Ras-like small GTPase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ras-like small GTPases, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X732_LEIDO

TriTrypDb:

LdBPK_332530.1 , LdCL_330032400 , LDHU3_33.3620

Length:

567

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X732

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X732

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	5
GO:0003924	GTPase activity	7	5
GO:0003925	G protein activity	2	5
GO:0005488	binding	1	11
GO:0005525	GTP binding	5	11
GO:0016462	pyrophosphatase activity	5	5
GO:0016787	hydrolase activity	2	5
GO:0016817	hydrolase activity, acting on acid anhydrides	3	5
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	5
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	5
GO:0019001	guanyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032561	guanyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0098772	molecular function regulator activity	1	5
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	248	252	PF00656	0.362
CLV_C14_Caspase3-7	466	470	PF00656	0.345
CLV_C14_Caspase3-7	556	560	PF00656	0.592
CLV_NRD_NRD_1	132	134	PF00675	0.466
CLV_NRD_NRD_1	178	180	PF00675	0.490
CLV_NRD_NRD_1	230	232	PF00675	0.480
CLV_NRD_NRD_1	286	288	PF00675	0.347
CLV_NRD_NRD_1	299	301	PF00675	0.440
CLV_NRD_NRD_1	323	325	PF00675	0.251
CLV_NRD_NRD_1	444	446	PF00675	0.396
CLV_NRD_NRD_1	53	55	PF00675	0.605
CLV_PCSK_KEX2_1	131	133	PF00082	0.475
CLV_PCSK_KEX2_1	178	180	PF00082	0.497
CLV_PCSK_KEX2_1	286	288	PF00082	0.347
CLV_PCSK_KEX2_1	323	325	PF00082	0.251
CLV_PCSK_KEX2_1	444	446	PF00082	0.396
CLV_PCSK_KEX2_1	53	55	PF00082	0.656
CLV_PCSK_KEX2_1	546	548	PF00082	0.623
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.251
CLV_PCSK_PC1ET2_1	546	548	PF00082	0.675
CLV_PCSK_SKI1_1	133	137	PF00082	0.485
CLV_PCSK_SKI1_1	247	251	PF00082	0.433
CLV_PCSK_SKI1_1	29	33	PF00082	0.565
CLV_PCSK_SKI1_1	461	465	PF00082	0.342
CLV_PCSK_SKI1_1	520	524	PF00082	0.539
DEG_Kelch_Keap1_1	294	299	PF01344	0.540
DOC_CYCLIN_yCln2_LP_2	378	384	PF00134	0.351
DOC_MAPK_DCC_7	413	422	PF00069	0.488
DOC_MAPK_gen_1	131	140	PF00069	0.472
DOC_MAPK_gen_1	231	238	PF00069	0.326
DOC_MAPK_gen_1	29	37	PF00069	0.650
DOC_MAPK_gen_1	300	307	PF00069	0.401
DOC_MAPK_gen_1	323	330	PF00069	0.420
DOC_MAPK_gen_1	53	61	PF00069	0.650
DOC_MAPK_HePTP_8	128	140	PF00069	0.582
DOC_MAPK_MEF2A_6	131	140	PF00069	0.581
DOC_MAPK_MEF2A_6	231	238	PF00069	0.324
DOC_MAPK_MEF2A_6	300	307	PF00069	0.369
DOC_MAPK_NFAT4_5	133	141	PF00069	0.581
