WD domain, G-beta repeat, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X707_LEIDO

TriTrypDb:

LdBPK_332270.1 , LdCL_330029700 , LDHU3_33.3270

Length:

873

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005840	ribosome	5	7
GO:0005875	microtubule associated complex	2	8
GO:0030286	dynein complex	3	8
GO:0032991	protein-containing complex	1	9
GO:0043226	organelle	2	7
GO:0043228	non-membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043232	intracellular non-membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7
GO:1902494	catalytic complex	2	8
GO:1990904	ribonucleoprotein complex	2	7

Expansion

Sequence features

A0A3S7X707

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X707

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	8
GO:0007018	microtubule-based movement	3	8
GO:0009987	cellular process	1	8

Molecular functions
Term	Name	Level	Count
GO:0003774	cytoskeletal motor activity	1	8
GO:0003777	microtubule motor activity	2	8
GO:0008569	minus-end-directed microtubule motor activity	3	8
GO:0140657	ATP-dependent activity	1	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	169	171	PF00675	0.553
CLV_NRD_NRD_1	200	202	PF00675	0.715
CLV_NRD_NRD_1	217	219	PF00675	0.524
CLV_NRD_NRD_1	744	746	PF00675	0.434
CLV_NRD_NRD_1	828	830	PF00675	0.440
CLV_PCSK_FUR_1	336	340	PF00082	0.490
CLV_PCSK_KEX2_1	169	171	PF00082	0.554
CLV_PCSK_KEX2_1	200	202	PF00082	0.715
CLV_PCSK_KEX2_1	217	219	PF00082	0.708
CLV_PCSK_KEX2_1	338	340	PF00082	0.383
CLV_PCSK_KEX2_1	372	374	PF00082	0.527
CLV_PCSK_KEX2_1	546	548	PF00082	0.652
CLV_PCSK_PC1ET2_1	338	340	PF00082	0.450
CLV_PCSK_PC1ET2_1	372	374	PF00082	0.363
CLV_PCSK_PC1ET2_1	546	548	PF00082	0.652
CLV_PCSK_PC7_1	165	171	PF00082	0.540
CLV_PCSK_SKI1_1	338	342	PF00082	0.480
CLV_PCSK_SKI1_1	42	46	PF00082	0.481
CLV_PCSK_SKI1_1	487	491	PF00082	0.527
CLV_PCSK_SKI1_1	519	523	PF00082	0.773
CLV_PCSK_SKI1_1	66	70	PF00082	0.410
CLV_Separin_Metazoa	309	313	PF03568	0.588
DEG_COP1_1	646	655	PF00400	0.545
DEG_MDM2_SWIB_1	866	873	PF02201	0.439
DEG_SCF_FBW7_1	511	516	PF00400	0.676
DOC_ANK_TNKS_1	311	318	PF00023	0.514
DOC_CKS1_1	97	102	PF01111	0.371
DOC_MAPK_DCC_7	670	679	PF00069	0.438
DOC_MAPK_gen_1	371	377	PF00069	0.559
DOC_MAPK_gen_1	519	527	PF00069	0.585
DOC_MAPK_gen_1	543	553	PF00069	0.625
DOC_MAPK_gen_1	745	752	PF00069	0.328
