Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X722_LEIDO

TriTrypDb:

LdBPK_332440.1 , LdCL_330031400 , LDHU3_33.3490

Length:

525

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X722

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X722

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	210	214	PF00656	0.535
CLV_C14_Caspase3-7	255	259	PF00656	0.776
CLV_C14_Caspase3-7	339	343	PF00656	0.534
CLV_C14_Caspase3-7	58	62	PF00656	0.580
CLV_NRD_NRD_1	176	178	PF00675	0.728
CLV_NRD_NRD_1	193	195	PF00675	0.532
CLV_NRD_NRD_1	458	460	PF00675	0.501
CLV_PCSK_FUR_1	190	194	PF00082	0.658
CLV_PCSK_KEX2_1	176	178	PF00082	0.682
CLV_PCSK_KEX2_1	192	194	PF00082	0.496
CLV_PCSK_KEX2_1	458	460	PF00082	0.501
CLV_PCSK_SKI1_1	193	197	PF00082	0.516
CLV_PCSK_SKI1_1	327	331	PF00082	0.759
CLV_PCSK_SKI1_1	365	369	PF00082	0.624
CLV_PCSK_SKI1_1	395	399	PF00082	0.488
CLV_PCSK_SKI1_1	8	12	PF00082	0.603
DEG_APCC_DBOX_1	364	372	PF00400	0.622
DEG_SCF_FBW7_1	310	315	PF00400	0.697
DEG_SPOP_SBC_1	304	308	PF00917	0.712
DEG_SPOP_SBC_1	312	316	PF00917	0.634
DOC_ANK_TNKS_1	469	476	PF00023	0.548
DOC_CKS1_1	442	447	PF01111	0.431
DOC_CYCLIN_RxL_1	190	197	PF00134	0.651
DOC_CYCLIN_RxL_1	392	401	PF00134	0.479
DOC_CYCLIN_yCln2_LP_2	519	525	PF00134	0.607
DOC_USP7_MATH_1	113	117	PF00917	0.596
DOC_USP7_MATH_1	156	160	PF00917	0.725
DOC_USP7_MATH_1	250	254	PF00917	0.692
DOC_USP7_MATH_1	304	308	PF00917	0.750
DOC_USP7_MATH_1	312	316	PF00917	0.694
DOC_USP7_MATH_1	344	348	PF00917	0.753
DOC_USP7_MATH_1	350	354	PF00917	0.691
DOC_USP7_MATH_1	413	417	PF00917	0.662
DOC_WW_Pin1_4	148	153	PF00397	0.626
DOC_WW_Pin1_4	308	313	PF00397	0.750
DOC_WW_Pin1_4	340	345	PF00397	0.756
DOC_WW_Pin1_4	346	351	PF00397	0.809
DOC_WW_Pin1_4	370	375	PF00397	0.503
DOC_WW_Pin1_4	441	446	PF00397	0.436
LIG_14-3-3_CanoR_1	130	135	PF00244	0.600
LIG_14-3-3_CanoR_1	198	204	PF00244	0.588
LIG_14-3-3_CanoR_1	23	31	PF00244	0.761
LIG_14-3-3_CanoR_1	325	332	PF00244	0.831
LIG_14-3-3_CanoR_1	379	385	PF00244	0.534
LIG_14-3-3_CanoR_1	395	400	PF00244	0.499
LIG_14-3-3_CanoR_1	88	92	PF00244	0.793
LIG_AP2alpha_2	83	85	PF02296	0.678
LIG_BRCT_BRCA1_1	69	73	PF00533	0.711
LIG_BRCT_BRCA1_2	69	75	PF00533	0.714
LIG_deltaCOP1_diTrp_1	127	131	PF00928	0.617
LIG_deltaCOP1_diTrp_1	411	418	PF00928	0.651
LIG_EVH1_2	288	292	PF00568	0.711
LIG_EVH1_2	445	449	PF00568	0.480
LIG_FHA_1	112	118	PF00498	0.520
LIG_FHA_1	2	8	PF00498	0.613
LIG_FHA_1	294	300	PF00498	0.728
LIG_FHA_1	359	365	PF00498	0.392
LIG_FHA_1	381	387	PF00498	0.555
LIG_FHA_1	388	394	PF00498	0.457
LIG_FHA_1	514	520	PF00498	0.480
LIG_FHA_2	178	184	PF00498	0.726
LIG_FHA_2	317	323	PF00498	0.839
LIG_FHA_2	396	402	PF00498	0.511
LIG_FHA_2	418	424	PF00498	0.602
LIG_FHA_2	88	94	PF00498	0.714
LIG_Integrin_RGD_1	234	236	PF01839	0.740
LIG_LIR_Apic_2	89	94	PF02991	0.677
LIG_LIR_Gen_1	127	134	PF02991	0.611
LIG_LIR_Gen_1	201	211	PF02991	0.603
LIG_LIR_Gen_1	248	257	PF02991	0.671
LIG_LIR_Gen_1	38	44	PF02991	0.660
LIG_LIR_Gen_1	415	425	PF02991	0.535
LIG_LIR_Nem_3	127	131	PF02991	0.558
LIG_LIR_Nem_3	197	203	PF02991	0.607
LIG_LIR_Nem_3	248	254	PF02991	0.666
LIG_LIR_Nem_3	38	43	PF02991	0.700
LIG_Pex14_2	124	128	PF04695	0.616
LIG_SH2_NCK_1	242	246	PF00017	0.668
