Mitochondrial_RNA_binding_complex_1_subunit/GeneD B:LmjF.33.2510

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial SSU ribosomal protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X701_LEIDO

TriTrypDb:

LdBPK_332640.1 , LdCL_330033500 , LDHU3_33.3760

Length:

677

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X701

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X701

PDB structure(s): 7ane_l

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009895	negative regulation of catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010628	positive regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0031330	negative regulation of cellular catabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043487	regulation of RNA stability	3	1
GO:0043488	regulation of mRNA stability	4	1
GO:0043489	RNA stabilization	4	1
GO:0043631	RNA polyadenylation	6	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0048255	mRNA stabilization	5	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061013	regulation of mRNA catabolic process	6	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1902369	negative regulation of RNA catabolic process	7	1
GO:1902373	negative regulation of mRNA catabolic process	7	1
GO:1903311	regulation of mRNA metabolic process	6	1
GO:1903312	negative regulation of mRNA metabolic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.665
CLV_C14_Caspase3-7	376	380	PF00656	0.780
CLV_C14_Caspase3-7	483	487	PF00656	0.559
CLV_NRD_NRD_1	228	230	PF00675	0.483
CLV_NRD_NRD_1	33	35	PF00675	0.545
CLV_NRD_NRD_1	388	390	PF00675	0.784
CLV_NRD_NRD_1	435	437	PF00675	0.496
CLV_NRD_NRD_1	601	603	PF00675	0.409
CLV_NRD_NRD_1	641	643	PF00675	0.465
CLV_NRD_NRD_1	78	80	PF00675	0.467
CLV_NRD_NRD_1	85	87	PF00675	0.452
CLV_PCSK_FUR_1	599	603	PF00082	0.417
CLV_PCSK_KEX2_1	228	230	PF00082	0.483
CLV_PCSK_KEX2_1	388	390	PF00082	0.784
CLV_PCSK_KEX2_1	411	413	PF00082	0.449
CLV_PCSK_KEX2_1	435	437	PF00082	0.496
CLV_PCSK_KEX2_1	601	603	PF00082	0.409
CLV_PCSK_KEX2_1	641	643	PF00082	0.445
CLV_PCSK_KEX2_1	78	80	PF00082	0.467
CLV_PCSK_KEX2_1	85	87	PF00082	0.452
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.484
CLV_PCSK_PC7_1	637	643	PF00082	0.547
CLV_PCSK_PC7_1	74	80	PF00082	0.599
CLV_PCSK_SKI1_1	146	150	PF00082	0.371
CLV_PCSK_SKI1_1	151	155	PF00082	0.376
CLV_PCSK_SKI1_1	166	170	PF00082	0.223
CLV_PCSK_SKI1_1	485	489	PF00082	0.482
CLV_PCSK_SKI1_1	517	521	PF00082	0.583
CLV_PCSK_SKI1_1	590	594	PF00082	0.506
CLV_PCSK_SKI1_1	617	621	PF00082	0.479
CLV_Separin_Metazoa	265	269	PF03568	0.604
DEG_Nend_Nbox_1	1	3	PF02207	0.555
DEG_ODPH_VHL_1	416	427	PF01847	0.568
DEG_SPOP_SBC_1	361	365	PF00917	0.521
DOC_CYCLIN_RxL_1	329	338	PF00134	0.411
DOC_MAPK_gen_1	119	128	PF00069	0.410
DOC_MAPK_gen_1	544	551	PF00069	0.410
DOC_MAPK_gen_1	601	610	PF00069	0.441
DOC_MAPK_gen_1	641	649	PF00069	0.423
DOC_MAPK_HePTP_8	105	117	PF00069	0.428
DOC_MAPK_MEF2A_6	108	117	PF00069	0.410
DOC_MAPK_MEF2A_6	544	551	PF00069	0.429
DOC_MAPK_MEF2A_6	586	595	PF00069	0.442
DOC_PP1_RVXF_1	330	337	PF00149	0.372
DOC_PP1_RVXF_1	506	512	PF00149	0.548
DOC_PP2B_LxvP_1	212	215	PF13499	0.559
DOC_PP2B_LxvP_1	415	418	PF13499	0.585
DOC_PP2B_PxIxI_1	112	118	PF00149	0.407
DOC_PP4_FxxP_1	255	258	PF00568	0.469
DOC_USP7_MATH_1	179	183	PF00917	0.631
DOC_USP7_MATH_1	196	200	PF00917	0.552
DOC_USP7_MATH_1	23	27	PF00917	0.535
DOC_USP7_MATH_1	248	252	PF00917	0.545
DOC_USP7_MATH_1	361	365	PF00917	0.599
DOC_USP7_MATH_1	370	374	PF00917	0.705
DOC_USP7_MATH_1	547	551	PF00917	0.507
DOC_USP7_MATH_1	569	573	PF00917	0.629
DOC_USP7_MATH_1	629	633	PF00917	0.610
DOC_USP7_MATH_1	673	677	PF00917	0.608
DOC_USP7_MATH_1	73	77	PF00917	0.594
DOC_WW_Pin1_4	10	15	PF00397	0.427
DOC_WW_Pin1_4	362	367	PF00397	0.639
LIG_14-3-3_CanoR_1	157	162	PF00244	0.452
LIG_14-3-3_CanoR_1	310	316	PF00244	0.582
LIG_14-3-3_CanoR_1	360	366	PF00244	0.585
LIG_14-3-3_CanoR_1	490	494	PF00244	0.588
LIG_14-3-3_CanoR_1	617	625	PF00244	0.435
LIG_14-3-3_CanoR_1	641	649	PF00244	0.493
LIG_14-3-3_CanoR_1	72	78	PF00244	0.517
LIG_Actin_RPEL_3	115	134	PF02755	0.405
LIG_Actin_WH2_2	13	31	PF00022	0.569
LIG_APCC_ABBA_1	126	131	PF00400	0.443
LIG_APCC_ABBA_1	333	338	PF00400	0.356
LIG_APCC_ABBAyCdc20_2	332	338	PF00400	0.375
LIG_CtBP_PxDLS_1	174	180	PF00389	0.550
LIG_deltaCOP1_diTrp_1	135	144	PF00928	0.533
LIG_deltaCOP1_diTrp_1	471	475	PF00928	0.440
LIG_EH_1	345	349	PF12763	0.432
LIG_FHA_1	209	215	PF00498	0.598
LIG_FHA_2	496	502	PF00498	0.491
LIG_GBD_Chelix_1	580	588	PF00786	0.491
LIG_LIR_Apic_2	252	258	PF02991	0.473
LIG_LIR_Apic_2	379	384	PF02991	0.725
LIG_LIR_Apic_2	471	477	PF02991	0.418
LIG_LIR_Gen_1	217	227	PF02991	0.488
LIG_LIR_Gen_1	345	356	PF02991	0.451
LIG_LIR_Gen_1	446	457	PF02991	0.513
LIG_LIR_Gen_1	470	480	PF02991	0.432
LIG_LIR_LC3C_4	578	582	PF02991	0.519
LIG_LIR_Nem_3	164	168	PF02991	0.421
LIG_LIR_Nem_3	18	24	PF02991	0.426
LIG_LIR_Nem_3	217	223	PF02991	0.383
LIG_LIR_Nem_3	313	318	PF02991	0.465
LIG_LIR_Nem_3	345	351	PF02991	0.434
LIG_LIR_Nem_3	38	44	PF02991	0.330
LIG_LIR_Nem_3	470	475	PF02991	0.445
LIG_LIR_Nem_3	518	523	PF02991	0.451
LIG_LIR_Nem_3	644	649	PF02991	0.483
LIG_LYPXL_yS_3	315	318	PF13949	0.427
LIG_MAD2	652	660	PF02301	0.535
LIG_PCNA_PIPBox_1	264	273	PF02747	0.542
LIG_PCNA_PIPBox_1	99	108	PF02747	0.556
LIG_PCNA_yPIPBox_3	261	271	PF02747	0.575
LIG_PCNA_yPIPBox_3	323	334	PF02747	0.470
LIG_PCNA_yPIPBox_3	92	106	PF02747	0.567
LIG_SH2_CRK	150	154	PF00017	0.354
LIG_SH2_CRK	165	169	PF00017	0.394
LIG_SH2_CRK	381	385	PF00017	0.726
LIG_SH2_GRB2like	474	477	PF00017	0.399
LIG_SH2_NCK_1	499	503	PF00017	0.423
LIG_SH2_NCK_1	561	565	PF00017	0.676
LIG_SH2_SRC	499	502	PF00017	0.479
LIG_SH2_STAP1	668	672	PF00017	0.410
LIG_SH2_STAT5	16	19	PF00017	0.407
LIG_SH2_STAT5	167	170	PF00017	0.395
LIG_SH2_STAT5	222	225	PF00017	0.347
LIG_SH2_STAT5	231	234	PF00017	0.364
LIG_SH2_STAT5	30	33	PF00017	0.471
LIG_SH2_STAT5	357	360	PF00017	0.570
LIG_SH2_STAT5	474	477	PF00017	0.407
LIG_SH2_STAT5	532	535	PF00017	0.458
LIG_SH2_STAT5	646	649	PF00017	0.486
LIG_SH3_3	107	113	PF00018	0.403
LIG_SH3_3	306	312	PF00018	0.586
LIG_SH3_3	346	352	PF00018	0.426
LIG_SH3_3	531	537	PF00018	0.459
LIG_SH3_3	552	558	PF00018	0.460
LIG_SH3_3	59	65	PF00018	0.573
LIG_SH3_3	625	631	PF00018	0.556
LIG_SUMO_SIM_par_1	101	107	PF11976	0.422
LIG_TRAF2_1	50	53	PF00917	0.523
LIG_TYR_ITIM	148	153	PF00017	0.353
MOD_CK1_1	182	188	PF00069	0.706
MOD_CK1_1	189	195	PF00069	0.713