DOC_MIT_MIM_1	210	219	PF04212	0.359
DOC_PP2B_LxvP_1	35	38	PF13499	0.630
DOC_PP2B_LxvP_1	59	62	PF13499	0.647
DOC_USP7_MATH_1	272	276	PF00917	0.506
DOC_USP7_MATH_1	494	498	PF00917	0.661
DOC_USP7_MATH_1	505	509	PF00917	0.661
DOC_USP7_UBL2_3	29	33	PF12436	0.562
DOC_USP7_UBL2_3	545	549	PF12436	0.657
DOC_USP7_UBL2_3	6	10	PF12436	0.571
DOC_WW_Pin1_4	356	361	PF00397	0.433
LIG_14-3-3_CanoR_1	141	149	PF00244	0.565
LIG_14-3-3_CanoR_1	215	223	PF00244	0.384
LIG_14-3-3_CanoR_1	224	228	PF00244	0.449
LIG_14-3-3_CanoR_1	286	292	PF00244	0.475
LIG_14-3-3_CanoR_1	374	382	PF00244	0.554
LIG_14-3-3_CanoR_1	493	501	PF00244	0.633
LIG_14-3-3_CanoR_1	520	525	PF00244	0.634
LIG_14-3-3_CanoR_1	53	59	PF00244	0.565
LIG_14-3-3_CanoR_1	547	555	PF00244	0.590
LIG_Actin_WH2_2	28	43	PF00022	0.587
LIG_APCC_ABBA_1	530	535	PF00400	0.463
LIG_deltaCOP1_diTrp_1	251	257	PF00928	0.323
LIG_Dynein_DLC8_1	44	50	PF01221	0.559
LIG_EH_1	379	383	PF12763	0.416
LIG_FHA_1	135	141	PF00498	0.492
LIG_FHA_1	527	533	PF00498	0.425
LIG_FHA_1	53	59	PF00498	0.629
LIG_FHA_2	125	131	PF00498	0.577
LIG_FHA_2	215	221	PF00498	0.382
LIG_FHA_2	224	230	PF00498	0.416
LIG_FHA_2	339	345	PF00498	0.420
LIG_FHA_2	508	514	PF00498	0.670
LIG_LIR_Apic_2	148	152	PF02991	0.629
LIG_LIR_Apic_2	552	558	PF02991	0.592
LIG_LIR_Gen_1	191	196	PF02991	0.343
LIG_LIR_Nem_3	191	195	PF02991	0.332
LIG_LIR_Nem_3	251	256	PF02991	0.329
LIG_LIR_Nem_3	282	288	PF02991	0.355
LIG_LIR_Nem_3	489	495	PF02991	0.689
LIG_LRP6_Inhibitor_1	368	374	PF00058	0.313
LIG_LYPXL_yS_3	310	313	PF13949	0.420
LIG_PDZ_Class_3	562	567	PF00595	0.707
LIG_Pex14_1	253	257	PF04695	0.312
LIG_Pex14_2	188	192	PF04695	0.357
LIG_SH2_CRK	475	479	PF00017	0.347
LIG_SH2_CRK	492	496	PF00017	0.501
LIG_SH2_NCK_1	555	559	PF00017	0.707
LIG_SH2_SRC	555	558	PF00017	0.591
LIG_SH2_STAT3	256	259	PF00017	0.401
LIG_SH2_STAT5	256	259	PF00017	0.452
LIG_SH2_STAT5	280	283	PF00017	0.329
LIG_SH2_STAT5	475	478	PF00017	0.343
LIG_SH3_3	354	360	PF00018	0.420
LIG_SH3_3	378	384	PF00018	0.351
LIG_SUMO_SIM_par_1	136	144	PF11976	0.578
LIG_TYR_ITIM	308	313	PF00017	0.257
LIG_UBA3_1	318	325	PF00899	0.301
LIG_WRC_WIRS_1	527	532	PF05994	0.417
MOD_CK1_1	294	300	PF00069	0.557
MOD_CK1_1	5	11	PF00069	0.692
MOD_CK1_1	57	63	PF00069	0.614
MOD_CK1_1	73	79	PF00069	0.666
MOD_CK2_1	214	220	PF00069	0.369
MOD_CK2_1	223	229	PF00069	0.404
MOD_CK2_1	338	344	PF00069	0.257
MOD_CK2_1	356	362	PF00069	0.257
MOD_CK2_1	507	513	PF00069	0.638
MOD_GlcNHglycan	116	119	PF01048	0.611
MOD_GlcNHglycan	293	296	PF01048	0.438