LIG_SH2_STAP1	203	207	PF00017	0.585
LIG_SH2_STAP1	40	44	PF00017	0.661
LIG_SH2_STAT5	362	365	PF00017	0.511
LIG_SH3_3	26	32	PF00018	0.715
LIG_SH3_3	282	288	PF00018	0.795
LIG_SH3_3	439	445	PF00018	0.506
LIG_SH3_3	78	84	PF00018	0.679
LIG_TRAF2_1	180	183	PF00917	0.614
LIG_WW_3	444	448	PF00397	0.500
MOD_CDK_SPxK_1	441	447	PF00069	0.436
MOD_CK1_1	151	157	PF00069	0.683
MOD_CK1_1	243	249	PF00069	0.660
MOD_CK1_1	308	314	PF00069	0.798
MOD_CK1_1	316	322	PF00069	0.702
MOD_CK1_1	331	337	PF00069	0.606
MOD_CK1_1	349	355	PF00069	0.793
MOD_CK1_1	406	412	PF00069	0.661
MOD_CK1_1	416	422	PF00069	0.637
MOD_CK2_1	177	183	PF00069	0.624
MOD_CK2_1	198	204	PF00069	0.690
MOD_CK2_1	249	255	PF00069	0.660
MOD_CK2_1	316	322	PF00069	0.741
MOD_CK2_1	330	336	PF00069	0.755
MOD_CK2_1	340	346	PF00069	0.626
MOD_CK2_1	395	401	PF00069	0.501
MOD_CK2_1	52	58	PF00069	0.723
MOD_CK2_1	86	92	PF00069	0.663
MOD_GlcNHglycan	153	156	PF01048	0.825
MOD_GlcNHglycan	242	245	PF01048	0.696
MOD_GlcNHglycan	248	251	PF01048	0.719
MOD_GlcNHglycan	315	318	PF01048	0.718
MOD_GlcNHglycan	346	349	PF01048	0.825
MOD_GlcNHglycan	352	355	PF01048	0.634
MOD_GlcNHglycan	405	408	PF01048	0.677
MOD_GlcNHglycan	415	418	PF01048	0.683
MOD_GSK3_1	246	253	PF00069	0.689
MOD_GSK3_1	304	311	PF00069	0.776
MOD_GSK3_1	312	319	PF00069	0.838
MOD_GSK3_1	321	328	PF00069	0.780
MOD_GSK3_1	336	343	PF00069	0.611
MOD_GSK3_1	344	351	PF00069	0.739
MOD_GSK3_1	412	419	PF00069	0.627
MOD_GSK3_1	421	428	PF00069	0.439
MOD_N-GLC_1	111	116	PF02516	0.566
MOD_N-GLC_1	198	203	PF02516	0.688
MOD_N-GLC_1	308	313	PF02516	0.714
MOD_NEK2_1	1	6	PF00069	0.687
MOD_NEK2_1	305	310	PF00069	0.793
MOD_NEK2_1	421	426	PF00069	0.507
MOD_NEK2_1	73	78	PF00069	0.803
MOD_NEK2_2	135	140	PF00069	0.608
MOD_PIKK_1	158	164	PF00454	0.759
MOD_PK_1	3	9	PF00069	0.614
MOD_PKA_2	129	135	PF00069	0.599
MOD_PKA_2	22	28	PF00069	0.725
MOD_PKA_2	272	278	PF00069	0.661
MOD_PKA_2	35	41	PF00069	0.629
MOD_PKA_2	67	73	PF00069	0.681
MOD_PKA_2	87	93	PF00069	0.721
MOD_Plk_1	198	204	PF00069	0.692
MOD_Plk_1	421	427	PF00069	0.491
MOD_Plk_1	86	92	PF00069	0.694
MOD_Plk_2-3	336	342	PF00069	0.529
MOD_Plk_2-3	87	93	PF00069	0.674
MOD_Plk_4	358	364	PF00069	0.405
MOD_Plk_4	38	44	PF00069	0.699
MOD_Plk_4	395	401	PF00069	0.501
MOD_Plk_4	435	441	PF00069	0.494
MOD_Plk_4	513	519	PF00069	0.474
MOD_ProDKin_1	148	154	PF00069	0.632
MOD_ProDKin_1	308	314	PF00069	0.752
MOD_ProDKin_1	340	346	PF00069	0.759
MOD_ProDKin_1	370	376	PF00069	0.502
MOD_ProDKin_1	441	447	PF00069	0.436
MOD_SUMO_rev_2	144	148	PF00179	0.547
TRG_DiLeu_BaLyEn_6	191	196	PF01217	0.590
TRG_ENDOCYTIC_2	203	206	PF00928	0.523
TRG_ENDOCYTIC_2	40	43	PF00928	0.701
TRG_ER_diArg_1	176	178	PF00400	0.739
TRG_ER_diArg_1	189	192	PF00400	0.544
TRG_ER_diArg_1	193	195	PF00400	0.495
TRG_ER_diArg_1	457	459	PF00400	0.506
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	510	515	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	77	82	PF00026	0.684

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF55	Leptomonas seymouri	53%	98%
A4HLU4	Leishmania braziliensis	70%	100%
E9AHP9	Leishmania infantum	99%	100%
E9B470	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q3V6	Leishmania major	88%	100%