Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X6Z5_LEIDO

TriTrypDb:

LdBPK_332180.1 , LdCL_330028800 , LDHU3_33.3160

Length:

116

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X6Z5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6Z5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.660
CLV_NRD_NRD_1	13	15	PF00675	0.647
CLV_NRD_NRD_1	3	5	PF00675	0.597
CLV_PCSK_KEX2_1	13	15	PF00082	0.623
CLV_PCSK_KEX2_1	3	5	PF00082	0.597
CLV_PCSK_SKI1_1	4	8	PF00082	0.663
DEG_APCC_DBOX_1	3	11	PF00400	0.424
DEG_Nend_Nbox_1	1	3	PF02207	0.413
DOC_USP7_MATH_1	15	19	PF00917	0.465
LIG_14-3-3_CanoR_1	63	71	PF00244	0.588
LIG_FHA_1	35	41	PF00498	0.382
LIG_FHA_2	81	87	PF00498	0.607
LIG_SH2_GRB2like	25	28	PF00017	0.446
LIG_SH2_STAT5	23	26	PF00017	0.398
LIG_SH2_STAT5	58	61	PF00017	0.470
LIG_UBA3_1	101	109	PF00899	0.463
MOD_CK1_1	34	40	PF00069	0.466
MOD_CK2_1	80	86	PF00069	0.510
MOD_Cter_Amidation	11	14	PF01082	0.534
MOD_GlcNHglycan	17	20	PF01048	0.660
MOD_GlcNHglycan	33	36	PF01048	0.451
MOD_GSK3_1	15	22	PF00069	0.614
MOD_NEK2_1	42	47	PF00069	0.290
MOD_PKA_2	62	68	PF00069	0.465
MOD_Plk_4	42	48	PF00069	0.285
TRG_ENDOCYTIC_2	58	61	PF00928	0.422
TRG_ER_diArg_1	2	4	PF00400	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDB8	Leptomonas seymouri	70%	100%
A0A0S4J4D8	Bodo saltans	55%	100%
A0A1X0P3Q8	Trypanosomatidae	60%	97%
A0A422N431	Trypanosoma rangeli	62%	97%
A4HLR8	Leishmania braziliensis	86%	100%
A4I944	Leishmania infantum	100%	100%
D0A6A7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	96%
E9B444	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q3Y1	Leishmania major	94%	100%