LeishMANIAdb
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UDP-N-acetylglucosamine pyrophosphorylase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
UDP-N-acetylglucosamine pyrophosphorylase, putative
Gene product:
UDP-N-acetylglucosamine pyrophosphorylase, putative
Species:
Leishmania donovani
UniProt:
A0A3S7X721_LEIDO
TriTrypDb:
LdBPK_332650.1 * , LdCL_330033600 , LDHU3_33.3770
Length:
571

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 1
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 2
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Expansion

Sequence features

A0A3S7X721
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X721

Function

Biological processes
TermNameLevelCount
GO:0006040 amino sugar metabolic process 4 1
GO:0006047 UDP-N-acetylglucosamine metabolic process 4 1
GO:0006048 UDP-N-acetylglucosamine biosynthetic process 5 1
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006793 phosphorus metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009058 biosynthetic process 2 1
GO:0009225 nucleotide-sugar metabolic process 4 1
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 12
GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity 6 8
GO:0016740 transferase activity 2 12
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 12
GO:0016779 nucleotidyltransferase activity 4 12
GO:0070569 uridylyltransferase activity 5 12
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_MEL_PAP_1 301 307 PF00089 0.353
CLV_NRD_NRD_1 160 162 PF00675 0.270
CLV_NRD_NRD_1 356 358 PF00675 0.357
CLV_NRD_NRD_1 401 403 PF00675 0.287
CLV_PCSK_KEX2_1 356 358 PF00082 0.321
CLV_PCSK_KEX2_1 98 100 PF00082 0.301
CLV_PCSK_PC1ET2_1 98 100 PF00082 0.301
CLV_PCSK_SKI1_1 138 142 PF00082 0.261
CLV_PCSK_SKI1_1 150 154 PF00082 0.270
CLV_PCSK_SKI1_1 212 216 PF00082 0.262
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1PG62 Leptomonas seymouri 64% 100%
A0A0S4IVW9 Bodo saltans 39% 100%
A0A1X0P444 Trypanosomatidae 45% 100%
A0A422P028 Trypanosoma rangeli 39% 100%
D0A658 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
E9AHS0 Leishmania infantum 100% 100%
E9AIV6 Leishmania braziliensis 80% 98%
E9B491 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 98%
O64765 Arabidopsis thaliana 34% 100%
O74933 Candida albicans 34% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS