Enoyl-CoA hydratase/Enoyl-CoA isomerase/3-hydroxyacyl-CoA dehydrogenase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

enoyl-CoA hydratase/Enoyl-CoA isomerase/3- hydroxyacyl-CoA dehydrogenase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X716_LEIDO

TriTrypDb:

LdBPK_332740.1 , LdCL_330034500 , LDHU3_33.3880

Length:

934

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X716

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X716

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	11
GO:0006629	lipid metabolic process	3	11
GO:0006631	fatty acid metabolic process	4	11
GO:0006635	fatty acid beta-oxidation	6	10
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	10
GO:0009062	fatty acid catabolic process	5	10
GO:0009987	cellular process	1	11
GO:0016042	lipid catabolic process	4	10
GO:0016054	organic acid catabolic process	4	10
GO:0019395	fatty acid oxidation	5	10
GO:0019752	carboxylic acid metabolic process	5	11
GO:0030258	lipid modification	4	10
GO:0032787	monocarboxylic acid metabolic process	6	11
GO:0034440	lipid oxidation	5	10
GO:0043436	oxoacid metabolic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044242	cellular lipid catabolic process	4	10
GO:0044248	cellular catabolic process	3	10
GO:0044255	cellular lipid metabolic process	3	11
GO:0044281	small molecule metabolic process	2	11
GO:0044282	small molecule catabolic process	3	10
GO:0046395	carboxylic acid catabolic process	5	10
GO:0071704	organic substance metabolic process	2	11
GO:0072329	monocarboxylic acid catabolic process	6	10
GO:1901575	organic substance catabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004300	enoyl-CoA hydratase activity	5	6
GO:0005488	binding	1	11
GO:0016491	oxidoreductase activity	2	11
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	11
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	11
GO:0016829	lyase activity	2	6
GO:0016835	carbon-oxygen lyase activity	3	6
GO:0016836	hydro-lyase activity	4	6
GO:0016853	isomerase activity	2	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0051287	NAD binding	4	11
GO:0070403	NAD+ binding	4	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity	5	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	320	324	PF00656	0.484
CLV_C14_Caspase3-7	761	765	PF00656	0.532
CLV_NRD_NRD_1	185	187	PF00675	0.287
CLV_NRD_NRD_1	21	23	PF00675	0.445
CLV_NRD_NRD_1	255	257	PF00675	0.387
CLV_NRD_NRD_1	310	312	PF00675	0.482
CLV_NRD_NRD_1	363	365	PF00675	0.597
CLV_NRD_NRD_1	633	635	PF00675	0.333
CLV_NRD_NRD_1	717	719	PF00675	0.486
CLV_NRD_NRD_1	827	829	PF00675	0.434
CLV_NRD_NRD_1	831	833	PF00675	0.398
CLV_NRD_NRD_1	897	899	PF00675	0.285
CLV_PCSK_KEX2_1	185	187	PF00082	0.466
CLV_PCSK_KEX2_1	2	4	PF00082	0.543
