UDP-N-acetylglucosamine pyrophosphorylase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UDP-N-acetylglucosamine pyrophosphorylase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X721_LEIDO

TriTrypDb:

LdBPK_332650.1 , LdCL_330033600 , LDHU3_33.3770

Length:

571

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

A0A3S7X721

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X721

Function

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Biological processes
Term	Name	Level	Count
GO:0006040	amino sugar metabolic process	4	1
GO:0006047	UDP-N-acetylglucosamine metabolic process	4	1
GO:0006048	UDP-N-acetylglucosamine biosynthetic process	5	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009225	nucleotide-sugar metabolic process	4	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0003977	UDP-N-acetylglucosamine diphosphorylase activity	6	8
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016779	nucleotidyltransferase activity	4	12
GO:0070569	uridylyltransferase activity	5	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	301	307	PF00089	0.353
CLV_NRD_NRD_1	160	162	PF00675	0.270
CLV_NRD_NRD_1	356	358	PF00675	0.357
CLV_NRD_NRD_1	401	403	PF00675	0.287
CLV_PCSK_KEX2_1	356	358	PF00082	0.321
CLV_PCSK_KEX2_1	98	100	PF00082	0.301
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.301
CLV_PCSK_SKI1_1	138	142	PF00082	0.261
CLV_PCSK_SKI1_1	150	154	PF00082	0.270
CLV_PCSK_SKI1_1	212	216	PF00082	0.262

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PG62	Leptomonas seymouri	64%	100%
A0A0S4IVW9	Bodo saltans	39%	100%
A0A1X0P444	Trypanosomatidae	45%	100%
A0A422P028	Trypanosoma rangeli	39%	100%
D0A658	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AHS0	Leishmania infantum	100%	100%
E9AIV6	Leishmania braziliensis	80%	98%
E9B491	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	98%
O64765	Arabidopsis thaliana	34%	100%
O74933	Candida albicans	34%	100%

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