DOC_MAPK_MEF2A_6	66	74	PF00069	0.459
DOC_MAPK_MEF2A_6	745	752	PF00069	0.328
DOC_MAPK_MEF2A_6	98	105	PF00069	0.384
DOC_PP1_RVXF_1	371	378	PF00149	0.364
DOC_PP1_RVXF_1	40	47	PF00149	0.470
DOC_PP2B_LxvP_1	772	775	PF13499	0.541
DOC_SPAK_OSR1_1	582	586	PF12202	0.349
DOC_USP7_MATH_1	206	210	PF00917	0.715
DOC_USP7_MATH_1	251	255	PF00917	0.613
DOC_USP7_MATH_1	34	38	PF00917	0.448
DOC_USP7_MATH_1	399	403	PF00917	0.432
DOC_USP7_MATH_1	411	415	PF00917	0.332
DOC_USP7_MATH_1	445	449	PF00917	0.362
DOC_USP7_MATH_1	584	588	PF00917	0.288
DOC_USP7_MATH_1	655	659	PF00917	0.402
DOC_USP7_UBL2_3	334	338	PF12436	0.475
DOC_USP7_UBL2_3	519	523	PF12436	0.704
DOC_WW_Pin1_4	129	134	PF00397	0.540
DOC_WW_Pin1_4	188	193	PF00397	0.721
DOC_WW_Pin1_4	202	207	PF00397	0.691
DOC_WW_Pin1_4	208	213	PF00397	0.721
DOC_WW_Pin1_4	218	223	PF00397	0.730
DOC_WW_Pin1_4	265	270	PF00397	0.639
DOC_WW_Pin1_4	287	292	PF00397	0.576
DOC_WW_Pin1_4	321	326	PF00397	0.630
DOC_WW_Pin1_4	509	514	PF00397	0.578
DOC_WW_Pin1_4	59	64	PF00397	0.426
DOC_WW_Pin1_4	672	677	PF00397	0.349
DOC_WW_Pin1_4	859	864	PF00397	0.420
DOC_WW_Pin1_4	96	101	PF00397	0.493
LIG_14-3-3_CanoR_1	169	173	PF00244	0.548
LIG_14-3-3_CanoR_1	200	205	PF00244	0.824
LIG_14-3-3_CanoR_1	217	222	PF00244	0.604
LIG_14-3-3_CanoR_1	487	494	PF00244	0.537
LIG_14-3-3_CanoR_1	50	58	PF00244	0.550
LIG_14-3-3_CanoR_1	514	518	PF00244	0.694
LIG_14-3-3_CanoR_1	526	534	PF00244	0.495
LIG_14-3-3_CanoR_1	636	642	PF00244	0.550
LIG_14-3-3_CanoR_1	829	835	PF00244	0.395
LIG_14-3-3_CanoR_1	868	873	PF00244	0.364
LIG_Actin_WH2_2	252	267	PF00022	0.682
LIG_Actin_WH2_2	298	314	PF00022	0.556
LIG_AP2alpha_1	617	621	PF02296	0.410
LIG_BRCT_BRCA1_1	19	23	PF00533	0.475
LIG_BRCT_BRCA1_1	252	256	PF00533	0.617
LIG_Clathr_ClatBox_1	295	299	PF01394	0.474
LIG_FHA_1	256	262	PF00498	0.714
LIG_FHA_1	290	296	PF00498	0.527
LIG_FHA_1	352	358	PF00498	0.472
LIG_FHA_1	415	421	PF00498	0.381
LIG_FHA_1	46	52	PF00498	0.508
LIG_FHA_1	5	11	PF00498	0.454
LIG_FHA_1	714	720	PF00498	0.352
LIG_FHA_1	742	748	PF00498	0.417
LIG_FHA_1	777	783	PF00498	0.547
LIG_FHA_1	796	802	PF00498	0.415
LIG_FHA_2	10	16	PF00498	0.376
LIG_FHA_2	322	328	PF00498	0.517
LIG_FHA_2	623	629	PF00498	0.355
LIG_FHA_2	737	743	PF00498	0.433
LIG_FHA_2	804	810	PF00498	0.331
LIG_FHA_2	81	87	PF00498	0.592
LIG_GBD_Chelix_1	375	383	PF00786	0.485