CLV_PCSK_KEX2_1	21	23	PF00082	0.365
CLV_PCSK_KEX2_1	254	256	PF00082	0.411
CLV_PCSK_KEX2_1	309	311	PF00082	0.491
CLV_PCSK_KEX2_1	525	527	PF00082	0.338
CLV_PCSK_KEX2_1	678	680	PF00082	0.606
CLV_PCSK_KEX2_1	825	827	PF00082	0.432
CLV_PCSK_KEX2_1	831	833	PF00082	0.391
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.633
CLV_PCSK_PC1ET2_1	525	527	PF00082	0.338
CLV_PCSK_PC1ET2_1	678	680	PF00082	0.606
CLV_PCSK_PC1ET2_1	825	827	PF00082	0.503
CLV_PCSK_PC7_1	306	312	PF00082	0.433
CLV_PCSK_PC7_1	827	833	PF00082	0.438
CLV_PCSK_SKI1_1	218	222	PF00082	0.528
CLV_PCSK_SKI1_1	245	249	PF00082	0.340
CLV_PCSK_SKI1_1	333	337	PF00082	0.341
CLV_PCSK_SKI1_1	607	611	PF00082	0.331
CLV_PCSK_SKI1_1	641	645	PF00082	0.372
CLV_PCSK_SKI1_1	701	705	PF00082	0.472
CLV_PCSK_SKI1_1	726	730	PF00082	0.377
CLV_PCSK_SKI1_1	827	831	PF00082	0.418
CLV_PCSK_SKI1_1	842	846	PF00082	0.185
CLV_PCSK_SKI1_1	925	929	PF00082	0.382
DEG_APCC_DBOX_1	409	417	PF00400	0.340
DEG_APCC_DBOX_1	606	614	PF00400	0.385
DEG_APCC_DBOX_1	798	806	PF00400	0.507
DEG_Nend_UBRbox_1	1	4	PF02207	0.551
DEG_SPOP_SBC_1	70	74	PF00917	0.371
DOC_CDC14_PxL_1	590	598	PF14671	0.324
DOC_CKS1_1	225	230	PF01111	0.523
DOC_CKS1_1	674	679	PF01111	0.472
DOC_CKS1_1	727	732	PF01111	0.497
DOC_CYCLIN_RxL_1	330	338	PF00134	0.469
DOC_CYCLIN_RxL_1	635	648	PF00134	0.385
DOC_CYCLIN_yClb3_PxF_3	698	704	PF00134	0.281
DOC_CYCLIN_yCln2_LP_2	45	51	PF00134	0.371
DOC_MAPK_FxFP_2	149	152	PF00069	0.255
DOC_MAPK_FxFP_2	874	877	PF00069	0.324
DOC_MAPK_gen_1	18	27	PF00069	0.404
DOC_MAPK_gen_1	797	805	PF00069	0.442
DOC_MAPK_HePTP_8	545	557	PF00069	0.308
DOC_MAPK_MEF2A_6	292	301	PF00069	0.450
DOC_MAPK_MEF2A_6	371	378	PF00069	0.541
DOC_MAPK_MEF2A_6	382	390	PF00069	0.491
DOC_MAPK_MEF2A_6	434	442	PF00069	0.319
DOC_MAPK_MEF2A_6	548	557	PF00069	0.308
DOC_MAPK_MEF2A_6	797	805	PF00069	0.529
DOC_PP1_RVXF_1	840	846	PF00149	0.271
DOC_PP2B_LxvP_1	340	343	PF13499	0.424
DOC_PP2B_LxvP_1	45	48	PF13499	0.336
DOC_PP4_FxxP_1	149	152	PF00568	0.237
DOC_PP4_FxxP_1	557	560	PF00568	0.253
DOC_PP4_FxxP_1	704	707	PF00568	0.432
DOC_PP4_FxxP_1	874	877	PF00568	0.324
DOC_PP4_FxxP_1	912	915	PF00568	0.271
DOC_SPAK_OSR1_1	155	159	PF12202	0.243
DOC_USP7_MATH_1	101	105	PF00917	0.324
DOC_USP7_MATH_1	262	266	PF00917	0.368
DOC_USP7_MATH_1	397	401	PF00917	0.755
DOC_USP7_MATH_1	531	535	PF00917	0.438
DOC_USP7_MATH_1	658	662	PF00917	0.337
DOC_USP7_MATH_1	667	671	PF00917	0.427
DOC_USP7_MATH_1	742	746	PF00917	0.561
DOC_USP7_MATH_1	790	794	PF00917	0.698
DOC_USP7_MATH_1	801	805	PF00917	0.428
DOC_USP7_MATH_1	906	910	PF00917	0.453
DOC_USP7_UBL2_3	895	899	PF12436	0.366
DOC_WW_Pin1_4	156	161	PF00397	0.314
DOC_WW_Pin1_4	221	226	PF00397	0.457
DOC_WW_Pin1_4	388	393	PF00397	0.676
DOC_WW_Pin1_4	561	566	PF00397	0.263
DOC_WW_Pin1_4	673	678	PF00397	0.550