MOD_CK1_1	199	205	PF00069	0.625
MOD_CK1_1	362	368	PF00069	0.565
MOD_CK1_1	403	409	PF00069	0.524
MOD_CK1_1	467	473	PF00069	0.510
MOD_CK1_1	489	495	PF00069	0.561
MOD_CK1_1	550	556	PF00069	0.451
MOD_CK2_1	195	201	PF00069	0.784
MOD_CK2_1	370	376	PF00069	0.612
MOD_CK2_1	495	501	PF00069	0.473
MOD_GlcNHglycan	181	184	PF01048	0.734
MOD_GlcNHglycan	201	204	PF01048	0.764
MOD_GlcNHglycan	300	303	PF01048	0.708
MOD_GlcNHglycan	455	458	PF01048	0.608
MOD_GlcNHglycan	466	469	PF01048	0.512
MOD_GlcNHglycan	517	520	PF01048	0.544
MOD_GlcNHglycan	643	646	PF01048	0.524
MOD_GlcNHglycan	655	659	PF01048	0.501
MOD_GSK3_1	157	164	PF00069	0.424
MOD_GSK3_1	182	189	PF00069	0.717
MOD_GSK3_1	195	202	PF00069	0.665
MOD_GSK3_1	272	279	PF00069	0.641
MOD_GSK3_1	298	305	PF00069	0.738
MOD_GSK3_1	356	363	PF00069	0.453
MOD_GSK3_1	528	535	PF00069	0.559
MOD_GSK3_1	654	661	PF00069	0.486
MOD_N-GLC_1	189	194	PF02516	0.706
MOD_N-GLC_1	199	204	PF02516	0.595
MOD_N-GLC_1	248	253	PF02516	0.511
MOD_NEK2_1	253	258	PF00069	0.460
MOD_NEK2_1	426	431	PF00069	0.586
MOD_NEK2_1	44	49	PF00069	0.738
MOD_NEK2_1	453	458	PF00069	0.512
MOD_NEK2_1	654	659	PF00069	0.461
MOD_NEK2_2	67	72	PF00069	0.606
MOD_NEK2_2	73	78	PF00069	0.567
MOD_PIKK_1	276	282	PF00454	0.772
MOD_PK_1	282	288	PF00069	0.732
MOD_PKA_1	641	647	PF00069	0.523
MOD_PKA_2	179	185	PF00069	0.684
MOD_PKA_2	196	202	PF00069	0.655
MOD_PKA_2	298	304	PF00069	0.700
MOD_PKA_2	359	365	PF00069	0.606
MOD_PKA_2	453	459	PF00069	0.517
MOD_PKA_2	489	495	PF00069	0.492
MOD_PKA_2	641	647	PF00069	0.463
MOD_PKA_2	73	79	PF00069	0.573
MOD_PKB_1	308	316	PF00069	0.611
MOD_Plk_1	282	288	PF00069	0.732
MOD_Plk_1	470	476	PF00069	0.424
MOD_Plk_4	208	214	PF00069	0.547
MOD_Plk_4	403	409	PF00069	0.532
MOD_Plk_4	528	534	PF00069	0.525
MOD_Plk_4	547	553	PF00069	0.518
MOD_Plk_4	610	616	PF00069	0.415
MOD_ProDKin_1	10	16	PF00069	0.424
MOD_ProDKin_1	362	368	PF00069	0.653
MOD_SUMO_for_1	260	263	PF00179	0.538
MOD_SUMO_rev_2	32	37	PF00179	0.490
TRG_DiLeu_BaEn_1	326	331	PF01217	0.458
TRG_DiLeu_BaEn_1	338	343	PF01217	0.459
TRG_DiLeu_BaEn_4	460	466	PF01217	0.633
TRG_DiLeu_BaEn_4	483	489	PF01217	0.465
TRG_ENDOCYTIC_2	150	153	PF00928	0.355
TRG_ENDOCYTIC_2	165	168	PF00928	0.398
TRG_ENDOCYTIC_2	220	223	PF00928	0.365
TRG_ENDOCYTIC_2	315	318	PF00928	0.427
TRG_ENDOCYTIC_2	646	649	PF00928	0.435
TRG_ER_diArg_1	227	229	PF00400	0.482
TRG_ER_diArg_1	308	311	PF00400	0.623
TRG_ER_diArg_1	434	436	PF00400	0.489
TRG_ER_diArg_1	599	602	PF00400	0.461
TRG_ER_diArg_1	641	643	PF00400	0.466
TRG_ER_diArg_1	71	74	PF00400	0.535
TRG_ER_diArg_1	77	79	PF00400	0.449
TRG_NES_CRM1_1	583	594	PF08389	0.310
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	435	439	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	652	656	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7Z6	Leptomonas seymouri	70%	92%
A0A0S4IW89	Bodo saltans	35%	100%
A0A1X0P3U7	Trypanosomatidae	50%	93%
A0A422P030	Trypanosoma rangeli	52%	96%
A4HLW2	Leishmania braziliensis	87%	100%
D0A659	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	91%
E9AHR9	Leishmania infantum	100%	100%
E9B490	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q3T6	Leishmania major	95%	100%
V5BP67	Trypanosoma cruzi	50%	98%