LIM_domain_containing_protein_putative/Pfam:PF004 12

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X718_LEIDO

TriTrypDb:

LdBPK_332780.1 , LdCL_330034900 , LDHU3_33.3920

Length:

429

Annotations

Annotations by Jardim et al.

Nucleic acid binding, guide RNA associated 1 Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X718

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X718

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	25	29	PF00656	0.663
CLV_C14_Caspase3-7	388	392	PF00656	0.625
CLV_C14_Caspase3-7	92	96	PF00656	0.784
CLV_NRD_NRD_1	247	249	PF00675	0.513
CLV_NRD_NRD_1	268	270	PF00675	0.411
CLV_NRD_NRD_1	333	335	PF00675	0.624
CLV_NRD_NRD_1	370	372	PF00675	0.613
CLV_NRD_NRD_1	411	413	PF00675	0.744
CLV_PCSK_FUR_1	331	335	PF00082	0.655
CLV_PCSK_KEX2_1	174	176	PF00082	0.683

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCS1	Leptomonas seymouri	54%	100%
A4HLX5	Leishmania braziliensis	65%	99%
A4I9A4	Leishmania infantum	100%	100%
E9B4A4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q3S2	Leishmania major	88%	100%

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