LIG_Integrin_isoDGR_2	55	57	PF01839	0.394
LIG_Integrin_RGD_1	306	308	PF01839	0.668
LIG_LIR_Gen_1	253	264	PF02991	0.625
LIG_LIR_Gen_1	297	305	PF02991	0.519
LIG_LIR_Gen_1	345	353	PF02991	0.347
LIG_LIR_Gen_1	569	577	PF02991	0.330
LIG_LIR_Gen_1	864	873	PF02991	0.345
LIG_LIR_LC3C_4	855	859	PF02991	0.284
LIG_LIR_Nem_3	253	259	PF02991	0.621
LIG_LIR_Nem_3	345	351	PF02991	0.430
LIG_LIR_Nem_3	562	566	PF02991	0.342
LIG_LIR_Nem_3	569	574	PF02991	0.304
LIG_LIR_Nem_3	864	869	PF02991	0.349
LIG_MYND_1	226	230	PF01753	0.574
LIG_PDZ_Class_1	868	873	PF00595	0.308
LIG_Pex14_1	613	617	PF04695	0.366
LIG_Pex14_2	617	621	PF04695	0.470
LIG_Pex14_2	759	763	PF04695	0.282
LIG_Pex14_2	866	870	PF04695	0.416
LIG_SH2_CRK	348	352	PF00017	0.328
LIG_SH2_NCK_1	204	208	PF00017	0.583
LIG_SH2_NCK_1	8	12	PF00017	0.398
LIG_SH2_STAT5	204	207	PF00017	0.556
LIG_SH2_STAT5	348	351	PF00017	0.348
LIG_SH2_STAT5	593	596	PF00017	0.343
LIG_SH2_STAT5	664	667	PF00017	0.292
LIG_SH2_STAT5	668	671	PF00017	0.329
LIG_SH2_STAT5	804	807	PF00017	0.335
LIG_SH2_STAT5	824	827	PF00017	0.341
LIG_SH3_3	127	133	PF00018	0.598
LIG_SH3_3	152	158	PF00018	0.645
LIG_SH3_3	219	225	PF00018	0.605
LIG_SH3_3	447	453	PF00018	0.431
LIG_SH3_3	514	520	PF00018	0.749
LIG_SH3_3	539	545	PF00018	0.561
LIG_SH3_3	647	653	PF00018	0.499
LIG_SH3_3	696	702	PF00018	0.486
LIG_SH3_3	94	100	PF00018	0.459
LIG_SH3_4	519	526	PF00018	0.659
LIG_SUMO_SIM_anti_2	362	367	PF11976	0.349
LIG_SUMO_SIM_par_1	364	369	PF11976	0.413
LIG_SUMO_SIM_par_1	442	448	PF11976	0.484
LIG_SUMO_SIM_par_1	548	554	PF11976	0.624
LIG_SUMO_SIM_par_1	697	703	PF11976	0.536
LIG_SUMO_SIM_par_1	727	733	PF11976	0.361
LIG_SUMO_SIM_par_1	99	104	PF11976	0.477
LIG_TRAF2_1	137	140	PF00917	0.631
LIG_TRAF2_1	149	152	PF00917	0.688
LIG_TRAF2_1	577	580	PF00917	0.367
LIG_TRAF2_1	83	86	PF00917	0.564
LIG_UBA3_1	365	372	PF00899	0.482
LIG_WRC_WIRS_1	560	565	PF05994	0.464
MOD_CDK_SPK_2	509	514	PF00069	0.533
MOD_CDK_SPxxK_3	59	66	PF00069	0.429
MOD_CK1_1	120	126	PF00069	0.673
MOD_CK1_1	132	138	PF00069	0.537
MOD_CK1_1	188	194	PF00069	0.726
MOD_CK1_1	199	205	PF00069	0.757
MOD_CK1_1	236	242	PF00069	0.650
MOD_CK1_1	249	255	PF00069	0.511
MOD_CK1_1	414	420	PF00069	0.333
MOD_CK1_1	473	479	PF00069	0.514
MOD_CK1_1	49	55	PF00069	0.379
MOD_CK1_1	503	509	PF00069	0.650
MOD_CK1_1	564	570	PF00069	0.478
MOD_CK1_1	658	664	PF00069	0.395