MOD_GlcNHglycan	362	366	PF01048	0.370
MOD_GlcNHglycan	414	417	PF01048	0.448
MOD_GlcNHglycan	497	500	PF01048	0.645
MOD_GlcNHglycan	515	518	PF01048	0.502
MOD_GlcNHglycan	7	10	PF01048	0.723
MOD_GlcNHglycan	77	80	PF01048	0.660
MOD_GSK3_1	272	279	PF00069	0.483
MOD_GSK3_1	287	294	PF00069	0.473
MOD_GSK3_1	334	341	PF00069	0.261
MOD_GSK3_1	401	408	PF00069	0.473
MOD_N-GLC_1	495	500	PF02516	0.557
MOD_NEK2_1	173	178	PF00069	0.468
MOD_NEK2_1	276	281	PF00069	0.388
MOD_NEK2_1	412	417	PF00069	0.465
MOD_NEK2_1	47	52	PF00069	0.503
MOD_NEK2_1	75	80	PF00069	0.668
MOD_NEK2_1	85	90	PF00069	0.495
MOD_PIKK_1	101	107	PF00454	0.728
MOD_PIKK_1	214	220	PF00454	0.380
MOD_PIKK_1	424	430	PF00454	0.382
MOD_PIKK_1	45	51	PF00454	0.613
MOD_PIKK_1	507	513	PF00454	0.544
MOD_PK_1	287	293	PF00069	0.312
MOD_PK_1	54	60	PF00069	0.607
MOD_PKA_2	140	146	PF00069	0.619
MOD_PKA_2	214	220	PF00069	0.369
MOD_PKA_2	223	229	PF00069	0.416
MOD_PKA_2	373	379	PF00069	0.544
MOD_PKA_2	390	396	PF00069	0.309
MOD_PKA_2	412	418	PF00069	0.513
MOD_PKA_2	446	452	PF00069	0.568
MOD_PKA_2	45	51	PF00069	0.595
MOD_PKA_2	52	58	PF00069	0.579
MOD_PKA_2	73	79	PF00069	0.671
MOD_PKA_2	85	91	PF00069	0.492
MOD_Plk_1	124	130	PF00069	0.573
MOD_Plk_1	181	187	PF00069	0.442
MOD_Plk_4	276	282	PF00069	0.355
MOD_Plk_4	314	320	PF00069	0.288
MOD_Plk_4	54	60	PF00069	0.626
MOD_ProDKin_1	356	362	PF00069	0.276
MOD_SUMO_rev_2	225	234	PF00179	0.403
MOD_SUMO_rev_2	294	303	PF00179	0.564
MOD_SUMO_rev_2	34	43	PF00179	0.513
TRG_DiLeu_BaEn_3	229	235	PF01217	0.501
TRG_DiLeu_BaLyEn_6	384	389	PF01217	0.325
TRG_ENDOCYTIC_2	189	192	PF00928	0.297
TRG_ENDOCYTIC_2	310	313	PF00928	0.257
TRG_ENDOCYTIC_2	492	495	PF00928	0.675
TRG_ER_diArg_1	131	133	PF00400	0.617
TRG_ER_diArg_1	285	287	PF00400	0.344
TRG_ER_diArg_1	443	445	PF00400	0.394
TRG_NES_CRM1_1	525	538	PF08389	0.563
TRG_NLS_MonoExtC_3	544	549	PF00514	0.645
TRG_NLS_MonoExtN_4	543	550	PF00514	0.656

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6X1	Leptomonas seymouri	75%	100%
A0A1X0P4K3	Trypanosomatidae	57%	100%
A0A3R7M8S7	Trypanosoma rangeli	54%	100%
A4HLV2	Leishmania braziliensis	84%	100%
D0A671	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AHQ8	Leishmania infantum	100%	100%
E9B479	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
P53145	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	89%
Q3T0J9	Bos taurus	34%	99%
Q4Q3U7	Leishmania major	95%	100%
Q6PGG6	Mus musculus	34%	98%
Q9SHS8	Arabidopsis thaliana	27%	100%
Q9SJF1	Arabidopsis thaliana	27%	96%
V5B8N5	Trypanosoma cruzi	61%	100%