Hypothetical_protein_conserved

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X736_LEIDO

TriTrypDb:

LdBPK_332940.1 , LdCL_330036500 , LDHU3_33.4090

Length:

151

Annotations

LeishMANIAdb annotations

Probably not embedded into the membranes.

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S7X736

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X736

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	56	60	PF00656	0.558
CLV_NRD_NRD_1	126	128	PF00675	0.534
CLV_PCSK_KEX2_1	10	12	PF00082	0.314
CLV_PCSK_KEX2_1	126	128	PF00082	0.534
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.314
CLV_PCSK_SKI1_1	109	113	PF00082	0.268
DOC_PP1_RVXF_1	77	84	PF00149	0.498
DOC_USP7_MATH_1	55	59	PF00917	0.529
DOC_WW_Pin1_4	131	136	PF00397	0.356
LIG_14-3-3_CanoR_1	109	118	PF00244	0.337
LIG_14-3-3_CanoR_1	11	20	PF00244	0.480
LIG_14-3-3_CanoR_1	126	130	PF00244	0.363
LIG_BIR_II_1	1	5	PF00653	0.608
LIG_FHA_2	54	60	PF00498	0.550
LIG_LIR_Nem_3	112	118	PF02991	0.427
LIG_LIR_Nem_3	128	133	PF02991	0.316
LIG_LIR_Nem_3	77	81	PF02991	0.520
LIG_LYPXL_S_1	129	133	PF13949	0.540
LIG_LYPXL_yS_3	130	133	PF13949	0.342
LIG_PCNA_yPIPBox_3	97	105	PF02747	0.573
LIG_PTB_Phospho_1	145	151	PF10480	0.361
LIG_SH2_CRK	78	82	PF00017	0.496
LIG_SH2_STAT5	89	92	PF00017	0.487
LIG_SH3_3	126	132	PF00018	0.335
LIG_SH3_3	17	23	PF00018	0.571
MOD_CK1_1	134	140	PF00069	0.325
MOD_Cter_Amidation	124	127	PF01082	0.430
MOD_GlcNHglycan	13	16	PF01048	0.379
MOD_GlcNHglycan	34	37	PF01048	0.287
MOD_GlcNHglycan	91	94	PF01048	0.312
MOD_GSK3_1	55	62	PF00069	0.575
MOD_N-GLC_1	97	102	PF02516	0.226
MOD_NEK2_2	125	130	PF00069	0.305
MOD_PIKK_1	109	115	PF00454	0.370
MOD_PK_1	97	103	PF00069	0.421
MOD_PKA_1	10	16	PF00069	0.549
MOD_PKA_2	10	16	PF00069	0.490
MOD_PKA_2	125	131	PF00069	0.307
MOD_Plk_1	97	103	PF00069	0.558
MOD_ProDKin_1	131	137	PF00069	0.350
TRG_DiLeu_BaEn_1	71	76	PF01217	0.529
TRG_ENDOCYTIC_2	130	133	PF00928	0.437
TRG_ENDOCYTIC_2	78	81	PF00928	0.496
TRG_ER_diArg_1	65	68	PF00400	0.589
TRG_Pf-PMV_PEXEL_1	67	71	PF00026	0.321

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTD3	Leptomonas seymouri	34%	94%
A0A0N1PDI5	Leptomonas seymouri	66%	100%
A0A0S4JQI6	Bodo saltans	42%	100%
A0A1X0NJU2	Trypanosomatidae	27%	100%
A0A1X0NR99	Trypanosomatidae	48%	100%
A0A3S7WP26	Leishmania donovani	32%	100%
A0A422N2T1	Trypanosoma rangeli	30%	100%
A0A422NKR0	Trypanosoma rangeli	48%	100%
A4H495	Leishmania braziliensis	34%	100%
A4HLZ1	Leishmania braziliensis	87%	100%
A4I9C1	Leishmania infantum	100%	100%
C9ZJA0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
C9ZUD9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AKF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B4C0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q3Q5	Leishmania major	90%	100%
V5BJW3	Trypanosoma cruzi	24%	100%
V5DB75	Trypanosoma cruzi	50%	100%