MOD_CK1_1	700	706	PF00069	0.525
MOD_CK1_1	762	768	PF00069	0.352
MOD_CK2_1	125	131	PF00069	0.541
MOD_CK2_1	146	152	PF00069	0.689
MOD_CK2_1	188	194	PF00069	0.685
MOD_CK2_1	573	579	PF00069	0.414
MOD_CK2_1	622	628	PF00069	0.354
MOD_CK2_1	80	86	PF00069	0.590
MOD_CK2_1	815	821	PF00069	0.303
MOD_CK2_1	9	15	PF00069	0.384
MOD_GlcNHglycan	134	137	PF01048	0.609
MOD_GlcNHglycan	187	190	PF01048	0.700
MOD_GlcNHglycan	208	211	PF01048	0.742
MOD_GlcNHglycan	401	404	PF01048	0.412
MOD_GlcNHglycan	437	441	PF01048	0.373
MOD_GlcNHglycan	502	505	PF01048	0.568
MOD_GlcNHglycan	51	54	PF01048	0.434
MOD_GlcNHglycan	527	530	PF01048	0.689
MOD_GlcNHglycan	552	556	PF01048	0.526
MOD_GlcNHglycan	563	566	PF01048	0.345
MOD_GlcNHglycan	575	578	PF01048	0.391
MOD_GlcNHglycan	631	634	PF01048	0.424
MOD_GlcNHglycan	713	716	PF01048	0.448
MOD_GSK3_1	101	108	PF00069	0.416
MOD_GSK3_1	113	120	PF00069	0.554
MOD_GSK3_1	125	132	PF00069	0.581
MOD_GSK3_1	164	171	PF00069	0.424
MOD_GSK3_1	188	195	PF00069	0.658
MOD_GSK3_1	19	26	PF00069	0.384
MOD_GSK3_1	196	203	PF00069	0.665
MOD_GSK3_1	213	220	PF00069	0.738
MOD_GSK3_1	233	240	PF00069	0.495
MOD_GSK3_1	242	249	PF00069	0.518
MOD_GSK3_1	251	258	PF00069	0.551
MOD_GSK3_1	317	324	PF00069	0.656
MOD_GSK3_1	45	52	PF00069	0.525
MOD_GSK3_1	469	476	PF00069	0.490
MOD_GSK3_1	503	510	PF00069	0.607
MOD_GSK3_1	594	601	PF00069	0.473
MOD_GSK3_1	651	658	PF00069	0.382
MOD_GSK3_1	759	766	PF00069	0.326
MOD_GSK3_1	85	92	PF00069	0.672
MOD_LATS_1	232	238	PF00433	0.713
MOD_N-GLC_1	17	22	PF02516	0.501
MOD_N-GLC_1	192	197	PF02516	0.751
MOD_N-GLC_1	234	239	PF02516	0.684
MOD_N-GLC_1	608	613	PF02516	0.487
MOD_NEK2_1	164	169	PF00069	0.454
MOD_NEK2_1	17	22	PF00069	0.385
MOD_NEK2_1	183	188	PF00069	0.516
MOD_NEK2_1	264	269	PF00069	0.668
MOD_NEK2_1	301	306	PF00069	0.643
MOD_NEK2_1	366	371	PF00069	0.527
MOD_NEK2_1	377	382	PF00069	0.531
MOD_NEK2_1	45	50	PF00069	0.426
MOD_NEK2_1	469	474	PF00069	0.508
MOD_NEK2_1	475	480	PF00069	0.533
MOD_NEK2_1	494	499	PF00069	0.579
MOD_NEK2_1	507	512	PF00069	0.573
MOD_NEK2_1	559	564	PF00069	0.419
MOD_NEK2_1	594	599	PF00069	0.330
MOD_NEK2_1	637	642	PF00069	0.559
MOD_NEK2_1	682	687	PF00069	0.347
MOD_NEK2_1	763	768	PF00069	0.346
MOD_NEK2_1	815	820	PF00069	0.295
MOD_NEK2_1	857	862	PF00069	0.389
MOD_NEK2_2	329	334	PF00069	0.537
MOD_NEK2_2	792	797	PF00069	0.466
MOD_PIKK_1	351	357	PF00454	0.479
