Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X715_LEIDO

TriTrypDb:

LdBPK_332610.1 , LdCL_330033200 , LDHU3_33.3720

Length:

586

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X715

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X715

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	532	536	PF00656	0.566
CLV_C14_Caspase3-7	550	554	PF00656	0.440
CLV_NRD_NRD_1	171	173	PF00675	0.543
CLV_NRD_NRD_1	29	31	PF00675	0.531
CLV_NRD_NRD_1	446	448	PF00675	0.722
CLV_NRD_NRD_1	483	485	PF00675	0.585
CLV_PCSK_FUR_1	11	15	PF00082	0.689
CLV_PCSK_KEX2_1	13	15	PF00082	0.759
CLV_PCSK_KEX2_1	171	173	PF00082	0.483
CLV_PCSK_KEX2_1	29	31	PF00082	0.439
CLV_PCSK_KEX2_1	370	372	PF00082	0.612
CLV_PCSK_KEX2_1	446	448	PF00082	0.722
CLV_PCSK_KEX2_1	483	485	PF00082	0.583
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.699
CLV_PCSK_PC1ET2_1	370	372	PF00082	0.612
CLV_PCSK_SKI1_1	337	341	PF00082	0.557
CLV_PCSK_SKI1_1	361	365	PF00082	0.350
CLV_PCSK_SKI1_1	418	422	PF00082	0.426
CLV_PCSK_SKI1_1	582	586	PF00082	0.755
CLV_PCSK_SKI1_1	99	103	PF00082	0.423
DEG_SPOP_SBC_1	328	332	PF00917	0.650
DOC_CYCLIN_RxL_1	358	368	PF00134	0.336
DOC_CYCLIN_yCln2_LP_2	116	122	PF00134	0.625
DOC_MAPK_gen_1	219	227	PF00069	0.518
DOC_PP1_RVXF_1	335	342	PF00149	0.678
DOC_USP7_MATH_1	127	131	PF00917	0.659
DOC_USP7_MATH_1	159	163	PF00917	0.600
DOC_USP7_MATH_1	328	332	PF00917	0.660
DOC_USP7_MATH_1	369	373	PF00917	0.669
DOC_USP7_MATH_1	378	382	PF00917	0.679
DOC_USP7_MATH_1	515	519	PF00917	0.704
DOC_USP7_MATH_1	537	541	PF00917	0.606
DOC_USP7_MATH_1	69	73	PF00917	0.604
DOC_USP7_MATH_1	7	11	PF00917	0.594
DOC_WW_Pin1_4	254	259	PF00397	0.631
DOC_WW_Pin1_4	322	327	PF00397	0.744
DOC_WW_Pin1_4	386	391	PF00397	0.675
DOC_WW_Pin1_4	403	408	PF00397	0.537
LIG_14-3-3_CanoR_1	29	33	PF00244	0.564
LIG_14-3-3_CanoR_1	298	304	PF00244	0.606
LIG_14-3-3_CanoR_1	371	376	PF00244	0.604
LIG_14-3-3_CanoR_1	483	491	PF00244	0.612
LIG_14-3-3_CanoR_1	68	74	PF00244	0.539
LIG_14-3-3_CanoR_1	93	101	PF00244	0.516
LIG_Actin_WH2_2	555	570	PF00022	0.486
LIG_BRCT_BRCA1_1	176	180	PF00533	0.572
LIG_CaM_IQ_9	40	56	PF13499	0.521
LIG_Clathr_ClatBox_1	363	367	PF01394	0.344
LIG_EVH1_1	574	578	PF00568	0.744
LIG_FHA_1	31	37	PF00498	0.509
LIG_FHA_1	41	47	PF00498	0.547
LIG_FHA_1	411	417	PF00498	0.619
LIG_FHA_1	553	559	PF00498	0.580
LIG_FHA_2	301	307	PF00498	0.670
LIG_FHA_2	308	314	PF00498	0.699
LIG_FHA_2	568	574	PF00498	0.537
LIG_Integrin_isoDGR_2	444	446	PF01839	0.562
LIG_LIR_Apic_2	573	577	PF02991	0.647
LIG_LIR_Gen_1	162	170	PF02991	0.512
LIG_LIR_Gen_1	177	187	PF02991	0.524
LIG_LIR_Gen_1	425	436	PF02991	0.526
LIG_LIR_Gen_1	49	55	PF02991	0.610
LIG_LIR_Gen_1	547	553	PF02991	0.572
LIG_LIR_Nem_3	162	166	PF02991	0.523
LIG_LIR_Nem_3	177	183	PF02991	0.507
LIG_LIR_Nem_3	425	431	PF02991	0.525
LIG_LIR_Nem_3	49	53	PF02991	0.502
LIG_LIR_Nem_3	547	552	PF02991	0.608
LIG_LIR_Nem_3	55	60	PF02991	0.521
LIG_NRBOX	472	478	PF00104	0.511
LIG_PCNA_PIPBox_1	466	475	PF02747	0.610
LIG_PCNA_yPIPBox_3	466	475	PF02747	0.610
LIG_Pex14_1	176	180	PF04695	0.572
LIG_Pex14_2	202	206	PF04695	0.571
LIG_SH2_CRK	428	432	PF00017	0.577
LIG_SH2_NCK_1	243	247	PF00017	0.548
LIG_SH2_NCK_1	428	432	PF00017	0.577
LIG_SH2_STAP1	32	36	PF00017	0.570
LIG_SH2_STAP1	349	353	PF00017	0.517
LIG_SH2_STAT5	163	166	PF00017	0.453
