
Q9PH08	Xylella fastidiosa (strain 9a5c)	30%	100%
V5BTR1	Trypanosoma cruzi	56%	95%
V5BWE3	Trypanosoma cruzi	51%	100%