MOD_PIKK_1	391	397	PF00454	0.287
MOD_PIKK_1	492	498	PF00454	0.664
MOD_PKA_1	200	206	PF00069	0.712
MOD_PKA_1	217	223	PF00069	0.697
MOD_PKA_2	164	170	PF00069	0.536
MOD_PKA_2	199	205	PF00069	0.733
MOD_PKA_2	216	222	PF00069	0.691
MOD_PKA_2	228	234	PF00069	0.616
MOD_PKA_2	49	55	PF00069	0.379
MOD_PKA_2	513	519	PF00069	0.676
MOD_PKA_2	525	531	PF00069	0.636
MOD_PKB_1	485	493	PF00069	0.530
MOD_Plk_1	17	23	PF00069	0.548
MOD_Plk_1	192	198	PF00069	0.561
MOD_Plk_1	329	335	PF00069	0.540
MOD_Plk_1	377	383	PF00069	0.493
MOD_Plk_1	608	614	PF00069	0.363
MOD_Plk_1	763	769	PF00069	0.386
MOD_Plk_1	85	91	PF00069	0.555
MOD_Plk_4	117	123	PF00069	0.577
MOD_Plk_4	470	476	PF00069	0.548
MOD_Plk_4	598	604	PF00069	0.349
MOD_Plk_4	608	614	PF00069	0.224
MOD_Plk_4	68	74	PF00069	0.523
MOD_Plk_4	682	688	PF00069	0.481
MOD_Plk_4	736	742	PF00069	0.465
MOD_Plk_4	763	769	PF00069	0.326
MOD_Plk_4	830	836	PF00069	0.500
MOD_ProDKin_1	129	135	PF00069	0.534
MOD_ProDKin_1	188	194	PF00069	0.722
MOD_ProDKin_1	202	208	PF00069	0.692
MOD_ProDKin_1	218	224	PF00069	0.730
MOD_ProDKin_1	265	271	PF00069	0.641
MOD_ProDKin_1	287	293	PF00069	0.568
MOD_ProDKin_1	321	327	PF00069	0.624
MOD_ProDKin_1	509	515	PF00069	0.576
MOD_ProDKin_1	59	65	PF00069	0.417
MOD_ProDKin_1	672	678	PF00069	0.342
MOD_ProDKin_1	859	865	PF00069	0.421
MOD_ProDKin_1	96	102	PF00069	0.487
MOD_SUMO_for_1	387	390	PF00179	0.431
MOD_SUMO_rev_2	61	68	PF00179	0.520
MOD_SUMO_rev_2	81	89	PF00179	0.470
TRG_DiLeu_BaLyEn_6	673	678	PF01217	0.316
TRG_ENDOCYTIC_2	348	351	PF00928	0.458
TRG_ER_diArg_1	168	170	PF00400	0.547
TRG_ER_diArg_1	383	386	PF00400	0.445
TRG_ER_diArg_1	485	488	PF00400	0.540
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	38	43	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCL0	Leptomonas seymouri	70%	99%
A0A1X0P3P9	Trypanosomatidae	46%	100%
A0A3R7KEX8	Trypanosoma rangeli	51%	100%
A0A3S7X3V5	Leishmania donovani	27%	100%
A4HIS9	Leishmania braziliensis	28%	100%
A4HLS7	Leishmania braziliensis	85%	99%
A4I631	Leishmania infantum	27%	100%
A4I986	Leishmania infantum	100%	100%
D0A6A0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9B1B6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B453	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q6U8	Leishmania major	27%	100%
Q9GRN2	Leishmania major	95%	100%
V5DQD1	Trypanosoma cruzi	52%	100%