HIT_zinc_finger_containing_protein_putative/Pfam: PF04438

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HIT zinc finger, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X700_LEIDO

TriTrypDb:

LdBPK_332240.1 , LdCL_330029400 , LDHU3_33.3220

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0070761	pre-snoRNP complex	3	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3S7X700

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X700

Function

Biological processes
Term	Name	Level	Count
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000470	maturation of LSU-rRNA	9	1
GO:0000491	small nucleolar ribonucleoprotein complex assembly	7	1
GO:0000492	box C/D snoRNP assembly	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006403	RNA localization	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0033036	macromolecule localization	2	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043933	protein-containing complex organization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0048254	snoRNA localization	4	1
GO:0051179	localization	1	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	188	192	PF00656	0.442
CLV_NRD_NRD_1	99	101	PF00675	0.564
CLV_PCSK_KEX2_1	73	75	PF00082	0.630
CLV_PCSK_KEX2_1	99	101	PF00082	0.564
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.598
CLV_PCSK_SKI1_1	119	123	PF00082	0.728
CLV_PCSK_SKI1_1	168	172	PF00082	0.490
CLV_PCSK_SKI1_1	178	182	PF00082	0.513
DEG_APCC_DBOX_1	186	194	PF00400	0.547
DEG_Nend_UBRbox_1	1	4	PF02207	0.406
DEG_SPOP_SBC_1	106	110	PF00917	0.655
DEG_SPOP_SBC_1	48	52	PF00917	0.626
DOC_USP7_MATH_1	135	139	PF00917	0.702
DOC_USP7_MATH_1	17	21	PF00917	0.546
DOC_USP7_MATH_1	48	52	PF00917	0.626
DOC_WW_Pin1_4	102	107	PF00397	0.623
DOC_WW_Pin1_4	170	175	PF00397	0.549
LIG_14-3-3_CanoR_1	166	174	PF00244	0.558
LIG_14-3-3_CanoR_1	74	83	PF00244	0.587
LIG_14-3-3_CanoR_1	99	107	PF00244	0.561
LIG_DLG_GKlike_1	172	179	PF00625	0.508
LIG_FHA_2	75	81	PF00498	0.594
LIG_LIR_Gen_1	50	61	PF02991	0.505
LIG_LIR_Gen_1	82	92	PF02991	0.619
LIG_LIR_Nem_3	202	206	PF02991	0.393
LIG_LIR_Nem_3	50	56	PF02991	0.524
LIG_LIR_Nem_3	82	87	PF02991	0.613
LIG_PTB_Apo_2	197	204	PF02174	0.453
LIG_SH2_NCK_1	198	202	PF00017	0.525
LIG_SH2_STAT3	151	154	PF00017	0.534
LIG_SH2_STAT5	151	154	PF00017	0.549
LIG_SH2_STAT5	22	25	PF00017	0.471
LIG_TRAF2_1	34	37	PF00917	0.558
MOD_CK1_1	185	191	PF00069	0.500
MOD_CK1_1	85	91	PF00069	0.619
MOD_CK2_1	74	80	PF00069	0.559
MOD_GlcNHglycan	137	140	PF01048	0.692
MOD_GlcNHglycan	168	171	PF01048	0.509
MOD_GlcNHglycan	19	22	PF01048	0.303
MOD_GSK3_1	166	173	PF00069	0.528
MOD_GSK3_1	17	24	PF00069	0.539
MOD_GSK3_1	179	186	PF00069	0.516
MOD_GSK3_1	98	105	PF00069	0.783
MOD_N-GLC_1	102	107	PF02516	0.614
MOD_NEK2_1	56	61	PF00069	0.500
MOD_PIKK_1	22	28	PF00454	0.510
MOD_PKA_2	98	104	PF00069	0.566
MOD_Plk_4	56	62	PF00069	0.510
MOD_ProDKin_1	102	108	PF00069	0.625
MOD_ProDKin_1	170	176	PF00069	0.541
TRG_ER_diArg_1	13	16	PF00400	0.471
TRG_ER_diArg_1	165	168	PF00400	0.576
TRG_ER_diArg_1	187	190	PF00400	0.470
TRG_ER_diArg_1	98	100	PF00400	0.565
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTG1	Leptomonas seymouri	50%	79%
A0A422NI17	Trypanosoma rangeli	32%	100%
A4HLS4	Leishmania braziliensis	73%	98%
A4I983	Leishmania infantum	100%	100%
D0A6A4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B450	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q3X5	Leishmania major	89%	100%