DOC_WW_Pin1_4	726	731	PF00397	0.495
DOC_WW_Pin1_4	783	788	PF00397	0.705
LIG_14-3-3_CanoR_1	254	259	PF00244	0.401
LIG_14-3-3_CanoR_1	29	35	PF00244	0.446
LIG_14-3-3_CanoR_1	309	314	PF00244	0.466
LIG_14-3-3_CanoR_1	353	360	PF00244	0.439
LIG_14-3-3_CanoR_1	364	374	PF00244	0.556
LIG_14-3-3_CanoR_1	382	390	PF00244	0.637
LIG_14-3-3_CanoR_1	434	442	PF00244	0.254
LIG_14-3-3_CanoR_1	571	580	PF00244	0.320
LIG_14-3-3_CanoR_1	607	617	PF00244	0.379
LIG_14-3-3_CanoR_1	659	663	PF00244	0.344
LIG_14-3-3_CanoR_1	77	85	PF00244	0.298
LIG_Actin_WH2_2	421	436	PF00022	0.361
LIG_BRCT_BRCA1_1	303	307	PF00533	0.462
LIG_BRCT_BRCA1_1	74	78	PF00533	0.371
LIG_BRCT_BRCA1_1	908	912	PF00533	0.324
LIG_Clathr_ClatBox_1	643	647	PF01394	0.385
LIG_eIF4E_1	261	267	PF01652	0.370
LIG_eIF4E_1	603	609	PF01652	0.278
LIG_FHA_1	107	113	PF00498	0.237
LIG_FHA_1	406	412	PF00498	0.572
LIG_FHA_1	604	610	PF00498	0.280
LIG_FHA_1	638	644	PF00498	0.355
LIG_FHA_1	783	789	PF00498	0.719
LIG_FHA_2	238	244	PF00498	0.520
LIG_FHA_2	327	333	PF00498	0.551
LIG_FHA_2	727	733	PF00498	0.475
LIG_FHA_2	759	765	PF00498	0.658
LIG_HP1_1	801	805	PF01393	0.498
LIG_LIR_Apic_2	693	699	PF02991	0.454
LIG_LIR_Apic_2	909	915	PF02991	0.312
LIG_LIR_Gen_1	13	20	PF02991	0.417
LIG_LIR_Gen_1	837	848	PF02991	0.399
LIG_LIR_Gen_1	928	933	PF02991	0.389
LIG_LIR_Nem_3	13	19	PF02991	0.474
LIG_LIR_Nem_3	591	596	PF02991	0.369
LIG_LIR_Nem_3	611	617	PF02991	0.126
LIG_LIR_Nem_3	722	728	PF02991	0.425
LIG_LIR_Nem_3	798	803	PF02991	0.594
LIG_LIR_Nem_3	815	821	PF02991	0.441
LIG_LIR_Nem_3	837	843	PF02991	0.399
LIG_LYPXL_SIV_4	327	335	PF13949	0.420
LIG_LYPXL_yS_3	593	596	PF13949	0.324
LIG_LYPXL_yS_3	800	803	PF13949	0.433
LIG_PCNA_TLS_4	454	461	PF02747	0.324
LIG_Pex14_2	267	271	PF04695	0.425
LIG_Pex14_2	88	92	PF04695	0.371
LIG_Pex14_2	929	933	PF04695	0.340
LIG_SH2_CRK	203	207	PF00017	0.367
LIG_SH2_CRK	725	729	PF00017	0.533
LIG_SH2_NCK_1	328	332	PF00017	0.466
LIG_SH2_SRC	886	889	PF00017	0.313
LIG_SH2_STAP1	188	192	PF00017	0.371
LIG_SH2_STAP1	814	818	PF00017	0.473
LIG_SH2_STAP1	886	890	PF00017	0.253
LIG_SH2_STAT5	328	331	PF00017	0.380
LIG_SH2_STAT5	460	463	PF00017	0.464
LIG_SH2_STAT5	603	606	PF00017	0.288
LIG_SH2_STAT5	727	730	PF00017	0.488
LIG_SH3_3	169	175	PF00018	0.371
LIG_SH3_3	195	201	PF00018	0.171
LIG_SH3_3	222	228	PF00018	0.485
LIG_SH3_3	284	290	PF00018	0.382
LIG_SH3_3	387	393	PF00018	0.702
LIG_SH3_3	488	494	PF00018	0.395
LIG_SH3_3	671	677	PF00018	0.669
LIG_SH3_3	681	687	PF00018	0.664
LIG_SH3_3	696	702	PF00018	0.375
LIG_SH3_3	97	103	PF00018	0.281
LIG_SUMO_SIM_anti_2	426	432	PF11976	0.296
LIG_SUMO_SIM_anti_2	436	442	PF11976	0.342
LIG_SUMO_SIM_par_1	439	444	PF11976	0.256
LIG_SUMO_SIM_par_1	594	599	PF11976	0.443
LIG_SUMO_SIM_par_1	67	75	PF11976	0.294