LIG_SH2_STAT5	32	35	PF00017	0.566
LIG_SH2_STAT5	64	67	PF00017	0.652
LIG_SH3_3	116	122	PF00018	0.741
LIG_SH3_3	384	390	PF00018	0.670
LIG_SH3_3	494	500	PF00018	0.638
LIG_SH3_3	509	515	PF00018	0.680
LIG_SH3_3	572	578	PF00018	0.749
LIG_SUMO_SIM_anti_2	186	191	PF11976	0.527
LIG_SUMO_SIM_par_1	361	368	PF11976	0.646
LIG_TRAF2_1	374	377	PF00917	0.775
LIG_TRAF2_1	78	81	PF00917	0.642
LIG_TYR_ITIM	241	246	PF00017	0.650
LIG_UBA3_1	105	111	PF00899	0.431
MOD_CK1_1	110	116	PF00069	0.665
MOD_CK1_1	143	149	PF00069	0.782
MOD_CK1_1	229	235	PF00069	0.415
MOD_CK1_1	300	306	PF00069	0.472
MOD_CK1_1	327	333	PF00069	0.692
MOD_CK1_1	388	394	PF00069	0.772
MOD_CK1_1	456	462	PF00069	0.620
MOD_CK1_1	544	550	PF00069	0.627
MOD_CK2_1	233	239	PF00069	0.570
MOD_CK2_1	300	306	PF00069	0.737
MOD_CK2_1	371	377	PF00069	0.538
MOD_CK2_1	74	80	PF00069	0.649
MOD_CK2_1	86	92	PF00069	0.523
MOD_Cter_Amidation	444	447	PF01082	0.676
MOD_GlcNHglycan	127	130	PF01048	0.735
MOD_GlcNHglycan	146	149	PF01048	0.606
MOD_GlcNHglycan	190	193	PF01048	0.566
MOD_GlcNHglycan	228	231	PF01048	0.708
MOD_GlcNHglycan	294	297	PF01048	0.579
MOD_GlcNHglycan	299	302	PF01048	0.624
MOD_GlcNHglycan	331	334	PF01048	0.730
MOD_GlcNHglycan	355	360	PF01048	0.629
MOD_GlcNHglycan	449	452	PF01048	0.718
MOD_GlcNHglycan	76	79	PF01048	0.682
MOD_GlcNHglycan	88	91	PF01048	0.602
MOD_GSK3_1	140	147	PF00069	0.671
MOD_GSK3_1	188	195	PF00069	0.530
MOD_GSK3_1	229	236	PF00069	0.583
MOD_GSK3_1	28	35	PF00069	0.530
MOD_GSK3_1	324	331	PF00069	0.699
MOD_GSK3_1	365	372	PF00069	0.536
MOD_GSK3_1	378	385	PF00069	0.545
MOD_GSK3_1	526	533	PF00069	0.651
MOD_GSK3_1	537	544	PF00069	0.636
MOD_GSK3_1	93	100	PF00069	0.567
MOD_LATS_1	66	72	PF00433	0.616
MOD_NEK2_1	190	195	PF00069	0.531
MOD_NEK2_1	233	238	PF00069	0.661
MOD_NEK2_1	28	33	PF00069	0.560
MOD_NEK2_1	290	295	PF00069	0.640
MOD_NEK2_1	347	352	PF00069	0.434
MOD_NEK2_1	567	572	PF00069	0.584
MOD_PIKK_1	40	46	PF00454	0.537
MOD_PIKK_1	537	543	PF00454	0.720
MOD_PIKK_1	552	558	PF00454	0.333
MOD_PIKK_1	93	99	PF00454	0.491
MOD_PK_1	371	377	PF00069	0.538
MOD_PKA_2	28	34	PF00069	0.570
MOD_PKA_2	297	303	PF00069	0.597
MOD_PKA_2	40	46	PF00069	0.648
MOD_PKA_2	445	451	PF00069	0.718
MOD_PKA_2	529	535	PF00069	0.624
MOD_PKA_2	567	573	PF00069	0.689
MOD_Plk_4	159	165	PF00069	0.586
MOD_Plk_4	347	353	PF00069	0.596
MOD_ProDKin_1	254	260	PF00069	0.633
MOD_ProDKin_1	322	328	PF00069	0.744
MOD_ProDKin_1	386	392	PF00069	0.675
MOD_ProDKin_1	403	409	PF00069	0.528
MOD_SUMO_for_1	101	104	PF00179	0.471
MOD_SUMO_for_1	319	322	PF00179	0.776
TRG_DiLeu_BaLyEn_6	358	363	PF01217	0.544
TRG_DiLeu_BaLyEn_6	472	477	PF01217	0.505
TRG_ENDOCYTIC_2	163	166	PF00928	0.434
TRG_ENDOCYTIC_2	243	246	PF00928	0.547
TRG_ENDOCYTIC_2	349	352	PF00928	0.509
TRG_ENDOCYTIC_2	428	431	PF00928	0.520
TRG_ER_diArg_1	171	173	PF00400	0.483
TRG_ER_diArg_1	28	30	PF00400	0.520
TRG_ER_diArg_1	482	484	PF00400	0.578
TRG_ER_diArg_1	520	523	PF00400	0.659
TRG_NES_CRM1_1	186	199	PF08389	0.597
TRG_Pf-PMV_PEXEL_1	475	479	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	489	493	PF00026	0.643
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8S0	Leptomonas seymouri	38%	99%
A4HLV9	Leishmania braziliensis	62%	99%
E9AHR6	Leishmania infantum	99%	100%
E9B487	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q3T9	Leishmania major	87%	100%