LIG_SUMO_SIM_par_1	801	807	PF11976	0.457
LIG_TRAF2_1	240	243	PF00917	0.354
LIG_TRAF2_1	729	732	PF00917	0.445
LIG_TYR_ITIM	816	821	PF00017	0.348
LIG_UBA3_1	516	525	PF00899	0.385
LIG_UBA3_1	586	592	PF00899	0.382
LIG_WW_3	34	38	PF00397	0.443
MOD_CDK_SPK_2	673	678	PF00069	0.471
MOD_CDK_SPxK_1	673	679	PF00069	0.470
MOD_CK1_1	106	112	PF00069	0.198
MOD_CK1_1	312	318	PF00069	0.716
MOD_CK1_1	355	361	PF00069	0.478
MOD_CK1_1	395	401	PF00069	0.691
MOD_CK1_1	670	676	PF00069	0.596
MOD_CK1_1	685	691	PF00069	0.489
MOD_CK1_1	793	799	PF00069	0.669
MOD_CK1_1	804	810	PF00069	0.350
MOD_CK1_1	94	100	PF00069	0.304
MOD_CK2_1	101	107	PF00069	0.288
MOD_CK2_1	236	242	PF00069	0.536
MOD_CK2_1	326	332	PF00069	0.566
MOD_CK2_1	433	439	PF00069	0.404
MOD_CK2_1	460	466	PF00069	0.324
MOD_CK2_1	685	691	PF00069	0.550
MOD_CK2_1	726	732	PF00069	0.453
MOD_CMANNOS	271	274	PF00535	0.432
MOD_Cter_Amidation	183	186	PF01082	0.345
MOD_Cter_Amidation	716	719	PF01082	0.387
MOD_GlcNHglycan	203	206	PF01048	0.480
MOD_GlcNHglycan	32	35	PF01048	0.562
MOD_GlcNHglycan	383	386	PF01048	0.713
MOD_GlcNHglycan	394	397	PF01048	0.554
MOD_GlcNHglycan	534	537	PF01048	0.341
MOD_GlcNHglycan	669	672	PF01048	0.572
MOD_GlcNHglycan	687	690	PF01048	0.524
MOD_GlcNHglycan	750	753	PF01048	0.587
MOD_GlcNHglycan	764	768	PF01048	0.660
MOD_GlcNHglycan	792	795	PF01048	0.540
MOD_GlcNHglycan	80	83	PF01048	0.290
MOD_GSK3_1	233	240	PF00069	0.640
MOD_GSK3_1	309	316	PF00069	0.648
MOD_GSK3_1	352	359	PF00069	0.500
MOD_GSK3_1	388	395	PF00069	0.745
MOD_GSK3_1	397	404	PF00069	0.576
MOD_GSK3_1	420	427	PF00069	0.389
MOD_GSK3_1	525	532	PF00069	0.291
MOD_GSK3_1	669	676	PF00069	0.509
MOD_GSK3_1	742	749	PF00069	0.558
MOD_GSK3_1	789	796	PF00069	0.654
MOD_GSK3_1	817	824	PF00069	0.462
MOD_N-GLC_1	561	566	PF02516	0.385
MOD_N-GLC_1	812	817	PF02516	0.452
MOD_N-GLC_1	86	91	PF02516	0.289
MOD_NEK2_1	126	131	PF00069	0.279
MOD_NEK2_1	279	284	PF00069	0.461
MOD_NEK2_1	299	304	PF00069	0.341
MOD_NEK2_1	30	35	PF00069	0.470
MOD_NEK2_1	335	340	PF00069	0.401
MOD_NEK2_1	352	357	PF00069	0.297
MOD_NEK2_1	424	429	PF00069	0.364
MOD_NEK2_1	482	487	PF00069	0.253
MOD_NEK2_1	596	601	PF00069	0.493
MOD_NEK2_1	608	613	PF00069	0.312
MOD_NEK2_1	637	642	PF00069	0.366
MOD_NEK2_1	690	695	PF00069	0.610
MOD_NEK2_1	71	76	PF00069	0.354
MOD_NEK2_1	78	83	PF00069	0.243
MOD_NEK2_1	781	786	PF00069	0.501
MOD_NEK2_2	262	267	PF00069	0.364
MOD_PIKK_1	342	348	PF00454	0.463
MOD_PIKK_1	352	358	PF00454	0.515
MOD_PIKK_1	365	371	PF00454	0.439
MOD_PIKK_1	543	549	PF00454	0.366
MOD_PK_1	309	315	PF00069	0.466
MOD_PKA_1	254	260	PF00069	0.408
MOD_PKA_1	309	315	PF00069	0.466
MOD_PKA_1	525	531	PF00069	0.324
MOD_PKA_1	827	833	PF00069	0.447
MOD_PKA_2	254	260	PF00069	0.414
MOD_PKA_2	279	285	PF00069	0.529
MOD_PKA_2	309	315	PF00069	0.522
MOD_PKA_2	352	358	PF00069	0.400
MOD_PKA_2	381	387	PF00069	0.728
MOD_PKA_2	433	439	PF00069	0.254
MOD_PKA_2	468	474	PF00069	0.269
MOD_PKA_2	482	488	PF00069	0.238
MOD_PKA_2	525	531	PF00069	0.376
MOD_PKA_2	658	664	PF00069	0.324
MOD_PKA_2	667	673	PF00069	0.433
MOD_PKA_2	717	723	PF00069	0.459
MOD_PKA_2	827	833	PF00069	0.512
MOD_Plk_1	731	737	PF00069	0.487
MOD_Plk_1	812	818	PF00069	0.342
MOD_Plk_2-3	401	407	PF00069	0.570
MOD_Plk_2-3	817	823	PF00069	0.410
MOD_Plk_4	262	268	PF00069	0.415
MOD_Plk_4	525	531	PF00069	0.294
MOD_Plk_4	628	634	PF00069	0.403
MOD_Plk_4	658	664	PF00069	0.324
MOD_Plk_4	742	748	PF00069	0.547
MOD_Plk_4	775	781	PF00069	0.698
MOD_Plk_4	804	810	PF00069	0.524
MOD_Plk_4	928	934	PF00069	0.438
MOD_ProDKin_1	156	162	PF00069	0.314
MOD_ProDKin_1	221	227	PF00069	0.469
MOD_ProDKin_1	388	394	PF00069	0.677
MOD_ProDKin_1	561	567	PF00069	0.263
MOD_ProDKin_1	673	679	PF00069	0.549
MOD_ProDKin_1	726	732	PF00069	0.496
MOD_ProDKin_1	783	789	PF00069	0.705
MOD_SUMO_rev_2	359	367	PF00179	0.673
TRG_DiLeu_BaEn_1	337	342	PF01217	0.410
TRG_DiLeu_BaLyEn_6	604	609	PF01217	0.371
TRG_DiLeu_BaLyEn_6	64	69	PF01217	0.184
TRG_ENDOCYTIC_2	272	275	PF00928	0.416
TRG_ENDOCYTIC_2	291	294	PF00928	0.522
TRG_ENDOCYTIC_2	593	596	PF00928	0.449
TRG_ENDOCYTIC_2	617	620	PF00928	0.267
TRG_ENDOCYTIC_2	725	728	PF00928	0.530
TRG_ENDOCYTIC_2	800	803	PF00928	0.595
TRG_ENDOCYTIC_2	818	821	PF00928	0.350
TRG_ER_diArg_1	185	187	PF00400	0.466
TRG_ER_diArg_1	254	256	PF00400	0.356
TRG_ER_diArg_1	309	311	PF00400	0.451
TRG_ER_diArg_1	461	464	PF00400	0.331
TRG_ER_diArg_1	481	484	PF00400	0.126
TRG_ER_diArg_1	737	740	PF00400	0.622
TRG_ER_diArg_1	826	828	PF00400	0.450
TRG_ER_diArg_1	831	833	PF00400	0.407
TRG_NLS_MonoCore_2	824	829	PF00514	0.433
TRG_Pf-PMV_PEXEL_1	333	337	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	641	645	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	905	910	PF00026	0.331
TRG_PTS2	1	11	PF00400	0.602

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVX9	Leptomonas seymouri	58%	100%
A0A0S4JJU7	Bodo saltans	25%	100%
A0A1X0NSP5	Trypanosomatidae	30%	100%
A0A3R7KS65	Trypanosoma rangeli	31%	100%
A4HF10	Leishmania braziliensis	24%	100%
A4HLX1	Leishmania braziliensis	77%	100%
A4I9A0	Leishmania infantum	99%	100%
A6TC19	Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)	26%	100%
B5XVW2	Klebsiella pneumoniae (strain 342)	26%	100%
C9ZJC6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B4A0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
P40939	Homo sapiens	24%	100%
Q29554	Sus scrofa	23%	100%
Q4Q3S6	Leishmania major	91%	100%
Q64428	Rattus norvegicus	24%	100%
Q6NYL3	Danio rerio	28%	100%
Q8BMS1	Mus musculus	25%	100%
V5B7W6	Trypanosoma cruzi	24%	100%
V5BN63	Trypanosoma cruzi	31%	100%